JP4584464B2 - Ｓ−（−）−クロロコハク酸またはその誘導体からｒ−（−）−カルニチンを調製するための方法 - Google Patents

Ｓ−（−）−クロロコハク酸またはその誘導体からｒ−（−）−カルニチンを調製するための方法 Download PDF

Info

Publication number
JP4584464B2
JP4584464B2 JP2000618226A JP2000618226A JP4584464B2 JP 4584464 B2 JP4584464 B2 JP 4584464B2 JP 2000618226 A JP2000618226 A JP 2000618226A JP 2000618226 A JP2000618226 A JP 2000618226A JP 4584464 B2 JP4584464 B2 JP 4584464B2
Authority
JP
Japan
Prior art keywords
acid
chlorosuccinic
reaction
preparation
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000618226A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002544252A (ja
JP2002544252A5 (https=
Inventor
ピエロ・メッローニ
アルベルト・チェッリ
マルコ・サンタゴスティーノ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT1999RM000310 external-priority patent/IT1306142B1/it
Priority claimed from IT1999RM000670 external-priority patent/IT1306737B1/it
Priority claimed from IT2000RM000061 external-priority patent/IT1316989B1/it
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of JP2002544252A publication Critical patent/JP2002544252A/ja
Publication of JP2002544252A5 publication Critical patent/JP2002544252A5/ja
Application granted granted Critical
Publication of JP4584464B2 publication Critical patent/JP4584464B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/54—Preparation of carboxylic acid anhydrides
    • C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
JP2000618226A 1999-05-18 2000-05-12 Ｓ−（−）−クロロコハク酸またはその誘導体からｒ−（−）−カルニチンを調製するための方法 Expired - Fee Related JP4584464B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
IT1999RM000310 IT1306142B1 (it) 1999-05-18 1999-05-18 Procedimento per la preparazione di r-(-)-carnitina a partiredall'acido s-(-)-clorosuccinico.
IT1999RM000670 IT1306737B1 (it) 1999-10-29 1999-10-29 Procedimento per la preparazione di acidi carbossilici chirali.
IT99A000310 2000-02-10
IT2000RM000061 IT1316989B1 (it) 2000-02-10 2000-02-10 Procedimento per la preparazione di r-(-)- carnitina a partire daacido s-(-)- clorosuccinico o da un suo derivato.
IT99A000670 2000-02-10
IT2000A000061 2000-02-10
PCT/IT2000/000187 WO2000069808A1 (en) 1999-05-18 2000-05-12 Process for preparing r-(-)-carnitine from s-(-)-chlorosuccinic acid or from a derivative thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010153891A Division JP2010229157A (ja) 1999-05-18 2010-07-06 Ｓ−（−）−クロロコハク酸またはその誘導体からｒ−（−）−カルニチンを調製するための方法

Publications (3)

Publication Number Publication Date
JP2002544252A JP2002544252A (ja) 2002-12-24
JP2002544252A5 JP2002544252A5 (https=) 2007-06-28
JP4584464B2 true JP4584464B2 (ja) 2010-11-24

Family

ID=27274166

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000618226A Expired - Fee Related JP4584464B2 (ja) 1999-05-18 2000-05-12 Ｓ−（−）−クロロコハク酸またはその誘導体からｒ−（−）−カルニチンを調製するための方法
JP2010153891A Pending JP2010229157A (ja) 1999-05-18 2010-07-06 Ｓ−（−）−クロロコハク酸またはその誘導体からｒ−（−）−カルニチンを調製するための方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010153891A Pending JP2010229157A (ja) 1999-05-18 2010-07-06 Ｓ−（−）−クロロコハク酸またはその誘導体からｒ−（−）−カルニチンを調製するための方法

Country Status (19)

