KR101027977B1 - 퀴놀린 유도체 - Google Patents

퀴놀린 유도체 Download PDF

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Publication number
KR101027977B1
KR101027977B1 KR1020047012409A KR20047012409A KR101027977B1 KR 101027977 B1 KR101027977 B1 KR 101027977B1 KR 1020047012409 A KR1020047012409 A KR 1020047012409A KR 20047012409 A KR20047012409 A KR 20047012409A KR 101027977 B1 KR101027977 B1 KR 101027977B1
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KR
South Korea
Prior art keywords
compound
formula
present
compounds
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020047012409A
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English (en)
Korean (ko)
Other versions
KR20040089615A (ko
Inventor
굴피터
폼보빌라르에스테반
Original Assignee
노파르티스 아게
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Publication date
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20040089615A publication Critical patent/KR20040089615A/ko
Application granted granted Critical
Publication of KR101027977B1 publication Critical patent/KR101027977B1/ko
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020047012409A 2002-03-07 2003-03-06 퀴놀린 유도체 Expired - Fee Related KR101027977B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP02005117 2002-03-07
EP02005115 2002-03-07
EP02005115.7 2002-03-07
EP02005117.3 2002-03-07
PCT/EP2003/002321 WO2003074511A1 (en) 2002-03-07 2003-03-06 Quinoline derivatives

Publications (2)

Publication Number Publication Date
KR20040089615A KR20040089615A (ko) 2004-10-21
KR101027977B1 true KR101027977B1 (ko) 2011-04-13

Family

ID=27790094

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047012409A Expired - Fee Related KR101027977B1 (ko) 2002-03-07 2003-03-06 퀴놀린 유도체

Country Status (28)

Country Link
US (2) US7399768B2 (enExample)
EP (1) EP1480970B1 (enExample)
JP (2) JP2005519117A (enExample)
KR (1) KR101027977B1 (enExample)
CN (2) CN1939915A (enExample)
AR (1) AR038730A1 (enExample)
AU (1) AU2003219023B2 (enExample)
BR (1) BR0308201A (enExample)
CA (2) CA2706618A1 (enExample)
CO (1) CO5611196A2 (enExample)
CY (1) CY1106409T1 (enExample)
DE (1) DE60311233T2 (enExample)
DK (1) DK1480970T3 (enExample)
EC (1) ECSP045271A (enExample)
EG (1) EG24415A (enExample)
ES (1) ES2279100T3 (enExample)
IL (1) IL163769A0 (enExample)
MX (1) MXPA04008666A (enExample)
MY (1) MY134325A (enExample)
NO (1) NO20044117L (enExample)
NZ (1) NZ534732A (enExample)
PE (1) PE20030927A1 (enExample)
PL (2) PL210336B1 (enExample)
PT (1) PT1480970E (enExample)
RU (1) RU2345991C2 (enExample)
SI (1) SI1480970T1 (enExample)
TW (1) TW200406401A (enExample)
WO (1) WO2003074511A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60328732D1 (de) * 2002-03-07 2009-09-17 Novartis Ag Chinolinderivate und ihre Anwendung bei Glaukom und Kurzsichtigkeit
KR102712887B1 (ko) 2017-11-24 2024-10-02 하. 룬드벡 아크티에셀스카브 파킨슨병의 치료에 사용하기 위한 새로운 카테콜아민 전구약물
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
CN113677675B (zh) 2019-05-21 2024-07-26 H.隆德贝克有限公司 用于治疗帕金森病的新儿茶酚胺前药
JP7562562B2 (ja) 2019-05-21 2024-10-07 ハー・ルンドベック・アクチエゼルスカベット パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ
US12398106B2 (en) 2019-05-21 2025-08-26 H. Lundbeck A/S Catecholamine carbamate prodrugs for use in the treatment of parkinson's disease
EP3972970A1 (en) 2019-05-21 2022-03-30 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998001444A1 (en) * 1996-07-08 1998-01-15 Novartis Ag BENZO[g]QUINOLINE DERIVATIVES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100555A (en) * 1991-02-07 2000-08-31 Hoechst Marion Roussel Inc N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
GB9326010D0 (en) * 1993-12-21 1994-02-23 Sandoz Ltd Improvements in or relating to organic compounds
PE20030240A1 (es) * 2001-07-09 2003-04-16 Novartis Ag DERIVADOS DE BENZO [g] QUINOLINA

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998001444A1 (en) * 1996-07-08 1998-01-15 Novartis Ag BENZO[g]QUINOLINE DERIVATIVES

Also Published As

Publication number Publication date
CO5611196A2 (es) 2006-02-28
US20080255176A1 (en) 2008-10-16
WO2003074511A1 (en) 2003-09-12
CN1639148A (zh) 2005-07-13
PL210336B1 (pl) 2012-01-31
DK1480970T3 (da) 2007-03-05
RU2345991C2 (ru) 2009-02-10
CN1939915A (zh) 2007-04-04
PE20030927A1 (es) 2003-12-26
CY1106409T1 (el) 2011-10-12
PL370915A1 (en) 2005-06-13
ES2279100T3 (es) 2007-08-16
CA2477720A1 (en) 2003-09-12
BR0308201A (pt) 2005-01-04
KR20040089615A (ko) 2004-10-21
CN1293070C (zh) 2007-01-03
JP2010095550A (ja) 2010-04-30
AU2003219023B2 (en) 2006-11-30
EP1480970A1 (en) 2004-12-01
DE60311233D1 (de) 2007-03-08
CA2706618A1 (en) 2003-09-12
AR038730A1 (es) 2005-01-26
MXPA04008666A (es) 2004-12-06
US20050234085A1 (en) 2005-10-20
MY134325A (en) 2007-12-31
PL394208A1 (pl) 2011-08-16
SI1480970T1 (sl) 2007-06-30
ECSP045271A (es) 2004-10-26
PT1480970E (pt) 2007-03-30
EG24415A (en) 2009-05-25
CA2477720C (en) 2010-09-21
IL163769A0 (en) 2005-12-18
PL215012B1 (pl) 2013-10-31
TW200406401A (en) 2004-05-01
US7399768B2 (en) 2008-07-15
EP1480970B1 (en) 2007-01-17
JP2005519117A (ja) 2005-06-30
NO20044117L (no) 2004-09-28
NZ534732A (en) 2006-05-26
AU2003219023A1 (en) 2003-09-16
DE60311233T2 (de) 2007-11-15
RU2004129767A (ru) 2005-06-27
HK1071364A1 (en) 2005-07-15

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