CN100366243C - 制备分散体的方法 - Google Patents

制备分散体的方法 Download PDF

Info

Publication number
CN100366243C
CN100366243C CNB028121899A CN02812189A CN100366243C CN 100366243 C CN100366243 C CN 100366243C CN B028121899 A CNB028121899 A CN B028121899A CN 02812189 A CN02812189 A CN 02812189A CN 100366243 C CN100366243 C CN 100366243C
Authority
CN
China
Prior art keywords
mixing chamber
solvent
aqueous phase
active substance
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028121899A
Other languages
English (en)
Chinese (zh)
Other versions
CN1516578A (zh
Inventor
D·沙夫纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CN1516578A publication Critical patent/CN1516578A/zh
Application granted granted Critical
Publication of CN100366243C publication Critical patent/CN100366243C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/452—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
    • B01F25/4521—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through orifices in elements, e.g. flat plates or cylinders, which obstruct the whole diameter of the tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0422—Numerical values of angles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/044—Numerical composition values of components or mixtures, e.g. percentage of components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0468—Numerical pressure values
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/04—Specific aggregation state of one or more of the phases to be mixed
    • B01F23/043—Mixing fluids or with fluids in a supercritical state, in supercritical conditions or variable density fluids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Colloid Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
CNB028121899A 2001-06-19 2002-06-10 制备分散体的方法 Expired - Fee Related CN100366243C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01114619 2001-06-19
EP01114619.8 2001-06-19

Publications (2)

Publication Number Publication Date
CN1516578A CN1516578A (zh) 2004-07-28
CN100366243C true CN100366243C (zh) 2008-02-06

Family

ID=8177743

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028121899A Expired - Fee Related CN100366243C (zh) 2001-06-19 2002-06-10 制备分散体的方法

Country Status (10)

Country Link
US (1) US8137683B2 (enExample)
EP (1) EP1399136B1 (enExample)
JP (1) JP4630545B2 (enExample)
KR (1) KR100891601B1 (enExample)
CN (1) CN100366243C (enExample)
AT (1) ATE291905T1 (enExample)
CA (1) CA2448993A1 (enExample)
DE (1) DE60203501T2 (enExample)
ES (1) ES2238588T3 (enExample)
WO (1) WO2002102298A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10463061B2 (en) 2004-11-19 2019-11-05 Dsm Ip Assets B.V. Modified plant gums for preparations of active ingredients
US20060251727A1 (en) * 2005-04-11 2006-11-09 Gardiner Paul T Supplemental dietary composition for increasing muscle size, strength, athletic performance and/or exercise capacity
EP2210593A3 (en) 2009-01-21 2011-05-18 DSM IP Assets B.V. Tablettable formulations of vitamin A and derivatives thereof
EP2992950A1 (en) * 2014-09-03 2016-03-09 The Procter and Gamble Company Method for producing aqueous emulsions or suspensions
CN110115952B (zh) * 2018-02-05 2021-10-15 绍兴吉能纳米科技有限公司 一种可使用低温液化气体的高压均质方法
EP4040982A1 (en) * 2019-10-11 2022-08-17 DSM IP Assets B.V. New feed additives of fat-soluble vitamins
WO2022078924A1 (en) * 2020-10-12 2022-04-21 Dsm Ip Assets B.V. New feed additives of fat-soluble vitamins

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1233169A (zh) * 1996-10-14 1999-10-27 弗·哈夫曼-拉罗切有限公司 一种粉末状制剂的制备工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1801401B2 (de) * 1968-10-05 1975-11-20 Bayer Ag, 5090 Leverkusen Verfahre"1 zur Herstellung von Festbett'Oridationskatalysatoren
DE2943267A1 (de) 1979-10-26 1981-05-07 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinstverteilten carotinoiden
DE3119383A1 (de) 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
DE3611229A1 (de) 1986-04-04 1987-10-08 Basf Ag Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinoidpraeparaten
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
ES2104990T3 (es) * 1992-04-14 1997-10-16 Hoffmann La Roche Preparados de sustancias liposolubles.
DE4445341A1 (de) * 1994-12-19 1996-06-20 Basf Ag Verfahren und Vorrichtung zur Herstellung wirkstoffhaltiger Dispersionen
EP0885038B1 (en) 1996-03-01 2011-06-15 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
ES2272066T3 (es) * 1998-04-09 2007-04-16 F. Hoffmann-La Roche Ag Proceso para la manufactura de particulas con tamaño de (sub)micras por disolucion de gas comprimido y surfactantes.
AU5745599A (en) 1998-09-15 2000-04-03 Henkel Kommanditgesellschaft Auf Aktien Method for producing nanoparticles
DE19904990C2 (de) 1998-10-21 2002-05-08 Fraunhofer Ges Forschung Verfahren zur Herstellung nanoskaliger pulverförmiger Feststoffe

