KR20040012865A - 분산액의 제조방법 - Google Patents
분산액의 제조방법 Download PDFInfo
- Publication number
- KR20040012865A KR20040012865A KR10-2003-7015467A KR20037015467A KR20040012865A KR 20040012865 A KR20040012865 A KR 20040012865A KR 20037015467 A KR20037015467 A KR 20037015467A KR 20040012865 A KR20040012865 A KR 20040012865A
- Authority
- KR
- South Korea
- Prior art keywords
- solvent
- dispersion
- composition
- bar
- active substance
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
- B01F25/452—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
- B01F25/4521—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through orifices in elements, e.g. flat plates or cylinders, which obstruct the whole diameter of the tube
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0418—Geometrical information
- B01F2215/0422—Numerical values of angles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0418—Geometrical information
- B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/044—Numerical composition values of components or mixtures, e.g. percentage of components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0468—Numerical pressure values
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/04—Specific aggregation state of one or more of the phases to be mixed
- B01F23/043—Mixing fluids or with fluids in a supercritical state, in supercritical conditions or variable density fluids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Colloid Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
Abstract
Description
Claims (9)
- 수상 중의 활성 물질 또는 조성물의 용액을 디메틸에테르 또는 C4-탄화수소 또는 그것의 혼합물에 초- 또는 임계 근처 상태에서 분산하고, 혼합물을 감압하고 가스 상태의 용매로부터 분산액을 분리하는 것을 포함하는 분산액의 제조방법.
- 제 1항에 있어서, 활성물질 또는 조성물이 지용성 비타민, 제약, 카로테노이드 및 불포화 지방산 중합체로 이루어진 군에서 선택된 제조방법.
- 제 1항 또는 제 2항에 있어서, 활성물질 또는 조성물이 카로테노이드인 제조방법.
- 제 3항에 있어서, 카로테노이드가 β-카로틴인 제조방법.
- 제 1항 내지 제 4항 중 어느 한 항에 있어서, 용매가 디메틸에테르인 제조방법.
- 제 1항 내지 제 4항 중 어느 한 항에 있어서, 용매가 1-부텐인 제조방법.
- 제 1항 내지 제 4항 중 어느 한 항에 있어서, 용매가 트랜스부텐인 제조방법.
- 제 1항 내지 제 7항 중 어느 한 항에 있어서, 분산된 입자의 평균 직경이 약 20 내지 약 300㎚인 제조방법.
- 제 1항 내지 제 8항 중 어느 한 항에 있어서, 실질적으로 여기에서 기재된, 특히 도면과 실시예들을 참조한 제조방법.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01114619 | 2001-06-19 | ||
EP01114619.8 | 2001-06-19 | ||
PCT/EP2002/006328 WO2002102298A2 (en) | 2001-06-19 | 2002-06-10 | Process for the preparation of dispersions |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20040012865A true KR20040012865A (ko) | 2004-02-11 |
KR100891601B1 KR100891601B1 (ko) | 2009-04-08 |
Family
ID=8177743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020037015467A KR100891601B1 (ko) | 2001-06-19 | 2002-06-10 | 분산액의 제조방법 |
Country Status (10)
Country | Link |
---|---|
US (1) | US8137683B2 (ko) |
EP (1) | EP1399136B1 (ko) |
JP (1) | JP4630545B2 (ko) |
KR (1) | KR100891601B1 (ko) |
CN (1) | CN100366243C (ko) |
AT (1) | ATE291905T1 (ko) |
CA (1) | CA2448993A1 (ko) |
DE (1) | DE60203501T2 (ko) |
ES (1) | ES2238588T3 (ko) |
WO (1) | WO2002102298A2 (ko) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10463061B2 (en) | 2004-11-19 | 2019-11-05 | Dsm Ip Assets B.V. | Modified plant gums for preparations of active ingredients |
US20060251727A1 (en) * | 2005-04-11 | 2006-11-09 | Gardiner Paul T | Supplemental dietary composition for increasing muscle size, strength, athletic performance and/or exercise capacity |
EP2210593A3 (en) | 2009-01-21 | 2011-05-18 | DSM IP Assets B.V. | Tablettable formulations of vitamin A and derivatives thereof |
