KR100699396B1 - 자기 공명 연구 방법 - Google Patents
자기 공명 연구 방법 Download PDFInfo
- Publication number
- KR100699396B1 KR100699396B1 KR1020007007423A KR20007007423A KR100699396B1 KR 100699396 B1 KR100699396 B1 KR 100699396B1 KR 1020007007423 A KR1020007007423 A KR 1020007007423A KR 20007007423 A KR20007007423 A KR 20007007423A KR 100699396 B1 KR100699396 B1 KR 100699396B1
- Authority
- KR
- South Korea
- Prior art keywords
- delete delete
- formulation
- agent
- magnetic field
- polarization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C(c1c(*)c(C(*)=O)c(*)c(C(*)=O)c1*)=O Chemical compound *C(c1c(*)c(C(*)=O)c(*)c(C(*)=O)c1*)=O 0.000 description 11
- CDAISMWEOUEBRE-UHFFFAOYSA-N OC(C(C(C(C1O)O)O)O)C1O Chemical compound OC(C(C(C(C1O)O)O)O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- High Energy & Nuclear Physics (AREA)
- Signal Processing (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- General Induction Heating (AREA)
- Magnetic Ceramics (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9800158.9 | 1998-01-05 | ||
| GBGB9800158.9A GB9800158D0 (en) | 1998-01-05 | 1998-01-05 | Method |
| GB9813795.3 | 1998-06-25 | ||
| GBGB9813795.3A GB9813795D0 (en) | 1998-06-25 | 1998-06-25 | Method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20010040318A KR20010040318A (ko) | 2001-05-15 |
| KR100699396B1 true KR100699396B1 (ko) | 2007-03-27 |
Family
ID=26312888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020007007423A Expired - Fee Related KR100699396B1 (ko) | 1998-01-05 | 1998-12-23 | 자기 공명 연구 방법 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6278893B1 (enExample) |
| EP (2) | EP2119457B1 (enExample) |
| JP (1) | JP4764548B2 (enExample) |
| KR (1) | KR100699396B1 (enExample) |
| CN (2) | CN100347562C (enExample) |
| AU (1) | AU752308C (enExample) |
| BR (1) | BRPI9813244B1 (enExample) |
| CA (1) | CA2317526C (enExample) |
| ES (1) | ES2393833T3 (enExample) |
| HU (1) | HU229718B1 (enExample) |
| IL (1) | IL136780A0 (enExample) |
| NO (1) | NO334035B1 (enExample) |
| NZ (1) | NZ505151A (enExample) |
| RU (1) | RU2221255C2 (enExample) |
| WO (1) | WO1999035508A1 (enExample) |
Families Citing this family (150)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001503646A (ja) * | 1996-03-29 | 2001-03-21 | ローレンス バークレー ナショナル ラボラトリィ | 過分極化希ガス存在下でのnmrまたはmriの増強 |
| US8765099B2 (en) * | 1996-04-08 | 2014-07-01 | Koninklijke Philips N.V. | Magnetic resonance imaging hyperpolarization of liquids or solids by light with orbital angular momentum |
| EP0951650B1 (en) * | 1997-01-08 | 2003-12-10 | Amersham Health AS | Method of magnetic resonance imaging |
| US6278893B1 (en) * | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| NZ508719A (en) | 1998-06-17 | 2002-10-25 | Medi Physics Inc | Hyperpolarized gas transport device with at least one gas chamber and a electromagnet providing a magnetic holding field |
| US6237363B1 (en) * | 1998-09-30 | 2001-05-29 | Medi-Physics, Inc. | Hyperpolarized noble gas extraction methods masking methods and associated transport containers |
| US6284222B1 (en) | 1998-11-03 | 2001-09-04 | Medi--Physics, Inc. | Hyperpolarized helium-3 microbubble gas entrapment methods |
| JP2002534687A (ja) * | 1998-12-30 | 2002-10-15 | アメルシャム・パブリック・リミテッド・カンパニー | 過分極を使用したnmr分光学アッセイ |
| US6566875B1 (en) | 1999-02-23 | 2003-05-20 | Medi-Physics, Inc. | Portable hyperpolarized gas monitoring systems, computer program products, and related methods using NMR and/or MRI during transport |
| US20020058869A1 (en) * | 1999-05-19 | 2002-05-16 | Oskar Axelsson | Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials |
