KR101014544B1 - 감염성 키메라 dna 클론, 키메라 돼지 서코바이러스 및이의 용도 - Google Patents

감염성 키메라 dna 클론, 키메라 돼지 서코바이러스 및이의 용도 Download PDF

Info

Publication number
KR101014544B1
KR101014544B1 KR1020047009126A KR20047009126A KR101014544B1 KR 101014544 B1 KR101014544 B1 KR 101014544B1 KR 1020047009126 A KR1020047009126 A KR 1020047009126A KR 20047009126 A KR20047009126 A KR 20047009126A KR 101014544 B1 KR101014544 B1 KR 101014544B1
Authority
KR
South Korea
Prior art keywords
pcv2
pcv1
chimeric
pigs
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1020047009126A
Other languages
English (en)
Korean (ko)
Other versions
KR20040086243A (ko
Inventor
샹-진 멍
마르틴 페녹스
패트릭 지 할부르
Original Assignee
아이오와 스테이트 유니버시티 리서치 파운데이션, 인코퍼레이티드
버지니아 테크 인터렉추얼 프라퍼티스, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아이오와 스테이트 유니버시티 리서치 파운데이션, 인코퍼레이티드, 버지니아 테크 인터렉추얼 프라퍼티스, 인크. filed Critical 아이오와 스테이트 유니버시티 리서치 파운데이션, 인코퍼레이티드
Publication of KR20040086243A publication Critical patent/KR20040086243A/ko
Application granted granted Critical
Publication of KR101014544B1 publication Critical patent/KR101014544B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/10011Circoviridae
    • C12N2750/10022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/10011Circoviridae
    • C12N2750/10034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/10011Circoviridae
    • C12N2750/10061Methods of inactivation or attenuation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020047009126A 2001-12-12 2002-12-11 감염성 키메라 dna 클론, 키메라 돼지 서코바이러스 및이의 용도 Expired - Lifetime KR101014544B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US34077501P 2001-12-12 2001-12-12
US60/340,775 2001-12-12
US42484002P 2002-11-08 2002-11-08
US60/424,840 2002-11-08
US10/314,512 2002-12-09
US10/314,512 US7276353B2 (en) 2001-12-12 2002-12-09 Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
PCT/US2002/039646 WO2003049703A2 (en) 2001-12-12 2002-12-11 Chimeric infectious dna clones, chimeric porcine circoviruses and uses thereof

Publications (2)

Publication Number Publication Date
KR20040086243A KR20040086243A (ko) 2004-10-08
KR101014544B1 true KR101014544B1 (ko) 2011-02-16

Family

ID=27405726

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047009126A Expired - Lifetime KR101014544B1 (ko) 2001-12-12 2002-12-11 감염성 키메라 dna 클론, 키메라 돼지 서코바이러스 및이의 용도

Country Status (30)