EP2992950A1 (en) * | 2014-09-03 | 2016-03-09 | The Procter and Gamble Company | Method for producing aqueous emulsions or suspensions |
CN110115952B (zh) * | 2018-02-05 | 2021-10-15 | 绍兴吉能纳米科技有限公司 | 一种可使用低温液化气体的高压均质方法 |
MX2022004188A (es) * | 2019-10-11 | 2022-05-02 | Dsm Ip Assets Bv | Nuevos aditivos de vitaminas liposolubles para piensos. |
WO2022078924A1 (en) * | 2020-10-12 | 2022-04-21 | Dsm Ip Assets B.V. | New feed additives of fat-soluble vitamins |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1801401B2 (de) * | 1968-10-05 | 1975-11-20 | Bayer Ag, 5090 Leverkusen | Verfahre"1 zur Herstellung von Festbett'Oridationskatalysatoren |
DE2943267A1 (de) | 1979-10-26 | 1981-05-07 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von feinstverteilten carotinoiden |
DE3119383A1 (de) | 1981-05-15 | 1982-12-02 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten |
DE3611229A1 (de) * | 1986-04-04 | 1987-10-08 | Basf Ag | Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinoidpraeparaten |
US5639441A (en) * | 1992-03-06 | 1997-06-17 | Board Of Regents Of University Of Colorado | Methods for fine particle formation |
ATE154822T1 (de) * | 1992-04-14 | 1997-07-15 | Hoffmann La Roche | Präparate von fettlöslichen substanzen |
DE4445341A1 (de) * | 1994-12-19 | 1996-06-20 | Basf Ag | Verfahren und Vorrichtung zur Herstellung wirkstoffhaltiger Dispersionen |
WO1997031691A1 (en) | 1996-03-01 | 1997-09-04 | The University Of Kansas | Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents |
WO1998016204A1 (en) * | 1996-10-14 | 1998-04-23 | F. Hoffmann-La Roche Ag | Process for the manufacture of a pulverous preparation |
WO1999052504A1 (en) * | 1998-04-09 | 1999-10-21 | F. Hoffmann-La Roche Ag | Process for the manufacture of (sub)micron sized particles by dissolving in compressed gas and surfactants |
AU5745599A (en) | 1998-09-15 | 2000-04-03 | Henkel Kommanditgesellschaft Auf Aktien | Method for producing nanoparticles |
DE19904990C2 (de) | 1998-10-21 | 2002-05-08 | Fraunhofer Ges Forschung | Verfahren zur Herstellung nanoskaliger pulverförmiger Feststoffe |
-
2002
- 2002-06-10 EP EP02754647A patent/EP1399136B1/en not_active Expired - Lifetime
- 2002-06-10 CN CNB028121899A patent/CN100366243C/zh not_active Expired - Fee Related
- 2002-06-10 JP JP2003504887A patent/JP4630545B2/ja not_active Expired - Fee Related
- 2002-06-10 CA CA002448993A patent/CA2448993A1/en not_active Abandoned
- 2002-06-10 ES ES02754647T patent/ES2238588T3/es not_active Expired - Lifetime
- 2002-06-10 US US10/481,167 patent/US8137683B2/en not_active Expired - Fee Related
- 2002-06-10 AT AT02754647T patent/ATE291905T1/de not_active IP Right Cessation
- 2002-06-10 DE DE60203501T patent/DE60203501T2/de not_active Expired - Lifetime
- 2002-06-10 KR KR1020037015467A patent/KR100891601B1/ko active IP Right Grant
- 2002-06-10 WO PCT/EP2002/006328 patent/WO2002102298A2/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
KR100891601B1 (ko) | 2009-04-08 |
DE60203501T2 (de) | 2006-02-09 |
JP2004529206A (ja) | 2004-09-24 |
WO2002102298A2 (en) | 2002-12-27 |
EP1399136A2 (en) | 2004-03-24 |
ES2238588T3 (es) | 2005-09-01 |
US8137683B2 (en) | 2012-03-20 |
DE60203501D1 (de) | 2005-05-04 |
CA2448993A1 (en) | 2002-12-27 |
JP4630545B2 (ja) | 2011-02-09 |
CN100366243C (zh) | 2008-02-06 |
WO2002102298A3 (en) | 2003-11-06 |
ATE291905T1 (de) | 2005-04-15 |
US20040209963A1 (en) | 2004-10-21 |
CN1516578A (zh) | 2004-07-28 |
EP1399136B1 (en) | 2005-03-30 |
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