KR100472842B1 - 피롤리딜티오카르바페넴 유도체의 신형결정 - Google Patents

피롤리딜티오카르바페넴 유도체의 신형결정 Download PDF

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Publication number
KR100472842B1
KR100472842B1 KR10-2002-7012979A KR20027012979A KR100472842B1 KR 100472842 B1 KR100472842 B1 KR 100472842B1 KR 20027012979 A KR20027012979 A KR 20027012979A KR 100472842 B1 KR100472842 B1 KR 100472842B1
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South Korea
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crystal
crystals
diffraction
powder
type
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KR10-2002-7012979A
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English (en)
Korean (ko)
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KR20020087446A (ko
Inventor
사이토이즈미
다카히라마사유키
가와키타도시오
요시오카야스유키
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시오노기 앤드 컴파니, 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
KR10-2002-7012979A 2000-03-31 2001-03-30 피롤리딜티오카르바페넴 유도체의 신형결정 Expired - Lifetime KR100472842B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000099868 2000-03-31
JPJP-P-2000-00099868 2000-03-31

Publications (2)

Publication Number Publication Date
KR20020087446A KR20020087446A (ko) 2002-11-22
KR100472842B1 true KR100472842B1 (ko) 2005-03-10

Family

ID=18614158

Family Applications (1)

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KR10-2002-7012979A Expired - Lifetime KR100472842B1 (ko) 2000-03-31 2001-03-30 피롤리딜티오카르바페넴 유도체의 신형결정

Country Status (17)

Country Link
US (5) US20030153191A1 (enExample)
EP (1) EP1270575B1 (enExample)
JP (1) JP3375084B2 (enExample)
KR (1) KR100472842B1 (enExample)
CN (1) CN1192030C (enExample)
AT (1) ATE304014T1 (enExample)
AU (2) AU4469201A (enExample)
BR (1) BRPI0109712B8 (enExample)
CA (1) CA2404703C (enExample)
CY (2) CY1105674T1 (enExample)
DE (1) DE60113243T2 (enExample)
DK (1) DK1270575T3 (enExample)
ES (1) ES2252205T3 (enExample)
MX (1) MXPA02009592A (enExample)
TW (1) TWI293631B (enExample)
WO (1) WO2001072750A1 (enExample)
ZA (1) ZA200207675B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015167148A1 (ko) * 2014-04-28 2015-11-05 제이더블유중외제약 주식회사 도리페넴의 신규한 결정 및 이의 제조방법
KR20160007679A (ko) 2016-01-04 2016-01-20 제일약품주식회사 도리페넴의 신규한 결정형

