JPH07504190A - ウイルス病治療用のスルホン酸誘導体類 - Google Patents
ウイルス病治療用のスルホン酸誘導体類Info
- Publication number
- JPH07504190A JPH07504190A JP5514843A JP51484393A JPH07504190A JP H07504190 A JPH07504190 A JP H07504190A JP 5514843 A JP5514843 A JP 5514843A JP 51484393 A JP51484393 A JP 51484393A JP H07504190 A JPH07504190 A JP H07504190A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- amino
- bis
- salt
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/41—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
- C07C309/42—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C327/42—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
- C07C329/02—Monothiocarbonic acids; Derivatives thereof
- C07C329/04—Esters of monothiocarbonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
- C07C329/12—Dithiocarbonic acids; Derivatives thereof
- C07C329/14—Esters of dithiocarbonic acids
- C07C329/20—Esters of dithiocarbonic acids having sulfur atoms of dithiocarbonic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/08—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/14—Dithiocarbamic acids; Derivatives thereof
- C07C333/18—Esters of dithiocarbamic acids
- C07C333/24—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (28)
- 1.式 ▲数式、化学式、表等があります▼(I)〔式中 Bは−C=CH−(シス又はトランス)、−CH2CH2−又は結合であり; XはNH又は酸素であり; Yは酸素又は硫黄であり; ZはNH、CH2、酸素、又は硫黄であり;R1は水素、C1−C4アルキル、 −CH2−Ar、又は−Arであって、ここでArはフェニル又はナフチル基で あり、フェニル又はナフチル基はC1−C4アルキル又はSO3M3基で置換さ れることもでき、 M1、M2、及びM3は各々独立に水素又は製薬上受入れられる陽イオンである 。〕の化合物。
- 2.Bが−C=C−基である、請求項第1項の化合物。
- 3.XとZが各々独立にNHであり、Yが硫黄である、特許請求の範囲第1項の 化合物。
- 4.R1がm−フェニルスルホネート又はp−フェニルスルホネートである、特 許請求の範囲第1項の化合物。
- 5.M1とM2が各々独立に水素又はナトリウム陽イオンである、特許請求の範 囲第1項の化合物。
- 6.化合物が2,2′−(1,2−エテンジイル)ビス[5−[[(4−スルホ フェニル)アミノ〕チオキソメチル〕アミノ]ベンゼンスルホン酸四ナトリウム 塩である、特許請求の範囲第1項の化合物。
- 7.化合物が2,2′−(1,2−エテンジイル)ビス[6−[[(4−スルホ フェニル)アミノ]チオキソメチル]アミノ]ベンゼンスルホン酸四ナトリウム 塩である、特許請求の範囲第1項の化合物。
- 8.化合物が2,2′−(1,2−エテンジイル)ビス[5−[[(3−スルホ フェニル)アミノ]チオキソメチル]アミノ]ベンゼンスルホン酸四ナトリウム 塩である、特許請求の範囲第1項の化合物。
- 9.化合物が2,2′−(1,2−エタンジイル)ビス[5−[[(4−スルホ フェニル)アミノ〕チオキソメチル〕アミノ〕ベンゼンスルホン酸四ナトリウム 塩である、特許請求の範囲第1項の化合物。
- 10.化合物が2,2′−(1,2−エテンジイル)ビス[5−[メチルカルボ ニル]アミノ]ベンゼンスルホン酸ニナトリウム塩である、特許請求の範囲第1 項の化合物。
- 11.化合物が2,2′−(1,2−エタンジイル)ピス[5−[[(4−メチ ルフェニル)アミノ]チオキソメチル]アミノ]ベンゼンスルホン酸ニナトリウ ム塩である、特許請求の範囲第1項の化合物。
- 12.化合物が2.2′−(1,2−エテンジイル)ビス[5−〔[(4−メチ ルフェニル)アミノ]チオキソメチル]アミノ]ベンゼンスルホン酸ニナトリウ ム塩である、特許請求の範囲第1項の化合物。
- 13.処置を必要とする患者のウイルス感染の処置用薬剤としての、特許請求の 範囲第1−12項のいずれか一に記載の化合物の用途。
- 14.薬剤としての特許請求の範囲第1−12項のいずれか一に記載の化合物の 用途。
- 15.不活性担体と混合した特許請求の範囲第1−12項のいずれか一に記載の 化合物を含めてなる組成物。
- 16.上記の不活性担体が製薬担体である、特許請求の範囲第15項に記載の組 成物。
- 17.宿主となる可能性のある細胞中でのHIV、HSV、及びCMVから選ば れるウイルスによる感染を防止する方法であって、該細胞の表面を、式▲数式、 化学式、表等があります▼I 〔式中 Bは−C=CH−(シス又はトランス)、−CH2CH2−又は結合であり; XはNH又は酸素であり; Yは酸素又は硫黄であり; ZはNH、CH2、酸素、又は硫黄であり;R1は水素、C1−C4アルキル、 −CH2−Ar、又は−Arであって、ここでArはフェニル又はナフチル基で あり、フェニル又はナフチル基はC1−C4アルキル又はSO3M3基で置換さ れることもでき、 M1、M2、及びM3は各々独立に水素又は製薬上受入れられる陽イオンである 。〕の化合物と接触させることからなる方法。
