KR100569771B1 - 프로테아제 억제제로서 유용한 4-히드록시-2-옥소-피란유도체의 제조 방법 - Google Patents

프로테아제 억제제로서 유용한 4-히드록시-2-옥소-피란유도체의 제조 방법 Download PDF

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KR100569771B1
KR100569771B1 KR1020007002546A KR20007002546A KR100569771B1 KR 100569771 B1 KR100569771 B1 KR 100569771B1 KR 1020007002546 A KR1020007002546 A KR 1020007002546A KR 20007002546 A KR20007002546 A KR 20007002546A KR 100569771 B1 KR100569771 B1 KR 100569771B1
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KR20010023864A (ko
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제임스 알. 게이지
로버트 씨. 켈리
브래들리 디. 휴이트
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파마시아 앤드 업존 캄파니 엘엘씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020007002546A 1997-09-11 1998-09-03 프로테아제 억제제로서 유용한 4-히드록시-2-옥소-피란유도체의 제조 방법 Expired - Lifetime KR100569771B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5861897P 1997-09-11 1997-09-11
US60/058,618 1997-09-11
PCT/US1998/017993 WO1999012919A1 (en) 1997-09-11 1998-09-03 Process to produce 4-hydroxy-2-oxo-pyrane derivates useful as protease inhibitors

Publications (2)

Publication Number Publication Date
KR20010023864A KR20010023864A (ko) 2001-03-26
KR100569771B1 true KR100569771B1 (ko) 2006-04-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007002546A Expired - Lifetime KR100569771B1 (ko) 1997-09-11 1998-09-03 프로테아제 억제제로서 유용한 4-히드록시-2-옥소-피란유도체의 제조 방법

Country Status (20)

Country Link
US (2) US6077963A (enExample)
EP (1) EP1015441B1 (enExample)
JP (3) JP4462760B2 (enExample)
KR (1) KR100569771B1 (enExample)
CN (3) CN1284763C (enExample)
AT (1) ATE266654T1 (enExample)
CA (1) CA2300204C (enExample)
CZ (1) CZ298847B6 (enExample)
DE (1) DE69823844T2 (enExample)
DK (1) DK1015441T3 (enExample)
ES (1) ES2221199T3 (enExample)
FI (1) FI120973B (enExample)
HU (1) HU228986B1 (enExample)
NO (1) NO321835B1 (enExample)
NZ (1) NZ503338A (enExample)
PL (1) PL193240B1 (enExample)
PT (1) PT1015441E (enExample)
RU (2) RU2223958C2 (enExample)
SK (1) SK284974B6 (enExample)
WO (1) WO1999012919A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1161427B1 (en) * 1999-03-18 2002-10-23 PHARMACIA & UPJOHN COMPANY Improved process for asymmetric hydrogenation
US6552204B1 (en) * 2000-02-04 2003-04-22 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
DE10108470A1 (de) * 2001-02-22 2002-09-05 Boehringer Ingelheim Pharma Verfahren zur Herstellung optisch aktiver Dihydropyrone
US6500963B2 (en) 2001-02-22 2002-12-31 Boehringer Ingelheim Pharma Kg Process for preparing optically active dihydropyrones
US6987123B2 (en) 2001-07-26 2006-01-17 Cadila Healthcare Limited Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
AU2002344438B2 (en) 2002-02-07 2008-09-11 Sumitomo Chemical Company, Limited Process for producing (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid and its intermediate
DE10313118A1 (de) 2003-03-24 2004-10-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Enantioselektive Hydrierung von Intermediaten bei der Tipranavir-Synthese
US7512945B2 (en) * 2003-12-29 2009-03-31 Intel Corporation Method and apparatus for scheduling the processing of commands for execution by cryptographic algorithm cores in a programmable network processor
CN100448836C (zh) * 2005-06-03 2009-01-07 浙江中贝化工有限公司 一种抗艾滋病药物关键中间体的制备方法
BRPI0615016A2 (pt) * 2005-08-24 2011-05-03 Pfizer compostos inibidores de hcv polimerase, métodos para prepará-los e forma cristalina
CN103996798B (zh) * 2007-11-30 2017-09-08 株式会社半导体能源研究所 发光元件、发光装置以及电子装置
US8853393B2 (en) * 2011-07-29 2014-10-07 Anhui New Star Pharmaceutical Development Co., Ltd. Intermediate for preparing tapentadol or analogues thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1355668A (fr) * 1963-02-05 1964-03-20 Moteur rotatif à combustion interne perfectionné
FR1355667A (fr) * 1963-02-05 1964-03-20 Meci Materiel Elect Contr Gaine tubulaire pour électrode servant à la mesure du ph
FR2096877B1 (enExample) * 1970-07-09 1973-08-10 Hexachimie
JPH0665657B2 (ja) * 1984-11-08 1994-08-24 日本化薬株式会社 光学活性マンデル酸の製法
JPH072677B2 (ja) * 1988-02-19 1995-01-18 株式会社クラレ （±）―２―ヒドロキシ―４―フェニルブタン酸の光学分割法
JPH01221345A (ja) * 1988-02-27 1989-09-04 Ajinomoto Co Inc マンデル酸誘導体の光学分割方法
JP3084577B2 (ja) * 1991-09-27 2000-09-04 山川薬品工業株式会社 光学活性なアトロラクチン酸の製造方法および製造の中間体
JP3178086B2 (ja) * 1992-06-17 2001-06-18 山川薬品工業株式会社 光学活性α−メチルベンジルアミンの製造方法
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
PT1142887E (pt) * 1993-11-19 2004-08-31 Parke Davis & Co Derivados de 5,6-di-hidropirona como inibidores de protease e agentes antivirais
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
RU2074169C1 (ru) * 1995-05-10 1997-02-27 Акционерное общество открытого типа "Химпром" Способ получения этилового эфира п-нитробензойной кислоты