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI293631B (enExample) * 2000-03-31 2008-02-21 Shionogi & Co
JP5004355B2 (ja) * 2001-05-10 2012-08-22 塩野義製薬株式会社 アセチルチオピロリジン誘導体の製法
JP2005509037A (ja) * 2001-11-16 2005-04-07 ランバクシー ラボラトリーズ リミテッド 結晶イミペネム製造方法
TWI353855B (en) 2005-05-26 2011-12-11 Shionogi & Co Method for preparing an aqueous solution of doripe
JP5671204B2 (ja) * 2006-04-28 2015-02-18 株式会社カネカ カルバペネム抗生物質中間体の改良された晶析方法
WO2008006298A1 (en) * 2006-07-03 2008-01-17 Chengdu Di'ao Jiuhong Pharmaceutical Factory Novel crystal form of doripenem, preparation method and uses thereof
CN101191787B (zh) * 2006-11-21 2011-07-27 上海医药工业研究院 高效液相色谱法测定多利培南含量的方法
WO2009118680A1 (en) 2008-03-24 2009-10-01 Ranbaxy Laboratories Limited Process for the preparation of sterile doripenem
US8822445B2 (en) 2010-06-03 2014-09-02 Xuanzhu Pharma Co., Ltd. Crystalline form of carbapenem derivative or its hydrates and preparation methods and uses thereof
CN102977101A (zh) * 2011-09-07 2013-03-20 中国人民解放军军事医学科学院毒物药物研究所 多尼培南一水合物、其药物组合物、其制备方法和用途
CN102285988B (zh) * 2011-09-08 2012-09-05 上海希迈医药科技有限公司 一种多尼培南水合物晶体及其制备方法
US20150291591A1 (en) * 2011-11-08 2015-10-15 Ranbaxy Laboratories Limited Process for the preparation of polymorphs of doripenem
CN104072497B (zh) * 2013-03-29 2017-10-03 石药集团中奇制药技术（石家庄）有限公司 一种多尼培南新结晶及其制备方法
CN103389347B (zh) * 2013-07-26 2015-12-09 深圳市海滨制药有限公司 高效液相色谱法测定多尼培南的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317016A (en) 1991-08-20 1994-05-31 Shionogi Seiyaku Kabushiki Kaisha Pyrrolidylthiocarbapenem derivative
US5539102A (en) * 1992-02-21 1996-07-23 Shionogi Seiyaku Kabushiki Kaisha Production method for sulfamide
US6111098A (en) * 1994-05-02 2000-08-29 Shionogi & Co., Ltd. Crystal of pyrrolidylthiocarbapenem derivative, lyophilized preparation containing said crystal, and process for producing the same
JP3558684B2 (ja) * 1994-06-28 2004-08-25 塩野義製薬株式会社 ピロリジルチオカルバペネム誘導体の乾燥方法
TWI293631B (enExample) * 2000-03-31 2008-02-21 Shionogi & Co
WO2004072073A1 (ja) * 2003-02-14 2004-08-26 Shionogi & Co., Ltd. カルバペネム合成中間体の結晶
WO2010097686A1 (en) 2009-02-26 2010-09-02 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of carbapenem antibiotic

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015167148A1 (ko) * 2014-04-28 2015-11-05 제이더블유중외제약 주식회사 도리페넴의 신규한 결정 및 이의 제조방법
US9840506B2 (en) 2014-04-28 2017-12-12 Jw Pharmaceutical Corporation Crystal of doripenem, and preparation method therefor
KR101910048B1 (ko) 2014-04-28 2018-10-22 제이더블유중외제약 주식회사 도리페넴의 신규한 결정 및 이의 제조방법
KR20160007679A (ko) 2016-01-04 2016-01-20 제일약품주식회사 도리페넴의 신규한 결정형

Also Published As

Publication number Publication date
CA2404703C (en) 2007-06-05
JP3375084B2 (ja) 2003-02-10
ZA200207675B (en) 2003-09-25
CN1192030C (zh) 2005-03-09
DE60113243D1 (de) 2005-10-13
BR0109712A (pt) 2003-04-29
DK1270575T3 (da) 2006-01-16
WO2001072750A1 (en) 2001-10-04
CY2009001I1 (el) 2009-11-04
TWI293631B (enExample) 2008-02-21
US8247402B2 (en) 2012-08-21
US9221823B2 (en) 2015-12-29
CA2404703A1 (en) 2002-09-26
DE60113243T2 (de) 2006-02-16
ATE304014T1 (de) 2005-09-15
AU4469201A (en) 2001-10-08
US20130059831A1 (en) 2013-03-07
CY1105674T1 (el) 2010-07-28
ES2252205T3 (es) 2006-05-16
MXPA02009592A (es) 2003-03-12
EP1270575B1 (en) 2005-09-07
BRPI0109712B8 (pt) 2021-05-25
KR20020087446A (ko) 2002-11-22
US20080207586A1 (en) 2008-08-28
CY2009001I2 (el) 2009-11-04
EP1270575A1 (en) 2003-01-02
AU2001244692B2 (en) 2004-10-14
US20030153191A1 (en) 2003-08-14
US20150031664A1 (en) 2015-01-29
CN1432016A (zh) 2003-07-23
BRPI0109712B1 (pt) 2017-10-24
US20070060562A1 (en) 2007-03-15
EP1270575A4 (en) 2004-02-18

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