KR100919914B1 - 신규한 돌연변이체 알레르겐 - Google Patents

신규한 돌연변이체 알레르겐 Download PDF

Info

Publication number
KR100919914B1
KR100919914B1 KR1020037006644A KR20037006644A KR100919914B1 KR 100919914 B1 KR100919914 B1 KR 100919914B1 KR 1020037006644 A KR1020037006644 A KR 1020037006644A KR 20037006644 A KR20037006644 A KR 20037006644A KR 100919914 B1 KR100919914 B1 KR 100919914B1
Authority
KR
South Korea
Prior art keywords
ala
ile
val
gly
asn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020037006644A
Other languages
English (en)
Korean (ko)
Other versions
KR20030076577A (ko
Inventor
젠스 홀름
헨리크 입센
조르겐 네데르가라르센
미첼도 스판포르트
Original Assignee
알크-아벨로 에이/에스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27222455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100919914(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 알크-아벨로 에이/에스 filed Critical 알크-아벨로 에이/에스
Publication of KR20030076577A publication Critical patent/KR20030076577A/ko
Application granted granted Critical
Publication of KR100919914B1 publication Critical patent/KR100919914B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43568—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from wasps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43572—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Insects & Arthropods (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020037006644A 2000-11-16 2001-11-16 신규한 돌연변이체 알레르겐 Expired - Fee Related KR100919914B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US24936100P 2000-11-16 2000-11-16
DKPA200001718 2000-11-16
US60/249,361 2000-11-16
DKPA200001718 2000-11-16
US29817001P 2001-06-14 2001-06-14
US60/298,170 2001-06-14
PCT/DK2001/000764 WO2002040676A2 (en) 2000-11-16 2001-11-16 Mutant allergens

Publications (2)

Publication Number Publication Date
KR20030076577A KR20030076577A (ko) 2003-09-26
KR100919914B1 true KR100919914B1 (ko) 2009-10-06

Family

ID=27222455

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037006644A Expired - Fee Related KR100919914B1 (ko) 2000-11-16 2001-11-16 신규한 돌연변이체 알레르겐

Country Status (17)

