KR100595353B1 - 비페닐설포닐 시안아미드, 이의 제조방법 및 이를 포함하는 약제학적 제제 - Google Patents

비페닐설포닐 시안아미드, 이의 제조방법 및 이를 포함하는 약제학적 제제 Download PDF

Info

Publication number
KR100595353B1
KR100595353B1 KR1020007008433A KR20007008433A KR100595353B1 KR 100595353 B1 KR100595353 B1 KR 100595353B1 KR 1020007008433 A KR1020007008433 A KR 1020007008433A KR 20007008433 A KR20007008433 A KR 20007008433A KR 100595353 B1 KR100595353 B1 KR 100595353B1
Authority
KR
South Korea
Prior art keywords
carbon atoms
phenyl
alkyl
substituted
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020007008433A
Other languages
English (en)
Korean (ko)
Other versions
KR20010040564A (ko
Inventor
클레만하인쯔-베르너
랑한스-요헨
슈바르크얀-로베르트
바이체르트안드레아스
파버사비네
얀젠한스-빌리
페트리슈테판
Original Assignee
사노피-아벤티스 도이칠란트 게엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 사노피-아벤티스 도이칠란트 게엠베하 filed Critical 사노피-아벤티스 도이칠란트 게엠베하
Publication of KR20010040564A publication Critical patent/KR20010040564A/ko
Application granted granted Critical
Publication of KR100595353B1 publication Critical patent/KR100595353B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/47—Y being a hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
KR1020007008433A 1998-02-04 1999-02-04 비페닐설포닐 시안아미드, 이의 제조방법 및 이를 포함하는 약제학적 제제 Expired - Fee Related KR100595353B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19804251A DE19804251A1 (de) 1998-02-04 1998-02-04 Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19804251.5 1998-02-04

Publications (2)

Publication Number Publication Date
KR20010040564A KR20010040564A (ko) 2001-05-15
KR100595353B1 true KR100595353B1 (ko) 2006-07-03

Family

ID=7856542

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007008433A Expired - Fee Related KR100595353B1 (ko) 1998-02-04 1999-02-04 비페닐설포닐 시안아미드, 이의 제조방법 및 이를 포함하는 약제학적 제제

Country Status (19)

Country Link
US (1) US6369069B1 (enExample)
EP (1) EP1053224B1 (enExample)
JP (1) JP4464559B2 (enExample)
KR (1) KR100595353B1 (enExample)
CN (1) CN1231465C (enExample)
AR (1) AR016448A1 (enExample)
AT (1) ATE222584T1 (enExample)
AU (1) AU758154B2 (enExample)
BR (1) BR9907667A (enExample)
CA (1) CA2319555A1 (enExample)
DE (2) DE19804251A1 (enExample)
DK (1) DK1053224T3 (enExample)
ES (1) ES2182504T3 (enExample)
HU (1) HU224618B1 (enExample)
PL (1) PL342453A1 (enExample)
PT (1) PT1053224E (enExample)
RU (1) RU2247111C2 (enExample)
TR (1) TR200002255T2 (enExample)
WO (1) WO1999040064A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19820064A1 (de) 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
US6906069B1 (en) 1999-01-08 2005-06-14 Amgen Inc. LXR modulators
WO2001060818A1 (en) * 2000-02-14 2001-08-23 Tularik Inc. Lxr modulators
MXPA03000688A (es) 2000-07-24 2004-11-01 Bayer Cropscience Ag Bifenilcarboxiamidas.
CA2474702A1 (en) 2002-01-30 2003-08-07 Tularik Inc Heterocyclic arylsulfonamidobenzylic compounds
DE10206354A1 (de) * 2002-02-14 2003-08-28 Aventis Pharma Gmbh Verwendung von Inhibitoren des Natrium-abhängigen Chlorid-Bicarbonat-Austauschers zur Behandlung von thrombotischen und inflammatorischer Erkrankungen
US8841483B2 (en) * 2006-04-11 2014-09-23 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of voltage-gated sodium channels
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2062558A1 (en) * 1991-03-08 1992-09-09 Prasun K. Chakravarty Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists
EP0586513A1 (en) * 1991-05-10 1994-03-16 Merck & Co. Inc. Acidic aralkyl triazole derivatives active as angiotensin ii antagonists
FR2716883B1 (fr) * 1994-03-04 1996-04-26 Roussel Uclaf Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant.
EP0855392A3 (de) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19741635A1 (de) 1997-09-22 1999-03-25 Hoechst Marion Roussel De Gmbh Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament

Also Published As

Publication number Publication date
JP2002502840A (ja) 2002-01-29
AU758154B2 (en) 2003-03-13
JP4464559B2 (ja) 2010-05-19
ES2182504T3 (es) 2003-03-01
BR9907667A (pt) 2000-10-24
KR20010040564A (ko) 2001-05-15
AU3139899A (en) 1999-08-23
ATE222584T1 (de) 2002-09-15
HUP0102576A1 (hu) 2002-03-28
DK1053224T3 (da) 2002-12-23
CN1231465C (zh) 2005-12-14
CN1289321A (zh) 2001-03-28
HU224618B1 (hu) 2005-11-28
HUP0102576A3 (en) 2002-12-28
EP1053224B1 (de) 2002-08-21
WO1999040064A1 (de) 1999-08-12
RU2247111C2 (ru) 2005-02-27
US6369069B1 (en) 2002-04-09
TR200002255T2 (tr) 2001-06-21
PT1053224E (pt) 2002-12-31
HK1034706A1 (en) 2001-11-02
CA2319555A1 (en) 1999-08-12
DE59902408D1 (de) 2002-09-26
AR016448A1 (es) 2001-07-04
DE19804251A1 (de) 1999-08-05
EP1053224A1 (de) 2000-11-22
PL342453A1 (en) 2001-06-04

Similar Documents

Publication Publication Date Title
RU2140412C1 (ru) 4-амино-1-пиперидилбензоилгуанидины или их физиологически приемлемые соли, способы их получения, фармацевтическая композиция и способ ее получения
US6162819A (en) Pyrazole derivatives, their preparation and their use in pharmaceuticals
KR100865250B1 (ko) 안트라닐산 아미드 및 이를 함유하는 약제학적 제제
JP4196678B2 (ja) 複素環化合物
JPWO2003029199A1 (ja) ベンゼン誘導体、その製造法および用途
US7514465B2 (en) Synthesis of N2-(substituted arylmethyl)-3-(substituted phenyl)indazoles as novel anti-angiogenic agents
JP4272278B2 (ja) ビフェニルスルホニルシアナミド、その製造法および医薬としてのその使用
KR100595353B1 (ko) 비페닐설포닐 시안아미드, 이의 제조방법 및 이를 포함하는 약제학적 제제
RU2153490C2 (ru) Арилбензоилгуанидины, способ их получения и фармацевтическая композиция
US5504089A (en) 2-hydroxyalkyl-benzimidazoles, -quinazolines and -benzothiazoles as potassium channel agonists
JPH11158171A (ja) スルホンアミド置換クロマン、その製法、医薬としてのその使用およびそれを含有する医薬製剤
US20040220247A1 (en) Substituted arylamides as IP antagonists
KR20010071957A (ko) 비페닐설포닐 치환된 이미다졸 유도체, 이의 제조 방법 및약제 또는 진단제로서의 이의 용도
JP2002520387A (ja) ２，５−置換されたベンゼンスルホニル尿素および−チオ尿素、それらの製法、それらの使用およびそれらを含有する医薬製剤
KR100820173B1 (ko) 4-메틸이미다졸-5-카보닐구아니딘 유도체, 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로함유하는 허혈성 심장질환의 예방 및 치료용 약학적 조성물
JP4546644B2 (ja) 置換スルホニルシアナミド、その調製方法および医薬としての使用
MX2008016399A (es) Inhibidores de canal de potasio kv1.5.
JP2007503378A (ja) ペンタフルオロスルファニルフェニル−置換ベンゾイルグアニジン、それらの製造法、医薬又は診断薬としてのそれらの使用及び該化合物を含有する医薬品
AU2002223631B2 (en) Heteroarylacryloylaminoalkyl-substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them
MXPA00007492A (en) Biphenylsulfonyl cyanamides, method for the production thereof and their utilization as a medicament
CZ20002808A3 (cs) Bifenylsulfonylkyanamidy a farmaceutický prostředek, který je obsahuje
RU2271350C2 (ru) Производные ацилфенилмочевины, фармацевтическая композиция и способ ее получения
KR20070053747A (ko) 펜타플루오로설파닐페닐-치환된 벤조일구아니딘, 이의 제조방법, 약물 또는 진단제로서의 이의 용도 및 이를포함하는 약물
JP2006036730A (ja) 新規ピロール誘導体

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20090624

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20090624

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000