KR100273937B1 - 4,13-디옥사바이사이클로[8.2.1]트리데세논 유도체와 그의 제조방법 및 이 화합물이 함유된 약학조성물 - Google Patents

4,13-디옥사바이사이클로[8.2.1]트리데세논 유도체와 그의 제조방법 및 이 화합물이 함유된 약학조성물 Download PDF

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Publication number
KR100273937B1
KR100273937B1 KR1019920026335A KR920026335A KR100273937B1 KR 100273937 B1 KR100273937 B1 KR 100273937B1 KR 1019920026335 A KR1019920026335 A KR 1019920026335A KR 920026335 A KR920026335 A KR 920026335A KR 100273937 B1 KR100273937 B1 KR 100273937B1
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South Korea
Prior art keywords
formula
compound
methyl
dioxabicyclo
alkylation
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KR1019920026335A
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English (en)
Korean (ko)
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KR930016436A (ko
Inventor
횔테다그마
프레우스코프울프
에크호우트크리스티안
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독토르 디터 라우어
솔베이 파머슈티컬스 게엠베하
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Publication of KR930016436A publication Critical patent/KR930016436A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019920026335A 1992-01-07 1992-12-28 4,13-디옥사바이사이클로[8.2.1]트리데세논 유도체와 그의 제조방법 및 이 화합물이 함유된 약학조성물 Expired - Fee Related KR100273937B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4200145A DE4200145A1 (de) 1992-01-07 1992-01-07 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DEP4200145.5 1992-01-07

Publications (2)

Publication Number Publication Date
KR930016436A KR930016436A (ko) 1993-08-26
KR100273937B1 true KR100273937B1 (ko) 2000-12-15

Family

ID=6449136

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920026335A Expired - Fee Related KR100273937B1 (ko) 1992-01-07 1992-12-28 4,13-디옥사바이사이클로[8.2.1]트리데세논 유도체와 그의 제조방법 및 이 화합물이 함유된 약학조성물

Country Status (27)

Country Link
US (1) US5418224A (https=)
EP (1) EP0550895B1 (https=)
JP (1) JP3300084B2 (https=)
KR (1) KR100273937B1 (https=)
CN (1) CN1033646C (https=)
AT (1) ATE155478T1 (https=)
AU (1) AU667699B2 (https=)
CA (1) CA2086811C (https=)
CZ (1) CZ281773B6 (https=)
DE (2) DE4200145A1 (https=)
DK (1) DK0550895T3 (https=)
DZ (1) DZ1652A1 (https=)
ES (1) ES2104808T3 (https=)
FI (1) FI106862B (https=)
GR (1) GR3024859T3 (https=)
HU (2) HU212272B (https=)
IL (1) IL104158A (https=)
LT (1) LT3015B (https=)
LV (1) LV10458B (https=)
MX (1) MX9300045A (https=)
NO (1) NO179586C (https=)
PH (1) PH30098A (https=)
RU (1) RU2107070C1 (https=)
SK (1) SK279251B6 (https=)
TW (1) TW238308B (https=)
UA (1) UA29393C2 (https=)
ZA (1) ZA9339B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69637097T2 (de) * 1995-10-13 2007-09-20 Neurosearch A/S 8-Azabicyclo(3.2.1)Oct-2-en-Derivate, deren Herstellung und Anwendung
US6077943A (en) * 1996-03-01 2000-06-20 Takeda Chemical Industries, Ltd. Method of producing erythromycin derivative
CA2247929A1 (en) * 1996-03-01 1997-09-04 Miichiro Arita Processes for the preparation of erythromycin derivatives
DE19644195A1 (de) * 1996-10-24 1998-04-30 Solvay Pharm Gmbh 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19805822B4 (de) * 1998-02-13 2009-02-05 Solvay Pharmaceuticals Gmbh 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6165985A (en) * 1998-02-13 2000-12-26 Solvay Pharmaceuticals Gmbh 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
HRP980496B1 (en) * 1998-09-10 2007-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. New thilozine hydroxy derivatives and a process for the preparation thereof
ATE321770T1 (de) * 2000-08-17 2006-04-15 Kitasato Inst Pseudoerythromycin-derivate
CN100358912C (zh) * 2000-09-01 2008-01-02 中外制药株式会社 红霉素衍生物的制备方法
EP1392679B1 (de) * 2001-05-10 2005-11-02 Solvay Pharmaceuticals GmbH Neue 1-amidomethylcarbonyl-piperidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US20040067896A1 (en) * 2002-07-25 2004-04-08 The Kitasato Institute Novel pseudoerythromycin derivatives
DK1633774T3 (da) 2003-06-18 2010-05-25 Tranzyme Pharma Inc Makrocykliske motilinreceptorantagonister
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
JP2009518396A (ja) * 2005-12-08 2009-05-07 ファイザー・インク エリスロマイシン化合物の３’−ジメチルアミノ基を脱メチルする方法
EP2431380A3 (en) 2006-09-11 2013-07-03 Tranzyme Pharma, Inc. Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders
CA2670482C (en) * 2006-12-05 2011-10-11 Pfizer Inc. Motilide polymorphs
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
TWI662967B (zh) * 2013-03-25 2019-06-21 日商志瑞亞新藥工業股份有限公司 食後期之胃運動亢進劑

