KR100869037B1 - 치환된 아크릴로일 디스타마이신 유도체 및 알킬화제를 포함하는 항종양 조성물 - Google Patents

치환된 아크릴로일 디스타마이신 유도체 및 알킬화제를 포함하는 항종양 조성물 Download PDF

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Publication number
KR100869037B1
KR100869037B1 KR1020027017565A KR20027017565A KR100869037B1 KR 100869037 B1 KR100869037 B1 KR 100869037B1 KR 1020027017565 A KR1020027017565 A KR 1020027017565A KR 20027017565 A KR20027017565 A KR 20027017565A KR 100869037 B1 KR100869037 B1 KR 100869037B1
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South Korea
Prior art keywords
amino
methyl
carbonyl
pyrrole
formula
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Expired - Fee Related
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English (en)
Korean (ko)
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KR20030011105A (ko
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제로니마리아크리스티나로사
코지파올로
베리아이탈로
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네르비아노 메디칼 사이언시스 에스.알.엘.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1020027017565A 2000-06-23 2001-06-20 치환된 아크릴로일 디스타마이신 유도체 및 알킬화제를 포함하는 항종양 조성물 Expired - Fee Related KR100869037B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0015447.6A GB0015447D0 (en) 2000-06-23 2000-06-23 Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015447.6 2000-06-23
PCT/EP2001/007064 WO2001097790A2 (en) 2000-06-23 2001-06-20 Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and alkylating agents

Publications (2)

Publication Number Publication Date
KR20030011105A KR20030011105A (ko) 2003-02-06
KR100869037B1 true KR100869037B1 (ko) 2008-11-17

Family

ID=9894288

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027017565A Expired - Fee Related KR100869037B1 (ko) 2000-06-23 2001-06-20 치환된 아크릴로일 디스타마이신 유도체 및 알킬화제를 포함하는 항종양 조성물

Country Status (28)

Country Link
US (1) US8642580B2 (enExample)
EP (1) EP1303307B1 (enExample)
JP (1) JP2003535891A (enExample)
KR (1) KR100869037B1 (enExample)
CN (1) CN100479860C (enExample)
AT (1) ATE362365T1 (enExample)
AU (2) AU8186701A (enExample)
BR (1) BR0111740A (enExample)
CA (1) CA2410160C (enExample)
CY (1) CY1106713T1 (enExample)
CZ (1) CZ301053B6 (enExample)
DE (1) DE60128472T2 (enExample)
DK (1) DK1303307T3 (enExample)
EA (1) EA008502B1 (enExample)
EE (1) EE05300B1 (enExample)
ES (1) ES2284674T3 (enExample)
GB (1) GB0015447D0 (enExample)
HK (1) HK1054335B (enExample)
HU (1) HUP0301234A2 (enExample)
IL (2) IL152956A0 (enExample)
MX (1) MXPA02012209A (enExample)
NO (1) NO329782B1 (enExample)
NZ (1) NZ522999A (enExample)
PL (1) PL202053B1 (enExample)
PT (1) PT1303307E (enExample)
SK (1) SK18342002A3 (enExample)
WO (1) WO2001097790A2 (enExample)
ZA (1) ZA200209836B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL371179A1 (en) * 2002-01-02 2005-06-13 Pharmacia Italia S.P.A. Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors
IL164356A0 (en) * 2002-04-02 2005-12-18 Pharmacia Italia Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy
MD35Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
MD36Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
MD24Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
MD23Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare
US9527863B2 (en) * 2012-04-05 2016-12-27 Nerviano Medical Sciences S.R.L. Thieno-indole moieties and methods of treating using the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004524A1 (en) * 1996-07-25 1998-02-05 Pharmacia & Upjohn S.P.A. Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
WO1998021202A1 (en) 1996-11-11 1998-05-22 Pharmacia & Upjohn S.P.A. Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
WO1999050266A1 (en) 1998-03-27 1999-10-07 Pharmacia & Upjohn S.P.A. Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor agents

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Publication number Priority date Publication date Assignee Title
JPS56154493A (en) * 1980-04-30 1981-11-30 Shionogi & Co Ltd Novel platinum complex
CN85103908A (zh) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 制备4′-表多克索红菌素的新方法
AT387013B (de) 1985-07-16 1988-11-25 Erba Farmitalia Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
GB8612218D0 (en) 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
KR950013762B1 (en) 1986-10-07 1995-11-15 Boehringer Mannheim Italia Pharmaceutical compositions having antineoplastic activity
GB8906709D0 (en) 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja) 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
IT1272234B (it) 1994-05-02 1997-06-16 Consiglio Nazionale Ricerche Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en) 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
US5880097A (en) 1996-01-04 1999-03-09 Terrapin Techologies, Inc. Tethered prodrugs
WO1997028123A1 (en) 1996-02-02 1997-08-07 Pharmacia & Upjohn S.P.A. Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9610079D0 (en) 1996-05-14 1996-07-17 Pharmacia Spa Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9727524D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
GB9806689D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9816653D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816652D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en) 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB0011059D0 (en) * 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004524A1 (en) * 1996-07-25 1998-02-05 Pharmacia & Upjohn S.P.A. Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
WO1998021202A1 (en) 1996-11-11 1998-05-22 Pharmacia & Upjohn S.P.A. Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
WO1999050266A1 (en) 1998-03-27 1999-10-07 Pharmacia & Upjohn S.P.A. Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor agents

Also Published As

Publication number Publication date
ATE362365T1 (de) 2007-06-15
NO329782B1 (no) 2010-12-13
PL365158A1 (en) 2004-12-27
NZ522999A (en) 2004-10-29
EE200200660A (et) 2004-06-15
IL152956A0 (en) 2003-06-24
DK1303307T3 (da) 2007-07-16
CN1437485A (zh) 2003-08-20
WO2001097790A2 (en) 2001-12-27
CZ301053B6 (cs) 2009-10-21
CY1106713T1 (el) 2012-05-23
MXPA02012209A (es) 2003-06-04
DE60128472D1 (de) 2007-06-28
PL202053B1 (pl) 2009-05-29
KR20030011105A (ko) 2003-02-06
BR0111740A (pt) 2003-07-08
US20030180383A1 (en) 2003-09-25
EP1303307A2 (en) 2003-04-23
HK1054335B (zh) 2010-06-11
AU8186701A (en) 2002-01-02
IL152956A (en) 2010-06-30
HK1054335A1 (zh) 2003-11-28
CZ20024106A3 (cs) 2003-05-14
EA200300061A1 (ru) 2003-04-24
SK18342002A3 (sk) 2003-06-03
CA2410160C (en) 2009-06-02
US8642580B2 (en) 2014-02-04
PT1303307E (pt) 2007-07-04
CA2410160A1 (en) 2001-12-27
WO2001097790A3 (en) 2002-05-16
GB0015447D0 (en) 2000-08-16
ES2284674T3 (es) 2007-11-16
ZA200209836B (en) 2003-12-04
NO20026077D0 (no) 2002-12-18
NO20026077L (no) 2002-12-18
EA008502B1 (ru) 2007-06-29
HUP0301234A2 (hu) 2003-08-28
EE05300B1 (et) 2010-06-15
AU2001281867B2 (en) 2006-02-23
JP2003535891A (ja) 2003-12-02
CN100479860C (zh) 2009-04-22
DE60128472T2 (de) 2008-01-24
EP1303307B1 (en) 2007-05-16

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