KR100699099B1 - 1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법 - Google Patents

1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법 Download PDF

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Publication number
KR100699099B1
KR100699099B1 KR1020050041278A KR20050041278A KR100699099B1 KR 100699099 B1 KR100699099 B1 KR 100699099B1 KR 1020050041278 A KR1020050041278 A KR 1020050041278A KR 20050041278 A KR20050041278 A KR 20050041278A KR 100699099 B1 KR100699099 B1 KR 100699099B1
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KR
South Korea
Prior art keywords
formula
phenyl
halo
compound
anomer
Prior art date
Application number
KR1020050041278A
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English (en)
Korean (ko)
Other versions
KR20060047970A (ko
Inventor
이재헌
박가승
이문섭
김한경
방효정
장영길
이관순
Original Assignee
한미약품 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한미약품 주식회사 filed Critical 한미약품 주식회사
Priority to RU2007107607/04A priority Critical patent/RU2346948C2/ru
Priority to MX2007000959A priority patent/MX2007000959A/es
Priority to PCT/KR2005/001922 priority patent/WO2006011713A1/en
Priority to US11/572,790 priority patent/US7858761B2/en
Priority to AU2005265494A priority patent/AU2005265494B2/en
Priority to CA2574954A priority patent/CA2574954C/en
Priority to JP2007523465A priority patent/JP4691101B2/ja
Priority to EP05756757A priority patent/EP1781678A4/en
Priority to BRPI0513783-7A priority patent/BRPI0513783A/pt
Priority to CN2005800251579A priority patent/CN1989148B/zh
Publication of KR20060047970A publication Critical patent/KR20060047970A/ko
Priority to IL180894A priority patent/IL180894A/en
Priority to NO20071106A priority patent/NO20071106L/no
Application granted granted Critical
Publication of KR100699099B1 publication Critical patent/KR100699099B1/ko
Priority to HK07108984.4A priority patent/HK1100946A1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/08—Deoxysugars; Unsaturated sugars; Osones

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020050041278A 2004-07-29 2005-05-17 1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법 KR100699099B1 (ko)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP2007523465A JP4691101B2 (ja) 2004-07-29 2005-06-21 １−α−ハロ−２，２−ジフルオロ−２−デオキシ−Ｄ−リボフラノース誘導体及びその製造方法
PCT/KR2005/001922 WO2006011713A1 (en) 2004-07-29 2005-06-21 1-α-HALO-2,2-DIFLUORO-2-DEOXY-D-RIBOFURANOSE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
US11/572,790 US7858761B2 (en) 2004-07-29 2005-06-21 1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivatives and process for the preparation thereof
BRPI0513783-7A BRPI0513783A (pt) 2004-07-29 2005-06-21 derivados 1-(alfa)-halo-2, 2-diflúor-2-desóxi-d-ribofuranose e processo para a sua preparação
CA2574954A CA2574954C (en) 2004-07-29 2005-06-21 1-.alpha.-halo-2,2-difluoro-2-deoxy-d-ribofuranose derivatives and process for the preparation thereof
MX2007000959A MX2007000959A (es) 2004-07-29 2005-06-21 Derivados de 1-alfa-halo-2,2-difluoro-2-desoxi-d-ribofuranosa y proceso para la preparacion de los mismos.
RU2007107607/04A RU2346948C2 (ru) 2004-07-29 2005-06-21 ПРОИЗВОДНЫЕ 1-α-ГАЛОГЕН-2,2-ДИФТОР-2-ДЕЗОКСИ-D-РИБОФУРАНОЗЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
AU2005265494A AU2005265494B2 (en) 2004-07-29 2005-06-21 1-alpha-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivatives and process for the preparation thereof
CN2005800251579A CN1989148B (zh) 2004-07-29 2005-06-21 1-α-卤代-2,2-二氟-2-脱氧-D-呋喃核糖衍生物及其制备方法
EP05756757A EP1781678A4 (en) 2004-07-29 2005-06-21 1 -? - HALOGEN-2,2-DIFLUOR-2-DESOXY-D-RIBOFURANOSEDERIVATE AND PROCESS FOR THE PRODUCTION THEREOF
IL180894A IL180894A (en) 2004-07-29 2007-01-23 1-alpha-halo-2,2-difluoro-2-deoxy-d-ribofuranose derivatives and processes for the preparation thereof
NO20071106A NO20071106L (no) 2004-07-29 2007-02-27 1-alfa-halo-2,2-difluor-2-deoksy-D-ribofuranosederivater og fremgangsmate for fremstilling derav
HK07108984.4A HK1100946A1 (en) 2004-07-29 2007-08-17 1-a-HALO-2,2-DIFLUORO-2-DEOXY-D-RIBOFURANOSE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020040059623 2004-07-29
KR20040059623 2004-07-29

