KR100568063B1 - 제약상 활성인 모르폴리놀 - Google Patents

제약상 활성인 모르폴리놀 Download PDF

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Publication number
KR100568063B1
KR100568063B1 KR1020007007996A KR20007007996A KR100568063B1 KR 100568063 B1 KR100568063 B1 KR 100568063B1 KR 1020007007996 A KR1020007007996 A KR 1020007007996A KR 20007007996 A KR20007007996 A KR 20007007996A KR 100568063 B1 KR100568063 B1 KR 100568063B1
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KR
South Korea
Prior art keywords
morpholinol
formula
chlorophenyl
trimethyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020007007996A
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English (en)
Korean (ko)
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KR20010034285A (ko
Inventor
필립 프레데릭 모건
데이빗 리 무소
존 조셉 파트리지
Original Assignee
글락소 그룹 리미티드
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Priority claimed from GBGB9801230.5A external-priority patent/GB9801230D0/en
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Publication of KR20010034285A publication Critical patent/KR20010034285A/ko
Application granted granted Critical
Publication of KR100568063B1 publication Critical patent/KR100568063B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020007007996A 1998-01-21 1999-01-20 제약상 활성인 모르폴리놀 Expired - Fee Related KR100568063B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9801230.5A GB9801230D0 (en) 1998-01-21 1998-01-21 Pharmaceutically active morpholinol
GB9801230.5 1998-01-21
US7218098P 1998-01-22 1998-01-22
US60/072,180 1998-01-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR10-2004-7000715A Division KR20040023653A (ko) 1998-01-21 1999-01-20 제약상 활성인 모르폴리놀

Publications (2)

Publication Number Publication Date
KR20010034285A KR20010034285A (ko) 2001-04-25
KR100568063B1 true KR100568063B1 (ko) 2006-04-07

Family

ID=26312986

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007007996A Expired - Fee Related KR100568063B1 (ko) 1998-01-21 1999-01-20 제약상 활성인 모르폴리놀

Country Status (30)

Country Link
US (2) US6274579B1 (cg-RX-API-DMAC7.html)
EP (2) EP1047428B1 (cg-RX-API-DMAC7.html)
JP (1) JP2002501025A (cg-RX-API-DMAC7.html)
KR (1) KR100568063B1 (cg-RX-API-DMAC7.html)
CN (2) CN1255389C (cg-RX-API-DMAC7.html)
AP (1) AP1229A (cg-RX-API-DMAC7.html)
AT (1) ATE365042T1 (cg-RX-API-DMAC7.html)
AU (1) AU755536B2 (cg-RX-API-DMAC7.html)
BR (1) BR9907203A (cg-RX-API-DMAC7.html)
CA (1) CA2318268A1 (cg-RX-API-DMAC7.html)
CY (1) CY1106828T1 (cg-RX-API-DMAC7.html)
DE (1) DE69936335T2 (cg-RX-API-DMAC7.html)
DK (1) DK1047428T3 (cg-RX-API-DMAC7.html)
EA (1) EA002410B1 (cg-RX-API-DMAC7.html)
EE (1) EE04452B1 (cg-RX-API-DMAC7.html)
ES (1) ES2288012T3 (cg-RX-API-DMAC7.html)
HR (2) HRP20051024A2 (cg-RX-API-DMAC7.html)
HU (1) HUP0100900A3 (cg-RX-API-DMAC7.html)
ID (1) ID26334A (cg-RX-API-DMAC7.html)
IL (2) IL161942A0 (cg-RX-API-DMAC7.html)
IS (1) IS2494B (cg-RX-API-DMAC7.html)
NO (2) NO326878B1 (cg-RX-API-DMAC7.html)
NZ (3) NZ520349A (cg-RX-API-DMAC7.html)
PL (1) PL193622B1 (cg-RX-API-DMAC7.html)
PT (1) PT1047428E (cg-RX-API-DMAC7.html)
SG (1) SG115489A1 (cg-RX-API-DMAC7.html)
SK (1) SK10912000A3 (cg-RX-API-DMAC7.html)
TR (1) TR200002126T2 (cg-RX-API-DMAC7.html)
WO (1) WO1999037305A1 (cg-RX-API-DMAC7.html)
YU (1) YU67102A (cg-RX-API-DMAC7.html)