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725385A (en) * 1970-11-02 1973-04-03 Abbott Lab Process for the demethylation of 3-amino macrolides
EP0349100A2 (en) * 1988-04-18 1990-01-03 Eli Lilly And Company Macrolide compositions for treating gastro-intestinal motility disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1321581C (en) * 1987-05-26 1993-08-24 Herbert A. Kirst Ring-contracted macrolides
US5106961A (en) * 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725385A (en) * 1970-11-02 1973-04-03 Abbott Lab Process for the demethylation of 3-amino macrolides
EP0349100A2 (en) * 1988-04-18 1990-01-03 Eli Lilly And Company Macrolide compositions for treating gastro-intestinal motility disorders

Also Published As

Publication number Publication date
US5418224A (en) 1995-05-23
ATE155478T1 (de) 1997-08-15
EP0550895B1 (de) 1997-07-16
HU210216A9 (en) 1995-02-28
CA2086811C (en) 2003-12-09
PH30098A (en) 1996-12-27
FI930051L (fi) 1993-07-08
ES2104808T3 (es) 1997-10-16
RU2107070C1 (ru) 1998-03-20
LT3015B (lt) 1994-08-25
KR930016436A (ko) 1993-08-26
NO179586B (no) 1996-07-29
CN1075320A (zh) 1993-08-18
LTIP187A (lt) 1994-03-25
FI106862B (fi) 2001-04-30
LV10458B (en) 1996-02-20
TW238308B (https=) 1995-01-11
ZA9339B (en) 1993-08-05
JP3300084B2 (ja) 2002-07-08
AU3103693A (en) 1993-07-08
FI930051A0 (fi) 1993-01-07
SK279251B6 (sk) 1998-08-05
IL104158A (en) 1997-07-13
CN1033646C (zh) 1996-12-25
NO179586C (no) 1996-11-06
HUT66234A (en) 1994-10-28
GR3024859T3 (en) 1998-01-30
HU212272B (en) 1996-04-29
JPH07247299A (ja) 1995-09-26
DE59208710D1 (de) 1997-08-21
NO930029L (no) 1993-07-08
DK0550895T3 (da) 1997-08-25
HU9204076D0 (en) 1993-04-28
UA29393C2 (uk) 2000-11-15
HK1014003A1 (en) 1999-09-17
NO930029D0 (no) 1993-01-06
CA2086811A1 (en) 1993-07-08
CZ281773B6 (cs) 1997-01-15
EP0550895A1 (de) 1993-07-14
SK341492A3 (en) 1995-05-10
LV10458A (lv) 1995-02-20
CZ341492A3 (en) 1993-07-14
DZ1652A1 (fr) 2002-02-17
AU667699B2 (en) 1996-04-04
DE4200145A1 (de) 1993-07-08
MX9300045A (es) 1993-12-01
IL104158A0 (en) 1993-05-13

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