Country Link
US (1) US7276353B2 (enExample)
EP (5) EP3388515A1 (enExample)
JP (1) JP4623964B2 (enExample)
KR (1) KR101014544B1 (enExample)
CN (2) CN1620310B (enExample)
AT (1) ATE487490T1 (enExample)
AU (3) AU2002362147C1 (enExample)
BE (1) BE2011C008I2 (enExample)
BR (1) BRPI0214919B1 (enExample)
CA (2) CA2784260C (enExample)
CO (1) CO5590938A2 (enExample)
CY (3) CY1111167T1 (enExample)
DE (2) DE60238278D1 (enExample)
DK (3) DK2263689T3 (enExample)
ES (3) ES2694505T3 (enExample)
FR (1) FR11C0014I2 (enExample)
HR (3) HRP20140003B1 (enExample)
HU (5) HU230576B1 (enExample)
LT (1) LT2264050T (enExample)
LU (1) LU91814I2 (enExample)
ME (1) ME00126B (enExample)
MX (1) MXPA04005364A (enExample)
NL (1) NL300480I2 (enExample)
NZ (2) NZ533256A (enExample)
PL (3) PL214803B1 (enExample)
PT (3) PT2263689E (enExample)
RS (1) RS51288B (enExample)
SI (3) SI1487483T1 (enExample)
TW (1) TWI314580B (enExample)
WO (1) WO2003049703A2 (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2772047B1 (fr) * 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
CN1749397B (zh) * 2004-08-18 2010-12-08 金宁一 共表达猪圆环病毒及口蹄疫病毒的二联重组活载体疫苗
US7700285B1 (en) 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
US7833707B2 (en) * 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
PT2281829E (pt) 2004-12-30 2015-02-18 Boehringer Ingelheim Vetmed Composições imunogénicas de pcv2 para utilização num método de prevenção de infecção de pcv2
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
CN1328373C (zh) * 2005-04-07 2007-07-25 南京农业大学 猪ⅱ型圆环病毒重组腺病毒
MX2007016083A (es) * 2005-06-24 2008-03-10 Intervet Int Bv Vacunas quimericas inactivadas y metodos relacionados de uso.
UA95458C2 (ru) * 2005-09-09 2011-08-10 Интервет Интернешонал Б.В. Вакцина против pcv-2 у mda-положительных поросят
CN102698263B (zh) 2005-12-29 2016-07-06 贝林格尔.英格海姆维特梅迪卡有限公司 多价pcv2免疫原性组合物和制备此类组合物的方法
ES2553254T3 (es) * 2005-12-29 2015-12-07 Boehringer Ingelheim Vetmedica, Inc. Uso de una composición inmunogénica de PCV2 para reducir los síntomas clínicos en cerdos
JP4625485B2 (ja) * 2006-09-29 2011-02-02 財団法人大阪産業振興機構 高病原性トリインフルエンザウイルスに対するモノクローナル抗体
EP2099927A4 (en) * 2006-11-22 2010-05-05 Boehringer Ingelheim Vetmed Methods of reducing porcine circovirus-associated disease outbreaks
EP2101815A4 (en) 2006-12-11 2010-10-06 Boehringer Ingelheim Vetmed Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
RU2520087C2 (ru) 2006-12-15 2014-06-20 Бёрингер Ингельхайм Ветмедика, Инк. Лечение свиней с помощью антигена pcv2
EP1941903A1 (en) * 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
BRPI0812124A2 (pt) * 2007-05-30 2014-10-14 Wyeth Llc Poxviridae de guaxinim expressando genes de vírus suíno
US20090017064A1 (en) * 2007-07-10 2009-01-15 Wyeth Methods and Compositions for Immunizing Pigs Against Porcine Circovirus
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
KR101225304B1 (ko) * 2007-11-06 2013-01-22 와이어쓰 엘엘씨 마이코플라스마 하이오뉴모니아에 비독성 항원보강된 살아있는 백신
EP2225367A1 (en) * 2007-12-21 2010-09-08 Wyeth LLC Methods and compositions for immunizing pigs against porcine circovirus
WO2009088950A2 (en) * 2007-12-31 2009-07-16 Boehringer Ingelheim Vetmedica, Inc. Pcv2 orf2 virus like particle with foreign amino acid insertion
EP2242511A4 (en) * 2008-01-23 2012-10-24 Boehringer Ingelheim Vetmed IMMUNOGENIC COMPOSITIONS OF MYCOPLASMA HYOPNEUMONIAE PCV2, AND METHODS FOR PRODUCING SUCH COMPOSITIONS
US20110033495A1 (en) * 2008-02-15 2011-02-10 Boehringer Ingelheim Vetmedica, Inc. Methods and compositions for reducing the impact of enteric diseases
CA2721513A1 (en) * 2008-04-16 2009-10-22 Virginia Tech Intellectual Properties, Inc. Chimeric porcine circovirus pcv2gen-1rep and uses thereof
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
ES2773722T3 (es) 2010-03-16 2020-07-14 Virginia Tech Intellectual Properties Inc Vacuna de circovirus porcino quimérico atenuado vivo
TWI508974B (zh) 2010-12-22 2015-11-21 Sbc Virbac Ltd 豬第二型環狀病毒(Porcine Circovirus Type 2)、含彼之免疫組合物、檢測套組及其應用
EP2660356A4 (en) 2010-12-28 2014-07-09 Jx Nippon Oil & Energy Corp DEVICE FOR HYDROGENATING ORGANIC COMPOUNDS AND HYDROGENATION METHODS
HUP1100470A2 (en) * 2011-08-30 2013-03-28 Mezoegazdasagi Biotechnologiai Kutatokoezpont Nanoparticle-based veterinary vaccine
UA113192C2 (xx) 2011-12-06 2016-12-26 Імуногенна композиція проти цирковірусу свиней типу 2 (pcv2)
US9120859B2 (en) 2012-04-04 2015-09-01 Zoetis Services Llc Mycoplasma hyopneumoniae vaccine
UA114504C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs
UA114503C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv та mycoplasma hyopneumoniae
KR102217387B1 (ko) * 2013-03-11 2021-02-19 주식회사 중앙백신연구소 재조합 효모 전세포(yeast whole cell)을 이용한 돼지 써코바이러스(PCV2) 서브유닛 백신과 그의 제조 방법
BR112016006192A2 (pt) 2013-09-25 2017-09-26 Zoetis Services Llc composição de vacina de divergente de pcv2b e métodos de uso
MX373884B (es) 2013-10-02 2020-03-26 Boehringer Ingelheim Animal Health Usa Inc Variante de la proteína pcv2 orf2 y partículas similares al virus compuestas por ésta.
CN103602759B (zh) * 2013-11-22 2015-09-23 福建省农业科学院畜牧兽医研究所 一种区别鸭圆环病毒和鹅圆环病毒的pcr-rflp方法
BR112016012435A8 (pt) 2013-12-03 2018-01-30 Intervet Int Bv vacina, e, usos de uma proteína orf2 recombinantemente expressada do circovírus porcino tipo 2
EP3426293A4 (en) * 2016-03-07 2019-10-30 Virginia Tech Intellectual Properties, Inc. CHIMERIC VACCINES AGAINST PORCINE CIRCOVIRUS TYPE 2 (PCV2)
CN106497892A (zh) * 2016-09-07 2017-03-15 扬州大学 带KT3标签的重组病毒rPCV2‑KT3的构建方法
AU2019242601B2 (en) 2018-03-26 2025-12-04 Boehringer Ingelheim Animal Health USA Inc. Method of producing an immunogenic composition
CN112898435B (zh) * 2021-01-14 2023-03-31 山西农业大学 一种可溶性融合蛋白DT390-Cap及其制备方法与应用
AU2024266173A1 (en) 2023-05-03 2025-12-11 Boehringer Ingelheim Vetmedica Gmbh Immunogenic composition useful for self-administration by pigs
AR132582A1 (es) 2023-05-03 2025-07-16 Boehringer Ingelheim Vetmedica Gmbh Método para inducir una respuesta inmunitaria
US20250332242A1 (en) 2024-04-30 2025-10-30 Zoetis Services Llc Porcine endogenous retrovirus (perv)-free porcine circovirus type 2d-based vaccines and methods of use
US20250332243A1 (en) 2024-04-30 2025-10-30 Zoetis Services Llc Methods of manufacturing porcine endogenous retrovirus (perv) free animal health vaccines

