DE60203501D1 - Verfahren zur herstellung von dispersionen - Google Patents

Verfahren zur herstellung von dispersionen

Info

Publication number
DE60203501D1
DE60203501D1 DE60203501T DE60203501T DE60203501D1 DE 60203501 D1 DE60203501 D1 DE 60203501D1 DE 60203501 T DE60203501 T DE 60203501T DE 60203501 T DE60203501 T DE 60203501T DE 60203501 D1 DE60203501 D1 DE 60203501D1
Authority
DE
Germany
Prior art keywords
dispersions
preparation
dispersion
composition
aqueous phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60203501T
Other languages
English (en)
Other versions
DE60203501T2 (de
Inventor
David Schaffner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Application granted granted Critical
Publication of DE60203501D1 publication Critical patent/DE60203501D1/de
Publication of DE60203501T2 publication Critical patent/DE60203501T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/04—Specific aggregation state of one or more of the phases to be mixed
    • B01F23/043—Mixing fluids or with fluids in a supercritical state, in supercritical conditions or variable density fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/452—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
    • B01F25/4521—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through orifices in elements, e.g. flat plates or cylinders, which obstruct the whole diameter of the tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0422—Numerical values of angles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/044—Numerical composition values of components or mixtures, e.g. percentage of components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0468—Numerical pressure values

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Colloid Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
DE60203501T 2001-06-19 2002-06-10 Verfahren zur herstellung von dispersionen Expired - Lifetime DE60203501T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01114619 2001-06-19
EP01114619 2001-06-19
PCT/EP2002/006328 WO2002102298A2 (en) 2001-06-19 2002-06-10 Process for the preparation of dispersions

Publications (2)

Publication Number Publication Date
DE60203501D1 true DE60203501D1 (de) 2005-05-04
DE60203501T2 DE60203501T2 (de) 2006-02-09

Family

ID=8177743

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60203501T Expired - Lifetime DE60203501T2 (de) 2001-06-19 2002-06-10 Verfahren zur herstellung von dispersionen

Country Status (10)

Country Link
US (1) US8137683B2 (de)
EP (1) EP1399136B1 (de)
JP (1) JP4630545B2 (de)
KR (1) KR100891601B1 (de)
CN (1) CN100366243C (de)
AT (1) ATE291905T1 (de)
CA (1) CA2448993A1 (de)
DE (1) DE60203501T2 (de)
ES (1) ES2238588T3 (de)
WO (1) WO2002102298A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10463061B2 (en) 2004-11-19 2019-11-05 Dsm Ip Assets B.V. Modified plant gums for preparations of active ingredients
US20060251727A1 (en) * 2005-04-11 2006-11-09 Gardiner Paul T Supplemental dietary composition for increasing muscle size, strength, athletic performance and/or exercise capacity
EP2210593A3 (de) 2009-01-21 2011-05-18 DSM IP Assets B.V. Tablettierbare Formulierungen von Vitamin A und Derivate davon
EP2992950A1 (de) * 2014-09-03 2016-03-09 The Procter and Gamble Company Verfahren zur Herstellung wässriger Emulsionen oder Suspensionen
CN110115952B (zh) * 2018-02-05 2021-10-15 绍兴吉能纳米科技有限公司 一种可使用低温液化气体的高压均质方法
MX2022004188A (es) * 2019-10-11 2022-05-02 Dsm Ip Assets Bv Nuevos aditivos de vitaminas liposolubles para piensos.
WO2022078924A1 (en) * 2020-10-12 2022-04-21 Dsm Ip Assets B.V. New feed additives of fat-soluble vitamins

