KR950700245A - 바이러스성 질환의 치료에 있어서의 설폰산 유도체(Sulfonic acid derivatives in the treatment of viral diseases) - Google Patents

바이러스성 질환의 치료에 있어서의 설폰산 유도체(Sulfonic acid derivatives in the treatment of viral diseases)

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KR950700245A
KR950700245A KR1019940702899A KR19940702899A KR950700245A KR 950700245 A KR950700245 A KR 950700245A KR 1019940702899 A KR1019940702899 A KR 1019940702899A KR 19940702899 A KR19940702899 A KR 19940702899A KR 950700245 A KR950700245 A KR 950700245A
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amino
compound
thioxomethyl
benzenesulfonic acid
bis
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디. 카딘 앨런
피. 피트 노턴
엘. 렌츠 낼슨
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개리 디. 스트리트
메렐 다우 파마슈티컬즈 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/41—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
    • C07C309/42—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/42—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/02—Monothiocarbonic acids; Derivatives thereof
    • C07C329/04—Esters of monothiocarbonic acids
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/12—Dithiocarbonic acids; Derivatives thereof
    • C07C329/14—Esters of dithiocarbonic acids
    • C07C329/20—Esters of dithiocarbonic acids having sulfur atoms of dithiocarbonic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/08—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of six-membered aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14—Dithiocarbamic acids; Derivatives thereof
    • C07C333/18—Esters of dithiocarbamic acids
    • C07C333/24—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups

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  • Animal Behavior & Ethology (AREA)
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Abstract

하기 일반식(Ⅰ)의 설폰산 스틸벤은 HSV, HIV 및 CMV에 의한 세포의 감염을 차단하며, 이들 화합물은 바이러스성 감염을 예방하는데 사용될 수 있다.
상기식에서, B는 -CH=CH-(시스 또는 트랜스), CH2CH, 또는 결합이고, X는 NH 또는 산소이며, Y는 산소 또는 황이고, Z는 NH,CH2, 산소 또는 황이며, R1은 소수, C1-C4알킬, -CH2-Ar 또는 -Ar(여기서, Ar은 C1-C4알킬 또는 SO3M3그룹에 의해 임의로 치환된 페닐 또는 나프틸 그룹이다)이고, M1, M2및 M3은 각각 독립적으로 수소 또는 약제학적으로 허용되는 양이온이다.

Description

바이러스성 질환의 치료에 있어서의 설폰산 유도체(Sulfonic acid derivatives in the treatment of viral diseases)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (28)

