CN100479860C - 包含取代的丙烯酰基偏端霉素衍生物和烷基化剂的抗肿瘤联合疗法 - Google Patents

包含取代的丙烯酰基偏端霉素衍生物和烷基化剂的抗肿瘤联合疗法 Download PDF

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Publication number
CN100479860C
CN100479860C CNB018114776A CN01811477A CN100479860C CN 100479860 C CN100479860 C CN 100479860C CN B018114776 A CNB018114776 A CN B018114776A CN 01811477 A CN01811477 A CN 01811477A CN 100479860 C CN100479860 C CN 100479860C
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China
Prior art keywords
amino
methyl
carbonyl
pyrrol
group
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Expired - Fee Related
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CNB018114776A
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English (en)
Chinese (zh)
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CN1437485A (zh
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M·C·R·格罗尼
P·科兹
I·伯利亚
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Nerviano Medical Sciences SRL
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Nerviano Medical Sciences SRL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB018114776A 2000-06-23 2001-06-20 包含取代的丙烯酰基偏端霉素衍生物和烷基化剂的抗肿瘤联合疗法 Expired - Fee Related CN100479860C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0015447.6A GB0015447D0 (en) 2000-06-23 2000-06-23 Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015447.6 2000-06-23

Publications (2)

Publication Number Publication Date
CN1437485A CN1437485A (zh) 2003-08-20
CN100479860C true CN100479860C (zh) 2009-04-22

Family

ID=9894288

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018114776A Expired - Fee Related CN100479860C (zh) 2000-06-23 2001-06-20 包含取代的丙烯酰基偏端霉素衍生物和烷基化剂的抗肿瘤联合疗法

Country Status (28)

Country Link
US (1) US8642580B2 (enExample)
EP (1) EP1303307B1 (enExample)
JP (1) JP2003535891A (enExample)
KR (1) KR100869037B1 (enExample)
CN (1) CN100479860C (enExample)
AT (1) ATE362365T1 (enExample)
AU (2) AU2001281867B2 (enExample)
BR (1) BR0111740A (enExample)
CA (1) CA2410160C (enExample)
CY (1) CY1106713T1 (enExample)
CZ (1) CZ301053B6 (enExample)
DE (1) DE60128472T2 (enExample)
DK (1) DK1303307T3 (enExample)
EA (1) EA008502B1 (enExample)
EE (1) EE05300B1 (enExample)
ES (1) ES2284674T3 (enExample)
GB (1) GB0015447D0 (enExample)
HK (1) HK1054335B (enExample)
HU (1) HUP0301234A2 (enExample)
IL (2) IL152956A0 (enExample)
MX (1) MXPA02012209A (enExample)
NO (1) NO329782B1 (enExample)
NZ (1) NZ522999A (enExample)
PL (1) PL202053B1 (enExample)
PT (1) PT1303307E (enExample)
SK (1) SK18342002A3 (enExample)
WO (1) WO2001097790A2 (enExample)
ZA (1) ZA200209836B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1461083T3 (da) * 2002-01-02 2006-07-10 Nerviano Medical Sciences Srl Kombineret terapi mod tumorer omfattende substitueret acryloyl distamycinderivater og proteinkinase- (serin/threoninkinase) inhibitorer
AU2003219102B2 (en) * 2002-04-02 2008-05-08 Nerviano Medical Sciences S.R.L. Combined therapy against tumors comprising subtituted acryloyl distamycin derivatives and radiotherapy
MD36Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
MD23Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare
MD24Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
MD35Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
JP6314128B2 (ja) * 2012-04-05 2018-04-18 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 新たなアルキル化剤

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1226232A (zh) * 1996-07-25 1999-08-18 法玛西雅厄普约翰公司 丙烯酰取代的偏端霉素衍生物,其制备方法,及其作为抗肿瘤和抗病毒剂的应用

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JPS56154493A (en) * 1980-04-30 1981-11-30 Shionogi & Co Ltd Novel platinum complex
CN85103908A (zh) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 制备4′-表多克索红菌素的新方法
SE468642B (sv) 1985-07-16 1993-02-22 Erba Farmitalia Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en) 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
AU605512B2 (en) 1986-10-07 1991-01-17 Boehringer Mannheim Italia S.P.A. Pharmaceutical compositions having antineoplastic activity
GB8906709D0 (en) 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja) 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
IT1272234B (it) 1994-05-02 1997-06-16 Consiglio Nazionale Ricerche Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en) 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
US5880097A (en) 1996-01-04 1999-03-09 Terrapin Techologies, Inc. Tethered prodrugs
WO1997028123A1 (en) 1996-02-02 1997-08-07 Pharmacia & Upjohn S.P.A. Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9610079D0 (en) 1996-05-14 1996-07-17 Pharmacia Spa Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
GB9806692D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9806689D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9816652D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816653D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en) 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1226232A (zh) * 1996-07-25 1999-08-18 法玛西雅厄普约翰公司 丙烯酰取代的偏端霉素衍生物,其制备方法,及其作为抗肿瘤和抗病毒剂的应用

Also Published As

Publication number Publication date
PT1303307E (pt) 2007-07-04
DE60128472D1 (de) 2007-06-28
ZA200209836B (en) 2003-12-04
WO2001097790A3 (en) 2002-05-16
NO20026077D0 (no) 2002-12-18
CY1106713T1 (el) 2012-05-23
AU8186701A (en) 2002-01-02
NO329782B1 (no) 2010-12-13
EE200200660A (et) 2004-06-15
EE05300B1 (et) 2010-06-15
ES2284674T3 (es) 2007-11-16
KR20030011105A (ko) 2003-02-06
AU2001281867B2 (en) 2006-02-23
NO20026077L (no) 2002-12-18
EA200300061A1 (ru) 2003-04-24
CZ301053B6 (cs) 2009-10-21
CN1437485A (zh) 2003-08-20
CA2410160A1 (en) 2001-12-27
US8642580B2 (en) 2014-02-04
PL365158A1 (en) 2004-12-27
JP2003535891A (ja) 2003-12-02
HUP0301234A2 (hu) 2003-08-28
DK1303307T3 (da) 2007-07-16
SK18342002A3 (sk) 2003-06-03
EP1303307B1 (en) 2007-05-16
CZ20024106A3 (cs) 2003-05-14
EP1303307A2 (en) 2003-04-23
DE60128472T2 (de) 2008-01-24
BR0111740A (pt) 2003-07-08
CA2410160C (en) 2009-06-02
GB0015447D0 (en) 2000-08-16
US20030180383A1 (en) 2003-09-25
ATE362365T1 (de) 2007-06-15
HK1054335A1 (zh) 2003-11-28
IL152956A (en) 2010-06-30
KR100869037B1 (ko) 2008-11-17
EA008502B1 (ru) 2007-06-29
WO2001097790A2 (en) 2001-12-27
PL202053B1 (pl) 2009-05-29
HK1054335B (zh) 2010-06-11
MXPA02012209A (es) 2003-06-04
IL152956A0 (en) 2003-06-24
NZ522999A (en) 2004-10-29

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