Publications (2)

Publication Number Publication Date
KR20060047970A KR20060047970A (ko) 2006-05-18
KR100699099B1 true KR100699099B1 (ko) 2007-03-22

Family

ID=37149831

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020050041278A KR100699099B1 (ko) 2004-07-29 2005-05-17 1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법

Country Status (7)

Country Link
JP (1) JP4691101B2 (ru)
KR (1) KR100699099B1 (ru)
CN (1) CN1989148B (ru)
HK (1) HK1100946A1 (ru)
IL (1) IL180894A (ru)
MX (1) MX2007000959A (ru)
RU (1) RU2346948C2 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2139884B1 (en) 2007-03-23 2013-12-04 Dongwoo Syntech Co., Ltd. Process for preparing of 2'-deoxy-2'2'-difluorocytidine
KR100858842B1 (ko) * 2007-03-23 2008-09-22 동우신테크 주식회사 키랄아민을 이용한 광학활성 옥소라이보스유도체의제조방법
CN101628927B (zh) * 2009-08-07 2012-10-10 卡硼瑞（北京）科技有限公司 以1,3,5-三-O-苯甲酰基-α-D-呋喃核糖为原料立体选择性制备β-二氟胞苷盐酸盐的方法
CN103897008A (zh) * 2012-12-28 2014-07-02 石药集团中奇制药技术（石家庄）有限公司 一种地西他滨及其中间体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453499A (en) * 1992-06-22 1995-09-26 Chou; Ta-Sen Process for preparing alpha-anomer enriched 1-halo-2-deoxy-2,2-difluoro-D-ribofuranosyl derivatives
KR20000070351A (ko) * 1997-01-24 2000-11-25 앨린 앤더슨 젬시타빈 유도체

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2039403A1 (en) * 1990-04-04 1991-10-05 Gerald Saischek Process for the manufacture of 2-deoxy-d-threo-pentofuranosides, intermediates for their manufacture and their use
JP2003055364A (ja) * 2001-06-07 2003-02-26 Mitsui Chemicals Inc ２，３−ジデオキシ−２，３−デヒドロペントフラノース誘導体に関する新規製造法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453499A (en) * 1992-06-22 1995-09-26 Chou; Ta-Sen Process for preparing alpha-anomer enriched 1-halo-2-deoxy-2,2-difluoro-D-ribofuranosyl derivatives
KR20000070351A (ko) * 1997-01-24 2000-11-25 앨린 앤더슨 젬시타빈 유도체

Also Published As

Publication number Publication date
MX2007000959A (es) 2007-04-16
IL180894A0 (en) 2007-07-04
CN1989148B (zh) 2010-05-12
RU2346948C2 (ru) 2009-02-20
RU2007107607A (ru) 2008-09-10
HK1100946A1 (en) 2007-10-05
IL180894A (en) 2011-09-27
KR20060047970A (ko) 2006-05-18
JP4691101B2 (ja) 2011-06-01
JP2008508261A (ja) 2008-03-21
CN1989148A (zh) 2007-06-27

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