Country Link
US (3) US6677476B1 (https=)
EP (2) EP1468979A1 (https=)
JP (2) JP4584464B2 (https=)
KR (2) KR100789468B1 (https=)
CN (1) CN1158244C (https=)
AT (1) ATE346838T1 (https=)
AU (1) AU4612100A (https=)
CA (1) CA2372424A1 (https=)
CY (1) CY1107566T1 (https=)
CZ (1) CZ20013816A3 (https=)
DE (1) DE60032139T2 (https=)
DK (1) DK1187805T3 (https=)
ES (1) ES2277838T3 (https=)
HU (1) HUP0201418A3 (https=)
MX (1) MXPA01011758A (https=)
PL (1) PL203993B1 (https=)
PT (1) PT1187805E (https=)
SK (1) SK286155B6 (https=)
WO (1) WO2000069808A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI367882B (en) 2003-03-26 2012-07-11 Du Pont Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates
WO2007139238A1 (en) * 2006-05-26 2007-12-06 Enzytech, Ltd. Process for l-carnitine and acetyl l-carnitine hydrochloride
KR101097006B1 (ko) 2006-11-09 2011-12-20 미츠비시 레이온 가부시키가이샤 베타인의 제조 방법
EP2325164A1 (en) * 2009-11-18 2011-05-25 Lonza Ltd. Methods for the production of l-carnitine
US8310256B2 (en) 2009-12-22 2012-11-13 Teradyne, Inc. Capacitive opens testing in low signal environments
EP2595973B1 (en) * 2010-07-21 2017-07-12 Lonza Ltd. A process for the production of carnitine from beta-lactones
KR101110206B1 (ko) * 2011-05-02 2012-02-15 송명호 개폐가 용이하도록 완충기가 구비된 진동선별장치
CN118638020B (zh) * 2024-08-08 2024-11-19 杭州海尔希畜牧科技有限公司 L-天门冬氨酸l(-)肉碱(1:1)的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45594A (en) * 1973-11-12 1977-12-30 Stauffer Chemical Co Bis-substituted succinamides and their use as herbicides
GB1513257A (en) * 1975-02-03 1978-06-07 Stauffer Chemical Co Bis-substituted succinamides and the use thereof as herbicides
US4265247A (en) * 1979-11-07 1981-05-05 Research Corporation Malic acid polymers
ZA826022B (en) * 1981-08-21 1983-08-31 Univ Miami Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
DE3144698A1 (de) 1981-11-11 1983-05-19 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von hydantoinen
DE3144697A1 (de) * 1981-11-11 1983-05-19 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von hydantoinen
US5473104A (en) * 1994-09-13 1995-12-05 Neurocrine Biosciences, Inc. Process for the preparation of L-carnitine
KR100255039B1 (ko) 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법

Also Published As

Publication number Publication date
WO2000069808A1 (en) 2000-11-23
EP1187805A1 (en) 2002-03-20
US20050245762A1 (en) 2005-11-03
DE60032139D1 (de) 2007-01-11
KR20020009609A (ko) 2002-02-01
CY1107566T1 (el) 2013-03-13
ATE346838T1 (de) 2006-12-15
HUP0201418A3 (en) 2002-11-28
US6984739B2 (en) 2006-01-10
DK1187805T3 (da) 2007-04-16
JP2010229157A (ja) 2010-10-14
AU4612100A (en) 2000-12-05
MXPA01011758A (es) 2002-05-14
KR100684379B1 (ko) 2007-02-20
US20040102645A1 (en) 2004-05-27
EP1468979A1 (en) 2004-10-20
JP2002544252A (ja) 2002-12-24
CA2372424A1 (en) 2000-11-23
DE60032139T2 (de) 2007-09-27
PT1187805E (pt) 2007-01-31
KR100789468B1 (ko) 2008-01-02
PL203993B1 (pl) 2009-11-30
US6677476B1 (en) 2004-01-13
CZ20013816A3 (cs) 2002-02-13
EP1187805B1 (en) 2006-11-29
PL351646A1 (en) 2003-05-19
KR20060114044A (ko) 2006-11-03
ES2277838T3 (es) 2007-08-01
CN1158244C (zh) 2004-07-21
SK16012001A3 (sk) 2002-04-04
US7247747B2 (en) 2007-07-24
CN1352630A (zh) 2002-06-05
HUP0201418A2 (en) 2002-08-28
SK286155B6 (sk) 2008-04-07

Similar Documents

Publication Publication Date Title
JP2010229157A (ja) Ｓ−（−）−クロロコハク酸またはその誘導体からｒ−（−）−カルニチンを調製するための方法
CA2623355A1 (en) Resolution of .alpha.-(phenoxy) phenylacetic acid derivatives with naphthyl-alkylamines
EP1940387B1 (en) Process for the stereoselective preparation of (-)-halofenate and intermediates thereof
JPH0417938B2 (https=)
JP2605366B2 (ja) 光学活性α−イソプロピル−Ｐ−クロロフェニル酢酸エステル類のラセミ化方法
IE911917A1 (en) Process for racemate resolution of 2,2-dimethylcyclopropanecarboxylic acid
JP2003137835A (ja) （ｒ）−３−ヒドロキシ−３−（２−フェニルエチル）ヘキサン酸の製造方法
JPS6056942A (ja) ２，２−ジメチルシクロプロパンカルボン酸の光学活性ν−メチルエフェドリンエステル及びその塩
JP3828197B2 (ja) 光学活性３−（ｐ−メトキシフェニル）グリシッド酸アルカリ金属塩の製造法
ITRM20000061A1 (it) Procedimento per la preparazione di r-(-)- carnitina a partire da acido s-(-)- clorosuccinico o da un suo derivato.
JPH01146841A (ja) α−イソプロピル−ｐ−クロロフェニル酢酸エステル類およびその製造法
HK1119953B (en) Process for the stereoselective preparation of (-)-halofenate and intermediates thereof
ITRM990310A1 (it) Procedimento per la preparazione di r-(-)-carnitina a partire dall'acido s-(-)-clorosuccinico.
JPH06100482A (ja) 光学活性エキソ−２−ノルボルナノ−ルの製造方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070508

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070508

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100406

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100706

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20100803

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20100902

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130910

Year of fee payment: 3

LAPS Cancellation because of no payment of annual fees