- 18.Bが−C=C−基である、特許請求の範囲第17項の方法。
- 19.XとZが各々独立にNHであり、Yが硫黄である、特許請求の範囲第17 項の方法。
- 20.R1がm−フェニルスルホネート又はp−フェニルスルホネートである、 特許請求の範囲第17項の方法。
- 21.M1とM2が各々独立に水素又はナトリウム陽イオンである、特許請求の 範囲第17項の方法。
- 22.化合物が2,2′−(1,2−エテンジイル)ビス[5−〔[(4−スル ホフェニル)アミノ]チオキソメチル〕アミノ]ベンゼンスルホン酸四ナトリウ ム塩である、特許請求の範囲第17項の化合物方法。
- 23.化合物が2,2′−(1,2−エデンジイル)ビス[6−[[(4−スル ホフェニル)アミノ〕チオキソメチル]アミノ]ベンゼンスルホン酸四ナトリウ ム塩である、特許請求の範囲第17項の化合物。
- 24.化合物が2,2′−(1,2−エテンジイル)ビス[5−[〔(3−スル ホフェニル)アミノ]チオキソメチル]アミノ]ベンゼンスルホン酸四ナトリウ ム塩である、特許請求の範囲第17項の化合物。
- 25.化合物が2,2′−(1,2−エタンジイル)ビス[5−〔〔(4−スル ホフェニル)アミノ]チオキソメチル]アミノ]ベンゼンスルホン酸四ナトリウ ム塩である、特許請求の範囲第17項の化合物。
- 26.化合物が2,2′−(1,2−エテンジイル)ビス[5−[メチルカルボ ニル]アミノ]ベンゼンスルホン酸ニナトリウム塩である、特許請求の範囲第1 7項の化合物。
- 27.化合物が2,2′−(1,2−エタンジイル)ビス[5−[[(4−メチ ルフェニル)アミノ〕チオキソメチル〕アミノ]ベンゼンスルホン酸ニナトリウ ム塩である、特許請求の範囲第17項の化合物。
- 28.化合物が2,2′−(1,2−エテンジイル)ビス〔5−〔〔(4−メチ ルフェニル)アミノ]チオキソメチル〕アミノ]ベンゼンスルホン酸二ナトリウ ム塩である、特許請求の範囲第17項の化合物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83863992A | 1992-02-20 | 1992-02-20 | |
US838,639 | 1992-02-20 | ||
PCT/US1993/000564 WO1993016992A1 (en) | 1992-02-20 | 1993-01-22 | Sulfonic acid derivatives in the treatment of viral diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH07504190A true JPH07504190A (ja) | 1995-05-11 |
JP3309104B2 JP3309104B2 (ja) | 2002-07-29 |
Family
ID=25277670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51484393A Expired - Lifetime JP3309104B2 (ja) | 1992-02-20 | 1993-01-22 | ウイルス病治療用のスルホン酸誘導体類 |
Country Status (15)
Country | Link |
---|---|
US (1) | US5359131A (ja) |
EP (1) | EP0626945B1 (ja) |
JP (1) | JP3309104B2 (ja) |
KR (1) | KR100275843B1 (ja) |
AT (1) | ATE165345T1 (ja) |
AU (1) | AU663925B2 (ja) |
CA (1) | CA2130360C (ja) |
DE (1) | DE69318136T2 (ja) |
ES (1) | ES2115756T3 (ja) |
IL (1) | IL104780A (ja) |
MX (1) | MX9300836A (ja) |
NZ (1) | NZ249032A (ja) |
TW (1) | TW224968B (ja) |
WO (1) | WO1993016992A1 (ja) |
ZA (1) | ZA931035B (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5276182A (en) * | 1990-07-09 | 1994-01-04 | The Dow Chemical Company | Process for preparing polyurea oligomers |
US5670144A (en) * | 1990-07-09 | 1997-09-23 | Merrell Pharmaceuticals Inc. | Anti-herpes virus and cytomegalovirus polyester oligomers |
US5424063A (en) * | 1992-01-09 | 1995-06-13 | The Dow Chemical Company | Narrow poly- and mono-dispersed anionic oligomers, and their uses, formulations and process |
IL112174A (en) * | 1994-01-03 | 1999-05-09 | Merrell Dow Pharma | Oligomers of polythioureas pharmaceutical compositions containing them and a process for their preparation |
US5681832A (en) * | 1995-02-17 | 1997-10-28 | The United States Of America As Represented By The Department Of Health And Human Services | Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity |
WO1996025157A1 (en) | 1995-02-17 | 1996-08-22 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
