KR100275843B1 - 설폰산 유도체 및 이를 포함하는 약제학적 조성물 - Google Patents

설폰산 유도체 및 이를 포함하는 약제학적 조성물 Download PDF

Info

Publication number
KR100275843B1
KR100275843B1 KR1019940702899A KR19940702899A KR100275843B1 KR 100275843 B1 KR100275843 B1 KR 100275843B1 KR 1019940702899 A KR1019940702899 A KR 1019940702899A KR 19940702899 A KR19940702899 A KR 19940702899A KR 100275843 B1 KR100275843 B1 KR 100275843B1
Authority
KR
South Korea
Prior art keywords
amino
compound
bis
ethenediyl
thioxomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019940702899A
Other languages
English (en)
Korean (ko)
Other versions
KR950700245A (ko
Inventor
디. 카딘 앨런
피. 피트 노턴
엘. 렌츠 넬슨
Original Assignee
슈테펜엘.네스비트
메렐 다우 파마슈티칼스 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 슈테펜엘.네스비트, 메렐 다우 파마슈티칼스 인크. filed Critical 슈테펜엘.네스비트
Publication of KR950700245A publication Critical patent/KR950700245A/ko
Application granted granted Critical
Publication of KR100275843B1 publication Critical patent/KR100275843B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/41—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
    • C07C309/42—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/42—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/02—Monothiocarbonic acids; Derivatives thereof
    • C07C329/04—Esters of monothiocarbonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/12—Dithiocarbonic acids; Derivatives thereof
    • C07C329/14—Esters of dithiocarbonic acids
    • C07C329/20—Esters of dithiocarbonic acids having sulfur atoms of dithiocarbonic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/08—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14—Dithiocarbamic acids; Derivatives thereof
    • C07C333/18—Esters of dithiocarbamic acids
    • C07C333/24—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1019940702899A 1992-02-20 1993-01-22 설폰산 유도체 및 이를 포함하는 약제학적 조성물 Expired - Fee Related KR100275843B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83863992A 1992-02-20 1992-02-20
US07/838,639 1992-02-20
US07/838639 1992-02-20
PCT/US1993/000564 WO1993016992A1 (en) 1992-02-20 1993-01-22 Sulfonic acid derivatives in the treatment of viral diseases

Publications (2)

Publication Number Publication Date
KR950700245A KR950700245A (ko) 1995-01-16
KR100275843B1 true KR100275843B1 (ko) 2000-12-15

Family

ID=25277670

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940702899A Expired - Fee Related KR100275843B1 (ko) 1992-02-20 1993-01-22 설폰산 유도체 및 이를 포함하는 약제학적 조성물

Country Status (15)

