KR100705525B1 - 치환되고 분지화된3-아미노-1-페닐-1ｈ-〔1,2,4〕트리아졸의 신규한 아미노유도체, 이의 제조 방법, 및 이를 포함하는 제약 조성물 - Google Patents

치환되고 분지화된3-아미노-1-페닐-1ｈ-〔1,2,4〕트리아졸의 신규한 아미노유도체, 이의 제조 방법, 및 이를 포함하는 제약 조성물 Download PDF

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Publication number
KR100705525B1
KR100705525B1 KR1020027007736A KR20027007736A KR100705525B1 KR 100705525 B1 KR100705525 B1 KR 100705525B1 KR 1020027007736 A KR1020027007736 A KR 1020027007736A KR 20027007736 A KR20027007736 A KR 20027007736A KR 100705525 B1 KR100705525 B1 KR 100705525B1
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South Korea
Prior art keywords
cyclopropyl
alkyl
propyl
methylphenyl
amine hydrochloride
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Expired - Fee Related
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KR1020027007736A
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English (en)
Korean (ko)
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KR20020061002A (ko
Inventor
미첼 게슬링
다니엘 굴리
장-삐에르 마프란드
삐에르 로저
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사노피-아벤티스
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020027007736A 1999-12-17 2000-12-14 치환되고 분지화된3-아미노-1-페닐-1ｈ-〔1,2,4〕트리아졸의 신규한 아미노유도체, 이의 제조 방법, 및 이를 포함하는 제약 조성물 Expired - Fee Related KR100705525B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR99/15935 1999-12-17
FR9915935A FR2802530B1 (fr) 1999-12-17 1999-12-17 Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
KR20020061002A KR20020061002A (ko) 2002-07-19
KR100705525B1 true KR100705525B1 (ko) 2007-04-10

Family

ID=9553380

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027007736A Expired - Fee Related KR100705525B1 (ko) 1999-12-17 2000-12-14 치환되고 분지화된3-아미노-1-페닐-1ｈ-〔1,2,4〕트리아졸의 신규한 아미노유도체, 이의 제조 방법, 및 이를 포함하는 제약 조성물

Country Status (33)

Country Link
US (1) US6806282B2 (https=)
EP (1) EP1242389B1 (https=)
JP (1) JP4146641B2 (https=)
KR (1) KR100705525B1 (https=)
CN (1) CN1293061C (https=)
AR (1) AR031837A1 (https=)
AT (1) ATE264847T1 (https=)
AU (1) AU780711B2 (https=)
BR (1) BR0017023A (https=)
CA (1) CA2398772C (https=)
CO (1) CO5251379A1 (https=)
CZ (1) CZ302460B6 (https=)
DE (1) DE60010126T2 (https=)
DK (1) DK1242389T3 (https=)
EA (1) EA004957B1 (https=)
EE (1) EE04778B1 (https=)
ES (1) ES2219436T3 (https=)
FR (1) FR2802530B1 (https=)
HU (1) HUP0204080A3 (https=)
IL (2) IL150037A0 (https=)
IS (1) IS2315B (https=)
ME (1) MEP12108A (https=)
MX (1) MXPA02006033A (https=)
NO (1) NO20022828L (https=)
PL (1) PL203819B1 (https=)
PT (1) PT1242389E (https=)
RS (1) RS50289B (https=)
SK (1) SK285994B6 (https=)
TR (2) TR200401775T4 (https=)
TW (1) TWI289554B (https=)
UA (1) UA73333C2 (https=)
WO (1) WO2001044207A2 (https=)
ZA (1) ZA200204422B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005013982A1 (en) * 2003-08-06 2005-02-17 Vertex Pharmaceuticals Incorporated Aminotriazole compounds useful as inhibitors of protein kinases
JO3019B1 (ar) 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
JP2011500625A (ja) 2007-10-18 2011-01-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ トリ置換された１，２，４−トリアゾール
AR070936A1 (es) 2008-03-19 2010-05-12 Janssen Pharmaceutica Nv 1,2,4 -triazoles trisustituidos
JP5486591B2 (ja) 2008-05-09 2014-05-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アセチルコリン受容体モジュレーターとしての三置換ピラゾール
EP2629616A4 (en) * 2010-10-21 2014-03-26 Merck Sharp & Dohme SUBSTITUTED AMINO-TRIAZOLYL-PDE10-HEMMER
WO2015112642A1 (en) 2014-01-21 2015-07-30 Neurocrine Biosciences, Inc. Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia
CN104059027B (zh) * 2014-07-01 2015-10-28 河北大学 一类含1,2,4-三唑的(e)-甲氧基亚氨基苯乙酸甲酯类化合物及其制备方法和用途
CA3121920A1 (en) 2018-12-07 2020-06-11 Neurocrine Biosciences, Inc. Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia
IL291569B2 (en) * 2019-09-25 2025-04-01 Oncoarendi Therapeutics Sa Process for the production of 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1H-4,2,1-triazol-3-amine
JP7623365B2 (ja) 2019-09-27 2025-01-28 ニューロクライン バイオサイエンシーズ，インコーポレイテッド Ｃｒｆ受容体アンタゴニストおよび使用方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039400A1 (en) * 1995-06-06 1996-12-12 Neurocrine Biosciences, Inc. Amino-substituted thiadiazoles, pyrimidines, triazines or triazoles useful as ctf receptor antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0285893B1 (en) * 1987-03-27 1992-03-18 Kumiai Chemical Industry Co., Ltd. Phenyltriazole derivative and insecticide
FR2763337B1 (fr) * 1997-05-13 1999-08-20 Sanofi Sa Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039400A1 (en) * 1995-06-06 1996-12-12 Neurocrine Biosciences, Inc. Amino-substituted thiadiazoles, pyrimidines, triazines or triazoles useful as ctf receptor antagonists

