KR100891601B1 - 분산액의 제조방법 - Google Patents

분산액의 제조방법 Download PDF

Info

Publication number
KR100891601B1
KR100891601B1 KR1020037015467A KR20037015467A KR100891601B1 KR 100891601 B1 KR100891601 B1 KR 100891601B1 KR 1020037015467 A KR1020037015467 A KR 1020037015467A KR 20037015467 A KR20037015467 A KR 20037015467A KR 100891601 B1 KR100891601 B1 KR 100891601B1
Authority
KR
South Korea
Prior art keywords
fat
soluble vitamin
mixing chamber
group
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020037015467A
Other languages
English (en)
Korean (ko)
Other versions
KR20040012865A (ko
Inventor
다피트 샤프너
Original Assignee
디에스엠 아이피 어셋츠 비.브이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 디에스엠 아이피 어셋츠 비.브이. filed Critical 디에스엠 아이피 어셋츠 비.브이.
Publication of KR20040012865A publication Critical patent/KR20040012865A/ko
Application granted granted Critical
Publication of KR100891601B1 publication Critical patent/KR100891601B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/452—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
    • B01F25/4521—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through orifices in elements, e.g. flat plates or cylinders, which obstruct the whole diameter of the tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0422—Numerical values of angles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/044—Numerical composition values of components or mixtures, e.g. percentage of components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0468—Numerical pressure values
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/04—Specific aggregation state of one or more of the phases to be mixed
    • B01F23/043—Mixing fluids or with fluids in a supercritical state, in supercritical conditions or variable density fluids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Colloid Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
KR1020037015467A 2001-06-19 2002-06-10 분산액의 제조방법 Expired - Fee Related KR100891601B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01114619 2001-06-19
EP01114619.8 2001-06-19
PCT/EP2002/006328 WO2002102298A2 (en) 2001-06-19 2002-06-10 Process for the preparation of dispersions

Publications (2)

Publication Number Publication Date
KR20040012865A KR20040012865A (ko) 2004-02-11
KR100891601B1 true KR100891601B1 (ko) 2009-04-08

Family

ID=8177743

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037015467A Expired - Fee Related KR100891601B1 (ko) 2001-06-19 2002-06-10 분산액의 제조방법

Country Status (10)

Country Link
US (1) US8137683B2 (enExample)
EP (1) EP1399136B1 (enExample)
JP (1) JP4630545B2 (enExample)
KR (1) KR100891601B1 (enExample)
CN (1) CN100366243C (enExample)
AT (1) ATE291905T1 (enExample)
CA (1) CA2448993A1 (enExample)
DE (1) DE60203501T2 (enExample)
ES (1) ES2238588T3 (enExample)
WO (1) WO2002102298A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10463061B2 (en) 2004-11-19 2019-11-05 Dsm Ip Assets B.V. Modified plant gums for preparations of active ingredients
US20060251727A1 (en) * 2005-04-11 2006-11-09 Gardiner Paul T Supplemental dietary composition for increasing muscle size, strength, athletic performance and/or exercise capacity
EP2210593A3 (en) 2009-01-21 2011-05-18 DSM IP Assets B.V. Tablettable formulations of vitamin A and derivatives thereof
EP2992950A1 (en) * 2014-09-03 2016-03-09 The Procter and Gamble Company Method for producing aqueous emulsions or suspensions
CN110115952B (zh) * 2018-02-05 2021-10-15 绍兴吉能纳米科技有限公司 一种可使用低温液化气体的高压均质方法
EP4040982A1 (en) * 2019-10-11 2022-08-17 DSM IP Assets B.V. New feed additives of fat-soluble vitamins
WO2022078924A1 (en) * 2020-10-12 2022-04-21 Dsm Ip Assets B.V. New feed additives of fat-soluble vitamins

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016204A1 (en) * 1996-10-14 1998-04-23 F. Hoffmann-La Roche Ag Process for the manufacture of a pulverous preparation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1801401B2 (de) * 1968-10-05 1975-11-20 Bayer Ag, 5090 Leverkusen Verfahre"1 zur Herstellung von Festbett'Oridationskatalysatoren
DE2943267A1 (de) 1979-10-26 1981-05-07 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinstverteilten carotinoiden
DE3119383A1 (de) 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
DE3611229A1 (de) 1986-04-04 1987-10-08 Basf Ag Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinoidpraeparaten
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
ES2104990T3 (es) * 1992-04-14 1997-10-16 Hoffmann La Roche Preparados de sustancias liposolubles.
DE4445341A1 (de) * 1994-12-19 1996-06-20 Basf Ag Verfahren und Vorrichtung zur Herstellung wirkstoffhaltiger Dispersionen
EP0885038B1 (en) 1996-03-01 2011-06-15 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
ES2272066T3 (es) * 1998-04-09 2007-04-16 F. Hoffmann-La Roche Ag Proceso para la manufactura de particulas con tamaño de (sub)micras por disolucion de gas comprimido y surfactantes.
AU5745599A (en) 1998-09-15 2000-04-03 Henkel Kommanditgesellschaft Auf Aktien Method for producing nanoparticles
DE19904990C2 (de) 1998-10-21 2002-05-08 Fraunhofer Ges Forschung Verfahren zur Herstellung nanoskaliger pulverförmiger Feststoffe

