KR100789468B1 - Ｓ-(-)-클로로숙신산의 제조방법 - Google Patents

Ｓ-(-)-클로로숙신산의 제조방법 Download PDF

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Publication number
KR100789468B1
KR100789468B1 KR1020067021556A KR20067021556A KR100789468B1 KR 100789468 B1 KR100789468 B1 KR 100789468B1 KR 1020067021556 A KR1020067021556 A KR 1020067021556A KR 20067021556 A KR20067021556 A KR 20067021556A KR 100789468 B1 KR100789468 B1 KR 100789468B1
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KR
South Korea
Prior art keywords
acid
reaction
chlorosuccinic
carnitine
mother liquor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020067021556A
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English (en)
Korean (ko)
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KR20060114044A (ko
Inventor
피에로 멜로니
알베르토 세리
마르코 산타고스티노
Original Assignee
시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이.
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Filing date
Publication date
Priority claimed from IT1999RM000310 external-priority patent/IT1306142B1/it
Priority claimed from IT1999RM000670 external-priority patent/IT1306737B1/it
Priority claimed from IT2000RM000061 external-priority patent/IT1316989B1/it
Application filed by 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. filed Critical 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이.
Publication of KR20060114044A publication Critical patent/KR20060114044A/ko
Application granted granted Critical
Publication of KR100789468B1 publication Critical patent/KR100789468B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/54—Preparation of carboxylic acid anhydrides
    • C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
KR1020067021556A 1999-05-18 2000-05-12 Ｓ-(-)-클로로숙신산의 제조방법 Expired - Fee Related KR100789468B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
ITRM99A000310 1999-05-18
IT1999RM000310 IT1306142B1 (it) 1999-05-18 1999-05-18 Procedimento per la preparazione di r-(-)-carnitina a partiredall'acido s-(-)-clorosuccinico.
ITRM99A000670 1999-10-29
IT1999RM000670 IT1306737B1 (it) 1999-10-29 1999-10-29 Procedimento per la preparazione di acidi carbossilici chirali.
IT2000RM000061 IT1316989B1 (it) 2000-02-10 2000-02-10 Procedimento per la preparazione di r-(-)- carnitina a partire daacido s-(-)- clorosuccinico o da un suo derivato.
ITRM00A000061 2000-02-10

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020017014397A Division KR100684379B1 (ko) 1999-05-18 2000-05-12 Ｓ-(-)-클로로숙신산 또는 그의 유도체로부터의ｒ-(-)-카르니틴의 제조 방법

Publications (2)

Publication Number Publication Date
KR20060114044A KR20060114044A (ko) 2006-11-03
KR100789468B1 true KR100789468B1 (ko) 2008-01-02

Family

ID=27274166

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020067021556A Expired - Fee Related KR100789468B1 (ko) 1999-05-18 2000-05-12 Ｓ-(-)-클로로숙신산의 제조방법
KR1020017014397A Expired - Fee Related KR100684379B1 (ko) 1999-05-18 2000-05-12 Ｓ-(-)-클로로숙신산 또는 그의 유도체로부터의ｒ-(-)-카르니틴의 제조 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020017014397A Expired - Fee Related KR100684379B1 (ko) 1999-05-18 2000-05-12 Ｓ-(-)-클로로숙신산 또는 그의 유도체로부터의ｒ-(-)-카르니틴의 제조 방법

Country Status (19)