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391314B1 (en) 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
FR2769321B1 (fr) 1997-10-03 2001-10-26 Merial Sas Nouveaux circovirus porcins, vaccins et reactifs de diagnostics
FR2781159B1 (fr) 1998-07-06 2000-10-06 Merial Sas Vaccin circovirus et parvovirus porcin
WO1999029717A2 (en) * 1997-12-11 1999-06-17 University Of Saskatchewan Postweaning multisystemic wasting syndrome virus from pigs
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
FR2769322B1 (fr) 1997-10-03 2002-03-08 Merial Sas Nouveaux circovirus porcins, vaccins et reactifs de diagnostic
UA78180C2 (uk) 1997-10-03 2007-03-15 Меріаль Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти
FR2772047B1 (fr) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
AU770002B2 (en) 1998-03-13 2004-02-12 University Of Georgia Research Foundation, Inc., The Vaccines against circovirus infections
US6497883B1 (en) 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
US6943152B1 (en) 1999-06-10 2005-09-13 Merial DNA vaccine-PCV
CA2413265A1 (en) 2000-05-03 2001-11-08 University Of Guelph Porcine adenovirus type 5 vector and vaccine
PL360096A1 (en) 2000-05-24 2004-09-06 Merial Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine
JP2004503234A (ja) 2000-06-15 2004-02-05 パーデュー・リサーチ・ファウンデーション ブタの先天性振せん用ワクチン
DE10044648A1 (de) 2000-09-08 2002-03-21 Aventis Behring Gmbh Verfahren zur Vermehrung oder zur Entfernung von Cirocoviren aus biologischem Material
US6794163B2 (en) 2001-03-27 2004-09-21 University Of Saskatchewan Methods to culture circovirus
AUPR567401A0 (en) 2001-06-14 2001-07-12 University Of Melbourne, The Circovirus vaccines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of Virology, vol.77(20), pp. 11232-11243.(2003. 10.)*
Viral Immunology, vol.13(2), pp.143-153(2000.)*

