PE20030927A1 - Derivados de quinolina - Google Patents

Derivados de quinolina

Info

Publication number
PE20030927A1
PE20030927A1 PE2003000212A PE2003000212A PE20030927A1 PE 20030927 A1 PE20030927 A1 PE 20030927A1 PE 2003000212 A PE2003000212 A PE 2003000212A PE 2003000212 A PE2003000212 A PE 2003000212A PE 20030927 A1 PE20030927 A1 PE 20030927A1
Authority
PE
Peru
Prior art keywords
quinoline
octahidrobenzo
metoxy
methyl
quinoline derivatives
Prior art date
Application number
PE2003000212A
Other languages
English (en)
Inventor
Villar Esteban Pombo
Peter Gull
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20030927A1 publication Critical patent/PE20030927A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA Ia DONDE A Y Q SON H O JUNTOS FORMAN UN ENLACE ADICIONAL DONDE EL CENTRO ASIMETRICO EN LA POSICION 3 PUEDE SER RACEMICO O PUEDE ESTAR EN UNA FORMA OPTICAMENTE ACTIVA Y R ES EL GRUPO Ib, Ic; R1 ES ALQUILO EN FORMA DE BASE LIBRE O SAL DE ADICION DE ACIDO. SON COMPUESTOS PREFERIDOS [3R,4aR,10aR]-1-METIL-3ß-HIDROXIMETIL-6-METOXI-1,2,3,4,4aO,5,10,10,10aß-OCTAHIDROBENZO[g]QUINOLINA, [3R,4aR,10aR]-1-METIL-3ß-MESILOXIMETIL-6-METOXI-1,2,3,4,4aO,5,10,10,10aß-OCTAHIDROBENZO[g]QUINOLINA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON UTILES EN EL TRATAMIENTO DE GLAUCOMA, MIOPIA
PE2003000212A 2002-03-07 2003-03-05 Derivados de quinolina PE20030927A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02005117 2002-03-07
EP02005115 2002-03-07

Publications (1)

Publication Number Publication Date
PE20030927A1 true PE20030927A1 (es) 2003-12-26

Family

ID=27790094

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000212A PE20030927A1 (es) 2002-03-07 2003-03-05 Derivados de quinolina

Country Status (29)

Country Link
US (2) US7399768B2 (es)
EP (1) EP1480970B1 (es)
JP (2) JP2005519117A (es)
KR (1) KR101027977B1 (es)
CN (2) CN1939915A (es)
AR (1) AR038730A1 (es)
AU (1) AU2003219023B2 (es)
BR (1) BR0308201A (es)
CA (2) CA2477720C (es)
CO (1) CO5611196A2 (es)
CY (1) CY1106409T1 (es)
DE (1) DE60311233T2 (es)
DK (1) DK1480970T3 (es)
EC (1) ECSP045271A (es)
EG (1) EG24415A (es)
ES (1) ES2279100T3 (es)
HK (1) HK1071364A1 (es)
IL (1) IL163769A0 (es)
MX (1) MXPA04008666A (es)
MY (1) MY134325A (es)
NO (1) NO20044117L (es)
NZ (1) NZ534732A (es)
PE (1) PE20030927A1 (es)
PL (2) PL215012B1 (es)
PT (1) PT1480970E (es)
RU (1) RU2345991C2 (es)
SI (1) SI1480970T1 (es)
TW (1) TW200406401A (es)
WO (1) WO2003074511A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1757601B1 (en) * 2002-03-07 2009-08-05 Novartis AG Quinoline derivatives and their use in glaucoma and myopia
US10729710B2 (en) 2017-11-24 2020-08-04 H. Lundbeck A/S Catecholamine prodrugs for use in the treatment of Parkinson's disease
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100555A (en) * 1991-02-07 2000-08-31 Hoechst Marion Roussel Inc N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
GB9326010D0 (en) * 1993-12-21 1994-02-23 Sandoz Ltd Improvements in or relating to organic compounds
TW378209B (en) * 1996-07-08 2000-01-01 Novartis Ag Benzo[g]quinoline derivatives, their preparation and the pharmaceutical composition containing them
PE20030240A1 (es) * 2001-07-09 2003-04-16 Novartis Ag DERIVADOS DE BENZO [g] QUINOLINA

