KR100726699B1 - 부프레노르핀을 함유하는 진통 조성물 - Google Patents

부프레노르핀을 함유하는 진통 조성물 Download PDF

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Publication number
KR100726699B1
KR100726699B1 KR1020027006375A KR20027006375A KR100726699B1 KR 100726699 B1 KR100726699 B1 KR 100726699B1 KR 1020027006375 A KR1020027006375 A KR 1020027006375A KR 20027006375 A KR20027006375 A KR 20027006375A KR 100726699 B1 KR100726699 B1 KR 100726699B1
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South Korea
Prior art keywords
buprenorphine
naloxone
naltrexone
nalmefene
amount
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Expired - Fee Related
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KR1020027006375A
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English (en)
Korean (ko)
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KR20020058022A (ko
Inventor
쉐플레오크리스토퍼부른
맥커맥케이트
버레이니콜라스칼버트
Original Assignee
레킷트 벵키저 헬스케어(유케이)리미티드
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Priority claimed from GBGB9927359.1A external-priority patent/GB9927359D0/en
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Publication of KR20020058022A publication Critical patent/KR20020058022A/ko
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Publication of KR100726699B1 publication Critical patent/KR100726699B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020027006375A 1999-11-19 2000-11-17 부프레노르핀을 함유하는 진통 조성물 Expired - Fee Related KR100726699B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9927359.1A GB9927359D0 (en) 1999-11-19 1999-11-19 Improvements in or relating to organic compositions
GB9927359.1 1999-11-19
US17620800P 2000-01-14 2000-01-14
US60/176,208 2000-01-14

Publications (2)

Publication Number Publication Date
KR20020058022A KR20020058022A (ko) 2002-07-12
KR100726699B1 true KR100726699B1 (ko) 2007-06-13

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KR1020027006375A Expired - Fee Related KR100726699B1 (ko) 1999-11-19 2000-11-17 부프레노르핀을 함유하는 진통 조성물

Country Status (30)

Country Link
US (4) US6995169B2 (enrdf_load_stackoverflow)
EP (1) EP1242087B1 (enrdf_load_stackoverflow)
JP (1) JP4745576B2 (enrdf_load_stackoverflow)
KR (1) KR100726699B1 (enrdf_load_stackoverflow)
CN (1) CN100431543C (enrdf_load_stackoverflow)
AR (1) AR031682A1 (enrdf_load_stackoverflow)
AT (1) ATE262335T1 (enrdf_load_stackoverflow)
AU (1) AU777259B2 (enrdf_load_stackoverflow)
BR (1) BR0015580A (enrdf_load_stackoverflow)
CA (1) CA2392013C (enrdf_load_stackoverflow)
CO (1) CO5261517A1 (enrdf_load_stackoverflow)
CZ (1) CZ303160B6 (enrdf_load_stackoverflow)
DE (1) DE60009346T2 (enrdf_load_stackoverflow)
DK (1) DK1242087T3 (enrdf_load_stackoverflow)
ES (1) ES2214334T3 (enrdf_load_stackoverflow)
GB (1) GB2356348B (enrdf_load_stackoverflow)
HU (1) HU229565B1 (enrdf_load_stackoverflow)
IL (2) IL149580A0 (enrdf_load_stackoverflow)
MX (1) MXPA02004978A (enrdf_load_stackoverflow)
NO (1) NO321965B1 (enrdf_load_stackoverflow)
NZ (1) NZ519023A (enrdf_load_stackoverflow)
PL (1) PL199727B1 (enrdf_load_stackoverflow)
PT (1) PT1242087E (enrdf_load_stackoverflow)
RO (1) RO121174B1 (enrdf_load_stackoverflow)
RU (1) RU2255737C2 (enrdf_load_stackoverflow)
SI (1) SI21025B (enrdf_load_stackoverflow)
SK (1) SK286888B6 (enrdf_load_stackoverflow)
TR (1) TR200400653T4 (enrdf_load_stackoverflow)
TW (1) TW550070B (enrdf_load_stackoverflow)
WO (1) WO2001035942A2 (enrdf_load_stackoverflow)

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AR031682A1 (es) * 1999-11-19 2003-10-01 Reckitt Benckiser Helthcare Uk Composiciones farmaceuticas
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
US20150031718A1 (en) * 2001-08-06 2015-01-29 Purdue Pharma L.P. Pharmaceutical Formulation Containing Opioid Agonist, Opioid Antagonist and Gelling Agent
US7666876B2 (en) 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
PT2316456T (pt) 2003-04-29 2017-09-05 Orexigen Therapeutics Inc Composições para afetar a perda de peso compreendendo naltrexona e bupropion
CA2569958C (en) 2004-06-12 2016-03-22 Jane C. Hirsh Abuse-deterrent drug formulations
DK2135603T3 (da) * 2005-11-22 2013-03-25 Orexigen Therapeutics Inc Sammensætninger og fremgangsmåder til øgning af insulinsensitivitet
WO2007089318A2 (en) * 2005-11-23 2007-08-09 Orexigen Therapeutics, Inc. Compositions and methods for reducing food cravings
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
EP1897543A1 (en) 2006-08-30 2008-03-12 Euro-Celtique S.A. Buprenorphine- wafer for drug substitution therapy
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
EP2089010A1 (en) 2006-10-24 2009-08-19 The John Hopkins University Rapid release mini-tablets provide analgesia in laboratory animals
RU2009116834A (ru) 2006-11-09 2010-12-20 Ориксиджен Терапьютикс, Инкорпорэйтд Сша/Сша (Us) Способ введения лекарственных средств для снижения веса
US20080199407A1 (en) 2007-02-15 2008-08-21 Slater Kenneth C Drug Detoxification Protocol Using Microdosing
GB2447016A (en) * 2007-03-01 2008-09-03 Reckitt Benckiser Healthcare Buprenorphine/naloxone compositions
GB2447013A (en) * 2007-03-01 2008-09-03 Reckitt Benckiser Healthcare Analgesic composition containing buprenorphone and nalmefene
GB2447015A (en) * 2007-03-01 2008-09-03 Reckitt Benckiser Healthcare Analgesic composition comprising a specific ratio of buprenorphine and naltrexone
GB2447014A (en) 2007-03-01 2008-09-03 Reckitt Benckiser Healthcare Analgesic composition comprising a specific ratio of buprenorphine and naltrexone
DK2197429T3 (en) 2007-09-03 2016-05-30 Nanotherapeutics Inc Particulate compositions for delivery of poorly soluble drugs
US20090082383A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched buprenorphine
WO2009158114A1 (en) 2008-05-30 2009-12-30 Orexigen Therapeutics, Inc. Methods for treating visceral fat conditions
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
AU2011203867B2 (en) 2010-01-11 2015-12-03 Nalpropion Pharmaceuticals Llc Methods of providing weight loss therapy in patients with major depression
KR101647267B1 (ko) 2010-12-22 2016-08-09 퍼듀 퍼머 엘피 케이싱된 탬퍼 저항성 제어 방출 투여 형태
PH12013501345A1 (en) 2010-12-23 2022-10-24 Purdue Pharma Lp Tamper resistant solid oral dosage forms
SMT202100546T1 (it) 2011-09-19 2021-11-12 Orexo Ab Compresse per via sublinguale resistenti all'abuso comprendenti buprenorfina e naloxone
CA2875056C (en) 2012-06-06 2024-03-26 Orexigen Therapeutics, Inc. Methods of treating overweight and obesity
CA2899455C (en) 2013-01-30 2021-06-08 Pharmorx Therapeutics, Inc. Treatments for depression and other diseases with a low dose agent
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
CA2923811C (en) * 2013-09-10 2021-07-27 Insys Pharma, Inc. Sublingual buprenorphine spray
US8969371B1 (en) 2013-12-06 2015-03-03 Orexigen Therapeutics, Inc. Compositions and methods for weight loss in at risk patient populations
CA2946698A1 (en) 2014-04-22 2015-10-29 Otsuka Pharmaceutical Co., Ltd. Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders
WO2017222575A1 (en) 2016-06-23 2017-12-28 Collegium Pharmaceutical, Inc. Process of making more stable abuse-deterrent oral formulations
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Patent Citations (1)

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WO1996002251A1 (en) * 1994-07-19 1996-02-01 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opioid agonists

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HUP0203588A3 (en) 2005-01-28
PT1242087E (pt) 2004-06-30
PL355330A1 (en) 2004-04-19
TR200400653T4 (tr) 2004-04-21
US20060058333A1 (en) 2006-03-16
IL149580A0 (en) 2002-11-10
HU229565B1 (hu) 2014-02-28
JP4745576B2 (ja) 2011-08-10
AU1529701A (en) 2001-05-30
WO2001035942A2 (en) 2001-05-25
NO321965B1 (no) 2006-07-31
SI21025B (sl) 2008-04-30
AR031682A1 (es) 2003-10-01
DK1242087T3 (da) 2004-07-19
SK8762002A3 (en) 2002-12-03
SK286888B6 (sk) 2009-07-06
NO20022330D0 (no) 2002-05-15
ATE262335T1 (de) 2004-04-15
NO20022330L (no) 2002-07-04
CN100431543C (zh) 2008-11-12
CA2392013A1 (en) 2001-05-25
US6995169B2 (en) 2006-02-07
SI21025A (sl) 2003-04-30
US20030004178A1 (en) 2003-01-02
BR0015580A (pt) 2002-07-09
WO2001035942A9 (en) 2002-11-28
IL149580A (en) 2007-05-15
CN1413110A (zh) 2003-04-23
CZ303160B6 (cs) 2012-05-09
AU777259B2 (en) 2004-10-07
PL199727B1 (pl) 2008-10-31
US7402591B2 (en) 2008-07-22
CA2392013C (en) 2009-08-11
US20060069113A1 (en) 2006-03-30
US20060058332A1 (en) 2006-03-16
CO5261517A1 (es) 2003-03-31
HK1055389A1 (zh) 2004-01-09
DE60009346D1 (de) 2004-04-29
MXPA02004978A (es) 2003-01-28
JP2003514013A (ja) 2003-04-15
RU2255737C2 (ru) 2005-07-10
DE60009346T2 (de) 2005-02-10
HUP0203588A2 (hu) 2003-03-28
RU2002116361A (ru) 2004-01-27
GB2356348A (en) 2001-05-23
RO121174B1 (ro) 2007-01-30
GB0028088D0 (en) 2001-01-03
ES2214334T3 (es) 2004-09-16
EP1242087B1 (en) 2004-03-24
KR20020058022A (ko) 2002-07-12
NZ519023A (en) 2004-11-26
TW550070B (en) 2003-09-01
WO2001035942A3 (en) 2002-06-13
EP1242087A2 (en) 2002-09-25
GB2356348B (en) 2002-02-06

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