KR100459952B1 - 피페리디닐아미노메틸 트리플루오로메틸 사이클릭 에테르화합물의 제조 방법 - Google Patents

피페리디닐아미노메틸 트리플루오로메틸 사이클릭 에테르화합물의 제조 방법 Download PDF

Info

Publication number
KR100459952B1
KR100459952B1 KR10-2000-0060966A KR20000060966A KR100459952B1 KR 100459952 B1 KR100459952 B1 KR 100459952B1 KR 20000060966 A KR20000060966 A KR 20000060966A KR 100459952 B1 KR100459952 B1 KR 100459952B1
Authority
KR
South Korea
Prior art keywords
formula
acid
compounds
compound
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR10-2000-0060966A
Other languages
English (en)
Korean (ko)
Other versions
KR20010051069A (ko
Inventor
캐론스테판
바즈퀘즈엔리크
Original Assignee
화이자 프로덕츠 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 화이자 프로덕츠 인코포레이티드 filed Critical 화이자 프로덕츠 인코포레이티드
Publication of KR20010051069A publication Critical patent/KR20010051069A/ko
Application granted granted Critical
Publication of KR100459952B1 publication Critical patent/KR100459952B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR10-2000-0060966A 1999-10-18 2000-10-17 피페리디닐아미노메틸 트리플루오로메틸 사이클릭 에테르화합물의 제조 방법 Expired - Fee Related KR100459952B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16022699P 1999-10-18 1999-10-18
US60/160,226 1999-10-18

Publications (2)

Publication Number Publication Date
KR20010051069A KR20010051069A (ko) 2001-06-25
KR100459952B1 true KR100459952B1 (ko) 2004-12-04

Family

ID=22576040

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2000-0060966A Expired - Fee Related KR100459952B1 (ko) 1999-10-18 2000-10-17 피페리디닐아미노메틸 트리플루오로메틸 사이클릭 에테르화합물의 제조 방법

Country Status (24)

Country Link
US (2) US6486325B1 (enExample)
EP (1) EP1095939B1 (enExample)
JP (1) JP3564685B2 (enExample)
KR (1) KR100459952B1 (enExample)
CN (1) CN1293193A (enExample)
AR (1) AR026053A1 (enExample)
AT (1) ATE257477T1 (enExample)
AU (1) AU784275B2 (enExample)
BR (1) BR0004901A (enExample)
CA (1) CA2323315C (enExample)
CZ (1) CZ299029B6 (enExample)
DE (1) DE60007599T2 (enExample)
DK (1) DK1095939T3 (enExample)
ES (1) ES2211455T3 (enExample)
HU (1) HUP0004061A2 (enExample)
ID (1) ID27627A (enExample)
IL (1) IL139012A (enExample)
IN (1) IN190078B (enExample)
PL (1) PL343290A1 (enExample)
PT (1) PT1095939E (enExample)
RU (1) RU2184116C1 (enExample)
TR (1) TR200003002A2 (enExample)
YU (1) YU60600A (enExample)
ZA (1) ZA200005695B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW426667B (en) * 1997-11-19 2001-03-21 Pfizer Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists
EP1457487A4 (en) * 2001-12-21 2005-06-22 Toray Finechemicals Co Ltd PROCESS FOR PREPARING OPTICALLY ACTIVE CIS-PIPERIDINE DERIVATIVES

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025714A1 (en) * 1997-11-19 1999-05-27 Pfizer Pharmaceuticals Inc. Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance p antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
PL169993B1 (pl) * 1991-03-26 1996-09-30 Pfizer Sposób wytwarzania podstawionych piperydyn PL PL PL PL
US5294744A (en) * 1993-04-20 1994-03-15 Pfizer Inc. Formylation process for aromatic aldehydes
US5886011A (en) * 1995-03-27 1999-03-23 Hisamitsu Pharmaceutical Co., Inc. Piperidine derivatives as substance P antagonists
US6180647B1 (en) * 1995-07-07 2001-01-30 Pfizer Inc. Substituted benzolactam compounds as substance P antagonists
TW340842B (en) * 1995-08-24 1998-09-21 Pfizer Substituted benzylaminopiperidine compounds
PT1178984E (pt) * 1999-05-21 2003-06-30 Pfizer Prod Inc Derivados de 1-trifluorometil-4-hidroxi-7-piperidinilamimometilcromano

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025714A1 (en) * 1997-11-19 1999-05-27 Pfizer Pharmaceuticals Inc. Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance p antagonists

