KR100758141B1 - 아세틸-아미디니오페닐알라닐-사이클로헥실글리실-피리디니오알라닌아미드의 제조방법 - Google Patents

아세틸-아미디니오페닐알라닐-사이클로헥실글리실-피리디니오알라닌아미드의 제조방법 Download PDF

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Publication number
KR100758141B1
KR100758141B1 KR1020027009583A KR20027009583A KR100758141B1 KR 100758141 B1 KR100758141 B1 KR 100758141B1 KR 1020027009583 A KR1020027009583 A KR 1020027009583A KR 20027009583 A KR20027009583 A KR 20027009583A KR 100758141 B1 KR100758141 B1 KR 100758141B1
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South Korea
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formula
compound
salt
reaction
compounds
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English (en)
Korean (ko)
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KR20030019306A (ko
Inventor
브라이폴게르하르트
홀라볼프강
젠드랄라하이너
베크게르하르트
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사노피-아벤티스 도이칠란트 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020027009583A 2000-01-28 2001-01-18 아세틸-아미디니오페닐알라닐-사이클로헥실글리실-피리디니오알라닌아미드의 제조방법 Expired - Fee Related KR100758141B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10003586 2000-01-28
DE10003586.8 2000-01-28
PCT/EP2001/000523 WO2001055175A2 (en) 2000-01-28 2001-01-18 Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides

Publications (2)

Publication Number Publication Date
KR20030019306A KR20030019306A (ko) 2003-03-06
KR100758141B1 true KR100758141B1 (ko) 2007-09-13

Family

ID=7628946

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KR1020027009583A Expired - Fee Related KR100758141B1 (ko) 2000-01-28 2001-01-18 아세틸-아미디니오페닐알라닐-사이클로헥실글리실-피리디니오알라닌아미드의 제조방법

Country Status (29)

Country Link
US (2) US20010031858A1 (cg-RX-API-DMAC10.html)
EP (1) EP1254159B9 (cg-RX-API-DMAC10.html)
JP (1) JP4778181B2 (cg-RX-API-DMAC10.html)
KR (1) KR100758141B1 (cg-RX-API-DMAC10.html)
CN (1) CN1176104C (cg-RX-API-DMAC10.html)
AR (1) AR027246A1 (cg-RX-API-DMAC10.html)
AT (1) ATE325810T1 (cg-RX-API-DMAC10.html)
AU (1) AU779722B2 (cg-RX-API-DMAC10.html)
BR (1) BR0107804A (cg-RX-API-DMAC10.html)
CA (1) CA2398497C (cg-RX-API-DMAC10.html)
CZ (1) CZ20022583A3 (cg-RX-API-DMAC10.html)
DE (1) DE60119491T2 (cg-RX-API-DMAC10.html)
DK (1) DK1254159T3 (cg-RX-API-DMAC10.html)
EE (1) EE200200410A (cg-RX-API-DMAC10.html)
ES (1) ES2262632T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20020631A2 (cg-RX-API-DMAC10.html)
HU (1) HUP0301986A2 (cg-RX-API-DMAC10.html)
IL (2) IL150897A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA02006762A (cg-RX-API-DMAC10.html)
NO (1) NO20023577L (cg-RX-API-DMAC10.html)
NZ (1) NZ520427A (cg-RX-API-DMAC10.html)
PL (1) PL356801A1 (cg-RX-API-DMAC10.html)
PT (1) PT1254159E (cg-RX-API-DMAC10.html)
RU (1) RU2250212C2 (cg-RX-API-DMAC10.html)
SK (1) SK10842002A3 (cg-RX-API-DMAC10.html)
TW (1) TWI236481B (cg-RX-API-DMAC10.html)
WO (1) WO2001055175A2 (cg-RX-API-DMAC10.html)
YU (1) YU51202A (cg-RX-API-DMAC10.html)
ZA (1) ZA200205990B (cg-RX-API-DMAC10.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH695999A5 (de) 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
WO2007065691A2 (en) * 2005-12-07 2007-06-14 Technische Universität München Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
CN101774942B (zh) * 2010-01-27 2012-08-22 宁波武盛化学有限公司 制备n-乙酰基-dl-环己基甘氨酸的方法
US8558023B2 (en) * 2010-04-20 2013-10-15 Chiral Quest, Inc. Enantioselective process for cycloalkenyl β-substituted alanines
EP2646150A4 (en) * 2010-11-29 2014-10-08 Takasago Perfumery Co Ltd CATALYST FOR ASYMMETRIC HYDROGENATION AND METHOD FOR PRODUCING AN OPTICALLY ACTIVE CARBONYL COMPOUND THEREWITH
CN115068469B (zh) * 2022-07-08 2024-02-27 深圳市小分子新药创新中心有限公司 Tigit抑制剂及其应用
CN115612702A (zh) * 2022-10-09 2023-01-17 深圳市茵诺圣生物科技有限公司 L-丙氨酸类非天然氨基酸3-(3-吡啶基)-l-丙氨酸的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849510A (en) 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5866685A (en) * 1993-10-15 1999-02-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
ZA953361B (en) * 1994-04-26 1996-01-12 Selectide Corp Factor Xa inhibitors
SK281432B6 (sk) * 1995-12-20 2001-03-12 Hoechst Marion Roussel, Inc. Spôsob prípravy n-acetyl-(l)-4-kyanofenylalanínu ac-(l)-phe(4- -cn)-oh a n-acetyl-(l)-p-amidinofenylalanín-cyklohexylglycín- -beta-(3-n-metylpyridínium)-alanínu ac-(l)-paph-chg-palme(3)-nh2
DE19856443A1 (de) 1998-12-08 2000-06-21 Centeon Pharma Gmbh Stabilisiertes Antithrombin III-Präparat

