ATE406447T1 - Neue carbonylreduktase, diese codierendes gen und verfahren zur produktion optisch-aktiver alkohole damit - Google Patents
Neue carbonylreduktase, diese codierendes gen und verfahren zur produktion optisch-aktiver alkohole damitInfo
- Publication number
- ATE406447T1 ATE406447T1 AT03712750T AT03712750T ATE406447T1 AT E406447 T1 ATE406447 T1 AT E406447T1 AT 03712750 T AT03712750 T AT 03712750T AT 03712750 T AT03712750 T AT 03712750T AT E406447 T1 ATE406447 T1 AT E406447T1
- Authority
- AT
- Austria
- Prior art keywords
- sequence
- polypeptide
- base sequence
- dna
- carbonyl reductase
- Prior art date
Links
- 102000005751 Alcohol Oxidoreductases Human genes 0.000 title abstract 4
- 108010031132 Alcohol Oxidoreductases Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 150000001298 alcohols Chemical class 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 108020004414 DNA Proteins 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 108020004511 Recombinant DNA Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000013611 chromosomal DNA Substances 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002075921 | 2002-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE406447T1 true ATE406447T1 (de) | 2008-09-15 |
Family
ID=28035393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03712750T ATE406447T1 (de) | 2002-03-19 | 2003-03-18 | Neue carbonylreduktase, diese codierendes gen und verfahren zur produktion optisch-aktiver alkohole damit |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7335757B2 (de) |
| EP (1) | EP1491633B1 (de) |
| KR (1) | KR100998235B1 (de) |
| CN (1) | CN1322129C (de) |
| AT (1) | ATE406447T1 (de) |
| AU (1) | AU2003221082B2 (de) |
| CA (1) | CA2479705C (de) |
| DE (1) | DE60323215D1 (de) |
| TW (1) | TW200305645A (de) |
| WO (1) | WO2003078634A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10327454A1 (de) * | 2003-06-18 | 2005-01-20 | Juelich Enzyme Products Gmbh | Oxidoreduktase aus Pichia capsulata |
| KR20070050461A (ko) * | 2004-08-06 | 2007-05-15 | 가부시키가이샤 가네카 | 신규 카르보닐 환원 효소, 그의 유전자 및 그의 이용 방법 |
| CA2691799C (en) * | 2007-06-20 | 2016-06-07 | Basf Se | Method for producing optically active alcohol using azoarcus sp ebn1 dehydrogenase |
| CN101429514B (zh) * | 2007-11-08 | 2011-06-15 | 陈依军 | 一种双羰基还原酶、其基因及其应用 |
| AU2009348523B2 (en) * | 2009-06-22 | 2015-02-26 | Sk Biopharmaceuticals Co., Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
| US8404461B2 (en) * | 2009-10-15 | 2013-03-26 | SK Biopharmaceutical Co. Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
| CN102492668B (zh) * | 2011-11-29 | 2013-06-26 | 华东理工大学 | 一种羰基还原酶及其基因和在不对称还原羰基化合物中的应用 |
| CN102559520B (zh) * | 2011-12-15 | 2013-11-20 | 江南大学 | 一种利用微生物催化制备(s)-(4-氯苯基)-(吡啶-2-基)-甲醇的方法 |
| CN102653524A (zh) * | 2012-01-12 | 2012-09-05 | 东莞达信生物技术有限公司 | 一种匹伐他汀钙中间体的制备方法 |
| EP2980213B1 (de) | 2013-03-28 | 2019-03-13 | Kaneka Corporation | Modifiziertes carbonylreduzierendes enzym und gen |
| CN103695443B (zh) * | 2014-01-12 | 2015-12-09 | 中国科学院成都生物研究所 | 一种新型羰基还原酶、其基因及应用 |