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US7098206B2 (en) * 1998-01-21 2006-08-29 Smithkline Beecham Corporation Pharmaceutically active morpholinol
US6998400B2 (en) 1998-01-22 2006-02-14 Smithkline Beecham Corporation Pharmaceutically active morpholinol
EP1051167A1 (en) 1998-01-29 2000-11-15 Sepracor, Inc. Pharmaceutical uses of optically pure (-) -bupropion
AU2349999A (en) 1998-01-29 1999-08-16 Sepracor, Inc. Pharmacological uses of pure (+) -bupropion
US6734213B2 (en) 1999-01-20 2004-05-11 Smithkline Beecham Corporation Pharmaceutically active morpholinol
US6855820B2 (en) 1999-01-20 2005-02-15 Smithkline Beecham Corporation Pharmaceutically active morpholinol
US6342496B1 (en) * 1999-03-01 2002-01-29 Sepracor Inc. Bupropion metabolites and methods of use
US6337328B1 (en) * 1999-03-01 2002-01-08 Sepracor, Inc. Bupropion metabolites and methods of use
AU7750100A (en) * 1999-10-13 2001-04-23 Glaxo Group Limited Method for the treatment of obesity
GB0003232D0 (en) * 2000-02-11 2000-04-05 Smithkline Beecham Plc Novel composition
US7145649B2 (en) * 2000-12-21 2006-12-05 Brasscorp Limited Method of producing an ultra-violet or near ultra-violet light source for non-destructive inspection or testing
US6979104B2 (en) 2001-12-31 2005-12-27 R.J. Doran & Co. LTD LED inspection lamp
KR20110043664A (ko) * 2002-05-17 2011-04-27 듀크 유니버시티 비만치료방법
US20050215552A1 (en) * 2002-05-17 2005-09-29 Gadde Kishore M Method for treating obesity
AU2003269923A1 (en) * 2002-08-23 2004-03-11 Eli Lilly And Company 2- (phenoxymethyl)- and 2- (phenylthiomethyl)-morpholine derivatives for use as selective norepinephrine reuptake inhibitors
GB0219687D0 (en) * 2002-08-23 2002-10-02 Lilly Co Eli Benzyl morpholine derivatives
ATE388698T1 (de) 2003-04-29 2008-03-15 Orexigen Therapeutics Inc Zusammensetzungen zur beeinflussung des gewichtsverlusts
EP1678152A1 (en) * 2003-10-27 2006-07-12 Smithkline Beecham Corporation Enzyme-catalyzed dynamic kinetic resolution process for preparing (+)-(2s, 3s)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol, salts, and solvates thereof
GB0325055D0 (en) * 2003-10-27 2003-12-03 Smithkline Beecham Corp New process
GB0326148D0 (en) 2003-11-10 2003-12-17 Lilly Co Eli Morpholine derivatives
GB0327195D0 (en) * 2003-11-21 2003-12-24 Smithkline Beecham Corp Novel use
GB0327619D0 (en) * 2003-11-27 2003-12-31 Smithkline Beecham Corp New use
US7713959B2 (en) * 2004-01-13 2010-05-11 Duke University Compositions of an anticonvulsant and mirtazapine to prevent weight gain
BRPI0506829A (pt) 2004-01-13 2007-05-29 Univ Duke composições de anticonvulsivo e droga antipsicótica e métodos para sua utilização para afetar perda de peso
BRPI0510593A (pt) * 2004-05-03 2007-11-20 Univ Duke composições para afetar a perda de peso
FI117283B (fi) 2005-02-04 2006-08-31 Kone Corp Hissijärjestelmä
CN101370488B (zh) 2005-11-22 2012-07-18 奥雷西根治疗公司 增加胰岛素敏感性的组合物
US7763612B2 (en) * 2006-01-03 2010-07-27 Algebra, Inc. Therapeutic amine-arylsulfonamide conjugate compounds
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
WO2008060964A2 (en) 2006-11-09 2008-05-22 Orexigen Therapeutics, Inc. Unit dosage package and methods for administering weight loss medications
US8088786B2 (en) 2006-11-09 2012-01-03 Orexigen Therapeutics, Inc. Layered pharmaceutical formulations
US20090075994A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched radafaxine
MX2010012909A (es) 2008-05-30 2011-02-25 Orexigen Therapeutics Inc Metodos para tratamiento de condiciones de grasa visceral.
WO2010121022A1 (en) 2009-04-15 2010-10-21 Research Triangle Institute Monoamine reuptake inhibitors
JP6196041B2 (ja) 2010-01-11 2017-09-13 オレキシジェン・セラピューティクス・インコーポレーテッド 大うつ病を有する患者において減量療法を提供する方法
ES2687095T3 (es) 2010-05-21 2018-10-23 Research Triangle Institute Fenilimorfolinas y análogos de las mismas
EP2571859B1 (en) * 2010-05-21 2015-07-22 Research Triangle Institute 1-phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence
US9510405B2 (en) 2011-06-30 2016-11-29 Schneider Electric Industries Sas Dual power SMPS for a modular lighting system
CN102670617B (zh) * 2012-04-13 2013-03-20 湖南大学 布洛芬2-（2-芳基吗啉-4-基）乙酯作为制备抗抑郁药物的应用
PE20150358A1 (es) 2012-06-06 2015-04-06 Orexigen Therapeutics Inc Metodos para el tratamiento del sobrepeso y de la obesidad
CN105949142B (zh) * 2016-05-21 2018-03-27 南华大学 具有抗抑郁活性的单一手性化合物及其制备方法和应用
RU2763728C1 (ru) * 2021-06-17 2021-12-30 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) Применение 3-(2-(4-нитрофенил)-2-оксоэтилиден)морфолин-2-она в качестве средства, обладающего противомикробной активностью