Country Link
US (3) US6677476B1 (https=)
EP (2) EP1468979A1 (https=)
JP (2) JP4584464B2 (https=)
KR (2) KR100789468B1 (https=)
CN (1) CN1158244C (https=)
AT (1) ATE346838T1 (https=)
AU (1) AU4612100A (https=)
CA (1) CA2372424A1 (https=)
CY (1) CY1107566T1 (https=)
CZ (1) CZ20013816A3 (https=)
DE (1) DE60032139T2 (https=)
DK (1) DK1187805T3 (https=)
ES (1) ES2277838T3 (https=)
HU (1) HUP0201418A3 (https=)
MX (1) MXPA01011758A (https=)
PL (1) PL203993B1 (https=)
PT (1) PT1187805E (https=)
SK (1) SK286155B6 (https=)
WO (1) WO2000069808A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI367882B (en) 2003-03-26 2012-07-11 Du Pont Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates
WO2007139238A1 (en) * 2006-05-26 2007-12-06 Enzytech, Ltd. Process for l-carnitine and acetyl l-carnitine hydrochloride
KR101097006B1 (ko) 2006-11-09 2011-12-20 미츠비시 레이온 가부시키가이샤 베타인의 제조 방법
EP2325164A1 (en) * 2009-11-18 2011-05-25 Lonza Ltd. Methods for the production of l-carnitine
US8310256B2 (en) 2009-12-22 2012-11-13 Teradyne, Inc. Capacitive opens testing in low signal environments
EP2595973B1 (en) * 2010-07-21 2017-07-12 Lonza Ltd. A process for the production of carnitine from beta-lactones
KR101110206B1 (ko) * 2011-05-02 2012-02-15 송명호 개폐가 용이하도록 완충기가 구비된 진동선별장치
CN118638020B (zh) * 2024-08-08 2024-11-19 杭州海尔希畜牧科技有限公司 L-天门冬氨酸l(-)肉碱(1:1)的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3144698A1 (de) * 1981-11-11 1983-05-19 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von hydantoinen
US5473104A (en) 1994-09-13 1995-12-05 Neurocrine Biosciences, Inc. Process for the preparation of L-carnitine
WO1999005092A1 (en) * 1997-07-28 1999-02-04 Samsung Fine Chemicals Co., Ltd. Process for the preparation of l-carnitine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45594A (en) * 1973-11-12 1977-12-30 Stauffer Chemical Co Bis-substituted succinamides and their use as herbicides
GB1513257A (en) * 1975-02-03 1978-06-07 Stauffer Chemical Co Bis-substituted succinamides and the use thereof as herbicides
US4265247A (en) * 1979-11-07 1981-05-05 Research Corporation Malic acid polymers
ZA826022B (en) * 1981-08-21 1983-08-31 Univ Miami Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
DE3144697A1 (de) * 1981-11-11 1983-05-19 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von hydantoinen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3144698A1 (de) * 1981-11-11 1983-05-19 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von hydantoinen
US5473104A (en) 1994-09-13 1995-12-05 Neurocrine Biosciences, Inc. Process for the preparation of L-carnitine
WO1999005092A1 (en) * 1997-07-28 1999-02-04 Samsung Fine Chemicals Co., Ltd. Process for the preparation of l-carnitine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MAKROMOLECULARE CHEMIE, MACROMOLECULAR SYMPOSIA, 6, PP. 285-303, 1986

Also Published As

Publication number Publication date
WO2000069808A1 (en) 2000-11-23
EP1187805A1 (en) 2002-03-20
US20050245762A1 (en) 2005-11-03
JP4584464B2 (ja) 2010-11-24
DE60032139D1 (de) 2007-01-11
KR20020009609A (ko) 2002-02-01
CY1107566T1 (el) 2013-03-13
ATE346838T1 (de) 2006-12-15
HUP0201418A3 (en) 2002-11-28
US6984739B2 (en) 2006-01-10
DK1187805T3 (da) 2007-04-16
JP2010229157A (ja) 2010-10-14
AU4612100A (en) 2000-12-05
MXPA01011758A (es) 2002-05-14
KR100684379B1 (ko) 2007-02-20
US20040102645A1 (en) 2004-05-27
EP1468979A1 (en) 2004-10-20
JP2002544252A (ja) 2002-12-24
CA2372424A1 (en) 2000-11-23
DE60032139T2 (de) 2007-09-27
PT1187805E (pt) 2007-01-31
PL203993B1 (pl) 2009-11-30
US6677476B1 (en) 2004-01-13
CZ20013816A3 (cs) 2002-02-13
EP1187805B1 (en) 2006-11-29
PL351646A1 (en) 2003-05-19
KR20060114044A (ko) 2006-11-03
ES2277838T3 (es) 2007-08-01
CN1158244C (zh) 2004-07-21
SK16012001A3 (sk) 2002-04-04
US7247747B2 (en) 2007-07-24
CN1352630A (zh) 2002-06-05
HUP0201418A2 (en) 2002-08-28
SK286155B6 (sk) 2008-04-07

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