HUP0003593A2 - Új eljárás proteáz inhibitorként alkalmazható 4-hidroxi-2-oxo-piran-származékok előállítására - Google Patents

Új eljárás proteáz inhibitorként alkalmazható 4-hidroxi-2-oxo-piran-származékok előállítására

Info

Publication number
HUP0003593A2
HUP0003593A2 HU0003593A HUP0003593A HUP0003593A2 HU P0003593 A2 HUP0003593 A2 HU P0003593A2 HU 0003593 A HU0003593 A HU 0003593A HU P0003593 A HUP0003593 A HU P0003593A HU P0003593 A2 HUP0003593 A2 HU P0003593A2
Authority
HU
Hungary
Prior art keywords
oxo
hydroxy
produce
protease inhibitors
derivatives useful
Prior art date
Application number
HU0003593A
Other languages
English (en)
Inventor
James R. Gage
Bradley D. Hewitt
Robert C. Kelly
Original Assignee
Pharmacia & Upjohn Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co. filed Critical Pharmacia & Upjohn Co.
Publication of HUP0003593A2 publication Critical patent/HUP0003593A2/hu
Publication of HUP0003593A3 publication Critical patent/HUP0003593A3/hu
Publication of HU228986B1 publication Critical patent/HU228986B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány HIV-vírussal fertőzött humán páciensek kezelésében proteázinhibitorként használható, (XIX) képletű[R-(R*,R*)]- N-[3-[1-[5,6-dihidro-4-hidroxi-2-oxo-6-(2-feniletil)-6-propil-2H- piran-2-il]-propil]fenil]-5-(trifluormetil)-2-piridinszulfonamid új eljárássaltörténő előállítására és az eljárás új köztitermékeire vonatkozik. Ó
HU0003593A 1997-09-11 1998-09-03 Process to produce 4-hydroxy-2-oxo-pyrane derivatives useful as protease inhibitors HU228986B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5861897P 1997-09-11 1997-09-11
PCT/US1998/017993 WO1999012919A1 (en) 1997-09-11 1998-09-03 Process to produce 4-hydroxy-2-oxo-pyrane derivates useful as protease inhibitors

Publications (3)

Publication Number Publication Date
HUP0003593A2 true HUP0003593A2 (hu) 2001-02-28
HUP0003593A3 HUP0003593A3 (en) 2002-12-28
HU228986B1 HU228986B1 (en) 2013-07-29

Family

ID=22017924

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003593A HU228986B1 (en) 1997-09-11 1998-09-03 Process to produce 4-hydroxy-2-oxo-pyrane derivatives useful as protease inhibitors

Country Status (21)