Country Link
US (1) US5359131A (enExample)
EP (1) EP0626945B1 (enExample)
JP (1) JP3309104B2 (enExample)
KR (1) KR100275843B1 (enExample)
AT (1) ATE165345T1 (enExample)
AU (1) AU663925B2 (enExample)
CA (1) CA2130360C (enExample)
DE (1) DE69318136T2 (enExample)
ES (1) ES2115756T3 (enExample)
IL (1) IL104780A (enExample)
MX (1) MX9300836A (enExample)
NZ (1) NZ249032A (enExample)
TW (1) TW224968B (enExample)
WO (1) WO1993016992A1 (enExample)
ZA (1) ZA931035B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670144A (en) * 1990-07-09 1997-09-23 Merrell Pharmaceuticals Inc. Anti-herpes virus and cytomegalovirus polyester oligomers
US5276182A (en) * 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
US5424063A (en) * 1992-01-09 1995-06-13 The Dow Chemical Company Narrow poly- and mono-dispersed anionic oligomers, and their uses, formulations and process
IL112174A (en) * 1994-01-03 1999-05-09 Merrell Dow Pharma Oligomers of polythioureas pharmaceutical compositions containing them and a process for their preparation
US5681832A (en) * 1995-02-17 1997-10-28 The United States Of America As Represented By The Department Of Health And Human Services Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity
EP0809492A4 (en) 1995-02-17 2007-01-24 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
CA2240131A1 (en) * 1995-12-15 1997-06-26 Cryopreservation Technologies Cc Composition for organ cryopreservation and treatment of viral and bacterial infections
CN1163401A (zh) * 1996-02-13 1997-10-29 李占元 全自动血球计数仪试剂及配制方法
US5852015A (en) * 1997-01-27 1998-12-22 American Cyanamid Company Triazine containing anionic compounds useful as antiviral agents
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
IL127666A0 (en) * 1996-06-27 1999-10-28 Smithkline Beecham Corp IL-8 receptor antagonists
BR9709938A (pt) 1996-06-27 1999-08-10 Smithkline Beecham Corp Antagonistas dos receptores de il-8
ZA984649B (en) * 1997-06-13 1999-12-17 Cryopreservation Tech Cc "Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes".
GB9928418D0 (en) * 1999-12-01 2000-01-26 Novartis Ag Organic compounds
US6806366B2 (en) 2001-02-02 2004-10-19 Wyeth Preparation and purification of antiviral disulfonic acid disodium salt
JP2007523073A (ja) * 2004-02-04 2007-08-16 アクテイブ・バイオテツク・アクテイエボラーグ ジウレア誘導体
EP2043657A4 (en) * 2006-06-27 2014-07-16 Hadasit Med Res Service USE OF STILBENE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF AQUATIC MOLD INFECTIONS
CA2671900A1 (en) * 2006-12-22 2008-07-03 The Regents Of The University Of California Macromolecular conjugates of cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof
WO2010148177A2 (en) * 2009-06-17 2010-12-23 The Board Of Trustees Of The Leland Stanford Junior University Compounds, compositions, methods of synthesis, and methods of treatment
TW201702218A (zh) * 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
JP7611824B2 (ja) * 2018-11-22 2025-01-10 ナント ユニベルシテ 増殖性疾患の処置で使用するためのジスルホナートスチルベン

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD39717A (enExample) *
US2676982A (en) * 1951-06-08 1954-04-27 Gen Aniline & Film Corp Fluorescent agents
BE660945A (enExample) * 1964-03-12 1965-07-01
US4107202A (en) * 1977-03-28 1978-08-15 American Cyanamid Company Substituted 4,4'-biphenylylene bis(2-thioureylene)di-naphthalenetrisulfonic acids and salts thereof
FR2429782A1 (fr) 1978-06-27 1980-01-25 American Cyanamid Co Acides naphtalene-trisulfoniques substitues et leurs sels, leur preparation et leurs utilisations therapeutiques
US4328244A (en) * 1980-05-21 1982-05-04 The Dow Chemical Company Novel (((substituted-phenyl)methyl)amino)benzenesulfonic acids and pharmaceutically-acceptable salts thereof
US4349568A (en) * 1980-06-12 1982-09-14 The Dow Chemical Company Sulfur-substituted diphenyl ethers having antiviral activity
US4435394A (en) * 1981-12-17 1984-03-06 Shionogi & Co., Ltd. 3-Sulfonamido-benzophenonimine derivatives useful for treating virus infections
DE3528992A1 (de) * 1985-08-13 1987-02-26 Barthell Eduard Sulfonamidderivate, verfahren zu ihrer herstellung und verwendung
DE3600046A1 (de) * 1985-08-13 1987-07-09 Barthell Eduard Sulfonamidderivate, verfahren zu ihrer herstellung und verwendung
DE3530718A1 (de) * 1985-08-28 1987-03-12 Madaus & Co Dr Methylendioxyphenanthren- und -stilbenderivate, verfahren zur herstellung derselben und arzneimittel, die diese enthalten
EP0221021B1 (en) * 1985-10-16 1989-11-08 Ciba-Geigy Ag Bechamp reduction of dns to das using h2so4 and trace of hoac
DE3626309A1 (de) * 1986-08-02 1988-02-18 Stockhausen Chem Fab Gmbh Antivirusmittel
US5276182A (en) * 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
DK0498095T3 (da) * 1991-02-05 1995-06-19 Merrell Dow Pharma Sulfoniske stilbenderivater til behandling af virussygdomme

