KR100832617B1 - 뉴클레오사이드 동족체의 입체선택적 제조 방법 - Google Patents

뉴클레오사이드 동족체의 입체선택적 제조 방법 Download PDF

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Publication number
KR100832617B1
KR100832617B1 KR1020037016301A KR20037016301A KR100832617B1 KR 100832617 B1 KR100832617 B1 KR 100832617B1 KR 1020037016301 A KR1020037016301 A KR 1020037016301A KR 20037016301 A KR20037016301 A KR 20037016301A KR 100832617 B1 KR100832617 B1 KR 100832617B1
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South Korea
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coupling
alkyl
compound
formula
substituted
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English (en)
Korean (ko)
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KR20040017233A (ko
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킹 유
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샤이어 캐나다 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
KR1020037016301A 2001-06-15 2002-06-14 뉴클레오사이드 동족체의 입체선택적 제조 방법 Expired - Fee Related KR100832617B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29807901P 2001-06-15 2001-06-15
US60/298,079 2001-06-15
PCT/CA2002/000899 WO2002102796A1 (en) 2001-06-15 2002-06-14 Stereoselective method for the preparation of nucleoside analogues

Publications (2)

Publication Number Publication Date
KR20040017233A KR20040017233A (ko) 2004-02-26
KR100832617B1 true KR100832617B1 (ko) 2008-05-27

Family

ID=23148927

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037016301A Expired - Fee Related KR100832617B1 (ko) 2001-06-15 2002-06-14 뉴클레오사이드 동족체의 입체선택적 제조 방법

Country Status (28)

Country Link
US (2) US7109334B2 (https=)
EP (2) EP1406896B8 (https=)
JP (1) JP4542776B2 (https=)
KR (1) KR100832617B1 (https=)
CN (1) CN1297553C (https=)
AP (1) AP1559A (https=)
AT (2) ATE313542T1 (https=)
AU (2) AU2002344862C1 (https=)
BR (2) BRPI0210444B1 (https=)
CA (1) CA2449338C (https=)
CO (1) CO5550497A2 (https=)
CY (1) CY1107805T1 (https=)
DE (2) DE60208202T2 (https=)
DK (2) DK1632490T3 (https=)
EA (1) EA006372B1 (https=)
ES (2) ES2293445T3 (https=)
HR (1) HRP20031021B1 (https=)
IL (2) IL159139A0 (https=)
MX (1) MXPA03011627A (https=)
NO (1) NO326135B1 (https=)
NZ (1) NZ529906A (https=)
OA (1) OA12628A (https=)
PL (2) PL218777B1 (https=)
PT (1) PT1632490E (https=)
RS (1) RS50868B (https=)
SI (2) SI1632490T1 (https=)
WO (1) WO2002102796A1 (https=)
ZA (1) ZA200309307B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7501514B1 (en) 2003-10-15 2009-03-10 Shire Biochem, Inc. Enantiomeric resolution of 2-substituted 4-substituted 1,3-oxathiolanes nucleosides
JP4653966B2 (ja) * 2004-04-19 2011-03-16 ダイセル化学工業株式会社 ２−ベンゾイルオキシアセトアルデヒド誘導体の製造法
EP2190839B1 (en) * 2007-09-28 2015-04-15 Avexa Limited A process for chiral resolution of 2-substituted 4-substituted 1,3-oxathiolanes
US20130165350A1 (en) * 2011-12-22 2013-06-27 Affymetrix, Inc. Surface linkers for array synthesis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008717A1 (en) * 1990-11-13 1992-05-29 Biochem Pharma Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR840001591A (ko) 1981-09-29 1984-05-07 구라바야시 이꾸시로 당케탈류의 제조방법
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
US5532349A (en) 1993-07-20 1996-07-02 Mitsui Toatsu Chemicals, Inc. Process for producing 1-(2'-deoxy-β-D-erythro-pentofuranosyl)-5-trifluoromethyluracil derivatives
CA2340214C (en) 1998-08-12 2007-10-30 Triangle Pharmaceuticals, Inc. Method of manufacture of 1,3-oxathiolane nucleosides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008717A1 (en) * 1990-11-13 1992-05-29 Biochem Pharma Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties

Also Published As

Publication number Publication date
OA12628A (en) 2006-06-13
CY1107805T1 (el) 2013-06-19
PL218777B1 (pl) 2015-01-30
NZ529906A (en) 2006-03-31
DE60208202D1 (de) 2006-01-26
PT1632490E (pt) 2007-11-07
CN1543463A (zh) 2004-11-03
CO5550497A2 (es) 2005-08-31
DK1632490T3 (da) 2008-01-28
IL159139A (en) 2010-04-15
DE60222031T2 (de) 2008-05-21
PL366907A1 (en) 2005-02-07
US20060183899A1 (en) 2006-08-17
EP1406896B8 (en) 2006-11-15
EA006372B1 (ru) 2005-12-29
JP2004535428A (ja) 2004-11-25
US7230100B2 (en) 2007-06-12
HK1070652A1 (en) 2005-06-24
KR20040017233A (ko) 2004-02-26
AU2002344862C1 (en) 2009-02-19
AU2008203443A1 (en) 2008-08-21
MXPA03011627A (es) 2005-03-07
JP4542776B2 (ja) 2010-09-15
US20030135048A1 (en) 2003-07-17
AU2008203443B2 (en) 2011-06-16
SI1406896T1 (sl) 2006-04-30
WO2002102796A8 (en) 2003-09-18
ES2254695T3 (es) 2006-06-16
ATE370945T1 (de) 2007-09-15
YU97503A (sh) 2006-05-25
BR0210444A (pt) 2004-08-17
CN1297553C (zh) 2007-01-31
PL215267B1 (pl) 2013-11-29
EP1406896B1 (en) 2005-12-21
HRP20031021B1 (hr) 2007-09-30
US7109334B2 (en) 2006-09-19
IL159139A0 (en) 2004-06-01
NO20035556D0 (no) 2003-12-12
ZA200309307B (en) 2005-02-23
HRP20031021A2 (en) 2004-06-30
DK1406896T3 (da) 2006-05-08
DE60208202T2 (de) 2006-08-17
EP1632490B1 (en) 2007-08-22
EA200400042A1 (ru) 2004-06-24
DE60222031D1 (de) 2007-10-04
CA2449338C (en) 2012-02-07
BRPI0210444B1 (pt) 2017-06-20
AU2002344862B2 (en) 2008-05-01
ATE313542T1 (de) 2006-01-15
CA2449338A1 (en) 2002-12-27
RS50868B (sr) 2010-08-31
PL401835A1 (pl) 2013-02-18
AP1559A (en) 2006-01-24
WO2002102796A1 (en) 2002-12-27
SI1632490T1 (sl) 2008-02-29
EP1632490A1 (en) 2006-03-08
EP1406896A1 (en) 2004-04-14
ES2293445T3 (es) 2008-03-16
NO326135B1 (no) 2008-10-06

Similar Documents

Publication Publication Date Title
EP0757684B1 (en) Process for the diastereoselective synthesis of nucleoside analogues
US6831174B2 (en) Processes for preparing substituted 1, 3-oxathiolanes with antiviral properties
US20030013880A1 (en) Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers
KR100832617B1 (ko) 뉴클레오사이드 동족체의 입체선택적 제조 방법
JP3110461B2 (ja) 二環式中間体を使用したヌクレオシド類似体の立体選択的合成
AU2002344862A1 (en) Stereoselective method for the preparation of nucleoside analogues
HK1004221B (en) Process for the diastereoselective synthesis of nucleoside analogues

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