KR100495319B1 - 도라지 추출물을 포함하는 퇴행성 뇌질환의 예방 및 치료용 또는 기억력 증진용 식품 조성물 - Google Patents
도라지 추출물을 포함하는 퇴행성 뇌질환의 예방 및 치료용 또는 기억력 증진용 식품 조성물 Download PDFInfo
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- KR100495319B1 KR100495319B1 KR10-2002-0033344A KR20020033344A KR100495319B1 KR 100495319 B1 KR100495319 B1 KR 100495319B1 KR 20020033344 A KR20020033344 A KR 20020033344A KR 100495319 B1 KR100495319 B1 KR 100495319B1
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Abstract
Description
조성물번호 | AL-1 | AL-2 | AL-3 | AL-4 | AL-5 | AL-6 | AL-7 | AL-8 | AL-9 | AL-10 |
조성 | 장길 20 | 장길 20고본 3천마 3택사 6천궁 6당귀 3복령 3백출 3작약 10 | 장길 20고본 3천마 3황련 5황금 5황백 5치자 5 | 장길 20고본 3천마 3시호 2당귀 3창출 4복령 4감초 1.5천궁 3조구등 3진피 3반하 5 | 장길 20고본 3천마 3감국 3맥문동 3반하 3진피 3복령 3인삼 2조구등 3생강 1감초 1방풍 2 | 장길 20고본 3천마 3도인 5계지 4대황 1.5감초 1.5망초 0.9 | 장길 20고본 3천마 3시호 16반하 4황금 10작약 10대조 2지실 6생강 1대황 4 | 장길 20고본 3천마 3황련 3황금 3대황 3 | 장길 20고본 3천마 3계지 3작약 3복령 3도인 3목단피 3단삼 5잇꽃 3 | 장길 20고본 3천마 3작약 3지황 3당귀 3천궁 3 |
조성물 번호 | AL-11 | AL-12 | AL-13 | AL-14 | AL-15 | AL-16 | AL-17 | AL-18 | AL-19 |
조성 | 장길 20고본 3천마 3당귀 3작약 3시호 3백출 3복령 3박하 1목단피 2치자 2감초 2생강 1 | 장길 20백복신 4원지 4석창포 4 | 장길 20백복령 20석창포 3하수오 6원지 3산약 9황련 6천마 3고본 3저령 6계지 1.5 | 장길 20고본 3천마 3택사 6천궁 6당귀 3복령 3백출 3작약 10황련 5산약 4구자 5저령 10황백 5 | 장길 20감초 6.7결명자 5.6구기자 5.6황기 5.6지모 7.8독활 5.6방풍 5.6계지 5.6백출 5.6인진 1.1두충 5.6산약 22홍화자 7.2삼백초 5백화사 1.7 | 장길 20원지 6천마 4택사 6천궁 6당귀 6복령 3백출 3작약 5황련 5산약 5구자 5저령 10석송자 10목단피 8은행잎 10 | 장길 20원지 9황련 5산약 10구자 5당귀 10복령 10저령 10석송자 10목단피 8은행잎 10 | 장길 20황정 4산약 8연자육 4용골 4원지 8지골피 4구기자 4석창포 8두충 4우슬 4숙지황 4흑임자 4천마 8백자인 3맥아 3토사자 6당귀신 6파극 6인삼 6해송 4고본 4 | 장길 20황정 4산약 8연자육 4용골 4원지 10지골피 4구기자 4석창포 8두충 4우슬 4숙지황 4흑임자 4천마 12백자인 3맥아 3토사자 6당귀신 10파극 6인삼 6해송 8고본 4 |
조성물 번호 | 수용체 결합 저해율0.5(㎎/㎖), % | 조성물 번호 | 수용체 결합 저해율 0.5(㎎/㎖), % |
AL-1 | <0.0 | AL-11 | <0.0 |
AL-2 | <0.0 | AL-12 | <0.0 |
Al-3 | 87.39 | AL-13 | 69.4 |
AL-4 | <0.0 | AL-14 | 71.2 |
AL-5 | <0.0 | AL-15 | 40.9 |
AL-6 | <0.0 | AL-16 | 52.2 |
AL-7 | <0.0 | AL-17 | 25.3 |
AL-8 | 18.49 | AL-18 | 39.8 |
AL-9 | <0.0 | AL-19 | 40.8 |
AL-10 | <0.0 |
조성물 번호 | IC50(㎎) | 조성물 번호 | IC50(㎎) |
AL-1 | 0.051 | AL-11 | 0.044 |
AL-2 | 0.015 | AL-12 | 0.056 |
Al-3 | 0.052 | AL-13 | 0.057 |
AL-4 | 0.024 | AL-14 | 0.056 |
AL-5 | 0.051 | AL-15 | 0.048 |
AL-6 | 0.031 | AL-16 | 0.048 |
AL-7 | 0.041 | AL-17 | 0.050 |
AL-8 | 0.033 | AL-18 | 0.038 |
AL-9 | 0.025 | AL-19 | 0.041 |
AL-10 | 0.039 |
실험 물질 | 도달시간(초) | 실험 물질 | 도달시간(초) |
대조군 | 20 | AL-13 | 26 |
양성 대조군(타크린) | 31 | AL-14 | 131 |
AL-01 | 96 | AL-15 | 31 |
AL-02 | 101 | AL-16 | 233 |
AL-04 | 236 | AL-17 | 194 |
AL-06 | 236 | AL-18 | 13 |
AL-12 | 257 | AL-19 | 34 |
Claims (14)
- 삭제
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- 삭제
- 삭제
- 도라지 추출물 및 식품학적으로 허용되는 담체를 포함하는 퇴행성 뇌질환 예방용 식품 조성물.