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, vol.51, 113191j & Yuki Gosei Kakaku Kyokai Shi, 1970, 28, 1025-1031 *
Chemical Abstracts, vol.84, 32589v & Depposited Publ. 1972, 4341-4372 *

Also Published As

Publication number Publication date
JP3309104B2 (ja) 2002-07-29
US5359131A (en) 1994-10-25
JPH07504190A (ja) 1995-05-11
MX9300836A (es) 1993-09-01
CA2130360C (en) 1998-06-09
IL104780A (en) 1998-10-30
EP0626945A1 (en) 1994-12-07
AU663925B2 (en) 1995-10-26
WO1993016992A1 (en) 1993-09-02
ZA931035B (en) 1993-09-17
TW224968B (enExample) 1994-06-11
IL104780A0 (en) 1993-06-10
EP0626945B1 (en) 1998-04-22
KR950700245A (ko) 1995-01-16
ATE165345T1 (de) 1998-05-15
DE69318136D1 (de) 1998-05-28
DE69318136T2 (de) 1998-10-22
ES2115756T3 (es) 1998-07-01
NZ249032A (en) 1996-09-25
AU3481893A (en) 1993-09-13
CA2130360A1 (en) 1993-08-21

Similar Documents

Publication Publication Date Title
KR100275843B1 (ko) 설폰산 유도체 및 이를 포함하는 약제학적 조성물
US6500802B1 (en) Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors
JPH069545A (ja) ｏ−置換ベンゾイルグアニジン、その製造方法、医薬または診断剤としてのその使用およびそれを含有する医薬
HU208832B (en) Process for producing purinylphosphonic acid derivatives and pharmaceutical compositions comprising same as active ingredient
IL202633A (en) History of sulfonamides and the pharmaceutical preparations that feed them
PL184570B1 (pl) Nowe sulfonoimidoamidy sposób ich wytwarzania środek farmaceutyczny oraz zastosowanie sulfonoimidoamidów do wytwarzania leku
US5216026A (en) Antitumor compositions and methods of treatment
FR2623806A1 (fr) Esters d&#39;acides 3,6-dihydro-1,5(2h)-pyrimidinecarboxyliques a action therapeutique
JPH0333127B2 (enExample)
CA1331464C (en) Anti-tumor method and compounds
JPH11500130A (ja) 抗ウイルス性トリアザ化合物
CA2084469A1 (en) Antitumor compositions and methods of treatment
AU765950B2 (en) Novel immunosuppressants
JPH054951A (ja) １，４−ジヒドロナフトキノン誘導体およびその製造方法
US3510496A (en) Benzenesulfonyl-ureas with hypoglycemic activity
US3202680A (en) New benzenesulfonyl ureas and process for their manufacture
US6086864A (en) Pharmaceutical formulations comprising polythiourea and methods of use thereof
IL42558A (en) History of N - Transformed - &#39;N -} 4 -] 2 -) 2 - Aminobenzamido (ethyl [benzene {and N] 2 - Aminobenzamido (India] Sulfonylurea and process for their preparation
FR2865474A1 (fr) Nouveaux derives de benzothiazines fluorees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US3562256A (en) 1,3-dialkyl-5-(substituted arylsulfonyl)-tetrahydro-1,3,5-triazine-4-thiones
UA56205C2 (uk) Похідні нітрометилтіобензолу як інгібітори альдегідредуктази, спосіб їх отримання (варіанти) та фармацевтична композиція
NL7904975A (nl) Sulfonylurea, hun bereiding en geneesmiddelen met deze sulfonylurea als actieve stoffen.
FR2814953A1 (fr) Activateurs des recepteurs d&#39;insuline et compositions les contenant, pour le traitement de maladies induites par des inhibiteurs de proteases du vih
FR2521555A1 (fr) Nouveaux n-((alkylamino) carbonyl) n-(((alkylamino)carbonyl)oxy)-acylamides utiles notamment comme medicaments antineoplasiques

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 11

FPAY Annual fee payment

Payment date: 20110811

Year of fee payment: 12

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 12

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20120926

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20120926