CN100347562C - 磁共振研究方法 - Google Patents

磁共振研究方法 Download PDF

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Publication number
CN100347562C
CN100347562C CNB2003101131420A CN200310113142A CN100347562C CN 100347562 C CN100347562 C CN 100347562C CN B2003101131420 A CNB2003101131420 A CN B2003101131420A CN 200310113142 A CN200310113142 A CN 200310113142A CN 100347562 C CN100347562 C CN 100347562C
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China
Prior art keywords
reagent
acid
polarization
sample
nuclear
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Expired - Fee Related
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CNB2003101131420A
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English (en)
Chinese (zh)
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CN1527066A (zh
Inventor
简·H·阿登克贾－拉森
奥斯卡·阿克塞尔森
克莱斯·戈尔曼
拉斯-戈兰·威斯特兰德
乔格·汉森
伊勃·勒恩巴赫
斯蒂芬·彼得森
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GE Healthcare AS
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Nycomed Imaging AS
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Priority claimed from GBGB9800158.9A external-priority patent/GB9800158D0/en
Priority claimed from GBGB9813795.3A external-priority patent/GB9813795D0/en
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Publication of CN1527066A publication Critical patent/CN1527066A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Signal Processing (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • General Induction Heating (AREA)
  • Magnetic Ceramics (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
CNB2003101131420A 1998-01-05 1998-12-23 磁共振研究方法 Expired - Fee Related CN100347562C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9800158.9 1998-01-05
GBGB9800158.9A GB9800158D0 (en) 1998-01-05 1998-01-05 Method
GB9813795.3 1998-06-25
GBGB9813795.3A GB9813795D0 (en) 1998-06-25 1998-06-25 Method

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB988129531A Division CN1138154C (zh) 1998-01-05 1998-12-23 磁共振研究方法

Publications (2)

Publication Number Publication Date
CN1527066A CN1527066A (zh) 2004-09-08
CN100347562C true CN100347562C (zh) 2007-11-07

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CNB2003101131420A Expired - Fee Related CN100347562C (zh) 1998-01-05 1998-12-23 磁共振研究方法
CNB988129531A Expired - Fee Related CN1138154C (zh) 1998-01-05 1998-12-23 磁共振研究方法

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US (2) US6278893B1 (enExample)
EP (2) EP2119457B1 (enExample)
JP (1) JP4764548B2 (enExample)
KR (1) KR100699396B1 (enExample)
CN (2) CN100347562C (enExample)
AU (1) AU752308C (enExample)
BR (1) BRPI9813244B1 (enExample)
CA (1) CA2317526C (enExample)
ES (1) ES2393833T3 (enExample)
HU (1) HU229718B1 (enExample)
IL (1) IL136780A0 (enExample)
NO (1) NO334035B1 (enExample)
NZ (1) NZ505151A (enExample)
RU (1) RU2221255C2 (enExample)
WO (1) WO1999035508A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102782516A (zh) * 2009-12-30 2012-11-14 皇家飞利浦电子股份有限公司 具有样本传输系统的动态核极化设备

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