Country Link
US (2) US6077963A (hu)
EP (1) EP1015441B1 (hu)
JP (3) JP4462760B2 (hu)
KR (1) KR100569771B1 (hu)
CN (3) CN1284763C (hu)
AT (1) ATE266654T1 (hu)
CA (1) CA2300204C (hu)
CZ (1) CZ298847B6 (hu)
DE (1) DE69823844T2 (hu)
DK (1) DK1015441T3 (hu)
ES (1) ES2221199T3 (hu)
FI (1) FI120973B (hu)
HK (3) HK1030418A1 (hu)
HU (1) HU228986B1 (hu)
NO (1) NO321835B1 (hu)
NZ (1) NZ503338A (hu)
PL (1) PL193240B1 (hu)
PT (1) PT1015441E (hu)
RU (2) RU2223958C2 (hu)
SK (1) SK284974B6 (hu)
WO (1) WO1999012919A1 (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3610014B2 (ja) * 1999-03-18 2005-01-12 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー 不斉水素化のための改良された製法
US6552204B1 (en) * 2000-02-04 2003-04-22 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
US6500963B2 (en) 2001-02-22 2002-12-31 Boehringer Ingelheim Pharma Kg Process for preparing optically active dihydropyrones
DE10108470A1 (de) * 2001-02-22 2002-09-05 Boehringer Ingelheim Pharma Verfahren zur Herstellung optisch aktiver Dihydropyrone
US6987123B2 (en) 2001-07-26 2006-01-17 Cadila Healthcare Limited Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
BR0215593A (pt) * 2002-02-07 2004-12-21 Sumitomo Chemical Co Processo para produzir ácido (r)-3-hidróxi-3-(2-feniletil)-hexanóico e seu intermediário
DE10313118A1 (de) * 2003-03-24 2004-10-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Enantioselektive Hydrierung von Intermediaten bei der Tipranavir-Synthese
US7512945B2 (en) * 2003-12-29 2009-03-31 Intel Corporation Method and apparatus for scheduling the processing of commands for execution by cryptographic algorithm cores in a programmable network processor
CN100448836C (zh) * 2005-06-03 2009-01-07 浙江中贝化工有限公司 一种抗艾滋病药物关键中间体的制备方法
CA2619077C (en) * 2005-08-24 2011-09-13 Pfizer Inc. Methods for the preparation of hcv polymerase inhibitors
CN103996798B (zh) * 2007-11-30 2017-09-08 株式会社半导体能源研究所 发光元件、发光装置以及电子装置
WO2013016840A1 (zh) * 2011-07-29 2013-02-07 安徽省新星药物开发有限责任公司 用于合成他喷他多或其类似物的新中间体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1355668A (fr) * 1963-02-05 1964-03-20 Moteur rotatif à combustion interne perfectionné
FR1355667A (fr) * 1963-02-05 1964-03-20 Meci Materiel Elect Contr Gaine tubulaire pour électrode servant à la mesure du ph
FR2096877B1 (hu) * 1970-07-09 1973-08-10 Hexachimie
JPH0665657B2 (ja) * 1984-11-08 1994-08-24 日本化薬株式会社 光学活性マンデル酸の製法
JPH072677B2 (ja) * 1988-02-19 1995-01-18 株式会社クラレ （±）―２―ヒドロキシ―４―フェニルブタン酸の光学分割法
JPH01221345A (ja) * 1988-02-27 1989-09-04 Ajinomoto Co Inc マンデル酸誘導体の光学分割方法
JP3084577B2 (ja) * 1991-09-27 2000-09-04 山川薬品工業株式会社 光学活性なアトロラクチン酸の製造方法および製造の中間体
JP3178086B2 (ja) * 1992-06-17 2001-06-18 山川薬品工業株式会社 光学活性α−メチルベンジルアミンの製造方法
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
RU2140917C1 (ru) * 1993-11-19 1999-11-10 Парк, Дэвис энд Компани Производные 5,6-дигидропирона и фармацевтическая композиция на их основе
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections

Also Published As

Publication number Publication date
NO321835B1 (no) 2006-07-10
EP1015441A1 (en) 2000-07-05
NO20001274L (no) 2000-05-10
HK1104027A1 (en) 2008-01-04
RU2263106C2 (ru) 2005-10-27
JP2001515895A (ja) 2001-09-25
JP5016621B2 (ja) 2012-09-05
CA2300204A1 (en) 1999-03-18
CZ298847B6 (cs) 2008-02-27
DE69823844T2 (de) 2005-04-14
CN1284763C (zh) 2006-11-15
PT1015441E (pt) 2004-08-31
PL339138A1 (en) 2000-12-04
CZ2000804A3 (cs) 2000-08-16
CN1298714C (zh) 2007-02-07
CA2300204C (en) 2006-12-12
SK284974B6 (sk) 2006-03-02
HK1063776A1 (en) 2005-01-14
FI120973B (fi) 2010-05-31
US6077963A (en) 2000-06-20
DK1015441T3 (da) 2004-07-26
ATE266654T1 (de) 2004-05-15
US6265604B1 (en) 2001-07-24
CN100471832C (zh) 2009-03-25
JP2010090157A (ja) 2010-04-22
RU2003131081A (ru) 2005-04-10
AU9296598A (en) 1999-03-29
JP2009138002A (ja) 2009-06-25
DE69823844D1 (de) 2004-06-17
PL193240B1 (pl) 2007-01-31
HK1030418A1 (en) 2001-05-04
ES2221199T3 (es) 2004-12-16
KR20010023864A (ko) 2001-03-26
EP1015441B1 (en) 2004-05-12
KR100569771B1 (ko) 2006-04-11
SK2262000A3 (en) 2000-10-09
JP4462760B2 (ja) 2010-05-12
RU2223958C2 (ru) 2004-02-20
CN1268947A (zh) 2000-10-04
JP5266194B2 (ja) 2013-08-21
AU743496B2 (en) 2002-01-24
HU228986B1 (en) 2013-07-29
FI20000553A (fi) 2000-03-10
CN1511820A (zh) 2004-07-14
NO20001274D0 (no) 2000-03-10
HUP0003593A3 (en) 2002-12-28
WO1999012919A1 (en) 1999-03-18
CN1990452A (zh) 2007-07-04
NZ503338A (en) 2002-03-01