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US6337328B1 (en) 1999-03-01 2002-01-08 Sepracor, Inc. Bupropion metabolites and methods of use

Also Published As

Publication number Publication date
US6391875B2 (en) 2002-05-21
NO20003721D0 (no) 2000-07-20
PL193622B1 (pl) 2007-02-28
DE69936335D1 (de) 2007-08-02
EP1047428A1 (en) 2000-11-02
EP1047428B1 (en) 2007-06-20
EP1047428A4 (en) 2001-12-19
EA002410B1 (ru) 2002-04-25
NO326878B1 (no) 2009-03-09
NZ505809A (en) 2002-09-27
CY1106828T1 (el) 2012-05-23
HRP20000494A2 (en) 2000-12-31
HUP0100900A3 (en) 2002-08-28
CA2318268A1 (en) 1999-07-29
IS2494B (is) 2009-02-15
AU2328099A (en) 1999-08-09
NO20083529L (no) 2000-09-19
BR9907203A (pt) 2000-10-17
AP2000001869A0 (en) 2000-09-30
EP1829544A1 (en) 2007-09-05
WO1999037305A1 (en) 1999-07-29
HRP20000494B1 (en) 2009-02-28
PT1047428E (pt) 2007-09-07
AP1229A (en) 2003-12-04
NO20003721L (no) 2000-09-19
CN1528753A (zh) 2004-09-15
IL137346A0 (en) 2001-07-24
SG115489A1 (en) 2005-10-28
ATE365042T1 (de) 2007-07-15
NZ520349A (en) 2004-02-27
US6274579B1 (en) 2001-08-14
CN1255389C (zh) 2006-05-10
IL161942A0 (en) 2005-11-20
EE04452B1 (et) 2005-04-15
EE200000438A (et) 2001-12-17
PL342012A1 (en) 2001-05-07
US20020019396A1 (en) 2002-02-14
DE69936335T2 (de) 2008-02-28
IS5568A (is) 2000-07-20
HRP20051024A2 (hr) 2006-04-30
AU755536B2 (en) 2002-12-12
HUP0100900A2 (hu) 2002-05-29
ID26334A (id) 2000-12-14
TR200002126T2 (tr) 2000-12-21
SK10912000A3 (sk) 2001-04-09
CN1294513A (zh) 2001-05-09
DK1047428T3 (da) 2007-10-08
EA200000691A1 (ru) 2001-04-23
KR20010034285A (ko) 2001-04-25
JP2002501025A (ja) 2002-01-15
ES2288012T3 (es) 2007-12-16
CN1203858C (zh) 2005-06-01
YU67102A (sh) 2004-12-31
NZ529316A (en) 2004-05-28

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