NZ501172A (en) * | 1995-12-15 | 2000-04-28 | Cyropreservation Technologies | Composition for organ cryopreservation comprising substituted amides |
US5852015A (en) * | 1997-01-27 | 1998-12-22 | American Cyanamid Company | Triazine containing anionic compounds useful as antiviral agents |
CN1163401A (zh) * | 1996-02-13 | 1997-10-29 | 李占元 | 全自动血球计数仪试剂及配制方法 |
US6211373B1 (en) | 1996-03-20 | 2001-04-03 | Smithkline Beecham Corporation | Phenyl urea antagonists of the IL-8 receptor |
US6262113B1 (en) | 1996-03-20 | 2001-07-17 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
AU3499497A (en) | 1996-06-27 | 1998-01-14 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
TR199802694T2 (xx) * | 1996-06-27 | 1999-03-22 | Smithkline Beecham Corporation | IL-8 resept�r kar��tlar� |
ZA984649B (en) * | 1997-06-13 | 1999-12-17 | Cryopreservation Tech Cc | "Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes". |
GB9928418D0 (en) * | 1999-12-01 | 2000-01-26 | Novartis Ag | Organic compounds |
WO2002062769A2 (en) | 2001-02-02 | 2002-08-15 | Wyeth | Preparation and purification of antiviral disulfonic acid disodium salt |
CA2551566A1 (en) * | 2004-02-04 | 2005-08-18 | Active Biotech Ab | Diurea derivatives |
US8377934B2 (en) * | 2006-06-27 | 2013-02-19 | State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization | Use of stilbene derivatives for treatment and prevention of aquatic mold infections |
US8552067B2 (en) * | 2006-12-22 | 2013-10-08 | The Regents Of The University Of California | Macromolecular conjugates of cystic fibrosis transmembrane conductance regulator protein inhibitors and uses therefor |
WO2010148177A2 (en) * | 2009-06-17 | 2010-12-23 | The Board Of Trustees Of The Leland Stanford Junior University | Compounds, compositions, methods of synthesis, and methods of treatment |
TW201702218A (zh) * | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
JP2022514195A (ja) * | 2018-11-22 | 2022-02-10 | ユニバーシテ デ ナンテス | 増殖性疾患の処置で使用するためのジスルホナートスチルベン |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD39717A (ja) * | ||||
US2676982A (en) * | 1951-06-08 | 1954-04-27 | Gen Aniline & Film Corp | Fluorescent agents |
BE660945A (ja) * | 1964-03-12 | 1965-07-01 | ||
US4107202A (en) * | 1977-03-28 | 1978-08-15 | American Cyanamid Company | Substituted 4,4'-biphenylylene bis(2-thioureylene)di-naphthalenetrisulfonic acids and salts thereof |
US4328244A (en) * | 1980-05-21 | 1982-05-04 | The Dow Chemical Company | Novel (((substituted-phenyl)methyl)amino)benzenesulfonic acids and pharmaceutically-acceptable salts thereof |
US4349568A (en) * | 1980-06-12 | 1982-09-14 | The Dow Chemical Company | Sulfur-substituted diphenyl ethers having antiviral activity |
US4435394A (en) * | 1981-12-17 | 1984-03-06 | Shionogi & Co., Ltd. | 3-Sulfonamido-benzophenonimine derivatives useful for treating virus infections |
