KR100579428B1 - 치환된아미노화합물,이의제조방법및이를포함하는약제학적조성물 - Google Patents

치환된아미노화합물,이의제조방법및이를포함하는약제학적조성물 Download PDF

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Publication number
KR100579428B1
KR100579428B1 KR1019980008435A KR19980008435A KR100579428B1 KR 100579428 B1 KR100579428 B1 KR 100579428B1 KR 1019980008435 A KR1019980008435 A KR 1019980008435A KR 19980008435 A KR19980008435 A KR 19980008435A KR 100579428 B1 KR100579428 B1 KR 100579428B1
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South Korea
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aryl
alkyl
formula
compound
phenyl
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KR1019980008435A
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Korean (ko)
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KR19980080219A (ko
Inventor
오스발트 침머
볼프강 베르너 알프레트 슈트라쓰부르거
헬무트 하인리히 부슈만
베르너 엥글베르거
엘마 요셉 프리데리히스
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그뤼넨탈 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1019980008435A 1997-03-14 1998-03-13 치환된아미노화합물,이의제조방법및이를포함하는약제학적조성물 Expired - Fee Related KR100579428B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19710628 1997-03-14
DE19710628.5 1997-03-14

Publications (2)

Publication Number Publication Date
KR19980080219A KR19980080219A (ko) 1998-11-25
KR100579428B1 true KR100579428B1 (ko) 2006-10-11

Family

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Family Applications (1)

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KR1019980008435A Expired - Fee Related KR100579428B1 (ko) 1997-03-14 1998-03-13 치환된아미노화합물,이의제조방법및이를포함하는약제학적조성물

Country Status (28)

Country Link
US (1) US6022895A (https=)
EP (1) EP0864559B1 (https=)
JP (1) JP4132189B2 (https=)
KR (1) KR100579428B1 (https=)
CN (1) CN1243721C (https=)
AR (1) AR010129A1 (https=)
AT (1) ATE218534T1 (https=)
AU (1) AU728501B2 (https=)
CA (1) CA2231975C (https=)
CO (1) CO4940510A1 (https=)
CZ (1) CZ295522B6 (https=)
DE (2) DE19805370A1 (https=)
DK (1) DK0864559T3 (https=)
ES (1) ES2178055T3 (https=)
HU (1) HU226060B1 (https=)
IL (1) IL123647A (https=)
MY (1) MY118828A (https=)
NO (1) NO311128B1 (https=)
NZ (1) NZ329951A (https=)
PE (1) PE59899A1 (https=)
PL (1) PL191727B1 (https=)
PT (1) PT864559E (https=)
RU (1) RU2197474C2 (https=)
SI (1) SI0864559T1 (https=)
SK (1) SK284279B6 (https=)
UA (1) UA56997C2 (https=)
UY (1) UY24919A1 (https=)
ZA (1) ZA982157B (https=)

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DE19830105C1 (de) * 1998-07-06 2000-02-17 Gruenenthal Gmbh Acridinderivate
DE19963179B4 (de) * 1999-12-27 2009-02-05 Grünenthal GmbH Substituierte 1- und 2-Naphthol-Mannichbasen
DE10033459A1 (de) * 2000-07-10 2002-01-24 Gruenenthal Gmbh Cyclische substituierte Aminomethylverbindungen und diese Verbindungen enthaltende Arzeimittel
EA006507B1 (ru) 2001-10-15 2005-12-29 Янссен Фармацевтика Н.В. Новые замещенные 4-фенил-4-[1h-имидазол-2-ил] пиперидиновые производные и их применение в качестве селективных непептидных агонистов дельта-опиоидов
DE10206403A1 (de) * 2002-02-14 2003-08-28 Gruenenthal Gmbh Synthese von Beta-Aminoketonen
DE10206405A1 (de) * 2002-02-14 2003-08-28 Gruenenthal Gmbh Synthese von substituierten Carbamidestern
CL2004000754A1 (es) * 2003-04-11 2005-02-25 Janssen Pharmaceutica Nv Uso de compuestos derivados de 4-fenil-4-(1h-imidazol-2-il)piperidina, como agonistas delta-opioides no peptidicos, para preparar un medicamento util en prevenir o tratar trastornos del sistema nervioso central.
DE10341534A1 (de) * 2003-09-09 2005-03-31 Bayer Chemicals Ag Difluoralkylaromaten
AR045939A1 (es) * 2003-09-25 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolona y quinazolinona como agonistas de los receptores orl 1 humanos
NZ546834A (en) 2003-10-01 2010-03-26 Adolor Corp Spirocyclic heterocyclic derivatives and methods of their use
DE102004030099A1 (de) * 2004-06-22 2006-01-12 Grünenthal GmbH Gesättigte und ungesättigte 3-Pyridyl-benzocycloalkylmethyl-amine als Serotonin- und/oder Noradrenalin-Reuptake-Hemmer und/oder µ-Opioidrezeptor-Modulatoren
WO2006023757A2 (en) * 2004-08-19 2006-03-02 University Of Virginia Patent Foundation Novel tricyclic, bicyclic, monocyclic, and acyclic amines as potent sodium channel blocking agents
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
RU2320342C2 (ru) * 2005-07-27 2008-03-27 ГУ Научно-исследовательский институт кардиологии Томского научного центра Сибирского отделения Российской академии медицинских наук, ГУ НИИ кардиологии ТНЦ СО РАМН Антиаритмическое средство
JP5090639B2 (ja) 2005-11-18 2012-12-05 出光興産株式会社 芳香族アミン誘導体及びそれを用いた有機エレクトロルミネッセンス素子
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
TWI401237B (zh) * 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
WO2008033299A2 (en) * 2006-09-12 2008-03-20 Adolor Corporation Use of n-containing spirocompounds for the enhancement of cognitive function
JP2010519206A (ja) * 2007-02-16 2010-06-03 シンタ ファーマシューティカルズ コーポレーション 炎症及び免疫関連使用のための置換縮合環化合物
WO2012100423A1 (en) * 2011-01-27 2012-08-02 Eli Lilly And Company Analgesic compounds, methods, and formulations
RU2538727C1 (ru) * 2013-11-15 2015-01-10 Закрытое акционерное общество "Институт экспериментальной фармакологии" Анальгетическое средство пептидной структуры на основе тридекапептида, содержащего d-октааргининовый вектор
CN104844471B (zh) * 2015-04-21 2017-05-03 苏州远智医药科技有限公司 一种作为dor受体拮抗剂的化合物
CN109896991B (zh) * 2017-12-08 2020-11-20 苏州远智医药科技有限公司 一种δ阿片受体拮抗剂及其用途和药物组合物