| US6574496B1 (en) * | 1999-05-19 | 2003-06-03 | Amersham Health As | Magnetic resonance imaging |
| US6295834B1 (en) | 1999-06-30 | 2001-10-02 | Medi-Physics, Inc. | NMR polarization monitoring coils, hyperpolarizers with same, and methods for determining the polarization level of accumulated hyperpolarized noble gases during production |
| DE10009166A1 (de) * | 2000-02-26 | 2001-08-30 | Philips Corp Intellectual Pty | Verfahren zur Lokalisierung von Objekten in der interventionellen Radiologie |
| CA2401308A1 (en) | 2000-03-13 | 2001-09-20 | Klaus D. Hagspiel | Diagnostic procedures using direct injection of gaseous hyperpolarized 129xe and associated systems and products |
| GB0009353D0 (en) * | 2000-04-14 | 2000-05-31 | Nycomed Imaging As | Method |
| GB0014463D0 (en) * | 2000-06-14 | 2000-08-09 | Nycomed Amersham Plc | NMR Method |
| US6696040B2 (en) * | 2000-07-13 | 2004-02-24 | Medi-Physics, Inc. | Diagnostic procedures using 129Xe spectroscopy characteristic chemical shift to detect pathology in vivo |
| GB0022341D0 (en) * | 2000-09-12 | 2000-10-25 | Nycomed Imaging As | Method |
| NO20004561D0 (no) * | 2000-09-13 | 2000-09-13 | Nycomed Imaging As | Metode for magnetisk resonansavbildning |
| CN100392422C (zh) | 2000-11-03 | 2008-06-04 | 通用电气医疗集团股份有限公司 | 为nmr分析溶解超极化固体材料的方法和装置 |
| AU1403902A (en) * | 2000-11-03 | 2002-05-15 | Amersham Health As | Methods and devices for polarised nmr samples |
| US7126332B2 (en) * | 2001-07-20 | 2006-10-24 | Baker Hughes Incorporated | Downhole high resolution NMR spectroscopy with polarization enhancement |
| GB0122049D0 (en) * | 2001-09-12 | 2001-10-31 | Nycomed Imaging As | Method |
| RU2281527C2 (ru) * | 2001-11-02 | 2006-08-10 | Амершем Хелт АС | Способ и устройство для плавления поляризованных ямр-образцов |
| NO20023357D0 (no) * | 2002-04-19 | 2002-07-11 | Amersham Health As | Blanding |
| GB0219954D0 (en) * | 2002-08-29 | 2002-10-02 | Amersham Health R & D Ab | Method and apparatus for producing contrast agents for magnetic resonance imaging |
| NO20025124D0 (no) | 2002-10-25 | 2002-10-25 | Amersham Health As | Metode |
| US20060173283A1 (en) * | 2002-11-27 | 2006-08-03 | Oskar Axelsson | Method of magnetic resonance imaging |
| NO20025711D0 (no) * | 2002-11-27 | 2002-11-27 | Amersham Health As | Magnetisk resonansmetode |
| NO20025738D0 (no) | 2002-11-29 | 2002-11-29 | Amersham Health As | Metode |
| DE10259793B4 (de) * | 2002-12-19 | 2009-10-15 | Siemens Ag | Verfahren zur Bildgebung eines Stoffwechselvorgangs eines Lebewesens |
| DE10335663A1 (de) * | 2003-08-04 | 2005-03-10 | Siemens Ag | Verfahren zur automatischen Kalibrierung von Perfusionsparameterbildern |
| NO338547B1 (no) * | 2004-07-30 | 2016-09-05 | Ge Healthcare As | Fremgangsmåte for fremstilling av en flytende sammensetning omfattende hyperpolarisert 13C-pyruvat, sammensetningen og anvendelse av den for fremstilling av hyperpolarisert 13C-pyruvat |
| BRPI0513896A (pt) * | 2004-07-30 | 2008-05-20 | Ge Healthcare As | método para a discriminação entre tecido saudável e de tumor |
| CN101027310B (zh) * | 2004-07-30 | 2012-08-22 | 通用电气医疗集团股份有限公司 | 基团及其在dnp方法中作为顺磁化剂的应用 |
| EP1797102B1 (en) * | 2004-07-30 | 2015-05-27 | Ge Healthcare As | Composition comprising triarylmethyl radical, useful in mri diagnostics |
| US8980224B2 (en) * | 2004-11-19 | 2015-03-17 | Ge Healthcare As | Method of cardiac imaging |
| US7276905B2 (en) * | 2005-07-11 | 2007-10-02 | General Electric Company | Method and system of tracking an intracorporeal device with MR imaging |