DE3528992A1 (de) * | 1985-08-13 | 1987-02-26 | Barthell Eduard | Sulfonamidderivate, verfahren zu ihrer herstellung und verwendung |
DE3600046A1 (de) * | 1985-08-13 | 1987-07-09 | Barthell Eduard | Sulfonamidderivate, verfahren zu ihrer herstellung und verwendung |
DE3530718A1 (de) * | 1985-08-28 | 1987-03-12 | Madaus & Co Dr | Methylendioxyphenanthren- und -stilbenderivate, verfahren zur herstellung derselben und arzneimittel, die diese enthalten |
EP0221021B1 (en) * | 1985-10-16 | 1989-11-08 | Ciba-Geigy Ag | Bechamp reduction of dns to das using h2so4 and trace of hoac |
DE3626309A1 (de) * | 1986-08-02 | 1988-02-18 | Stockhausen Chem Fab Gmbh | Antivirusmittel |
US5276182A (en) * | 1990-07-09 | 1994-01-04 | The Dow Chemical Company | Process for preparing polyurea oligomers |
ATE116637T1 (de) * | 1991-02-05 | 1995-01-15 | Merrell Dow Pharma | Sulfonische stilbenderivate zur behandlung von viruserkrankungen. |
-
1993
- 1993-01-22 AT AT93903629T patent/ATE165345T1/de active
- 1993-01-22 WO PCT/US1993/000564 patent/WO1993016992A1/en active IP Right Grant
- 1993-01-22 KR KR1019940702899A patent/KR100275843B1/ko not_active IP Right Cessation
- 1993-01-22 ES ES93903629T patent/ES2115756T3/es not_active Expired - Lifetime
- 1993-01-22 CA CA002130360A patent/CA2130360C/en not_active Expired - Lifetime
- 1993-01-22 DE DE69318136T patent/DE69318136T2/de not_active Expired - Lifetime
- 1993-01-22 JP JP51484393A patent/JP3309104B2/ja not_active Expired - Lifetime
- 1993-01-22 EP EP93903629A patent/EP0626945B1/en not_active Expired - Lifetime
- 1993-01-22 AU AU34818/93A patent/AU663925B2/en not_active Expired
- 1993-01-22 NZ NZ249032A patent/NZ249032A/en unknown
- 1993-02-15 ZA ZA931035A patent/ZA931035B/xx unknown
- 1993-02-16 TW TW082101064A patent/TW224968B/zh active
- 1993-02-17 MX MX9300836A patent/MX9300836A/es not_active IP Right Cessation
- 1993-02-18 IL IL10478093A patent/IL104780A/en not_active IP Right Cessation
- 1993-08-13 US US08/106,311 patent/US5359131A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0626945A1 (en) | 1994-12-07 |
AU663925B2 (en) | 1995-10-26 |
ATE165345T1 (de) | 1998-05-15 |
CA2130360C (en) | 1998-06-09 |
ZA931035B (en) | 1993-09-17 |
KR100275843B1 (ko) | 2000-12-15 |
IL104780A (en) | 1998-10-30 |
NZ249032A (en) | 1996-09-25 |
DE69318136T2 (de) | 1998-10-22 |
US5359131A (en) | 1994-10-25 |
EP0626945B1 (en) | 1998-04-22 |
JP3309104B2 (ja) | 2002-07-29 |
ES2115756T3 (es) | 1998-07-01 |
WO1993016992A1 (en) | 1993-09-02 |
MX9300836A (es) | 1993-09-01 |
DE69318136D1 (de) | 1998-05-28 |
KR950700245A (ko) | 1995-01-16 |
CA2130360A1 (en) | 1993-08-21 |
TW224968B (ja) | 1994-06-11 |
IL104780A0 (en) | 1993-06-10 |
AU3481893A (en) | 1993-09-13 |
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