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BE623394A (https=) *
GB872371A (en) * 1958-07-07 1961-07-05 Univ Kansas Reseach Foundation Benzyl amine compounds and means of obtaining the same
DE1203247B (de) * 1961-10-10 1965-10-21 Koninklijke Pharma Fab Nv Verfahren zur Herstellung von Diphenylalkenyl-aminen sowie deren nicht-toxischen Salzen
FR1578702A (https=) * 1961-10-10 1969-08-22
DE1149002B (de) * 1961-10-19 1963-05-22 Giulini Gmbh Geb Verfahren zur Herstellung von blutdrucksteigernden Salzen von N, N-Dialkyl-2-aethyl-3, 3-diphenyl-propen-(2)-yl-aminen
US3452094A (en) * 1967-07-19 1969-06-24 Geigy Chem Corp N - 2 - phenyl - 2 - (2 - hydroxy - 1 - naphthyl) ethyl-n-substituted amines and salts thereof
RU2005717C1 (ru) * 1989-02-17 1994-01-15 Такеда кемикал-индастриз Лтд Способ получения производных аралкиламинов или их кислотно-аддитивных солей
DE69333527T2 (de) * 1993-02-23 2005-06-16 Brigham & Women's Hospital, Inc., Boston Calciumrezeptoraktive moleküle

Also Published As

Publication number Publication date
NZ329951A (en) 1998-08-26
US6022895A (en) 2000-02-08
PL325322A1 (en) 1998-09-28
DE19805370A1 (de) 1998-09-17
KR19980080219A (ko) 1998-11-25
HK1015351A1 (en) 1999-10-15
HU9800555D0 (en) 1998-05-28
DK0864559T3 (da) 2002-08-05
CA2231975A1 (en) 1998-09-14
EP0864559B1 (de) 2002-06-05
HUP9800555A3 (en) 2000-04-28
JPH10338665A (ja) 1998-12-22
RU2197474C2 (ru) 2003-01-27
SK33398A3 (en) 1998-11-04
DE59804276D1 (de) 2002-07-11
CZ295522B6 (cs) 2005-08-17
PL191727B1 (pl) 2006-06-30
MY118828A (en) 2005-01-31
SK284279B6 (sk) 2004-12-01
AU5840898A (en) 1999-02-11
CO4940510A1 (es) 2000-07-24
AU728501B2 (en) 2001-01-11
JP4132189B2 (ja) 2008-08-13
PT864559E (pt) 2002-11-29
NO311128B1 (no) 2001-10-15
UY24919A1 (es) 2001-08-27
HU226060B1 (en) 2008-04-28
SI0864559T1 (en) 2002-08-31
EP0864559A1 (de) 1998-09-16
UA56997C2 (uk) 2003-06-16
NO981121D0 (no) 1998-03-13
ATE218534T1 (de) 2002-06-15
PE59899A1 (es) 1999-07-10
CZ75598A3 (cs) 1998-09-16
HUP9800555A2 (hu) 1999-06-28
CN1197059A (zh) 1998-10-28
IL123647A (en) 2004-01-04
NO981121L (no) 1998-09-15
ZA982157B (en) 1998-09-15
AR010129A1 (es) 2000-05-17
IL123647A0 (en) 1998-10-30
ES2178055T3 (es) 2002-12-16
CN1243721C (zh) 2006-03-01
CA2231975C (en) 2007-09-11

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