Also Published As

Publication number Publication date
BE2011C008I2 (enExample) 2022-02-02
EP2264050A3 (en) 2011-04-20
CN1620310B (zh) 2014-11-26
CN103536911B (zh) 2019-09-13
DE60238278D1 (de) 2010-12-23
DK2263689T3 (en) 2015-02-02
EP2263689A2 (en) 2010-12-22
DE122011100001I1 (de) 2011-09-08
SI1487483T1 (sl) 2011-03-31
US20030170270A1 (en) 2003-09-11
KR20040086243A (ko) 2004-10-08
EP1487483A2 (en) 2004-12-22
EP1487483A4 (en) 2006-02-15
PL374382A1 (en) 2005-10-17
HU228584B1 (en) 2013-04-29
HUP0501000A2 (en) 2007-12-28
HUP1300097A2 (en) 2007-12-28
PT2264050T (pt) 2018-11-21
CN1620310A (zh) 2005-05-25
LU91814I2 (fr) 2011-07-04
AU2002362147A1 (en) 2003-06-23
EP2263690A3 (en) 2011-06-08
CN103536911A (zh) 2014-01-29
ES2529726T3 (es) 2015-02-25
EP2264050A2 (en) 2010-12-22
AU2011200843A1 (en) 2011-03-17
WO2003049703A8 (en) 2005-12-01
HRP20140002B1 (hr) 2020-10-16
PL215058B1 (pl) 2013-10-31
FR11C0014I1 (enExample) 2011-06-17
HRP20040626B9 (hr) 2016-09-23
RS51704A (sr) 2006-10-27
EP2263689A3 (en) 2011-04-20
US7276353B2 (en) 2007-10-02
SI2264050T1 (sl) 2018-12-31
HRP20140002A2 (hr) 2014-11-07
AU2002362147C1 (en) 2012-05-17
NZ567688A (en) 2009-09-25
PT1487483E (pt) 2011-02-10
LT2264050T (lt) 2018-11-26
EP3388515A1 (en) 2018-10-17
HRP20140003A2 (hr) 2014-11-07
HUS2100036I1 (hu) 2021-09-28
BR0214919A (pt) 2006-05-30
ME00126B (me) 2010-10-10
HU231018B1 (hu) 2019-11-28
MXPA04005364A (es) 2004-09-27
BRPI0214919B1 (pt) 2015-09-15
PL395509A1 (pl) 2011-12-19
NZ533256A (en) 2008-06-30
EP2263690A2 (en) 2010-12-22
ES2694505T3 (es) 2018-12-21
JP4623964B2 (ja) 2011-02-02
ES2355814T3 (es) 2011-03-31
TWI314580B (en) 2009-09-11
PT2263689E (pt) 2015-02-13
AU2002362147B2 (en) 2008-03-13
PL395510A1 (pl) 2011-12-19
CA2469599C (en) 2012-10-23
TW200307042A (en) 2003-12-01
MEP17708A (bs) 2010-06-10
CA2469599A1 (en) 2003-06-19
CY1121112T1 (el) 2019-12-11
FR11C0014I2 (fr) 2022-03-11
HK1151988A1 (en) 2012-02-17
DK1487483T3 (da) 2011-02-21
EP1487483B1 (en) 2010-11-10
HRP20040626A2 (en) 2006-03-31
AU2008202333A1 (en) 2008-06-19
PL214803B1 (pl) 2013-09-30
HU230576B1 (hu) 2017-01-30
CA2784260A1 (en) 2003-06-19
HU231162B1 (hu) 2021-05-28
HRP20040626B1 (hr) 2016-08-26
RS51288B (sr) 2010-12-31
HRP20140003B1 (hr) 2020-10-16
WO2003049703A3 (en) 2004-09-30
EP2263689B1 (en) 2014-11-12
CY1111167T1 (el) 2014-04-09
AU2008202333B2 (en) 2010-11-25
AU2011200843B2 (en) 2012-01-19
DK2264050T3 (en) 2018-12-03
CY2011004I1 (el) 2014-04-09
EP2264050B1 (en) 2018-08-08
CY2011004I2 (el) 2015-10-07
WO2003049703A2 (en) 2003-06-19
JP2005511075A (ja) 2005-04-28
ATE487490T1 (de) 2010-11-15
CA2784260C (en) 2016-05-17
NL300480I2 (enExample) 2016-11-01
CO5590938A2 (es) 2005-12-30
SI2263689T1 (sl) 2015-03-31

