MX2022002881A - Proceso para la produccion de 5-(4-((2s,5s)-5-(4-clorobencil)-2-me tilmorfolino)piperidin-1-il)-1h-1,2,4-triazol-3-amina. - Google Patents
Proceso para la produccion de 5-(4-((2s,5s)-5-(4-clorobencil)-2-me tilmorfolino)piperidin-1-il)-1h-1,2,4-triazol-3-amina.Info
- Publication number
- MX2022002881A MX2022002881A MX2022002881A MX2022002881A MX2022002881A MX 2022002881 A MX2022002881 A MX 2022002881A MX 2022002881 A MX2022002881 A MX 2022002881A MX 2022002881 A MX2022002881 A MX 2022002881A MX 2022002881 A MX2022002881 A MX 2022002881A
- Authority
- MX
- Mexico
- Prior art keywords
- methylmorpholino
- chlorobenzyl
- triazol
- piperidin
- amine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención se relaciona con un proceso para la síntesis de la 5-(4-((2S,5S)-5-(4-clorobencil)-2-metilmorfolino)pi peridin-1-il)-1H-1,2,4-triazol-3-amina en dos formas cristalinas hidratadas y en una forma cristalina anhidra. La presente invención además se relaciona con el (Z)-4-((2S,5S)-5-(4-clorobenc il)-2-metilmorfolino)-N-ciano-piperidina-1-carbimidotioato de metilo que es el compuesto intermediario en este proceso.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962905494P | 2019-09-25 | 2019-09-25 | |
PL43126919 | 2019-09-25 | ||
PCT/IB2020/058984 WO2021059220A1 (en) | 2019-09-25 | 2020-09-25 | Process for the production of 5-(4-((2 s,5 s)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1 h-1,2,4-triazol-3-amine |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022002881A true MX2022002881A (es) | 2022-06-08 |
Family
ID=73139065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022002881A MX2022002881A (es) | 2019-09-25 | 2020-09-25 | Proceso para la produccion de 5-(4-((2s,5s)-5-(4-clorobencil)-2-me tilmorfolino)piperidin-1-il)-1h-1,2,4-triazol-3-amina. |
Country Status (13)
Country | Link |
---|---|
US (2) | US11746107B2 (es) |
EP (1) | EP4041726A1 (es) |
JP (1) | JP2022549863A (es) |
KR (1) | KR20220069008A (es) |
CN (1) | CN114466845A (es) |
AU (1) | AU2020356534A1 (es) |
BR (1) | BR112022005420A2 (es) |
CA (1) | CA3155177A1 (es) |
IL (1) | IL291569A (es) |
MX (1) | MX2022002881A (es) |
TW (2) | TW202237594A (es) |
WO (1) | WO2021059220A1 (es) |
ZA (1) | ZA202204542B (es) |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2802530B1 (fr) * | 1999-12-17 | 2002-02-22 | Sanofi Synthelabo | Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant |
AU8112101A (en) * | 2000-08-08 | 2002-02-18 | Ortho Mcneil Pharm Inc | Non-imidazole aryloxypiperidines |
SG11201406890YA (en) * | 2012-05-30 | 2014-11-27 | Hoffmann La Roche | Triazolo compounds as pde10 inhibitors |
SG11201605757SA (en) * | 2013-12-20 | 2016-08-30 | Inst Drug Discovery | Substituted amino triazoles, and methods using same |
PL415073A1 (pl) | 2014-12-19 | 2016-06-20 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków |
GB201513740D0 (en) * | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonist |
PL415078A1 (pl) | 2015-09-04 | 2017-03-13 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków |
CN114174280A (zh) | 2019-07-15 | 2022-03-11 | 昂科艾伦迪治疗法公司 | 可用作壳多糖酶抑制剂的取代的氨基三唑 |
-
2020
- 2020-09-25 CN CN202080067709.7A patent/CN114466845A/zh active Pending
- 2020-09-25 KR KR1020227009777A patent/KR20220069008A/ko unknown
- 2020-09-25 CA CA3155177A patent/CA3155177A1/en active Pending
- 2020-09-25 AU AU2020356534A patent/AU2020356534A1/en active Pending
- 2020-09-25 EP EP20803247.4A patent/EP4041726A1/en active Pending
- 2020-09-25 US US17/032,232 patent/US11746107B2/en active Active
- 2020-09-25 MX MX2022002881A patent/MX2022002881A/es unknown
- 2020-09-25 WO PCT/IB2020/058984 patent/WO2021059220A1/en unknown
- 2020-09-25 TW TW111121583A patent/TW202237594A/zh unknown
- 2020-09-25 BR BR112022005420A patent/BR112022005420A2/pt unknown
- 2020-09-25 JP JP2022519042A patent/JP2022549863A/ja active Pending
- 2020-09-25 TW TW109133211A patent/TWI769532B/zh active
-
2022
- 2022-03-21 IL IL291569A patent/IL291569A/en unknown
- 2022-04-22 ZA ZA2022/04542A patent/ZA202204542B/en unknown
-
2023
- 2023-07-17 US US18/222,679 patent/US20240025889A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US11746107B2 (en) | 2023-09-05 |
KR20220069008A (ko) | 2022-05-26 |
TWI769532B (zh) | 2022-07-01 |
ZA202204542B (en) | 2023-01-25 |
JP2022549863A (ja) | 2022-11-29 |
AU2020356534A1 (en) | 2022-05-19 |
TW202237594A (zh) | 2022-10-01 |
US20240025889A1 (en) | 2024-01-25 |
US20210147401A1 (en) | 2021-05-20 |
EP4041726A1 (en) | 2022-08-17 |
CA3155177A1 (en) | 2021-04-01 |
CN114466845A (zh) | 2022-05-10 |
BR112022005420A2 (pt) | 2022-06-21 |
TW202126644A (zh) | 2021-07-16 |
WO2021059220A1 (en) | 2021-04-01 |
IL291569A (en) | 2022-05-01 |
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