| JP2007021008A (ja) | 2005-07-20 | 2007-02-01 | Hitachi Ltd | Dnp過分極手段を備えた磁気共鳴イメージング装置 |
| US20070025918A1 (en) * | 2005-07-28 | 2007-02-01 | General Electric Company | Magnetic resonance imaging (MRI) agents: water soluble carbon-13 enriched fullerene and carbon nanotubes for use with dynamic nuclear polarization |
| US20100259259A1 (en) * | 2005-09-21 | 2010-10-14 | Markus Zahn | Systems and methods for tuning properties of nanoparticles |
| US8377419B2 (en) * | 2005-09-28 | 2013-02-19 | The President And Fellows Of Harvard College | Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging |
| EP1933884B1 (en) * | 2005-10-11 | 2017-09-06 | Huntington Medical Research Institutes | Imaging agents and methods of use thereof |
| AU2006310100B2 (en) * | 2005-11-06 | 2012-12-06 | Brain Watch Ltd. | Magnetic resonance imaging and spectroscopy means and methods thereof |
| NO20055681D0 (no) * | 2005-12-01 | 2005-12-01 | Amersham Health As | Method of dynamic nuclear polarisation |
| US8951502B2 (en) * | 2005-12-01 | 2015-02-10 | Ge Healthcare As | Method of dynamic nuclear polarisation (DNP) |
| US20080284429A1 (en) * | 2005-12-10 | 2008-11-20 | The President And Fellows Of Harvard College | Situ Hyperpolarization of Imaging Agents |
| JP5102221B2 (ja) * | 2005-12-16 | 2012-12-19 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 過分極カルボン酸塩の製造方法 |
| JP2009523172A (ja) * | 2006-01-11 | 2009-06-18 | プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | 造影剤のエクスビボ過分極 |
| US8703102B2 (en) | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| AU2013205838B2 (en) * | 2006-02-21 | 2016-03-17 | Avrum Belzer | Hyperpolarization Methods, Systems and Compositions |
| KR101095943B1 (ko) | 2006-02-21 | 2011-12-19 | 밀리켈빈 테크놀로지스 엘엘씨 | 과분극화 방법, 시스템 및 조성물 |
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| MX2008014396A (es) * | 2006-05-11 | 2009-02-06 | Textron Innovations Inc | Dispositivo y metodo para reparar componentes estructurales. |
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| US20090311189A1 (en) * | 2006-05-12 | 2009-12-17 | Massachusetts Institute Of Technology | Temperature-jump dynamic nuclear polarization |
| US8623327B2 (en) | 2006-06-19 | 2014-01-07 | Beth Israel Deaconess Medical Center, Inc. | Imaging agents for use in magnetic resonance blood flow/perfusion imaging |
| ATE549638T1 (de) * | 2006-08-18 | 2012-03-15 | Ge Healthcare As | 13c-mr-bildgebung oder spektroskopie von zelltod |
| KR101502180B1 (ko) | 2006-08-30 | 2015-03-12 | 지이 헬스케어 에이에스 | 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물 |
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| US20110274626A1 (en) | 2008-12-10 | 2011-11-10 | University Of York | Pulse sequencing with hyperpolarisable nuclei |
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| DE102010017568B4 (de) | 2010-06-24 | 2012-09-13 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Hyperpolarisationseinrichtung und Verfahren zur Verabreichung eines hyperpolarisierten flüssigen Kontrastmittels |
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| AU1775399A (en) | 1999-07-26 |
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| CN100347562C (zh) | 2007-11-07 |
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| ES2393833T3 (es) | 2012-12-28 |
| BRPI9813244B1 (pt) | 2016-12-13 |
| HUP0102093A2 (hu) | 2001-09-28 |
| US6466814B1 (en) | 2002-10-15 |
| EP2119457B1 (en) | 2012-10-03 |
| US6278893B1 (en) | 2001-08-21 |
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