Also Published As

Publication number Publication date
FI20000553L (fi) 2000-03-10
EP1015441B1 (en) 2004-05-12
CN1298714C (zh) 2007-02-07
EP1015441A1 (en) 2000-07-05
PL193240B1 (pl) 2007-01-31
RU2003131081A (ru) 2005-04-10
NO20001274D0 (no) 2000-03-10
KR20010023864A (ko) 2001-03-26
HU228986B1 (en) 2013-07-29
HK1030418A1 (en) 2001-05-04
AU9296598A (en) 1999-03-29
CA2300204A1 (en) 1999-03-18
US6077963A (en) 2000-06-20
CZ2000804A3 (cs) 2000-08-16
ATE266654T1 (de) 2004-05-15
PL339138A1 (en) 2000-12-04
NO321835B1 (no) 2006-07-10
FI120973B (fi) 2010-05-31
HUP0003593A2 (hu) 2001-02-28
PT1015441E (pt) 2004-08-31
RU2263106C2 (ru) 2005-10-27
WO1999012919A1 (en) 1999-03-18
RU2223958C2 (ru) 2004-02-20
JP5016621B2 (ja) 2012-09-05
JP2001515895A (ja) 2001-09-25
SK2262000A3 (en) 2000-10-09
CZ298847B6 (cs) 2008-02-27
HUP0003593A3 (en) 2002-12-28
NZ503338A (en) 2002-03-01
JP2009138002A (ja) 2009-06-25
CA2300204C (en) 2006-12-12
DE69823844D1 (de) 2004-06-17
CN100471832C (zh) 2009-03-25
DE69823844T2 (de) 2005-04-14
US6265604B1 (en) 2001-07-24
CN1268947A (zh) 2000-10-04
ES2221199T3 (es) 2004-12-16
HK1063776A1 (en) 2005-01-14
JP4462760B2 (ja) 2010-05-12
JP5266194B2 (ja) 2013-08-21
SK284974B6 (sk) 2006-03-02
AU743496B2 (en) 2002-01-24
CN1511820A (zh) 2004-07-14
NO20001274L (no) 2000-05-10
CN1284763C (zh) 2006-11-15
HK1104027A1 (zh) 2008-01-04
JP2010090157A (ja) 2010-04-22
CN1990452A (zh) 2007-07-04
DK1015441T3 (da) 2004-07-26

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