Country Link
EP (1) EP1373510B1 (https=)
JP (1) JP2004521618A (https=)
KR (1) KR100919914B1 (https=)
CN (1) CN100577804C (https=)
AT (1) ATE414773T1 (https=)
AU (2) AU2350502A (https=)
CA (1) CA2429172C (https=)
CZ (1) CZ20031653A3 (https=)
DE (1) DE60136653D1 (https=)
DK (1) DK1373510T3 (https=)
ES (1) ES2317955T3 (https=)
HU (1) HUP0302601A3 (https=)
MX (1) MXPA03004174A (https=)
NO (1) NO329721B1 (https=)
NZ (1) NZ525820A (https=)
PL (1) PL214225B1 (https=)
WO (1) WO2002040676A2 (https=)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2116257T3 (da) 2000-08-09 2013-02-04 Alk Abello As Parenterale vaccineformuleringer og anvendelser deraf
CN1668737A (zh) * 2002-05-16 2005-09-14 阿尔克-阿贝洛有限公司 重组Bet.V.1过敏原突变体及其方法和制备
FR2841906B1 (fr) * 2002-07-05 2006-08-18 Stallergenes Sa Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes
CA2503886A1 (en) * 2002-11-01 2004-05-13 Alk-Abello A/S Recombinant protein variants
WO2004047793A1 (en) 2002-11-26 2004-06-10 Alk-Abelló A/S Pharmaceutical allergen product
EP1599185A1 (en) 2003-02-28 2005-11-30 Alk-Abello A/S Dosage form having a saccharide matrix
US8012505B2 (en) 2003-02-28 2011-09-06 Alk-Abello A/S Dosage form having a saccharide matrix
EP2287180B9 (de) * 2003-06-04 2013-11-06 Merck Patent GmbH Lol p 5-Derivate mit reduzierter Allergenität und erhaltener T-Zellreaktivität
ES2363342T3 (es) * 2003-12-19 2011-08-01 Alk-Abelló A/S Procedimiento para criogranulación y almacenamiento de alérgenos.
RU2006126051A (ru) 2003-12-19 2008-01-27 Альк-Абелло А/С (Dk) Способы получения партии активного фармацевтического ингредиента, контейнер, содержащий криогранулы аллергенного продукта, и криогранула аллергенного продукта
WO2005103082A2 (en) * 2004-04-23 2005-11-03 Novozymes A/S Group 1 mite polypeptide variants
US20060115499A1 (en) * 2004-09-27 2006-06-01 Alk-Abello A/S Liquid allergy vaccine formulation for oromucosal administration
US20060121063A1 (en) * 2004-10-22 2006-06-08 Novozymes A/S Group 2 mite polypeptide variants
ZA200707413B (en) 2005-03-18 2009-01-28 Cytos Biotechnology Ag Cat allergen fusion proteins and uses thereof
AU2006299310A1 (en) 2005-10-04 2007-04-12 Alk-Abello A/S Solid vaccine formulation
EP1814516B1 (en) * 2005-11-04 2012-12-26 Alk-Abelló A/S Use of a liquid allergy vaccine formulation for oromucosal administration
CN103933562A (zh) * 2005-11-04 2014-07-23 爱尔开-阿贝优公司 用于口腔粘膜给药的液体变态反应性疫苗制剂的用途
ITMI20052517A1 (it) * 2005-12-29 2007-06-30 Lofarma Spa Varianbtio ipoallergeniche dell'allergene maggiore bet v 1 di polline di betula verrucosa
AT503297B1 (de) * 2006-05-18 2007-09-15 Biomay Ag Allergen-spezifische antikörper
AT503690A1 (de) 2006-06-09 2007-12-15 Biomay Ag Hypoallergene moleküle
EP1908777B1 (en) * 2006-10-06 2016-02-03 Stallergenes Mite fusion proteins
CA2682054A1 (en) 2007-03-28 2008-10-02 Alk-Abello A/S Use of an adjuvanted allergy vaccine formulation for parenteral administration
NZ583362A (en) * 2007-08-15 2012-06-29 Circassia Ltd Peptide with reduced dimer formation
DE202008006598U1 (de) 2008-04-11 2008-10-02 Alk-Abelló A/S Allergie-Impfstoff-Formulierung zur mucosalen Verabreichung
WO2010146171A1 (en) 2009-06-19 2010-12-23 Alk-Abelló A/S Novel manner of administering allergen in allergen specific immunotherapy
EP2523685A1 (de) * 2010-01-14 2012-11-21 Merck Patent GmbH VARIANTEN DER GRUPPE 5-ALLERGENE DER SÜßGRÄSER MIT REDUZIERTER ALLERGENITÄT DURCH MUTAGENESE VON PROLINRESTEN
EP2388268A1 (en) * 2010-05-18 2011-11-23 Stallergenes S.A. Recombinant Der p 2 expressed in Pichia pastoris as a "natural-like" allergen for immunotherapy and diagnostic purposes
FI20115374A0 (fi) 2011-04-18 2011-04-18 Teknologian Tutkimuskeskus Vtt Oy Uudet hypoallergeenit
FI20115375A0 (fi) 2011-04-18 2011-04-18 Teknologian Tutkimuskeskus Vtt Oy Uudet hypoallergeenit
ITMI20112301A1 (it) 2011-12-19 2013-06-20 Lofarma Spa Varianti ipoallergeniche dell'allergene maggiore phl p 5 di phleum pratense
EP2692732A1 (en) 2012-08-03 2014-02-05 Stallergenes S.A. Novel allergen from ragweed pollen and uses thereof
PL2914286T3 (pl) 2012-10-30 2022-01-31 Aravax Pty Ltd Nowe cząsteczki immunoterapeutyczne oraz ich zastosowania
CA2914037A1 (en) * 2013-06-06 2014-12-11 Anergis S.A. Contiguous overlapping peptides for treatment of house dust mites allergy
EP3050040A2 (en) 2013-09-24 2016-08-03 Fibar Group S.A. Intelligent smoke sensor
WO2015042664A1 (en) 2013-09-25 2015-04-02 Monash University Novel immunotherapeutic composition and uses thereof
EP2952200A1 (en) 2014-06-04 2015-12-09 Alk-Abelló A/S Allergen for prophylactic treatment of allergy
US9898175B2 (en) 2014-08-05 2018-02-20 Fibar Group S.A. Home network manager for home automation
EP3269730A1 (en) * 2016-07-12 2018-01-17 Universität Salzburg Allergen variant
CN110621773B (zh) 2017-05-19 2023-06-09 豪夫迈·罗氏有限公司 用于产生胸腺细胞上清液的方法
CN110093336B (zh) * 2018-01-29 2023-03-24 上海雅心生物技术有限公司 一种稳定的胰蛋白酶及其制备方法
RU2761431C9 (ru) 2020-10-26 2022-04-18 Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России (ФГБУ "ГНЦ Институт иммунологии" ФМБА России) Рекомбинантный полипептид на основе аллергена пыльцы березы и аллергена яблока в качестве вакцины от аллергии
EP4539877A1 (en) * 2022-06-17 2025-04-23 Danmarks Tekniske Universitet Allergy vaccines based on consensus allergens