Similar Documents

Publication Publication Date Title
HUP0003593A2 (hu) Új eljárás proteáz inhibitorként alkalmazható 4-hidroxi-2-oxo-piran-származékok előállítására
HUP0400689A2 (hu) ABCA-1 szint-emelő vegyületek
ATE508735T1 (de) Pulmonale verabreichung von aminoglykosiden
HUP0303996A2 (hu) Vakcinakészítmények
BR9510104A (pt) Novas sulfonamidas
HUP0202655A2 (hu) N-[(amino-imino-metil)- és N-[(amino-metil)-fenil]-propil-amid származékok
HUP0102516A2 (hu) Enzim inhibitorok
ATE494884T1 (de) Oxidative zusammensetzung zur behandlung von keratinfasern, die spezielle aminosilikone enthält
HUP0400782A2 (hu) Antikolinergikumokon és PDE-IV inhibitorokon alapuló új gyógyszerkészítmények
HUP0301991A2 (hu) IL-18-inhibitorok alkalmazása atheroszklerózis kezelésére és/vagy megelżzésére
HUP0400368A2 (hu) Oxitocin agonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk szexuális zavarok kezelésére
DE69928779D1 (de) Nichtnukleoside reverse transkriptase-hemmer zur behandlung von hiv-infektion
NO993670L (no) Quinoksalin i trippelkombinasjon med proteaseinhibitorer og reverse transkriptaseinhibitorer som medikamenter for behandling av AIDS
HUP0203295A2 (hu) Emphysema kezelése RAR-szelektív retinoid agonistákat tartalmazó gyógyszerkészítmények felhasználásával
HUP0302233A2 (hu) Virális betegségek kezelésére IL-18-cal és IL-18 kombinációkkal
HUP0203740A2 (en) Food product and process
WO2003100036A3 (fr) Sulfolipides antiretroviraux extraits de spirulines, leur procede d'obtention, les compositions les contenant et leur utilisation comme inhibiteurs de la transcriptase inverse des virus vih.
DE60213874D1 (de) Verfahren zur herstellung von protease hemmenden zwischenprodukten
DE60015098D1 (de) 3-cyclopropylmethoxy-4-difluormethoxy-n-(3,5-dichlor-pyrid-4-yl)-benzamid zur behandlung von multipler sklerose
EA200400751A1 (ru) Применение дезоксипеганина для лечения клинической депрессии
UA41338C2 (uk) Спосіб інгібування ретровірусної інфекції, яка викликана вірусом імунодефіциту людини (віл), спосіб інгібування вірусу імунодефіциту людини (віл)
NO20033541L (no) Anvendelse av fosfodiesteraseinhibitorer av type 4 ved hjertemuskelsykdommer
DE60311284D1 (de) 4-(3,5-dicyanophenoxy)pyrazol-derivate zur verwendung als reverse transkriptase modulatoren zur behandlung von u.a. hiv
ATE293667T1 (de) Tensidhaltige reinigungsmittel mit enzym- inhibitoren
LT2002131A (en) New use of fir oil for cosmetic