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1233169A (zh) * 1996-10-14 1999-10-27 弗·哈夫曼-拉罗切有限公司 一种粉末状制剂的制备工艺

Also Published As

Publication number Publication date
EP1399136A2 (en) 2004-03-24
ES2238588T3 (es) 2005-09-01
DE60203501D1 (de) 2005-05-04
JP4630545B2 (ja) 2011-02-09
CA2448993A1 (en) 2002-12-27
CN1516578A (zh) 2004-07-28
JP2004529206A (ja) 2004-09-24
KR100891601B1 (ko) 2009-04-08
US20040209963A1 (en) 2004-10-21
WO2002102298A3 (en) 2003-11-06
WO2002102298A2 (en) 2002-12-27
EP1399136B1 (en) 2005-03-30
ATE291905T1 (de) 2005-04-15
KR20040012865A (ko) 2004-02-11
US8137683B2 (en) 2012-03-20
DE60203501T2 (de) 2006-02-09

Similar Documents

Publication Publication Date Title
US6536940B1 (en) Preparation of liquid dispersions
Gómez-Mascaraque et al. Potential of microencapsulation through emulsion-electrospraying to improve the bioaccesibility of β-carotene
Tan et al. β-Carotene nanodispersions: preparation, characterization and stability evaluation
de Oca-Ávalos et al. Nanoemulsions: stability and physical properties
de Paz et al. Development of water-soluble β-carotene formulations by high-temperature, high-pressure emulsification and antisolvent precipitation
DK175237B1 (da) Stabile, koldtvandsdispergerbare præparater af fedtoplöselige substanser, en fremgangsmåde til fremstilling deraf samt anvendelse af fiskegelatine til fremstilling af sådanne præparater
CN104274428B (zh) 油分散性类胡萝卜素制剂的制备方法
US20010008644A1 (en) Process for preparing a finely divided pulverous carotenoid retinoid or natural colournt preparation
Jiao et al. Enhancing the formation and stability of oil-in-water emulsions prepared by microchannels using mixed protein emulsifiers
CN104135864A (zh) 挤出方法
CN1233169A (zh) 一种粉末状制剂的制备工艺
JP4630545B2 (ja) 分散液の製造工程
CN113208141A (zh) 用于生产离散固体挤出颗粒的方法
TW201944900A (zh) 製造噴霧乾燥粉末之方法
Zhang et al. Continuous production of Z-isomer-rich β-carotene nanosuspensions utilizing subcritical fluid and a swirl-type mixer
US7740775B2 (en) Method for the production of particles
AU2002320837A1 (en) Process for the preparation of dispersions
KR20050112105A (ko) 카로티노이드 에멀젼의 생산 공정
CN112040787A (zh) 喷雾干燥粉末的连续制造
JP2002316924A (ja) カロテノイド乳化液の製造方法
TWM628415U (zh) 機能原料超微米化設備
TW202541715A (zh) 用於製備粉末之設置

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
ASS Succession or assignment of patent right

Owner name: DSMIP ASSET CO., LTD.

Free format text: FORMER OWNER: ROCHE VITAMINE S.A.

Effective date: 20040618

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20040618

Address after: Holland Heerlen

Applicant after: DSMIP N. V.

Address before: Basel

Applicant before: Roche Vitamin S.A.

C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20080206

Termination date: 20210610

CF01 Termination of patent right due to non-payment of annual fee