- 도라지 추출물 및 식품학적으로 허용되는 담체를 포함하는 기억력 증진용 식품 조성물.
- 제8항 또는 제9항에 있어서,도라지가 20년생 이상의 장생 도라지인 조성물.
- 제8항 또는 제9항에 있어서,도라지 추출물이 도라지를 물 또는 에탄올로 추출한 것인 조성물.
- 제11항에 있어서,도라지 추출물이 도라지 분말에 5 내지 15 배의 물을 가하고 80 내지 100℃에서 1 내지 24시간동안 추출한 후 여과하여 얻어지는 조성물.
- 제8항 또는 제9항에 있어서,고본, 천마, 시호, 당귀, 도인, 계지, 대황, 감초, 천궁, 진피, 택사, 황련, 황금, 복령, 작약, 백출, 황백, 치자, 반하, 조구등, 지실, 인삼, 맥문동, 원지, 석창포, 창출, 감국, 방풍, 생강, 망초, 대조, 단삼, 도인, 목단피, 잇꽃, 지황, 박하, 산약, 저령, 하수오, 구자, 결명자, 구기자, 독활, 두충, 백화사설초, 삼백초, 인진, 지모, 홍화, 황기, 석송자, 은행잎, 황정, 연자육, 용골, 지골피, 우슬, 숙지황, 흑임자, 백자인, 맥아, 토사자, 파극천, 해송 및 이들의 혼합물로 이루어진 그룹으로부터 선택된 생약재 또는 이의 추출물을 추가로 포함하는 조성물.
- 삭제
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020010033779A KR20050021026A (ko) | 2001-06-15 | 2001-06-15 | 장생도라지 추출물을 포함하는 면역계의 이상으로부터발생하는 질병의 예방 및 치료용 약제학적 조성물 |
KR1020010033779 | 2001-06-15 | ||
KR1020010033777 | 2001-06-15 |
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Application Number | Title | Priority Date | Filing Date |
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KR10-2004-0115523A Division KR100495315B1 (ko) | 2001-06-15 | 2004-12-29 | 도라지 추출물을 포함하는 퇴행성 뇌질환의 예방 및치료용 또는 기억력 증진용 약학 조성물 |
Publications (2)
Publication Number | Publication Date |
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KR20020096925A KR20020096925A (ko) | 2002-12-31 |
KR100495319B1 true KR100495319B1 (ko) | 2005-06-14 |
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Application Number | Title | Priority Date | Filing Date |
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KR1020010033779A KR20050021026A (ko) | 2001-06-15 | 2001-06-15 | 장생도라지 추출물을 포함하는 면역계의 이상으로부터발생하는 질병의 예방 및 치료용 약제학적 조성물 |
KR10-2002-0033344A KR100495319B1 (ko) | 2001-06-15 | 2002-06-14 | 도라지 추출물을 포함하는 퇴행성 뇌질환의 예방 및 치료용 또는 기억력 증진용 식품 조성물 |
KR10-2004-0115523A KR100495315B1 (ko) | 2001-06-15 | 2004-12-29 | 도라지 추출물을 포함하는 퇴행성 뇌질환의 예방 및치료용 또는 기억력 증진용 약학 조성물 |
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US (1) | US20040185128A1 (ko) |
JP (1) | JP4128952B2 (ko) |
KR (3) | KR20050021026A (ko) |
WO (1) | WO2002102397A1 (ko) |
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KR20230029227A (ko) | 2021-08-24 | 2023-03-03 | 김좌진 | 뇌 신경세포 보호용 조성물 |
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KR20230047320A (ko) * | 2021-09-30 | 2023-04-07 | 한국 한의학 연구원 | 반하, 대추, 감초, 인삼, 건강, 황금 및 황련 혼합 추출물을 유효성분으로 포함하는, 알츠하이머 치료용 조성물 |
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KR20000037144A (ko) * | 2000-04-08 | 2000-07-05 | 김도현 | 혼합곡물 및 한약재 혼합음료 |
KR100373501B1 (ko) * | 2000-09-20 | 2003-02-25 | 최병학 | 스트레스 예방 및 치료를 위한 항스트레스제 조성물 |
JP2002241293A (ja) * | 2001-02-13 | 2002-08-28 | Ichimaru Pharcos Co Ltd | メイラード反応阻害剤 |
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- 2002-06-15 WO PCT/KR2002/001129 patent/WO2002102397A1/en active Application Filing
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KR20230029227A (ko) | 2021-08-24 | 2023-03-03 | 김좌진 | 뇌 신경세포 보호용 조성물 |
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KR20020096925A (ko) | 2002-12-31 |
KR100495315B1 (ko) | 2005-06-14 |
US20040185128A1 (en) | 2004-09-23 |
KR20050021026A (ko) | 2005-03-07 |
WO2002102397A1 (en) | 2002-12-27 |
JP2005501018A (ja) | 2005-01-13 |
KR20050008598A (ko) | 2005-01-21 |
JP4128952B2 (ja) | 2008-07-30 |
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