Also Published As

Publication number Publication date
HK1071364A1 (en) 2005-07-15
EP1480970B1 (en) 2007-01-17
ES2279100T3 (es) 2007-08-16
IL163769A0 (en) 2005-12-18
ECSP045271A (es) 2004-10-26
CN1639148A (zh) 2005-07-13
AU2003219023A1 (en) 2003-09-16
PT1480970E (pt) 2007-03-30
KR101027977B1 (ko) 2011-04-13
CN1939915A (zh) 2007-04-04
PL370915A1 (en) 2005-06-13
MXPA04008666A (es) 2004-12-06
US20080255176A1 (en) 2008-10-16
SI1480970T1 (sl) 2007-06-30
US7399768B2 (en) 2008-07-15
TW200406401A (en) 2004-05-01
AU2003219023B2 (en) 2006-11-30
PL210336B1 (pl) 2012-01-31
PL394208A1 (pl) 2011-08-16
BR0308201A (pt) 2005-01-04
DE60311233T2 (de) 2007-11-15
DK1480970T3 (da) 2007-03-05
CA2477720A1 (en) 2003-09-12
RU2345991C2 (ru) 2009-02-10
RU2004129767A (ru) 2005-06-27
US20050234085A1 (en) 2005-10-20
EP1480970A1 (en) 2004-12-01
JP2010095550A (ja) 2010-04-30
WO2003074511A1 (en) 2003-09-12
CA2706618A1 (en) 2003-09-12
CA2477720C (en) 2010-09-21
JP2005519117A (ja) 2005-06-30
DE60311233D1 (de) 2007-03-08
EG24415A (en) 2009-05-25
PL215012B1 (pl) 2013-10-31
NO20044117L (no) 2004-09-28
KR20040089615A (ko) 2004-10-21
CO5611196A2 (es) 2006-02-28
CN1293070C (zh) 2007-01-03
CY1106409T1 (el) 2011-10-12
AR038730A1 (es) 2005-01-26
NZ534732A (en) 2006-05-26
MY134325A (en) 2007-12-31

Similar Documents

Publication Publication Date Title
PE20040696A1 (es) Derivados de acido mandelico como inhibidores de la formacion de factores de coagulacion
UY32314A (es) Derivados de 4-fenil-piridina
PE1998A1 (es) DERIVADOS DE BENZO [g] QUINOLINA
FI904327A0 (fi) N-substituerad-4-pyrimidinaminer och -pyrimidindiaminer, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
PE20021002A1 (es) Compuestos heterociclicos condensados
PE20020719A1 (es) Derivados de carbamato de quinuclidina como agentes antimuscarinicos m3
PE20060589A1 (es) FENILAMINOTIAZOLES SUSTITUIDOS COMO AGONISTAS DE ADENOSINA A1 Y A2b
AR030324A1 (es) Derivados de 4-fenil-piridina
CO5580803A2 (es) Derivados de piperidin-bencensulfonamida
ATE68473T1 (de) 1-phenyl-3-naphthalenyloxy-propanamine.
AR038341A1 (es) Compuestos que son agonistas de receptores alfa-1 preferentemente agonistas de receptores alfa-1a/l
PE20060298A1 (es) Derivados de acido carboxilico de bencimidazolona
AR053109A1 (es) DERIVADOS DE PIPERIDINA Y PIPERAZINA, UN METODO PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y SU USO EN LA ELABORACIoN DE MEDICAMENTOS PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR EL RECEPTOR DE QUIMIOQUINA CCR2.
AR039226A2 (es) Compuestos utiles como intermediarios de preparacion y procedimientos
EA200300718A1 (ru) Производные 3-индолина, которые могут применяться при лечении психиатрических и неврологических расстройств
SE0101579D0 (sv) New compounds
PE20030927A1 (es) Derivados de quinolina
KR950011444A (ko) 갈란타민 유도체, 이의 제조방법 및 약제로서의 이의 용도
PE20020210A1 (es) Indoloquinazolinonas como inhibidores de poli(adp-ribosa)polimerasa (parp)
AR049995A1 (es) Un procedimiento de preparacion de derivados n-piperidino-1,5-difenilpirazol-3-carboxamida
AR041991A1 (es) Compuestos depirazol para el tratamiento de la hipertension ocular
NO20050612L (no) Pyrrolidinderivater som oksytocinantagonister
NO902555L (no) N-heteroaryl-purin-6-aminer og fremgangsmaate for fremstilling derav.
NO905172D0 (no) Aminokarbonylkarbamater beslektet med fysostigmin og fremgangsmaate for fremstilling derav.
PE20000724A1 (es) 1,2,3,4-tetrahidroquinolina

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed