JP4777588B2 - （ｓｓ，ｒｓ）−ｓ−アデノシル−ｌ−メチオニンの薬剤として許容される塩の調製方法 - Google Patents

（ｓｓ，ｒｓ）−ｓ−アデノシル−ｌ−メチオニンの薬剤として許容される塩の調製方法 Download PDF

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JP4777588B2
JP4777588B2 JP2001586317A JP2001586317A JP4777588B2 JP 4777588 B2 JP4777588 B2 JP 4777588B2 JP 2001586317 A JP2001586317 A JP 2001586317A JP 2001586317 A JP2001586317 A JP 2001586317A JP 4777588 B2 JP4777588 B2 JP 4777588B2
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Japan
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same
pharmaceutically acceptable
acid
methionine
adenosyl
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JP2003534349A5 (enExample
JP2003534349A (ja
Inventor
ベルナ，マルコ
シビーリ，リノ
サンタムブロージオ，ジヤンニ
バロテイ，エリマンノ
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ケメンテクノ・エツセ・エルレ・エルレ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2001586317A 2000-05-25 2001-03-30 （ｓｓ，ｒｓ）−ｓ−アデノシル−ｌ−メチオニンの薬剤として許容される塩の調製方法 Expired - Lifetime JP4777588B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT2000A001158 2000-05-25
IT2000MI001158A IT1318535B1 (it) 2000-05-25 2000-05-25 Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina.
ITMI2000A001158 2000-05-25
PCT/EP2001/003633 WO2001090130A1 (en) 2000-05-25 2001-03-30 Process for the preparation of pharmaceutically acceptable salts of (ss-rs)-s-adenosyl-l-methionine

Publications (3)

Publication Number Publication Date
JP2003534349A JP2003534349A (ja) 2003-11-18
JP2003534349A5 JP2003534349A5 (enExample) 2008-05-08
JP4777588B2 true JP4777588B2 (ja) 2011-09-21

Family

ID=11445118

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JP2001586317A Expired - Lifetime JP4777588B2 (ja) 2000-05-25 2001-03-30 （ｓｓ，ｒｓ）−ｓ−アデノシル−ｌ−メチオニンの薬剤として許容される塩の調製方法

Country Status (14)

Country Link
US (2) US20020010147A1 (enExample)
EP (1) EP1283845B1 (enExample)
JP (1) JP4777588B2 (enExample)
KR (1) KR100737193B1 (enExample)
AT (1) ATE256695T1 (enExample)
AU (2) AU6584801A (enExample)
CA (1) CA2407559C (enExample)
DE (1) DE60101575T2 (enExample)
DK (1) DK1283845T3 (enExample)
ES (1) ES2208610T3 (enExample)
IT (1) IT1318535B1 (enExample)
PT (1) PT1283845E (enExample)
TR (1) TR200302297T4 (enExample)
WO (1) WO2001090130A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7033815B2 (en) 2001-03-30 2006-04-25 Board Of Regents, The University Of Texas System Biosynthesis of S-adenosylmethionine in a recombinant yeast strain
CN100398659C (zh) * 2002-09-16 2008-07-02 上海青瑞生物医药技术有限公司 旋光纯(s,s)-腺甘甲硫氨酸制备的方法
US20050272687A1 (en) * 2004-06-08 2005-12-08 Hebert Rolland F Stable S-adenosyl-l-methionine
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
ES2406412T3 (es) * 2005-06-09 2013-06-06 Gnosis S.P.A. Células de Saccharomyces cerevisiae secas, liofilizadas y/o microencapsuladas con un alto contenido de (S)-(+)-S-adenosil-metionina
ITRM20050344A1 (it) * 2005-06-30 2007-01-01 Luca Maria De Sali o complessi di sostanze metil-donatrici con acido fitico o suoi derivati e relativo metodo di sintesi.
CN1955306B (zh) * 2005-10-28 2011-03-16 上海医药工业研究院 酵母菌生物合成、生产旋光纯腺苷甲硫氨酸的方法及其培养液
ITMI20060629A1 (it) 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
KR101070494B1 (ko) 2006-05-10 2011-10-05 미쓰비시 타나베 파마 코퍼레이션 Ｓ-아데노실-ｌ-메티오닌 함유 건조 효모의 제조방법 및 경구 섭취용 조성물
US20070265211A1 (en) * 2006-05-12 2007-11-15 Matthias Rath Novel composition and method effective in inhibiting the atherogenic process
ITMI20071374A1 (it) * 2007-07-10 2009-01-11 Gnosis Spa Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
JP6479681B2 (ja) 2013-01-16 2019-03-06 ヘーベルト サム−イー エルエルシー Ｓ−アデノシル−ｌ−メチオニンの安定なインドール−３−プロピオネート塩
ITMI20130426A1 (it) * 2013-03-20 2014-09-21 Gnosis Spa S-adenosilmetionina sterile ad alto contenuto di isomero attivo per soluzioni iniettabili e procedimento per ottenerla
CN106349311B (zh) * 2016-08-23 2018-04-13 北京金阳利康医药有限公司 从酵母发酵液中提取s‑腺苷蛋氨酸的方法
IT201700074957A1 (it) 2017-07-04 2019-01-04 Gnosis Spa Sale di (ss)-adenosil metionina con inositolo esafosfato e procedimento per ottenerlo
CN110396120B (zh) * 2019-02-13 2020-05-12 山东惠仕莱生物科技有限公司 一种从s-腺苷蛋氨酸发酵液中提取分离s-腺苷蛋氨酸的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56145299A (en) * 1980-04-11 1981-11-11 Kanegafuchi Chem Ind Co Ltd Purification of s-adenosyl-l-methionine
JPS5929700A (ja) * 1982-08-13 1984-02-16 Nippon Zeon Co Ltd Ｓ−アデノシル−ｌ−メチオニンの精製法
JPS60256394A (ja) * 1984-05-16 1985-12-18 バイオリサーチ・エス．ピー．エイ 非経口用に特に適した安定なスルホ‐アデノシル‐ｌ‐メチオニン塩

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE39517B1 (en) * 1973-06-27 1978-10-25 Bioresearch Sas Double salts of s-adenosyl-l-methhionine
IT1169773B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Processo per la produzione di sali stabili della solfo-adenosil-l-metionina

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56145299A (en) * 1980-04-11 1981-11-11 Kanegafuchi Chem Ind Co Ltd Purification of s-adenosyl-l-methionine
JPS5929700A (ja) * 1982-08-13 1984-02-16 Nippon Zeon Co Ltd Ｓ−アデノシル−ｌ−メチオニンの精製法
JPS60256394A (ja) * 1984-05-16 1985-12-18 バイオリサーチ・エス．ピー．エイ 非経口用に特に適した安定なスルホ‐アデノシル‐ｌ‐メチオニン塩

Also Published As

Publication number Publication date
CA2407559C (en) 2009-12-22
AU2001265848B8 (en) 2006-05-04
US6958233B2 (en) 2005-10-25
PT1283845E (pt) 2004-04-30
AU6584801A (en) 2001-12-03
EP1283845A1 (en) 2003-02-19
KR20030036183A (ko) 2003-05-09
ITMI20001158A0 (it) 2000-05-25
ITMI20001158A1 (it) 2001-11-25
TR200302297T4 (tr) 2004-02-23
DE60101575T2 (de) 2004-06-03
US20020173012A1 (en) 2002-11-21
ATE256695T1 (de) 2004-01-15
AU2001265848B2 (en) 2006-03-23
IT1318535B1 (it) 2003-08-27
DK1283845T3 (da) 2004-04-13
KR100737193B1 (ko) 2007-07-10
EP1283845B1 (en) 2003-12-17
DE60101575D1 (de) 2004-01-29
WO2001090130A1 (en) 2001-11-29
CA2407559A1 (en) 2001-11-29
US20020010147A1 (en) 2002-01-24
ES2208610T3 (es) 2004-06-16
JP2003534349A (ja) 2003-11-18

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