HUP0201418A3 - Process for preparing r-(-)-carnitine from s-(-)-chlorosuccinic acid or from a derative thereof - Google Patents

Process for preparing r-(-)-carnitine from s-(-)-chlorosuccinic acid or from a derative thereof

Info

Publication number
HUP0201418A3
HUP0201418A3 HU0201418A HUP0201418A HUP0201418A3 HU P0201418 A3 HUP0201418 A3 HU P0201418A3 HU 0201418 A HU0201418 A HU 0201418A HU P0201418 A HUP0201418 A HU P0201418A HU P0201418 A3 HUP0201418 A3 HU P0201418A3
Authority
HU
Hungary
Prior art keywords
derative
carnitine
preparing
chlorosuccinic acid
chlorosuccinic
Prior art date
Application number
HU0201418A
Other languages
English (en)
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT1999RM000310 external-priority patent/IT1306142B1/it
Priority claimed from IT1999RM000670 external-priority patent/IT1306737B1/it
Priority claimed from IT2000RM000061 external-priority patent/IT1316989B1/it
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of HUP0201418A2 publication Critical patent/HUP0201418A2/hu
Publication of HUP0201418A3 publication Critical patent/HUP0201418A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/54—Preparation of carboxylic acid anhydrides
    • C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
HU0201418A 1999-05-18 2000-05-12 Process for preparing r-(-)-carnitine from s-(-)-chlorosuccinic acid or from a derative thereof HUP0201418A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT1999RM000310 IT1306142B1 (it) 1999-05-18 1999-05-18 Procedimento per la preparazione di r-(-)-carnitina a partiredall'acido s-(-)-clorosuccinico.
IT1999RM000670 IT1306737B1 (it) 1999-10-29 1999-10-29 Procedimento per la preparazione di acidi carbossilici chirali.
IT2000RM000061 IT1316989B1 (it) 2000-02-10 2000-02-10 Procedimento per la preparazione di r-(-)- carnitina a partire daacido s-(-)- clorosuccinico o da un suo derivato.

Publications (2)

Publication Number Publication Date
HUP0201418A2 HUP0201418A2 (en) 2002-08-28
HUP0201418A3 true HUP0201418A3 (en) 2002-11-28

Family

ID=27274166

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0201418A HUP0201418A3 (en) 1999-05-18 2000-05-12 Process for preparing r-(-)-carnitine from s-(-)-chlorosuccinic acid or from a derative thereof

Country Status (19)

Country Link
US (3) US6677476B1 (hu)
EP (2) EP1468979A1 (hu)
JP (2) JP4584464B2 (hu)
KR (2) KR100789468B1 (hu)
CN (1) CN1158244C (hu)
AT (1) ATE346838T1 (hu)
AU (1) AU4612100A (hu)
CA (1) CA2372424A1 (hu)
CY (1) CY1107566T1 (hu)
CZ (1) CZ20013816A3 (hu)
DE (1) DE60032139T2 (hu)
DK (1) DK1187805T3 (hu)
ES (1) ES2277838T3 (hu)
HU (1) HUP0201418A3 (hu)
MX (1) MXPA01011758A (hu)
PL (1) PL203993B1 (hu)
PT (1) PT1187805E (hu)
SK (1) SK286155B6 (hu)
WO (1) WO2000069808A1 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI367882B (en) 2003-03-26 2012-07-11 Du Pont Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates
WO2007139238A1 (en) * 2006-05-26 2007-12-06 Enzytech, Ltd. Process for l-carnitine and acetyl l-carnitine hydrochloride
WO2008056827A1 (en) 2006-11-09 2008-05-15 Mitsubishi Rayon Co., Ltd. Process for production of betaine
EP2325164A1 (en) * 2009-11-18 2011-05-25 Lonza Ltd. Methods for the production of l-carnitine
US8310256B2 (en) 2009-12-22 2012-11-13 Teradyne, Inc. Capacitive opens testing in low signal environments
KR20130093078A (ko) * 2010-07-21 2013-08-21 론차리미티드 베타-락톤으로부터 카르니틴의 제조방법
KR101110206B1 (ko) * 2011-05-02 2012-02-15 송명호 개폐가 용이하도록 완충기가 구비된 진동선별장치
CN118638020A (zh) * 2024-08-08 2024-09-13 杭州海尔希畜牧科技有限公司 L-天门冬氨酸l(-)肉碱(1:1)的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45594A (en) * 1973-11-12 1977-12-30 Stauffer Chemical Co Bis-substituted succinamides and their use as herbicides
GB1513257A (en) * 1975-02-03 1978-06-07 Stauffer Chemical Co Bis-substituted succinamides and the use thereof as herbicides
US4265247A (en) * 1979-11-07 1981-05-05 Research Corporation Malic acid polymers
ZA826022B (en) * 1981-08-21 1983-08-31 Univ Miami Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
DE3144697A1 (de) * 1981-11-11 1983-05-19 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von hydantoinen
DE3144698A1 (de) * 1981-11-11 1983-05-19 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von hydantoinen
US5473104A (en) * 1994-09-13 1995-12-05 Neurocrine Biosciences, Inc. Process for the preparation of L-carnitine
KR100255039B1 (ko) * 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법

Also Published As

Publication number Publication date
DE60032139D1 (de) 2007-01-11
US6677476B1 (en) 2004-01-13
JP4584464B2 (ja) 2010-11-24
KR100789468B1 (ko) 2008-01-02
JP2010229157A (ja) 2010-10-14
SK16012001A3 (sk) 2002-04-04
EP1468979A1 (en) 2004-10-20
ATE346838T1 (de) 2006-12-15
CN1352630A (zh) 2002-06-05
KR20060114044A (ko) 2006-11-03
CN1158244C (zh) 2004-07-21
DE60032139T2 (de) 2007-09-27
CZ20013816A3 (cs) 2002-02-13
WO2000069808A1 (en) 2000-11-23
CY1107566T1 (el) 2013-03-13
US20050245762A1 (en) 2005-11-03
ES2277838T3 (es) 2007-08-01
PT1187805E (pt) 2007-01-31
US7247747B2 (en) 2007-07-24
US20040102645A1 (en) 2004-05-27
KR100684379B1 (ko) 2007-02-20
US6984739B2 (en) 2006-01-10
AU4612100A (en) 2000-12-05
JP2002544252A (ja) 2002-12-24
HUP0201418A2 (en) 2002-08-28
MXPA01011758A (es) 2002-05-14
KR20020009609A (ko) 2002-02-01
DK1187805T3 (da) 2007-04-16
CA2372424A1 (en) 2000-11-23
PL351646A1 (en) 2003-05-19
PL203993B1 (pl) 2009-11-30
EP1187805B1 (en) 2006-11-29
EP1187805A1 (en) 2002-03-20
SK286155B6 (sk) 2008-04-07

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees