KR100286624B1 - 치환된 피리미딘 및 이의 제조방법 - Google Patents

치환된 피리미딘 및 이의 제조방법 Download PDF

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Publication number
KR100286624B1
KR100286624B1 KR1019920019580A KR920019580A KR100286624B1 KR 100286624 B1 KR100286624 B1 KR 100286624B1 KR 1019920019580 A KR1019920019580 A KR 1019920019580A KR 920019580 A KR920019580 A KR 920019580A KR 100286624 B1 KR100286624 B1 KR 100286624B1
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KR
South Korea
Prior art keywords
compound
formula
carbon atoms
methyl
pyrimidin
Prior art date
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Expired - Fee Related
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KR1019920019580A
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English (en)
Korean (ko)
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KR930007949A (ko
Inventor
왓슨 엘링보이 존
니케이도 마들렌
프램로즈 바글리 지한
Original Assignee
이곤 이 버그
아메리칸 홈 푸로닥츠 코포레이션
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Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Priority claimed from GB9207560A external-priority patent/GB2265899A/en
Priority claimed from US07/901,485 external-priority patent/US5256654A/en
Application filed by 이곤 이 버그, 아메리칸 홈 푸로닥츠 코포레이션 filed Critical 이곤 이 버그
Publication of KR930007949A publication Critical patent/KR930007949A/ko
Application granted granted Critical
Publication of KR100286624B1 publication Critical patent/KR100286624B1/ko
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019920019580A 1991-10-24 1992-10-23 치환된 피리미딘 및 이의 제조방법 Expired - Fee Related KR100286624B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US7/782,025 1991-10-24
US07/782,025 1991-10-24
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560A GB2265899A (en) 1992-04-07 1992-04-07 Substituted pyrimidines
GB9207560.5 1992-04-07
US07/901,485 1992-06-25
US7/901,485 1992-06-25
US07/901,485 US5256654A (en) 1991-10-24 1992-06-25 Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists

Publications (2)

Publication Number Publication Date
KR930007949A KR930007949A (ko) 1993-05-20
KR100286624B1 true KR100286624B1 (ko) 2001-05-02

Family

ID=27266132

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920019580A Expired - Fee Related KR100286624B1 (ko) 1991-10-24 1992-10-23 치환된 피리미딘 및 이의 제조방법

Country Status (21)

Country Link
EP (1) EP0539086B1 (https=)
JP (1) JP3240192B2 (https=)
KR (1) KR100286624B1 (https=)
CN (2) CN1039324C (https=)
AT (1) ATE161537T1 (https=)
AU (1) AU653635B2 (https=)
CA (1) CA2080705C (https=)
DE (1) DE69223734T2 (https=)
DK (1) DK0539086T3 (https=)
ES (1) ES2111617T3 (https=)
FI (1) FI103971B (https=)
GR (1) GR3025926T3 (https=)
HK (1) HK1003031A1 (https=)
HU (2) HU218786B (https=)
IL (1) IL103436A (https=)
LV (1) LV12047B (https=)
NO (1) NO301275B1 (https=)
SG (1) SG47626A1 (https=)
SK (1) SK322192A3 (https=)
TW (1) TW226375B (https=)
UA (1) UA27748C2 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69233734D1 (de) * 1991-11-18 2008-06-26 Du Pont 2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)phenylborsäure als Zwischenprodukt zur Synthese von A II Receptorenantagonisten
SG47714A1 (en) * 1993-03-24 1998-04-17 American Home Prod Substituted pyridopyrimidines as antihypertensives
US5965738A (en) * 1994-09-20 1999-10-12 Wakunaga Seiyaku Kabushiki Kaisha Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
NZ549535A (en) 2004-03-17 2010-11-26 Novartis Ag Use of aliskiren for treating renal and other disorders
AU2005294318A1 (en) 2004-10-08 2006-04-20 Novartis Ag Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure
EP1749828A1 (en) 2005-08-04 2007-02-07 Farmaprojects S.L. Process for preparing an angiotensin II receptor antagonist
AU2008220785B2 (en) 2007-03-01 2013-02-21 Vivoryon Therapeutics N.V. New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
PT2160190E (pt) * 2007-06-07 2016-01-27 Sigma Tau Ind Farmaceuti Derivados de 5beta, 14 beta-androstano úteis para o tratamento de doenças causadas por fibroses de órgão
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
AP2014007766A0 (en) 2011-12-15 2014-07-31 Takeda Pharmaceuticals Usa Inc Combination os azilsartan and chlorthlidone for treating hypertension black patients
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
CA2075627A1 (en) * 1990-02-13 1991-08-14 William J. Greenlee Angiotensin ii antagonists incorporating a substituted benzyl element
IL100917A0 (en) 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
EP0539086A2 (en) 1993-04-28
CN1072682A (zh) 1993-06-02
TW226375B (https=) 1994-07-11
UA27748C2 (uk) 2000-10-16
HU218786B (hu) 2000-12-28
DE69223734D1 (de) 1998-02-05
CA2080705C (en) 2002-12-03
HU211915A9 (en) 1996-01-29
ATE161537T1 (de) 1998-01-15
HUT62893A (en) 1993-06-28
JP3240192B2 (ja) 2001-12-17
IL103436A (en) 1996-03-31
SK280292B6 (sk) 1999-11-08
NO924121D0 (no) 1992-10-23
JPH05222039A (ja) 1993-08-31
HK1003031A1 (en) 1998-09-30
CA2080705A1 (en) 1993-04-25
FI103971B1 (fi) 1999-10-29
EP0539086B1 (en) 1997-12-29
SG47626A1 (en) 1998-04-17
DE69223734T2 (de) 1998-04-16
AU2607992A (en) 1993-04-29
EP0539086A3 (en) 1993-06-16
KR930007949A (ko) 1993-05-20
GR3025926T3 (en) 1998-04-30
CN1175414A (zh) 1998-03-11
NO301275B1 (no) 1997-10-06
LV12047B (en) 1998-08-20
SK322192A3 (en) 1999-11-08
FI924397L (fi) 1993-04-25
FI103971B (fi) 1999-10-29
NO924121L (no) 1993-04-26
HU9203161D0 (en) 1992-12-28
CN1039324C (zh) 1998-07-29
AU653635B2 (en) 1994-10-06
LV12047A (lv) 1998-05-20
IL103436A0 (en) 1993-03-15
DK0539086T3 (da) 1998-02-02
FI924397A0 (fi) 1992-09-30
ES2111617T3 (es) 1998-03-16

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