Similar Documents

Publication Publication Date Title
KR101014544B1 (ko) 감염성 키메라 dna 클론, 키메라 돼지 서코바이러스 및이의 용도
US10507238B2 (en) Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
HK1151988B (en) Chimeric infectious dna clones of porcine circovirus and uses thereof
HK1151539A (en) Chimeric infectious dna clones of porcine circovirus and uses thereof
HK1151465A (en) Chimeric infectious dna clones of porcine circovirus and uses thereof
HK1151539B (en) Chimeric infectious dna clones of porcine circovirus and uses thereof
AU2012202224A1 (en) Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20040611

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20071211

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20091120

Patent event code: PE09021S01D

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20100623

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20101228

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20110208

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20110209

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PA0101 Application to register extension of term of patent right by permit, etc.

Patent event date: 20120816

Patent event code: PA01011R01D

Comment text: Application to Register Extension of Term of Patent Right by Permit, etc.

FPAY Annual fee payment

Payment date: 20140128

Year of fee payment: 4

PR1001 Payment of annual fee

Payment date: 20140128

Start annual number: 4

End annual number: 4

FPAY Annual fee payment

Payment date: 20150203

Year of fee payment: 5

PR1001 Payment of annual fee

Payment date: 20150203

Start annual number: 5

End annual number: 5

FPAY Annual fee payment

Payment date: 20160203

Year of fee payment: 6

PR1001 Payment of annual fee

Payment date: 20160203

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 20170201

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 20170201

Start annual number: 7

End annual number: 7

FPAY Annual fee payment

Payment date: 20180118

Year of fee payment: 8

PR1001 Payment of annual fee

Payment date: 20180118

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 20190208

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 20200115

Start annual number: 10

End annual number: 10

PR1001 Payment of annual fee

Payment date: 20210202

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20220203

Start annual number: 12

End annual number: 12

PR1001 Payment of annual fee

Payment date: 20230130

Start annual number: 13

End annual number: 13

PC1801 Expiration of term

Termination date: 20240109

Termination category: Expiration of duration