Also Published As

Publication number Publication date
EA200200523A1 (ru) 2002-12-26
WO2001044207B1 (fr) 2002-06-06
CN1434808A (zh) 2003-08-06
FR2802530B1 (fr) 2002-02-22
TR200201600T2 (tr) 2002-10-21
DK1242389T3 (da) 2004-08-09
AR031837A1 (es) 2003-10-08
KR20020061002A (ko) 2002-07-19
ES2219436T3 (es) 2004-12-01
WO2001044207A3 (fr) 2001-12-20
CA2398772C (fr) 2011-07-05
SK8502002A3 (en) 2003-02-04
CZ20022099A3 (cs) 2002-09-11
CZ302460B6 (cs) 2011-06-01
EE200200331A (et) 2003-06-16
FR2802530A1 (fr) 2001-06-22
ATE264847T1 (de) 2004-05-15
CO5251379A1 (es) 2003-02-28
EP1242389B1 (fr) 2004-04-21
EA004957B1 (ru) 2004-10-28
RS50289B (sr) 2009-09-08
WO2001044207A2 (fr) 2001-06-21
HK1055947A1 (en) 2004-01-30
ZA200204422B (en) 2003-11-26
HUP0204080A3 (en) 2005-01-28
MEP12108A (en) 2010-06-10
PL355811A1 (en) 2004-05-17
AU780711B2 (en) 2005-04-14
UA73333C2 (en) 2005-07-15
NO20022828L (no) 2002-08-19
CA2398772A1 (fr) 2001-06-21
SK285994B6 (sk) 2008-01-07
JP2003516975A (ja) 2003-05-20
YU43902A (sh) 2005-03-15
EP1242389A2 (fr) 2002-09-25
JP4146641B2 (ja) 2008-09-10
AU2525901A (en) 2001-06-25
HUP0204080A2 (hu) 2003-04-28
PT1242389E (pt) 2004-08-31
IS2315B (is) 2007-11-15
TR200401775T4 (tr) 2004-09-21
IS6402A (is) 2002-05-28
IL150037A0 (en) 2002-12-01
NO20022828D0 (no) 2002-06-13
TWI289554B (en) 2007-11-11
EE04778B1 (et) 2007-02-15
MXPA02006033A (es) 2003-01-28
US6806282B2 (en) 2004-10-19
BR0017023A (pt) 2002-12-03
DE60010126T2 (de) 2005-04-28
DE60010126D1 (de) 2004-05-27
WO2001044207A8 (fr) 2001-07-12
US20030162771A1 (en) 2003-08-28
PL203819B1 (pl) 2009-11-30
CN1293061C (zh) 2007-01-03
IL150037A (en) 2007-02-11

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