CN1322129C - 新型羰基还原酶及其编码基因、以及利用它们制备光学活性醇的方法 - Google Patents
新型羰基还原酶及其编码基因、以及利用它们制备光学活性醇的方法 Download PDFInfo
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- CN1322129C CN1322129C CNB038114607A CN03811460A CN1322129C CN 1322129 C CN1322129 C CN 1322129C CN B038114607 A CNB038114607 A CN B038114607A CN 03811460 A CN03811460 A CN 03811460A CN 1322129 C CN1322129 C CN 1322129C
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Abstract
Description
底物 | 比活性(%) |
邻-硝基苯甲醛 | 52.6 |
间-硝基苯甲醛 | 45.6 |
邻-氯苯甲醛 | 81.2 |
间-氯苯甲醛 | 14.3 |
对-氯苯甲醛 | 15.2 |
二乙酰基(Diacetyl) | 12.3 |
2,3-戊二酮 | 21.5 |
3-氯-2,4-戊二酮 | 32.7 |
1-溴-3,3-二甲基-2-丁酮 | 55.4 |
乙基-3-甲基-2-氧代丁酸酯(oxobutanoate) | 72.1 |
α-酮-泛内酯 | 26.3 |
2-氯-环己酮 | 163.0 |
2-氯-2-甲基-环己酮 | 105.4 |
苯基·乙基酮 | 18.8 |
苄基乙腈 | 25.9 |
乙基苯甲酰乙酸酯 | 10.9 |
间-氯-苯乙酮 | 30.7 |
对-氯-苯乙酮 | 10.2 |
间-溴-苯乙酮 | 21.3 |
2-氯-苯乙酮 | 19.6 |
2,2,2-三氟-苯乙酮 | 100.0 |
Claims (7)
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JP2002075921 | 2002-03-19 | ||
JP75921/2002 | 2002-03-19 |
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CN1656225A CN1656225A (zh) | 2005-08-17 |
CN1322129C true CN1322129C (zh) | 2007-06-20 |
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CNB038114607A Expired - Lifetime CN1322129C (zh) | 2002-03-19 | 2003-03-18 | 新型羰基还原酶及其编码基因、以及利用它们制备光学活性醇的方法 |
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US (1) | US7335757B2 (zh) |
EP (1) | EP1491633B1 (zh) |
KR (1) | KR100998235B1 (zh) |
CN (1) | CN1322129C (zh) |
AT (1) | ATE406447T1 (zh) |
AU (1) | AU2003221082B2 (zh) |
CA (1) | CA2479705C (zh) |
DE (1) | DE60323215D1 (zh) |
TW (1) | TW200305645A (zh) |
WO (1) | WO2003078634A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101429514B (zh) * | 2007-11-08 | 2011-06-15 | 陈依军 | 一种双羰基还原酶、其基因及其应用 |
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DE10327454A1 (de) * | 2003-06-18 | 2005-01-20 | Juelich Enzyme Products Gmbh | Oxidoreduktase aus Pichia capsulata |
CN1993464B (zh) * | 2004-08-06 | 2011-12-28 | 株式会社钟化 | 新羰基还原酶、其基因及它们的使用方法 |
US8338146B2 (en) * | 2007-06-20 | 2012-12-25 | Basf Se | Method for producing optically active alcohols using an Azoarcus sp. EbN1 dehydrogenase |
CN102803233B (zh) * | 2009-06-22 | 2017-03-01 | 爱思开生物制药株式会社 | 制备氨基甲酸(r)‑1‑芳基‑2‑四唑基‑乙酯的方法 |
US8404461B2 (en) | 2009-10-15 | 2013-03-26 | SK Biopharmaceutical Co. Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
CN102492668B (zh) * | 2011-11-29 | 2013-06-26 | 华东理工大学 | 一种羰基还原酶及其基因和在不对称还原羰基化合物中的应用 |
CN102559520B (zh) * | 2011-12-15 | 2013-11-20 | 江南大学 | 一种利用微生物催化制备(s)-(4-氯苯基)-(吡啶-2-基)-甲醇的方法 |
CN102653524A (zh) * | 2012-01-12 | 2012-09-05 | 东莞达信生物技术有限公司 | 一种匹伐他汀钙中间体的制备方法 |
US10294461B2 (en) | 2013-03-28 | 2019-05-21 | Kaneka Corporation | Modified carbonyl reducing enzyme and gene |
CN103695443B (zh) * | 2014-01-12 | 2015-12-09 | 中国科学院成都生物研究所 | 一种新型羰基还原酶、其基因及应用 |
US9695130B2 (en) | 2014-02-06 | 2017-07-04 | Api Corporation | Rosuvastatin calcium and process for producing intermediate thereof |
EP3333155B1 (en) | 2015-08-05 | 2023-05-24 | API Corporation | Method for producing pitavastatin calcium |
CN107058251B (zh) * | 2017-04-19 | 2020-10-09 | 浙江工业大学 | 重组羰基还原酶突变体、基因、载体、工程菌及其应用 |
CN111836899B (zh) * | 2017-12-20 | 2024-06-25 | 欧伦股份公司 | 制备用于通过酶还原合成光学活性β-氨基醇的中间体的方法以及合成中间体 |
JP7458680B2 (ja) * | 2018-03-30 | 2024-04-01 | 株式会社エーピーアイ コーポレーション | 新規加水分解酵素及びそれを利用した(1s,2s)-1-アルコキシカルボニル-2-ビニルシクロプロパンカルボン酸の製造方法 |
CN114729374A (zh) * | 2019-11-22 | 2022-07-08 | 株式会社Api | 羰基还原酶、编码该酶的核酸、以及利用它们的光学活性化合物的制造方法 |
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EP0304663A1 (en) * | 1987-07-31 | 1989-03-01 | Japan Immuno Research Laboratories Co., Ltd. | Detection method of abnormally responding lymphocytes as well as detection reagent and kit therefor |
CN1292818A (zh) * | 1998-03-12 | 2001-04-25 | 大正制药株式会社 | 新型二羰基还原酶及编码其的基因 |
WO2002063028A1 (fr) * | 2001-02-02 | 2002-08-15 | Mitsubishi Chemical Corporation | Procede de production d'esters d'acide (3r,5s)-(e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxyhept-6-enique |
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CA1336714C (en) * | 1987-08-20 | 1995-08-15 | Yoshihiro Fujikawa | Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis |
JP2569746B2 (ja) | 1987-08-20 | 1997-01-08 | 日産化学工業株式会社 | キノリン系メバロノラクトン類 |
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JP3554036B2 (ja) * | 1994-09-06 | 2004-08-11 | 宇部興産株式会社 | 光学活性な7−置換キノリル−3,5−ジヒドロキシ−ヘプト−6−エン酸エステル誘導体の製造方法 |
DE69731317T2 (de) * | 1997-02-07 | 2006-02-23 | Kaneka Corp. | Neue carbonyl-reduktase, gene welche diese kodieren und methoden zu deren verwendung |
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2003
- 2003-03-18 CA CA2479705A patent/CA2479705C/en not_active Expired - Fee Related
- 2003-03-18 AT AT03712750T patent/ATE406447T1/de not_active IP Right Cessation
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- 2003-03-18 KR KR1020047014689A patent/KR100998235B1/ko not_active IP Right Cessation
- 2003-03-18 AU AU2003221082A patent/AU2003221082B2/en not_active Ceased
- 2003-03-18 WO PCT/JP2003/003262 patent/WO2003078634A1/ja active IP Right Grant
- 2003-03-18 DE DE60323215T patent/DE60323215D1/de not_active Expired - Lifetime
- 2003-03-18 EP EP03712750A patent/EP1491633B1/en not_active Expired - Lifetime
- 2003-03-18 CN CNB038114607A patent/CN1322129C/zh not_active Expired - Lifetime
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- 2004-09-17 US US10/943,202 patent/US7335757B2/en not_active Expired - Lifetime
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EP0304663A1 (en) * | 1987-07-31 | 1989-03-01 | Japan Immuno Research Laboratories Co., Ltd. | Detection method of abnormally responding lymphocytes as well as detection reagent and kit therefor |
CN1292818A (zh) * | 1998-03-12 | 2001-04-25 | 大正制药株式会社 | 新型二羰基还原酶及编码其的基因 |
WO2002063028A1 (fr) * | 2001-02-02 | 2002-08-15 | Mitsubishi Chemical Corporation | Procede de production d'esters d'acide (3r,5s)-(e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxyhept-6-enique |
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CN101429514B (zh) * | 2007-11-08 | 2011-06-15 | 陈依军 | 一种双羰基还原酶、其基因及其应用 |
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Publication number | Publication date |
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EP1491633A1 (en) | 2004-12-29 |
CN1656225A (zh) | 2005-08-17 |
EP1491633B1 (en) | 2008-08-27 |
AU2003221082A1 (en) | 2003-09-29 |
US7335757B2 (en) | 2008-02-26 |
TW200305645A (en) | 2003-11-01 |
CA2479705A1 (en) | 2003-09-25 |
DE60323215D1 (de) | 2008-10-09 |
US20050048633A1 (en) | 2005-03-03 |
EP1491633A4 (en) | 2005-08-17 |
KR100998235B1 (ko) | 2010-12-06 |
AU2003221082B2 (en) | 2007-06-07 |
CA2479705C (en) | 2011-02-01 |
TWI304839B (zh) | 2009-01-01 |
ATE406447T1 (de) | 2008-09-15 |
WO2003078634A1 (fr) | 2003-09-25 |
KR20040111422A (ko) | 2004-12-31 |
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