  1. 다음 일반식(1)의 화합물.
    상기식에서, B는 -CH=CH-(시스 또는 트랜스), CH2CH2또는 결합이고, X는 NH 또는 산소이며, Y는 산소 또는 황이고, Z는 NH, CH2, 산소 또는 황이며, R1은 수소, C1-C4알킬, -CH2-Ar 또는 -Ar(여기서, Ar은 C1-C4알킬 또는 S03M|3그룹에 의해 임의로 치환된 페닐 또는 나프틸 그룹이다)이고, M1, M2및 M3은 각각 독립적으로 수소 또는 약제학적으로 허용되는 양이온이다.
  2. 제1항에 있어서, B가 -C=C-그룹인 화합물.
  3. 제1항에 있어서, X와 Z가 각각 독립적으로 NH이고, Y가 황인 화합물.
  4. 제1항에 있어서, R1이 각각 m-페닐설포네이트 또는 p-페닐설포네이트인 화합물.
  5. 제1항에 있어서, M1과 M2가 각각 독립적으로 수소 또는 나트륨 양이온인 화합물.
  6. 제1항에 있어서, 2,2'-(1,2-에텐디일)비닐[5-[[(4-설포페닐)아미노]티옥소메틸]아미노]벤젠설폰산, 사나트륨염인 화합물.
  7. 제1항에 있어서, 2,2'-(1,2-에텐디일)비닐[6-[[(4-설포페닐)아미노]티옥소메틸]아미노]벤젠설폰산, 사나트륨염인 화합물.
  8. 제1항에 있어서, 2,2'-(1,2-에텐디일)비닐[5-[[(3-설포페닐)아미노]티옥소메틸]아미노]벤젠설폰산, 사나트륨염인 화합물.
  9. 제1항에 있어서, 2,2'-(1,2-에텐디일)비닐[5-[[(4-설포페닐)아미노]티옥소메틸]아미노]벤젠설폰산, 사나트륨염인 화합물.
  10. 제1항에 있어서, 2,2'-(1,2-에텐디일)비스[5-(메틸카보닐)아미노]아미노]벤젠설폰산, 이나트륨염인 화합물.
  11. 제1항에 있어서, 2,2'-(1,2-에탄디일)비스[5-[[(4-메틸페닐)아미노]티옥소메틸]아미노]벤젠설폰산, 이나트륨염인 화합물.
  12. 제1항에 있어서, 2,2'-(1,2-에텐디일)비스[5-[[(4-메틸페닐)아미노]티옥소메틸]아미노]티옥소메틸]아미노]벤젠설폰산, 이나트륨염인 화합물.
  13. 바이러스성 감염의 치료를 요하는 환자에 있어서, 바이러스성 감염 치료용 약제로서의 제1항 내지 제12항 중의 어느 한 항에 따르는 화합물의 용도.
  14. 제1항 내지 제12항 중의 어느 한 항에 따르는 화합물의 약제로서의 용도.
  15. 제1항 내지 제12항 중의 어느 한 항에 따르는 화합물을 불활성 담체와의 혼합물로 포함하는 조성물.
  16. 제15항에 있어서, 불활성 담체가 약제학적 담체인 조성물.
  17. 잠재적인 숙주 세포의 표면을 다음 일반식(1)의 화합물과 접촉시킴을 포함하여, 잠재적인 숙주 세포에서의 HIV,HSV 및 CMV중에서 선택되는 바이러스에 의한 감염을 예방하는 방법.
    상기식에서, B는 -CH=CH-(시스 또는 트랜스), CH2CH2또는 결합이고, X는 NH 또는 산소이며, Y는 산소 또는 황이고, Z는 NB, CH2, 산소 또는 황이며, R1은 수소, C1-C4알킬, -CH2-Ar 또는 -Ar(여기서, Ar은 C1-C4알킬 또는 S03M|3그룹에 의해 임의로 치환된 페닐 또는 나프틸 그룹이다)이고, M1,M2및 M3은 각각 독립적으로 수소 또는 약제학적으로 허용되는 양이온이다.
  18. 제17항에 있어서, B가 -C=C-그룹인 방법.
  19. 제17항에 있어서, X와 Z가 각각 독립적으로 NH이고, Y가 황인 방법.
  20. 제17항에 있어서, R1이 각각 m-페닐설포네이트 또는 p-페닐설포네이트인 방법.
  21. 제17항에 있어서, M1과 M2가 각각 독립적으로 수소 또는 나트륨 양이온인 방법.
  22. 제17항에 있어서, 화합물이 2,2'-(1,2-에텐디일)비스[5-[[(4-설포페닐)아미노]티옥소메틸]아미노]벤젠설폰산, 사나트륨염인 화합물.
  23. 제17항에 있어서, 화합물이 2,2'-(1,2-에텐디일)비닐[6-[[(4-설포페닐)아미노]티옥소메틸]아미노]벤젠설폰산, 사나트륨염인 화합물.
  24. 제17항에 있어서, 화합물이 2,2'-(1,2-에텐디일)비스[5-[[(3-설포페닐)아미노]티옥소메틸]아미노]벤젠설폰산, 사나트륨염인 화합물.
  25. 제17항에 있어서, 화합물이 2,2'-(1,2-에탄디일)비스[5-[[(4-설포페닐)아미노]티옥소메틸]-아미노]벤젠설폰산, 사나트륨염인 화합물.
  26. 제17항에 있어서, 화합물이 2,2'-(1,2-에텐디일)비스[5-(메틸카보닐)아미노]벤젠설폰산, 이나트륨염인 화합물.
  27. 제17항에 있어서, 화합물이 2,2'-(1,2-에탄디일)비스[5-[[(4-메틸페닐)아미노]티옥소메틸]아미노]벤젠설폰산, 이나트륨염인 화합물.
  28. 제17항에 있어서, 화합물이 2,2'-(1,2-에텐디일)비스[5-[[(4-메틸페닐)아미노]티옥소메틸]아미노]벤젠설폰산, 이나트륨염인 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940702899A 1992-02-20 1993-01-22 설폰산 유도체 및 이를 포함하는 약제학적 조성물 KR100275843B1 (ko)

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PCT/US1993/000564 WO1993016992A1 (en) 1992-02-20 1993-01-22 Sulfonic acid derivatives in the treatment of viral diseases

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EP0626945A1 (en) 1994-12-07
KR100275843B1 (ko) 2000-12-15
IL104780A0 (en) 1993-06-10
AU3481893A (en) 1993-09-13
AU663925B2 (en) 1995-10-26
ATE165345T1 (de) 1998-05-15
DE69318136D1 (de) 1998-05-28
DE69318136T2 (de) 1998-10-22
EP0626945B1 (en) 1998-04-22
US5359131A (en) 1994-10-25
IL104780A (en) 1998-10-30
JP3309104B2 (ja) 2002-07-29
WO1993016992A1 (en) 1993-09-02
TW224968B (ko) 1994-06-11
CA2130360C (en) 1998-06-09
ZA931035B (en) 1993-09-17
NZ249032A (en) 1996-09-25
ES2115756T3 (es) 1998-07-01
CA2130360A1 (en) 1993-08-21
JPH07504190A (ja) 1995-05-11
MX9300836A (es) 1993-09-01

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