KR100588799B1 - 파네실 단백질 전이효소를 억제하기 위한 벤조(5,6)사이클로헵타(1,2-b)피리딘 유도체 및 이를 포함하는 약제학적 조성물 - Google Patents

파네실 단백질 전이효소를 억제하기 위한 벤조(5,6)사이클로헵타(1,2-b)피리딘 유도체 및 이를 포함하는 약제학적 조성물 Download PDF

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KR100588799B1
KR100588799B1 KR1019997011974A KR19997011974A KR100588799B1 KR 100588799 B1 KR100588799 B1 KR 100588799B1 KR 1019997011974 A KR1019997011974 A KR 1019997011974A KR 19997011974 A KR19997011974 A KR 19997011974A KR 100588799 B1 KR100588799 B1 KR 100588799B1
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South Korea
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formula
mmol
compound
preparation example
title compound
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KR1019997011974A
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Korean (ko)
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KR20010013948A (ko
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돌로날드제이
켈리조세프엠
몰람스알란케이
엔조지에프조지
레미스제위스키스타시더블유
타버라스아더지
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쉐링 코포레이션
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019997011974A 1997-06-17 1998-06-15 파네실 단백질 전이효소를 억제하기 위한 벤조(5,6)사이클로헵타(1,2-b)피리딘 유도체 및 이를 포함하는 약제학적 조성물 KR100588799B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87705797A 1997-06-17 1997-06-17
US08/877,057 1997-06-17
PCT/US1998/011500 WO1998057959A1 (en) 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives for the inhibition of farnesyl protein transferase

Publications (2)

Publication Number Publication Date
KR20010013948A KR20010013948A (ko) 2001-02-26
KR100588799B1 true KR100588799B1 (ko) 2006-06-13

Family

ID=25369159

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019997011974A KR100588799B1 (ko) 1997-06-17 1998-06-15 파네실 단백질 전이효소를 억제하기 위한 벤조(5,6)사이클로헵타(1,2-b)피리딘 유도체 및 이를 포함하는 약제학적 조성물

Country Status (30)

Country Link
EP (2) EP0988300B1 (no)
JP (1) JP2002504148A (no)
KR (1) KR100588799B1 (no)
CN (1) CN1131228C (no)
AR (1) AR016074A1 (no)
AT (1) ATE222905T1 (no)
AU (1) AU753863B2 (no)
BR (1) BR9811470A (no)
CA (1) CA2294347C (no)
CO (1) CO4940455A1 (no)
CZ (1) CZ297450B6 (no)
DE (1) DE69807477T2 (no)
DK (1) DK0988300T3 (no)
ES (1) ES2178224T3 (no)
HK (1) HK1022908A1 (no)
HU (1) HUP0003046A3 (no)
ID (1) ID30349A (no)
IL (2) IL133449A0 (no)
MY (1) MY117925A (no)
NO (1) NO318938B1 (no)
NZ (1) NZ501618A (no)
PE (1) PE83799A1 (no)
PL (1) PL191866B1 (no)
PT (1) PT988300E (no)
RU (1) RU2220139C2 (no)
SK (1) SK283820B6 (no)
TR (2) TR200003580T2 (no)
TW (1) TW544451B (no)
WO (1) WO1998057959A1 (no)
ZA (1) ZA985210B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9911869A (pt) 1998-07-06 2001-03-27 Janssen Pharmaceutica Nv Inibidores da transferase da proteìna farnesil para o tratamento das artropatias
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
PE20020635A1 (es) * 2000-11-29 2002-07-11 Schering Corp Compuestos triciclicos como inhibidores de la farnesil transferasa

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010516A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010516A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
RU2220139C2 (ru) 2003-12-27
DK0988300T3 (da) 2002-11-25
IL133449A (en) 2006-12-10
SK283820B6 (sk) 2004-02-03
NO318938B1 (no) 2005-05-30
PT988300E (pt) 2002-12-31
NO996236L (no) 2000-02-01
HUP0003046A2 (hu) 2001-06-28
TR200003580T2 (tr) 2002-10-21
AR016074A1 (es) 2001-06-20
CO4940455A1 (es) 2000-07-24
ES2178224T3 (es) 2002-12-16
ATE222905T1 (de) 2002-09-15
HK1022908A1 (en) 2000-08-25
CZ447199A3 (cs) 2000-06-14
DE69807477T2 (de) 2003-02-27
PL191866B1 (pl) 2006-07-31
CN1131228C (zh) 2003-12-17
WO1998057959A1 (en) 1998-12-23
JP2002504148A (ja) 2002-02-05
EP1156046A1 (en) 2001-11-21
KR20010013948A (ko) 2001-02-26
NZ501618A (en) 2001-10-26
CA2294347C (en) 2008-01-29
CZ297450B6 (cs) 2006-12-13
TR200000114T2 (tr) 2000-08-21
AU753863B2 (en) 2002-10-31
CA2294347A1 (en) 1998-12-23
TW544451B (en) 2003-08-01
DE69807477D1 (de) 2002-10-02
EP0988300B1 (en) 2002-08-28
HUP0003046A3 (en) 2002-11-28
ID30349A (id) 2001-11-22
NO996236D0 (no) 1999-12-16
EP0988300A1 (en) 2000-03-29
ZA985210B (en) 1999-01-07
SK182499A3 (en) 2000-09-12
MY117925A (en) 2004-08-30
PE83799A1 (es) 1999-10-23
CN1267294A (zh) 2000-09-20
BR9811470A (pt) 2000-09-19
PL337481A1 (en) 2000-08-28
IL133449A0 (en) 2001-04-30
AU8058298A (en) 1999-01-04

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