YU60600A - Postupak za dobijanje piperidinilaminoetil trifluorometil cikličnih etar jedinjenja - Google Patents
Postupak za dobijanje piperidinilaminoetil trifluorometil cikličnih etar jedinjenjaInfo
- Publication number
- YU60600A YU60600A YU60600A YUP60600A YU60600A YU 60600 A YU60600 A YU 60600A YU 60600 A YU60600 A YU 60600A YU P60600 A YUP60600 A YU P60600A YU 60600 A YU60600 A YU 60600A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- piperidinylaminoethyl
- trifluoro
- preparation
- cyclic ether
- ether compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Ovaj pronalazak se odnosi na novi postpak za dobijanje diastereomerne smeše piperidinila-minoetil trifluorometil cikličnih etar jedinjenja formula la i Ib: i njihovih farmaceutski prihvatljivih soli, gde R1 je C1-C6 alkil; R2 je C1-C6 alkil, halo C1-C6 alkil ili fenil ili supstituisani fenil; R3 je vodonik ili halo; m je 0, 1 ili 2, i gde je pomenuta smeša visoko obogaćena u jedinjenju formule la, i na novi postupak za dobijanje i prečišćavanje intermedijera jedinjenja korisnih u dobijanju jedinjenja formula Ia i Ib.[This invention refers to the new procedure for the obtaining of diastereomeric mixture of piperidinylaminoethyl trifluoromethyl cyclic eter of the formulas Ia and Ib: Ia, Ib and their pharmaceutically acceptable salts, where R1 is C1-C6-alkyl; R2 is C1-C6-alkyl or phenil; R3 is hydrogen or halo; m is 0, 1 or 2 and the mentioned mixture is highly anriched in the compounds of the formula Ia, and in a new procedure for the obtaining and purification of intermediares compounds useful in the obtaining of compounds of the formula Ia and Ib.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16022699P | 1999-10-18 | 1999-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU60600A true YU60600A (sh) | 2002-12-10 |
Family
ID=22576040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU60600A YU60600A (sh) | 1999-10-18 | 2000-10-05 | Postupak za dobijanje piperidinilaminoetil trifluorometil cikličnih etar jedinjenja |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6486325B1 (sh) |
| EP (1) | EP1095939B1 (sh) |
| JP (1) | JP3564685B2 (sh) |
| KR (1) | KR100459952B1 (sh) |
| CN (1) | CN1293193A (sh) |
| AR (1) | AR026053A1 (sh) |
| AT (1) | ATE257477T1 (sh) |
| AU (1) | AU784275B2 (sh) |
| BR (1) | BR0004901A (sh) |
| CA (1) | CA2323315C (sh) |
| CZ (1) | CZ299029B6 (sh) |
| DE (1) | DE60007599T2 (sh) |
| DK (1) | DK1095939T3 (sh) |
| ES (1) | ES2211455T3 (sh) |
| HU (1) | HUP0004061A2 (sh) |
| ID (1) | ID27627A (sh) |
| IL (1) | IL139012A (sh) |
| IN (1) | IN190078B (sh) |
| PL (1) | PL343290A1 (sh) |
| PT (1) | PT1095939E (sh) |
| RU (1) | RU2184116C1 (sh) |
| TR (1) | TR200003002A2 (sh) |
| YU (1) | YU60600A (sh) |
| ZA (1) | ZA200005695B (sh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW426667B (en) * | 1997-11-19 | 2001-03-21 | Pfizer | Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists |
| EP1457487A4 (en) * | 2001-12-21 | 2005-06-22 | Toray Finechemicals Co Ltd | PROCESS FOR PREPARING OPTICALLY ACTIVE CIS-PIPERIDINE DERIVATIVES |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ293955B6 (cs) * | 1991-03-26 | 2004-08-18 | Pfizeráinc | Postup přípravy substituovaných piperidinů |
| US5294744A (en) * | 1993-04-20 | 1994-03-15 | Pfizer Inc. | Formylation process for aromatic aldehydes |
| WO1997003066A1 (en) * | 1995-07-07 | 1997-01-30 | Pfizer Pharmaceuticals Inc. | Substituted benzolactam compounds as substance p antagonists |
| TW426667B (en) * | 1997-11-19 | 2001-03-21 | Pfizer | Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists |
| DK1178984T3 (da) * | 1999-05-21 | 2003-06-10 | Pfizer Prod Inc | 1-trifluormethyl-4-hydroxy-7-piperidinylaminomethylchroman-derivater |
-
2000
- 2000-10-02 ES ES00308640T patent/ES2211455T3/es not_active Expired - Lifetime
- 2000-10-02 PT PT00308640T patent/PT1095939E/pt unknown
- 2000-10-02 AT AT00308640T patent/ATE257477T1/de not_active IP Right Cessation
- 2000-10-02 DK DK00308640T patent/DK1095939T3/da active
- 2000-10-02 DE DE60007599T patent/DE60007599T2/de not_active Expired - Fee Related
- 2000-10-02 EP EP00308640A patent/EP1095939B1/en not_active Expired - Lifetime
- 2000-10-05 JP JP2000305667A patent/JP3564685B2/ja not_active Expired - Fee Related
- 2000-10-05 YU YU60600A patent/YU60600A/sh unknown
- 2000-10-12 IL IL139012A patent/IL139012A/en not_active IP Right Cessation
- 2000-10-12 AU AU65474/00A patent/AU784275B2/en not_active Ceased
- 2000-10-13 AR ARP000105423A patent/AR026053A1/es unknown
- 2000-10-13 IN IN924MU2000 patent/IN190078B/en unknown
- 2000-10-16 CA CA002323315A patent/CA2323315C/en not_active Expired - Fee Related
- 2000-10-16 ZA ZA200005695A patent/ZA200005695B/xx unknown
- 2000-10-16 TR TR2000/03002A patent/TR200003002A2/xx unknown
- 2000-10-16 ID IDP20000892D patent/ID27627A/id unknown
- 2000-10-17 US US09/690,346 patent/US6486325B1/en not_active Expired - Fee Related
- 2000-10-17 CN CN00125993A patent/CN1293193A/zh active Pending
- 2000-10-17 HU HU0004061A patent/HUP0004061A2/hu unknown
- 2000-10-17 CZ CZ20003840A patent/CZ299029B6/cs not_active IP Right Cessation
- 2000-10-17 KR KR10-2000-0060966A patent/KR100459952B1/ko not_active IP Right Cessation
- 2000-10-17 RU RU2000126151/04A patent/RU2184116C1/ru not_active IP Right Cessation
- 2000-10-18 PL PL00343290A patent/PL343290A1/xx not_active Application Discontinuation
- 2000-10-18 BR BR0004901-8A patent/BR0004901A/pt not_active Application Discontinuation
-
2002
- 2002-11-13 US US10/065,725 patent/US20030236268A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0004061A2 (hu) | 2002-05-29 |
| ATE257477T1 (de) | 2004-01-15 |
| BR0004901A (pt) | 2001-05-29 |
| KR100459952B1 (ko) | 2004-12-04 |
| PT1095939E (pt) | 2004-04-30 |
| ES2211455T3 (es) | 2004-07-16 |
| AU784275B2 (en) | 2006-03-02 |
| AR026053A1 (es) | 2002-12-26 |
| IL139012A0 (en) | 2001-11-25 |
| CA2323315A1 (en) | 2001-04-18 |
| AU6547400A (en) | 2001-04-26 |
| KR20010051069A (ko) | 2001-06-25 |
| US6486325B1 (en) | 2002-11-26 |
| DK1095939T3 (da) | 2004-04-13 |
| HU0004061D0 (en) | 2000-12-28 |
| CZ299029B6 (cs) | 2008-04-09 |
| TR200003002A2 (tr) | 2001-05-21 |
| EP1095939A2 (en) | 2001-05-02 |
| US20030236268A1 (en) | 2003-12-25 |
| EP1095939A3 (en) | 2001-05-23 |
| ID27627A (id) | 2001-04-19 |
| JP2001151773A (ja) | 2001-06-05 |
| DE60007599T2 (de) | 2004-11-11 |
| CA2323315C (en) | 2008-07-29 |
| IL139012A (en) | 2007-06-17 |
| JP3564685B2 (ja) | 2004-09-15 |
| IN190078B (sh) | 2003-06-07 |
| RU2184116C1 (ru) | 2002-06-27 |
| EP1095939B1 (en) | 2004-01-07 |
| CN1293193A (zh) | 2001-05-02 |
| CZ20003840A3 (cs) | 2002-02-13 |
| PL343290A1 (en) | 2001-04-23 |
| ZA200005695B (en) | 2002-04-16 |
| DE60007599D1 (de) | 2004-02-12 |
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