| CN113461619A (zh) * | 2014-02-06 | 2021-10-01 | 株式会社Api | 瑞舒伐他汀钙及其中间体的生产方法 |
| CN113620871A (zh) * | 2015-08-05 | 2021-11-09 | 株式会社Api | 生产匹伐他汀钙的方法 |
| CN107058251B (zh) * | 2017-04-19 | 2020-10-09 | 浙江工业大学 | 重组羰基还原酶突变体、基因、载体、工程菌及其应用 |
| CN111836899B (zh) * | 2017-12-20 | 2024-06-25 | 欧伦股份公司 | 制备用于通过酶还原合成光学活性β-氨基醇的中间体的方法以及合成中间体 |
| EP3778898A4 (de) * | 2018-03-30 | 2022-02-09 | API Corporation | Neuartige hydrolase und verfahren zur herstellung von (1s,2s)-1-alkoxycarbonyl-2-vinylcyclopropancarbonsäure damit |
| JPWO2021100848A1 (de) * | 2019-11-22 | 2021-05-27 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH083487B2 (ja) * | 1987-07-31 | 1996-01-17 | 株式会社日本抗体研究所 | 異常応答リンパ球の検出方法並びにこれに用いる検出用試薬及びキット |
| JP2569746B2 (ja) * | 1987-08-20 | 1997-01-08 | 日産化学工業株式会社 | キノリン系メバロノラクトン類 |
| CA1336714C (en) * | 1987-08-20 | 1995-08-15 | Yoshihiro Fujikawa | Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis |
| JP3481325B2 (ja) * | 1994-09-06 | 2003-12-22 | 宇部興産株式会社 | 光学活性な３−オキシ−５−オキソ−６−ヘプテン酸誘導体の製法 |
| JP3554036B2 (ja) * | 1994-09-06 | 2004-08-11 | 宇部興産株式会社 | 光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法 |
| IL131241A0 (en) * | 1997-02-07 | 2001-01-28 | Kaneka Corp | Novel carbonyl reductase gene coding same and method for using such reductase and gene |
| CN1292818A (zh) * | 1998-03-12 | 2001-04-25 | 大正制药株式会社 | 新型二羰基还原酶及编码其的基因 |
| WO2002063028A1 (fr) * | 2001-02-02 | 2002-08-15 | Mitsubishi Chemical Corporation | Procede de production d'esters d'acide (3r,5s)-(e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxyhept-6-enique |
-
2003
- 2003-03-18 TW TW092105945A patent/TW200305645A/zh not_active IP Right Cessation
- 2003-03-18 CA CA2479705A patent/CA2479705C/en not_active Expired - Fee Related
- 2003-03-18 KR KR1020047014689A patent/KR100998235B1/ko not_active IP Right Cessation
- 2003-03-18 WO PCT/JP2003/003262 patent/WO2003078634A1/ja active IP Right Grant
- 2003-03-18 CN CNB038114607A patent/CN1322129C/zh not_active Expired - Lifetime
- 2003-03-18 AT AT03712750T patent/ATE406447T1/de not_active IP Right Cessation
- 2003-03-18 DE DE60323215T patent/DE60323215D1/de not_active Expired - Lifetime
- 2003-03-18 EP EP03712750A patent/EP1491633B1/de not_active Expired - Lifetime
- 2003-03-18 AU AU2003221082A patent/AU2003221082B2/en not_active Ceased
-
2004
- 2004-09-17 US US10/943,202 patent/US7335757B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003221082B2 (en) | 2007-06-07 |
| CN1656225A (zh) | 2005-08-17 |
| WO2003078634A1 (fr) | 2003-09-25 |
| US20050048633A1 (en) | 2005-03-03 |
| US7335757B2 (en) | 2008-02-26 |
| KR20040111422A (ko) | 2004-12-31 |
| CA2479705A1 (en) | 2003-09-25 |
| EP1491633B1 (de) | 2008-08-27 |
| CN1322129C (zh) | 2007-06-20 |
| TW200305645A (en) | 2003-11-01 |
| TWI304839B (de) | 2009-01-01 |
| KR100998235B1 (ko) | 2010-12-06 |
| EP1491633A1 (de) | 2004-12-29 |
| CA2479705C (en) | 2011-02-01 |
| DE60323215D1 (de) | 2008-10-09 |
| AU2003221082A1 (en) | 2003-09-29 |
| EP1491633A4 (de) | 2005-08-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |