CN1329520C - 制备(3r,5s)－(e)－7－[2－环丙基－4－(4－氟苯基)－喹啉－3－基]－3,5－二羟基庚－6－烯酸酯的方法 - Google Patents
制备(3r,5s)－(e)－7－[2－环丙基－4－(4－氟苯基)－喹啉－3－基]－3,5－二羟基庚－6－烯酸酯的方法 Download PDFInfo
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- CN1329520C CN1329520C CNB028078527A CN02807852A CN1329520C CN 1329520 C CN1329520 C CN 1329520C CN B028078527 A CNB028078527 A CN B028078527A CN 02807852 A CN02807852 A CN 02807852A CN 1329520 C CN1329520 C CN 1329520C
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- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- CNFDGXZLMLFIJV-UHFFFAOYSA-L manganese(II) chloride tetrahydrate Chemical compound O.O.O.O.[Cl-].[Cl-].[Mn+2] CNFDGXZLMLFIJV-UHFFFAOYSA-L 0.000 description 1
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- 125000001477 organic nitrogen group Chemical group 0.000 description 1
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- RYGIHSLRMNXWCN-UHFFFAOYSA-N quinoline-3-carbaldehyde Chemical compound C1=CC=CC2=CC(C=O)=CN=C21 RYGIHSLRMNXWCN-UHFFFAOYSA-N 0.000 description 1
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- 239000010703 silicon Substances 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
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- JMXKSZRRTHPKDL-UHFFFAOYSA-N titanium ethoxide Chemical compound [Ti+4].CC[O-].CC[O-].CC[O-].CC[O-] JMXKSZRRTHPKDL-UHFFFAOYSA-N 0.000 description 1
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
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|---|---|---|---|
| JP2001026316 | 2001-02-02 | ||
| JP26316/2001 | 2001-02-02 | ||
| JP331480/2001 | 2001-10-29 | ||
| JP2001331480A JP2003137870A (ja) | 2001-10-29 | 2001-10-29 | ３，５−ジオキソ−６−ヘプテン酸誘導体類の製造方法及びその中間体 |
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|---|---|
| CN1633502A CN1633502A (zh) | 2005-06-29 |
| CN1329520C true CN1329520C (zh) | 2007-08-01 |
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| CNB028078527A Expired - Lifetime CN1329520C (zh) | 2001-02-02 | 2002-02-01 | 制备(3r,5s)－(e)－7－[2－环丙基－4－(4－氟苯基)－喹啉－3－基]－3,5－二羟基庚－6－烯酸酯的方法 |
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| US (1) | US6965031B2 (enExample) |
| EP (1) | EP1365029A4 (enExample) |
| KR (1) | KR100883874B1 (enExample) |
| CN (1) | CN1329520C (enExample) |
| AU (1) | AU2002228413B8 (enExample) |
| CA (1) | CA2437312C (enExample) |
| TW (1) | TWI322829B (enExample) |
| WO (1) | WO2002063028A1 (enExample) |
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| TWI322829B (enExample) * | 2001-02-02 | 2010-04-01 | Mitsubishi Chem Corp | |
| UA76984C2 (en) * | 2001-04-05 | 2006-10-16 | Nissan Chemical Ind Ltd | A method for preparing a 7-qunolinyl-3,5-dihydroxyhept-6-enoate |
| ATE426594T1 (de) * | 2002-01-31 | 2009-04-15 | Novartis Pharma Gmbh | Verfahren zur herstellung von inhibitoren der hmg-coa-reduktase |
| EP1491633B1 (en) * | 2002-03-19 | 2008-08-27 | Mitsubishi Chemical Corporation | Novel carbonyl reductase, gene encoding it and process for producing optically active alcohols using the same |
| ITMI20100753A1 (it) * | 2010-04-30 | 2011-10-31 | Dipharma Francis Srl | Procedimento per la preparazione di statine |
| EP2383260A3 (en) * | 2010-04-30 | 2011-12-28 | Dipharma Francis S.r.l. | Process for the preparation of statins |
| CN103848784B (zh) * | 2012-12-05 | 2016-12-21 | 安徽省庆云医药化工有限公司 | 匹伐他汀酯的晶型及其制备方法 |
| JP6150703B2 (ja) * | 2013-10-08 | 2017-06-21 | ダイト株式会社 | ピタバスタチンカルシウム塩の分解抑制方法 |
| CN106029895B (zh) * | 2014-02-06 | 2021-07-16 | 株式会社Api | 瑞舒伐他汀钙及其中间体的生产方法 |
| JP6649263B2 (ja) * | 2014-10-10 | 2020-02-19 | 株式会社エーピーアイ コーポレーション | スタチン系化合物の精製方法 |
| CN107949556B (zh) * | 2015-08-05 | 2021-12-07 | 株式会社Api | 生产匹伐他汀钙的方法 |
| CN105481838A (zh) * | 2015-11-18 | 2016-04-13 | 北京万全德众医药生物技术有限公司 | 一种制备匹伐他汀内酯杂质的方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5324662A (en) * | 1992-05-15 | 1994-06-28 | E. R. Squibb & Sons, Inc. | Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters |
| JPH0892217A (ja) * | 1994-09-06 | 1996-04-09 | Ube Ind Ltd | 光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1336714C (en) * | 1987-08-20 | 1995-08-15 | Yoshihiro Fujikawa | Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis |
| JP2648897B2 (ja) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| JP3149265B2 (ja) | 1992-05-12 | 2001-03-26 | 鐘淵化学工業株式会社 | 光学活性な３，５−ジヒドロキシ脂肪酸エステル誘導体の製造法 |
| JP3481325B2 (ja) * | 1994-09-06 | 2003-12-22 | 宇部興産株式会社 | 光学活性な３−オキシ−５−オキソ−６−ヘプテン酸誘導体の製法 |
| GB9512837D0 (en) | 1995-06-23 | 1995-08-23 | Zeneca Ltd | reduction of ketone groups |
| TWI322829B (enExample) * | 2001-02-02 | 2010-04-01 | Mitsubishi Chem Corp |
-
2002
- 2002-02-01 TW TW091101786A patent/TWI322829B/zh not_active IP Right Cessation
- 2002-02-01 CN CNB028078527A patent/CN1329520C/zh not_active Expired - Lifetime
- 2002-02-01 AU AU2002228413A patent/AU2002228413B8/en not_active Ceased
- 2002-02-01 KR KR1020037010128A patent/KR100883874B1/ko not_active Expired - Fee Related
- 2002-02-01 EP EP02710461A patent/EP1365029A4/en not_active Withdrawn
- 2002-02-01 CA CA2437312A patent/CA2437312C/en not_active Expired - Fee Related
- 2002-02-01 WO PCT/JP2002/000835 patent/WO2002063028A1/ja not_active Ceased
-
2003
- 2003-07-30 US US10/629,865 patent/US6965031B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5324662A (en) * | 1992-05-15 | 1994-06-28 | E. R. Squibb & Sons, Inc. | Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters |
| JPH0892217A (ja) * | 1994-09-06 | 1996-04-09 | Ube Ind Ltd | 光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1365029A4 (en) | 2009-07-29 |
| EP1365029A1 (en) | 2003-11-26 |
| AU2002228413A1 (en) | 2002-08-19 |
| US6965031B2 (en) | 2005-11-15 |
| AU2002228413B2 (en) | 2007-02-22 |
| AU2002228413B8 (en) | 2007-03-22 |
| WO2002063028A1 (fr) | 2002-08-15 |
| CA2437312A1 (en) | 2002-08-15 |
| TWI322829B (enExample) | 2010-04-01 |
| CA2437312C (en) | 2010-03-23 |
| KR100883874B1 (ko) | 2009-02-17 |
| US20040030139A1 (en) | 2004-02-12 |
| KR20030072618A (ko) | 2003-09-15 |
| CN1633502A (zh) | 2005-06-29 |
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