KR100541198B1 - 마이크로에멀젼예비농축물 - Google Patents

마이크로에멀젼예비농축물 Download PDF

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Publication number
KR100541198B1
KR100541198B1 KR1019970702753A KR19970702753A KR100541198B1 KR 100541198 B1 KR100541198 B1 KR 100541198B1 KR 1019970702753 A KR1019970702753 A KR 1019970702753A KR 19970702753 A KR19970702753 A KR 19970702753A KR 100541198 B1 KR100541198 B1 KR 100541198B1
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KR
South Korea
Prior art keywords
microemulsion
acid
composition
rapamycin
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019970702753A
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English (en)
Korean (ko)
Other versions
KR970706837A (ko
Inventor
실바인 코텐즈
바르바라 해베를린
리하르트 세트라니
자키 본데르셔
Original Assignee
노바티스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9421613A external-priority patent/GB9421613D0/en
Priority claimed from GB9422084A external-priority patent/GB9422084D0/en
Priority claimed from GBGB9425353.1A external-priority patent/GB9425353D0/en
Priority claimed from GBGB9517133.6A external-priority patent/GB9517133D0/en
Application filed by 노바티스 아게 filed Critical 노바티스 아게
Publication of KR970706837A publication Critical patent/KR970706837A/ko
Application granted granted Critical
Publication of KR100541198B1 publication Critical patent/KR100541198B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
  • Colloid Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1019970702753A 1994-10-26 1995-10-25 마이크로에멀젼예비농축물 Expired - Fee Related KR100541198B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB9421613.2 1994-10-26
GB9421613A GB9421613D0 (en) 1994-10-26 1994-10-26 Organic compounds
GB9422084A GB9422084D0 (en) 1994-11-02 1994-11-02 Organic compounds
GB9422084.5 1994-11-02
GBGB9425353.1A GB9425353D0 (en) 1994-12-15 1994-12-15 Organic compounds
GB9425353.1 1994-12-15
GB9517133.6 1995-08-22
GBGB9517133.6A GB9517133D0 (en) 1995-08-22 1995-08-22 Pharmaceutical compositions
PCT/EP1995/004187 WO1996013273A1 (en) 1994-10-26 1995-10-25 Pharmaceutical compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR10-2004-7010131A Division KR100518135B1 (ko) 1994-10-26 1995-10-25 매크롤라이드를 안정화하는 방법

Publications (2)

Publication Number Publication Date
KR970706837A KR970706837A (ko) 1997-12-01
KR100541198B1 true KR100541198B1 (ko) 2007-04-11

Family

ID=27451224

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019970702753A Expired - Fee Related KR100541198B1 (ko) 1994-10-26 1995-10-25 마이크로에멀젼예비농축물
KR10-2004-7010131A Expired - Fee Related KR100518135B1 (ko) 1994-10-26 1995-10-25 매크롤라이드를 안정화하는 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR10-2004-7010131A Expired - Fee Related KR100518135B1 (ko) 1994-10-26 1995-10-25 매크롤라이드를 안정화하는 방법

Country Status (25)

Country Link
EP (2) EP2039358A1 (https=)
JP (3) JPH10509699A (https=)
KR (2) KR100541198B1 (https=)
CN (3) CN1679938A (https=)
AT (1) ATE411800T1 (https=)
AU (1) AU714360B2 (https=)
BR (1) BR9509496A (https=)
CA (1) CA2200967C (https=)
CY (1) CY2210B1 (https=)
CZ (1) CZ289838B6 (https=)
DE (2) DE19581805T1 (https=)
ES (1) ES2316150T3 (https=)
FI (1) FI119497B (https=)
HU (1) HU225535B1 (https=)
IL (3) IL129547A (https=)
MY (1) MY129435A (https=)
NO (2) NO323078B1 (https=)
NZ (1) NZ295655A (https=)
PE (1) PE52896A1 (https=)
PL (1) PL184368B1 (https=)
PT (1) PT787011E (https=)
SK (2) SK286178B6 (https=)
TR (2) TR199500299A2 (https=)
TW (1) TW308544B (https=)
WO (1) WO1996013273A1 (https=)

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HU225535B1 (en) 2007-02-28
ES2316150T3 (es) 2009-04-01
MY129435A (en) 2007-04-30
KR970706837A (ko) 1997-12-01
EP0787011A1 (en) 1997-08-06
CA2200967C (en) 2007-09-25
PE52896A1 (es) 1996-12-12
NO971898D0 (no) 1997-04-24
PL319691A1 (en) 1997-08-18
FI119497B (fi) 2008-12-15
IL129547A0 (en) 2000-02-29
CN1161652A (zh) 1997-10-08
FI970995A0 (fi) 1997-03-10
NO20031901D0 (no) 2003-04-28
EP0787011B1 (en) 2008-10-22
ATE411800T1 (de) 2008-11-15
TR199501321A2 (tr) 1996-06-21
AU3924895A (en) 1996-05-23
CZ289838B6 (cs) 2002-04-17
NO323078B1 (no) 2006-12-27
JPH10509699A (ja) 1998-09-22
EP2039358A1 (en) 2009-03-25
CA2200967A1 (en) 1996-05-09
AU714360B2 (en) 1999-12-23
NO971898L (no) 1997-06-24
JP2005247870A (ja) 2005-09-15
SK52197A3 (en) 1997-09-10
NO20031901L (no) 1997-06-24
NO323063B1 (no) 2006-12-27
IL129547A (en) 2001-01-11
CZ123197A3 (en) 1997-07-16
FI970995L (fi) 1997-04-25
KR100518135B1 (ko) 2005-10-04
SK286178B6 (sk) 2008-04-07
NZ295655A (en) 1998-12-23
CY2210B1 (en) 2002-11-08
SK285809B6 (sk) 2007-08-02
CN1404833A (zh) 2003-03-26
IL115742A (en) 2000-06-01
IL115742A0 (en) 1996-01-19
JP2004359696A (ja) 2004-12-24
PL184368B1 (pl) 2002-10-31
KR20040074104A (ko) 2004-08-21
BR9509496A (pt) 1997-09-30
TW308544B (https=) 1997-06-21
HUT76858A (en) 1997-12-29
PT787011E (pt) 2009-01-23
DE19581805T1 (de) 1997-10-16
TR199500299A2 (tr) 1997-06-23
CN1679938A (zh) 2005-10-12
MX9702701A (es) 1997-10-31
WO1996013273A1 (en) 1996-05-09
DE69535869D1 (de) 2008-12-04

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