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030150A2 (en) * 1996-02-15 1997-08-21 Pangenetics B.V. Molecules for the induction of immunological tolerance

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19713001A1 (de) * 1997-03-27 1998-10-01 Merck Patent Gmbh Graminaenpollenallergenmutanten zur spezifischen Immuntherapie, deren Herstellung und Verwendung
AU743647B2 (en) * 1998-01-31 2002-01-31 Mt. Sinai School Of Medicine Of New York University Methods and reagents for decreasing allergic reactions
PL194804B1 (pl) * 1998-03-16 2007-07-31 Alk Abello As Zrekombinowany alergen, sposób przygotowywania zrekombinowanego alergenu, kompozycja farmaceutyczna oraz zastosowanie zrekombinowanego alergenu do przygotowywania leku do wywoływania odpowiedzi immunologicznej u osobnika i do przygotowywania leku do leczenia, zapobiegania lub osłabiania reakcji alergicznych

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030150A2 (en) * 1996-02-15 1997-08-21 Pangenetics B.V. Molecules for the induction of immunological tolerance

Also Published As

Publication number Publication date
KR20030076577A (ko) 2003-09-26
MXPA03004174A (es) 2004-12-02
ATE414773T1 (de) 2008-12-15
WO2002040676A3 (en) 2003-10-09
JP2004521618A (ja) 2004-07-22
ES2317955T3 (es) 2009-05-01
WO2002040676A2 (en) 2002-05-23
PL214225B1 (pl) 2013-07-31
AU2350502A (en) 2002-05-27
CN1484699A (zh) 2004-03-24
HUP0302601A2 (hu) 2003-11-28
AU2002223505B2 (en) 2006-12-07
NO20032213D0 (no) 2003-05-15
EP1373510B1 (en) 2008-11-19
CA2429172A1 (en) 2002-05-23
EP1373510A2 (en) 2004-01-02
NO329721B1 (no) 2010-12-06
PL362273A1 (en) 2004-10-18
DK1373510T3 (da) 2009-02-23
NO20032213L (no) 2003-07-02
DE60136653D1 (de) 2009-01-02
CA2429172C (en) 2012-03-20
NZ525820A (en) 2005-01-28
CZ20031653A3 (en) 2004-03-17
HUP0302601A3 (en) 2010-01-28
HK1060371A1 (en) 2004-08-06
CN100577804C (zh) 2010-01-06

Similar Documents

Publication Publication Date Title
KR100919914B1 (ko) 신규한 돌연변이체 알레르겐
CN1332029C (zh) 突变的重组过敏原
AU2002223505A1 (en) Mutant allergens
PL212139B1 (pl) Zrekombinowany alergen, zastosowanie zrekombinowanego alergenu, kompozycja zawierająca dwa lub więcej wariantów zrekombinowanych zmutowanych alergenów, zastosowanie takiej kompozycji, kompozycja farmaceutyczna zawierająca zrekombinowany alergen lub wymienioną kompozycję, zastosowanie zrekombinowanego alergenu, kompozycji lub kompozycji farmaceutycznej, sposób przygotowania kompozycji farmaceutycznej, sposób przygotowania zrekombinowanego alergenu, sposób przygotowania biblioteki zrekombinowanego alergenu, sekwencja DNA kodująca zrekombinowany alergen, wektor ekspresyjny obejmujący wymienione DNA, komórka gospodarza zawierająca taki wektor ekspresyjny, sposób produkcji zrekombinowanego mutanta alergenu, oraz oznaczenie diagnostyczne do oceny odpowiedniości, bezpieczeństwa lub wyniku terapii
US7384635B2 (en) Protein variants of naturally occurring allergens
US20110052639A1 (en) Allergen mutants
RU2285042C2 (ru) Новые мутантные аллергены
US20030175312A1 (en) Novel mutant allergens
Bonura et al. Genetic engineering of allergens for immunotherapy
HK1060371B (en) Mutant allergens
HK1033591B (en) Mutant recombinant allergens
ZA200303667B (en) Novel mutant allergens.

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20120823

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20130925

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20130925