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849510A (en) 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors

Also Published As

Publication number Publication date
WO2001055175A2 (en) 2001-08-02
JP4778181B2 (ja) 2011-09-21
CN1176104C (zh) 2004-11-17
NO20023577D0 (no) 2002-07-26
SK10842002A3 (sk) 2003-04-01
CA2398497A1 (en) 2001-08-02
WO2001055175A3 (en) 2002-02-21
ZA200205990B (en) 2003-04-30
EP1254159B1 (en) 2006-05-10
AR027246A1 (es) 2003-03-19
PL356801A1 (en) 2004-07-12
IL150897A0 (en) 2003-02-12
MXPA02006762A (es) 2002-10-23
DE60119491D1 (de) 2006-06-14
CN1396928A (zh) 2003-02-12
KR20030019306A (ko) 2003-03-06
RU2250212C2 (ru) 2005-04-20
JP2003523364A (ja) 2003-08-05
EP1254159A2 (en) 2002-11-06
AU4051601A (en) 2001-08-07
DE60119491T2 (de) 2006-11-16
NZ520427A (en) 2004-02-27
BR0107804A (pt) 2002-10-22
PT1254159E (pt) 2006-07-31
ATE325810T1 (de) 2006-06-15
ES2262632T3 (es) 2006-12-01
US20040225109A1 (en) 2004-11-11
US20010031858A1 (en) 2001-10-18
TWI236481B (en) 2005-07-21
HK1051866A1 (en) 2003-08-22
RU2002123046A (ru) 2004-01-10
IL150897A (en) 2008-08-07
NO20023577L (no) 2002-08-28
US7084250B2 (en) 2006-08-01
CZ20022583A3 (cs) 2002-10-16
HRP20020631A2 (en) 2004-12-31
CA2398497C (en) 2011-04-26
EP1254159B9 (en) 2006-06-28
AU779722B2 (en) 2005-02-10
DK1254159T3 (da) 2006-09-11
HUP0301986A2 (hu) 2003-09-29
YU51202A (sh) 2005-11-28
EE200200410A (et) 2003-12-15

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