KR100737193B1 - 약제학적으로 허용되는(ｓｓ-ｒｓ)-ｓ-아데노실-ｌ-메티오닌 염의 제조방법 - Google Patents

약제학적으로 허용되는(ｓｓ-ｒｓ)-ｓ-아데노실-ｌ-메티오닌 염의 제조방법 Download PDF

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Publication number
KR100737193B1
KR100737193B1 KR1020027015667A KR20027015667A KR100737193B1 KR 100737193 B1 KR100737193 B1 KR 100737193B1 KR 1020027015667 A KR1020027015667 A KR 1020027015667A KR 20027015667 A KR20027015667 A KR 20027015667A KR 100737193 B1 KR100737193 B1 KR 100737193B1
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KR
South Korea
Prior art keywords
adenosyl
methionine
pharmaceutically acceptable
acid
same
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English (en)
Korean (ko)
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KR20030036183A (ko
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베르나마르코
시비에리리노
산탐브로지오잔니
발로티에르만노
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케멘테크노 에스.알.엘.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020027015667A 2000-05-25 2001-03-30 약제학적으로 허용되는(ｓｓ-ｒｓ)-ｓ-아데노실-ｌ-메티오닌 염의 제조방법 Expired - Lifetime KR100737193B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2000MI001158A IT1318535B1 (it) 2000-05-25 2000-05-25 Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina.
ITMI2000A001158 2000-05-25
PCT/EP2001/003633 WO2001090130A1 (en) 2000-05-25 2001-03-30 Process for the preparation of pharmaceutically acceptable salts of (ss-rs)-s-adenosyl-l-methionine

Publications (2)

Publication Number Publication Date
KR20030036183A KR20030036183A (ko) 2003-05-09
KR100737193B1 true KR100737193B1 (ko) 2007-07-10

Family

ID=11445118

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027015667A Expired - Lifetime KR100737193B1 (ko) 2000-05-25 2001-03-30 약제학적으로 허용되는(ｓｓ-ｒｓ)-ｓ-아데노실-ｌ-메티오닌 염의 제조방법

Country Status (14)

Country Link
US (2) US20020010147A1 (enExample)
EP (1) EP1283845B1 (enExample)
JP (1) JP4777588B2 (enExample)
KR (1) KR100737193B1 (enExample)
AT (1) ATE256695T1 (enExample)
AU (2) AU6584801A (enExample)
CA (1) CA2407559C (enExample)
DE (1) DE60101575T2 (enExample)
DK (1) DK1283845T3 (enExample)
ES (1) ES2208610T3 (enExample)
IT (1) IT1318535B1 (enExample)
PT (1) PT1283845E (enExample)
TR (1) TR200302297T4 (enExample)
WO (1) WO2001090130A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7033815B2 (en) 2001-03-30 2006-04-25 Board Of Regents, The University Of Texas System Biosynthesis of S-adenosylmethionine in a recombinant yeast strain
CN100398659C (zh) * 2002-09-16 2008-07-02 上海青瑞生物医药技术有限公司 旋光纯(s,s)-腺甘甲硫氨酸制备的方法
US20050272687A1 (en) * 2004-06-08 2005-12-08 Hebert Rolland F Stable S-adenosyl-l-methionine
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
ES2406412T3 (es) * 2005-06-09 2013-06-06 Gnosis S.P.A. Células de Saccharomyces cerevisiae secas, liofilizadas y/o microencapsuladas con un alto contenido de (S)-(+)-S-adenosil-metionina
ITRM20050344A1 (it) * 2005-06-30 2007-01-01 Luca Maria De Sali o complessi di sostanze metil-donatrici con acido fitico o suoi derivati e relativo metodo di sintesi.
CN1955306B (zh) * 2005-10-28 2011-03-16 上海医药工业研究院 酵母菌生物合成、生产旋光纯腺苷甲硫氨酸的方法及其培养液
ITMI20060629A1 (it) 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
KR101070494B1 (ko) 2006-05-10 2011-10-05 미쓰비시 타나베 파마 코퍼레이션 Ｓ-아데노실-ｌ-메티오닌 함유 건조 효모의 제조방법 및 경구 섭취용 조성물
US20070265211A1 (en) * 2006-05-12 2007-11-15 Matthias Rath Novel composition and method effective in inhibiting the atherogenic process
ITMI20071374A1 (it) * 2007-07-10 2009-01-11 Gnosis Spa Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
JP6479681B2 (ja) 2013-01-16 2019-03-06 ヘーベルト サム−イー エルエルシー Ｓ−アデノシル−ｌ−メチオニンの安定なインドール−３−プロピオネート塩
ITMI20130426A1 (it) * 2013-03-20 2014-09-21 Gnosis Spa S-adenosilmetionina sterile ad alto contenuto di isomero attivo per soluzioni iniettabili e procedimento per ottenerla
CN106349311B (zh) * 2016-08-23 2018-04-13 北京金阳利康医药有限公司 从酵母发酵液中提取s‑腺苷蛋氨酸的方法
IT201700074957A1 (it) 2017-07-04 2019-01-04 Gnosis Spa Sale di (ss)-adenosil metionina con inositolo esafosfato e procedimento per ottenerlo
CN110396120B (zh) * 2019-02-13 2020-05-12 山东惠仕莱生物科技有限公司 一种从s-腺苷蛋氨酸发酵液中提取分离s-腺苷蛋氨酸的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531714A1 (fr) * 1982-08-13 1984-02-17 Nippon Zeon Co Procede de purification de s-adenosyl-l-methionine
US4621056A (en) 1983-08-24 1986-11-04 Bioresearch S.P.A Process for producing stable sulpho-adenosyl-L-methionine salts

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE39517B1 (en) * 1973-06-27 1978-10-25 Bioresearch Sas Double salts of s-adenosyl-l-methhionine
JPS56145299A (en) * 1980-04-11 1981-11-11 Kanegafuchi Chem Ind Co Ltd Purification of s-adenosyl-l-methionine
IT1173990B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531714A1 (fr) * 1982-08-13 1984-02-17 Nippon Zeon Co Procede de purification de s-adenosyl-l-methionine
US4621056A (en) 1983-08-24 1986-11-04 Bioresearch S.P.A Process for producing stable sulpho-adenosyl-L-methionine salts

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Biochemistry(1986)vol.25, pp4444-4449

Also Published As

Publication number Publication date
CA2407559C (en) 2009-12-22
AU2001265848B8 (en) 2006-05-04
US6958233B2 (en) 2005-10-25
PT1283845E (pt) 2004-04-30
AU6584801A (en) 2001-12-03
EP1283845A1 (en) 2003-02-19
KR20030036183A (ko) 2003-05-09
ITMI20001158A0 (it) 2000-05-25
ITMI20001158A1 (it) 2001-11-25
TR200302297T4 (tr) 2004-02-23
DE60101575T2 (de) 2004-06-03
US20020173012A1 (en) 2002-11-21
ATE256695T1 (de) 2004-01-15
AU2001265848B2 (en) 2006-03-23
JP4777588B2 (ja) 2011-09-21
IT1318535B1 (it) 2003-08-27
DK1283845T3 (da) 2004-04-13
EP1283845B1 (en) 2003-12-17
DE60101575D1 (de) 2004-01-29
WO2001090130A1 (en) 2001-11-29
CA2407559A1 (en) 2001-11-29
US20020010147A1 (en) 2002-01-24
ES2208610T3 (es) 2004-06-16
JP2003534349A (ja) 2003-11-18

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