KR100883874B1 - (3ｒ,5ｓ)-(ｅ)-7-[2-시클로프로필-4-(4-플루오로페닐)-퀴노린-3-일]-3,5-디하이드록시헵트-6-엔산 에스테르류의 제조방법 - Google Patents

(3ｒ,5ｓ)-(ｅ)-7-[2-시클로프로필-4-(4-플루오로페닐)-퀴노린-3-일]-3,5-디하이드록시헵트-6-엔산 에스테르류의 제조방법 Download PDF

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Publication number
KR100883874B1
KR100883874B1 KR1020037010128A KR20037010128A KR100883874B1 KR 100883874 B1 KR100883874 B1 KR 100883874B1 KR 1020037010128 A KR1020037010128 A KR 1020037010128A KR 20037010128 A KR20037010128 A KR 20037010128A KR 100883874 B1 KR100883874 B1 KR 100883874B1
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South Korea
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KR20030072618A (ko
Inventor
마리 하라
아케미 호소카와
유키 다쿠마
마나부 가츠라다
요우이치 마츠모토
유조 가스가
나오유키 와타나베
Original Assignee
미쯔비시 가가꾸 가부시끼가이샤
닛산 가가쿠 고교 가부시키 가이샤
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Priority claimed from JP2001331480A external-priority patent/JP2003137870A/ja
Application filed by 미쯔비시 가가꾸 가부시끼가이샤, 닛산 가가쿠 고교 가부시키 가이샤 filed Critical 미쯔비시 가가꾸 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020037010128A 2001-02-02 2002-02-01 (3ｒ,5ｓ)-(ｅ)-7-[2-시클로프로필-4-(4-플루오로페닐)-퀴노린-3-일]-3,5-디하이드록시헵트-6-엔산 에스테르류의 제조방법 Expired - Fee Related KR100883874B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JPJP-P-2001-00026316 2001-02-02
JP2001026316 2001-02-02
JP2001331480A JP2003137870A (ja) 2001-10-29 2001-10-29 ３，５−ジオキソ−６−ヘプテン酸誘導体類の製造方法及びその中間体
JPJP-P-2001-00331480 2001-10-29
PCT/JP2002/000835 WO2002063028A1 (fr) 2001-02-02 2002-02-01 Procede de production d'esters d'acide (3r,5s)-(e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxyhept-6-enique

Publications (2)

Publication Number Publication Date
KR20030072618A KR20030072618A (ko) 2003-09-15
KR100883874B1 true KR100883874B1 (ko) 2009-02-17

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KR1020037010128A Expired - Fee Related KR100883874B1 (ko) 2001-02-02 2002-02-01 (3ｒ,5ｓ)-(ｅ)-7-[2-시클로프로필-4-(4-플루오로페닐)-퀴노린-3-일]-3,5-디하이드록시헵트-6-엔산 에스테르류의 제조방법

Country Status (8)

Country Link
US (1) US6965031B2 (enExample)
EP (1) EP1365029A4 (enExample)
KR (1) KR100883874B1 (enExample)
CN (1) CN1329520C (enExample)
AU (1) AU2002228413B8 (enExample)
CA (1) CA2437312C (enExample)
TW (1) TWI322829B (enExample)
WO (1) WO2002063028A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1365029A4 (en) * 2001-02-02 2009-07-29 Mitsubishi Chem Corp "PROCESS FOR PREPARING (3R, 5S) - (E) -7-2-CYCLOPROPYL-4- (4-FLUORPHENYL) CHINOLINE-3-YL-3,5-DIHYDROXY-HEPT-6-ACID ESTERS"
WO2002081451A1 (en) * 2001-04-05 2002-10-17 Nissan Chemical Industries, Ltd. Method for preparing 7-quinolinyl-3,5-dihydroxyhept-6-enoate
US7371865B2 (en) * 2002-01-31 2008-05-13 Novartis Pharmaceuticals Corporation Process for the manufacture of HMG-CoA reductase inhibitors
ATE406447T1 (de) * 2002-03-19 2008-09-15 Mitsubishi Chem Corp Neue carbonylreduktase, diese codierendes gen und verfahren zur produktion optisch-aktiver alkohole damit
ITMI20100753A1 (it) * 2010-04-30 2011-10-31 Dipharma Francis Srl Procedimento per la preparazione di statine
EP2383260A3 (en) * 2010-04-30 2011-12-28 Dipharma Francis S.r.l. Process for the preparation of statins
CN103848784B (zh) * 2012-12-05 2016-12-21 安徽省庆云医药化工有限公司 匹伐他汀酯的晶型及其制备方法
JP6150703B2 (ja) * 2013-10-08 2017-06-21 ダイト株式会社 ピタバスタチンカルシウム塩の分解抑制方法
JP6596339B2 (ja) 2014-02-06 2019-10-23 株式会社エーピーアイ コーポレーション ロスバスタチンカルシウム及びその中間体の製造方法
WO2016056658A1 (ja) * 2014-10-10 2016-04-14 株式会社エーピーアイ コーポレーション スタチン系化合物の精製方法
US10676441B2 (en) 2015-08-05 2020-06-09 Api Corporation Method for producing pitavastatin calcium
CN105481838A (zh) * 2015-11-18 2016-04-13 北京万全德众医药生物技术有限公司 一种制备匹伐他汀内酯杂质的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0892217A (ja) * 1994-09-06 1996-04-09 Ube Ind Ltd 光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1336714C (en) * 1987-08-20 1995-08-15 Yoshihiro Fujikawa Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
JP3149265B2 (ja) 1992-05-12 2001-03-26 鐘淵化学工業株式会社 光学活性な３，５−ジヒドロキシ脂肪酸エステル誘導体の製造法
US5324662A (en) * 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
JP3481325B2 (ja) * 1994-09-06 2003-12-22 宇部興産株式会社 光学活性な３−オキシ−５−オキソ−６−ヘプテン酸誘導体の製法
GB9512837D0 (en) 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
EP1365029A4 (en) * 2001-02-02 2009-07-29 Mitsubishi Chem Corp "PROCESS FOR PREPARING (3R, 5S) - (E) -7-2-CYCLOPROPYL-4- (4-FLUORPHENYL) CHINOLINE-3-YL-3,5-DIHYDROXY-HEPT-6-ACID ESTERS"

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0892217A (ja) * 1994-09-06 1996-04-09 Ube Ind Ltd 光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法

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Publication number Publication date
EP1365029A1 (en) 2003-11-26
AU2002228413B2 (en) 2007-02-22
CN1329520C (zh) 2007-08-01
KR20030072618A (ko) 2003-09-15
CN1633502A (zh) 2005-06-29
US20040030139A1 (en) 2004-02-12
WO2002063028A1 (fr) 2002-08-15
EP1365029A4 (en) 2009-07-29
AU2002228413A1 (en) 2002-08-19
TWI322829B (enExample) 2010-04-01
AU2002228413B8 (en) 2007-03-22
US6965031B2 (en) 2005-11-15
CA2437312C (en) 2010-03-23
CA2437312A1 (en) 2002-08-15

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