Also Published As

Publication number Publication date
US6486325B1 (en) 2002-11-26
CN1293193A (zh) 2001-05-02
AU6547400A (en) 2001-04-26
TR200003002A2 (tr) 2001-05-21
EP1095939A3 (en) 2001-05-23
IN190078B (enExample) 2003-06-07
DE60007599T2 (de) 2004-11-11
DK1095939T3 (da) 2004-04-13
PL343290A1 (en) 2001-04-23
JP3564685B2 (ja) 2004-09-15
EP1095939B1 (en) 2004-01-07
IL139012A0 (en) 2001-11-25
HUP0004061A2 (hu) 2002-05-29
CA2323315A1 (en) 2001-04-18
AR026053A1 (es) 2002-12-26
CZ20003840A3 (cs) 2002-02-13
BR0004901A (pt) 2001-05-29
JP2001151773A (ja) 2001-06-05
DE60007599D1 (de) 2004-02-12
ID27627A (id) 2001-04-19
PT1095939E (pt) 2004-04-30
HU0004061D0 (en) 2000-12-28
IL139012A (en) 2007-06-17
CA2323315C (en) 2008-07-29
ZA200005695B (en) 2002-04-16
CZ299029B6 (cs) 2008-04-09
KR20010051069A (ko) 2001-06-25
ATE257477T1 (de) 2004-01-15
ES2211455T3 (es) 2004-07-16
AU784275B2 (en) 2006-03-02
EP1095939A2 (en) 2001-05-02
US20030236268A1 (en) 2003-12-25
RU2184116C1 (ru) 2002-06-27
YU60600A (sh) 2002-12-10

Similar Documents

Publication Publication Date Title
JP2818820B2 (ja) 抗炎症剤としての３−アリール−２−イソオキサゾリン類
US5563161A (en) Alcohols and ethers with aromatic substituents as tachykinin-antagonists
RS60600B1 (sr) Derivati pirazola kao inhibitori kalikreina plazme
CA2310627C (en) Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance p antagonists
JPH04500215A (ja) Ｎ―フェニルアルキル置換α―アミノカルボキシアミド誘導体およびその製造方法
JPH09503994A (ja) バラノイド
EP0766680A1 (en) Substituted dihydrobenzofuran derivatives as 5-ht 4 agonists
KR870000275B1 (ko) 3-메틸플라본-8-카르복실산 에스테르류의 제조방법
KR100459952B1 (ko) 피페리디닐아미노메틸 트리플루오로메틸 사이클릭 에테르화합물의 제조 방법
HU212268B (en) Process to prepare phenyl-ethanol-amino- and phenyl-ethanol-amino-methyl-tetralin derivs. and pharmaceutical comns. contg. them as activ agent
EP1960387B1 (fr) Derives de isoquinoline et benzo[h]isoquinoline, leur preparation et leur utilisation en therapeutique en tant qu antagonistes du recepteur de l histamine h3
EP0718307A2 (fr) Dérivés de 1-oxo-2-(phénylsulfonyl-amino)pentylpipéridine, leur préparation et leur application en thérapeutique
JP2010508334A (ja) アミノベンゾシクロヘプテン誘導体、その調製方法及び治療におけるその使用
JP3208142B2 (ja) キラルなエチル（５−アミノ−１，２−ジヒドロ−２−メチル−３−フェニルピリド〔３，４−ｂ〕ピラジン−７−イル）カーバメートの調製方法
AU619943B2 (en) Substituted-(3,4-dihydroxyphenyl) pyrrolidine compounds
JPS59101458A (ja) 新規なチアプロスタグランジン誘導体及びその製法
JPS63216890A (ja) チユアンシンマイシン類縁体の製造方法
MXPA00010173A (en) Process for the preparation of piperidinylaminomethyl trifluoromethyl cyclic ether compounds
WO2014040164A1 (en) Processes for the preparation of 3-alkyl indoles
JPH05279336A (ja) フェノキシ酢酸誘導体
JPH08208595A (ja) スルホンアミド化合物、その製造法および剤
JPS63192776A (ja) ３−メチレンスピロ〔ベンゾフランピペリジン〕
JP2500279C (enExample)
HU188171B (en) Process for producing new 3-square bracket-2-bracket-4-piperidyl-bracket closed-1-alkyl-ethyl-squre bracket closed-indole derivatives
JPH03173868A (ja) ピペリジンアクリル酸誘導体

Legal Events

Date Code Title Description
A201 Request for examination
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20071005

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20081126

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20081126