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016204A1 (en) * 1996-10-14 1998-04-23 F. Hoffmann-La Roche Ag Process for the manufacture of a pulverous preparation

Also Published As

Publication number Publication date
EP1399136A2 (en) 2004-03-24
ES2238588T3 (es) 2005-09-01
DE60203501D1 (de) 2005-05-04
JP4630545B2 (ja) 2011-02-09
CA2448993A1 (en) 2002-12-27
CN1516578A (zh) 2004-07-28
JP2004529206A (ja) 2004-09-24
US20040209963A1 (en) 2004-10-21
WO2002102298A3 (en) 2003-11-06
WO2002102298A2 (en) 2002-12-27
EP1399136B1 (en) 2005-03-30
ATE291905T1 (de) 2005-04-15
KR20040012865A (ko) 2004-02-11
US8137683B2 (en) 2012-03-20
DE60203501T2 (de) 2006-02-09
CN100366243C (zh) 2008-02-06

Similar Documents

Publication Publication Date Title
US5364563A (en) Powdered aqueous carotenoid dispersions
EP1008380B1 (en) Method and device for mixing or dispersing liquids
Ribeiro et al. Production of O/W emulsions containing astaxanthin by repeated premix membrane emulsification
Gómez-Mascaraque et al. Potential of microencapsulation through emulsion-electrospraying to improve the bioaccesibility of β-carotene
US4844934A (en) Preparation of finely divided, water-dispersable carotenoid formulations
US5863953A (en) Liquid, oil-miscible carotenoid preparations
JP2620277B2 (ja) 粉末状の水に分散しうるカロチノイド製剤及びその製法
EP0498824B2 (en) Process of preparing a water dispersible hydrophobic or aerophilic solid
US20230063291A1 (en) Stable carotenoid microcapsule having high bioavailability and preparation method therefor
EP0937412A1 (en) Preparation of a finely divided pulverous carotenoid preparation
CN104274428B (zh) 油分散性类胡萝卜素制剂的制备方法
US20010000143A1 (en) Process for the manufacture of a pulverous preparation
de Paz et al. Development of water-soluble β-carotene formulations by high-temperature, high-pressure emulsification and antisolvent precipitation
AU711746B2 (en) Finely dispersed carotenoid and retinoid suspensions and their preparation
WO2009068432A1 (de) Pulverförmige carotinoidzubereitung für die färbung von getränken
EP1794238A2 (de) Verfahren zur herstellung von trockenpulvern eines oder mehrerer carotinoide
US20080220071A1 (en) Aqueous Suspensions of Poorly Water-Soluble and Water-Insoluble Active Ingredients and Drying Powder Produced Therefrom
EP1399136B1 (en) Process for the preparation of dispersions
JP2019510495A (ja) 多相活性物質調製物
Zhang et al. Continuous production of Z-isomer-rich β-carotene nanosuspensions utilizing subcritical fluid and a swirl-type mixer
AU2002320837A1 (en) Process for the preparation of dispersions
KR20050112105A (ko) 카로티노이드 에멀젼의 생산 공정
JP2002316924A (ja) カロテノイド乳化液の製造方法
JP2002302479A (ja) カロテノイド乳化液の製造方法
CA2570870A1 (en) Aqueous dispersions of low-water-solubility or water-insoluble active substances and dry powders produced therefrom

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R15-X000 Change to inventor requested

St.27 status event code: A-3-3-R10-R15-oth-X000

R16-X000 Change to inventor recorded

St.27 status event code: A-3-3-R10-R16-oth-X000

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

FPAY Annual fee payment

Payment date: 20130305

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

FPAY Annual fee payment

Payment date: 20140228

Year of fee payment: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

FPAY Annual fee payment

Payment date: 20150302

Year of fee payment: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

FPAY Annual fee payment

Payment date: 20160303

Year of fee payment: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

FPAY Annual fee payment

Payment date: 20170302

Year of fee payment: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

FPAY Annual fee payment

Payment date: 20190227

Year of fee payment: 11

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 11

FPAY Annual fee payment

Payment date: 20200227

Year of fee payment: 12

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 12

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20210328

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20210328

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000