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1801401B2 (de) * 1968-10-05 1975-11-20 Bayer Ag, 5090 Leverkusen Verfahre"1 zur Herstellung von Festbett'Oridationskatalysatoren
DE2943267A1 (de) 1979-10-26 1981-05-07 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinstverteilten carotinoiden
DE3119383A1 (de) 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
DE3611229A1 (de) * 1986-04-04 1987-10-08 Basf Ag Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinoidpraeparaten
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
ATE154822T1 (de) * 1992-04-14 1997-07-15 Hoffmann La Roche Präparate von fettlöslichen substanzen
DE4445341A1 (de) * 1994-12-19 1996-06-20 Basf Ag Verfahren und Vorrichtung zur Herstellung wirkstoffhaltiger Dispersionen
WO1997031691A1 (en) 1996-03-01 1997-09-04 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
WO1998016204A1 (en) * 1996-10-14 1998-04-23 F. Hoffmann-La Roche Ag Process for the manufacture of a pulverous preparation
WO1999052504A1 (en) * 1998-04-09 1999-10-21 F. Hoffmann-La Roche Ag Process for the manufacture of (sub)micron sized particles by dissolving in compressed gas and surfactants
AU5745599A (en) 1998-09-15 2000-04-03 Henkel Kommanditgesellschaft Auf Aktien Method for producing nanoparticles
DE19904990C2 (de) 1998-10-21 2002-05-08 Fraunhofer Ges Forschung Verfahren zur Herstellung nanoskaliger pulverförmiger Feststoffe

Also Published As

Publication number Publication date
KR100891601B1 (ko) 2009-04-08
DE60203501T2 (de) 2006-02-09
JP2004529206A (ja) 2004-09-24
WO2002102298A2 (en) 2002-12-27
KR20040012865A (ko) 2004-02-11
EP1399136A2 (de) 2004-03-24
ES2238588T3 (es) 2005-09-01
US8137683B2 (en) 2012-03-20
CA2448993A1 (en) 2002-12-27
JP4630545B2 (ja) 2011-02-09
CN100366243C (zh) 2008-02-06
WO2002102298A3 (en) 2003-11-06
ATE291905T1 (de) 2005-04-15
US20040209963A1 (en) 2004-10-21
CN1516578A (zh) 2004-07-28
EP1399136B1 (de) 2005-03-30

Similar Documents

Publication Publication Date Title
DE59406065D1 (de) Verfahren zur Herstellung einer Liposomendispersion im Hochdruckbereich
DE69832293D1 (de) Zubereitungen zur abgabe von negativ geladenen molekülen
WO2000066087A8 (en) Emulsion-based processes for making microparticles
ATE243068T1 (de) Verfahren und mikrovermischer zur herstellung einer dispersion
DE60203501D1 (de) Verfahren zur herstellung von dispersionen
DE50310614D1 (de) Verfahren zur herstellung von c13-alkoholgemischen
DE60002564D1 (de) Verfahren zur herstellung von farbpigmenten
ATE460472T1 (de) Verfahren und zusammensetzungen zur synthese von nukleinsäuremolekülen unter verwendung multipler erkennungsstellen
DE602006005898D1 (de) Verfahren zur herstellung von cyclohexanon und cyclohexanol
NO20062248L (no) Rontgenkontrastmedium inneholdende liposom og fremgangsmate for fremstilling derav.
WO2002064618A3 (en) Methods of identifying agents that mediate polypeptide aggregation
BG106689A (en) Method for the production of particles
BR0014625A (pt) Processo de fracionamento de um material composto de diversos contituintes com o auxìlio de um solvente a pressão supercrìtica
ATE333502T1 (de) Verfahren zur herstellung von nukleinsäure- und polypeptidbanken durch in vivo rekombination und ihre verwendungen
DE60141680D1 (de) Verfahren zur herstellung von mikronisierte gefriergetrocknete partikeln
Schreier et al. Conformational basis for the biological activity of TOAC‐labeled angiotensin II and bradykinin: Electron paramagnetic resonance, circular dichroism, and fluorescence studies
DE602005025155D1 (de) Anwendung von zentrifugaler verteilungschromatographie zur aufreinigung von galanthamine
WO2003040402A3 (en) Alpha-helix mimicry by a class of organic molecules
Denieul et al. Trifluoroacetonyl radicals: a versatile approach to trifluoromethyl ketones
ATE317428T1 (de) Verfahren zur herstellung von submikropartikel- suspensionen pharmazeutischer substanzen
ATE233293T1 (de) Verfahren zur herstellung von polysaccharideperlen
DE69922792D1 (de) Verfahren zur herstellung von (r)-2-brom-3-phenylpropionsäure
AU2001258288A1 (en) Substance mixture containing bisphenol a
DE60026292D1 (de) Eine stabilisierte isothiazolon-zusammensetzung und ein verfahren zur stabilisierung von isothiazolon
DE60106633D1 (de) Verfahren zur herstellung von alkoxyaminen aus nitroxyle

Legal Events

Date Code Title Description
8364 No opposition during term of opposition