KR100270977B1 - 호흡기의 천식과 염증치료에 유용한 1,4-이치환된 피페라진 - Google Patents

호흡기의 천식과 염증치료에 유용한 1,4-이치환된 피페라진 Download PDF

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Publication number
KR100270977B1
KR100270977B1 KR1019950701200A KR19950701200A KR100270977B1 KR 100270977 B1 KR100270977 B1 KR 100270977B1 KR 1019950701200 A KR1019950701200 A KR 1019950701200A KR 19950701200 A KR19950701200 A KR 19950701200A KR 100270977 B1 KR100270977 B1 KR 100270977B1
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KR
South Korea
Prior art keywords
bis
pyrrolidin
compound
piperazine
carbonyl
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Expired - Fee Related
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KR1019950701200A
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English (en)
Korean (ko)
Inventor
지오르지오 롱
실바노 스피넬리
앤토넬라 로지
시모네타 달로
리시아 갈리코
Original Assignee
프리돌린 클라우스너, 롤란드 비. 보레르
에프. 호프만-라 로슈 아게
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Application granted granted Critical
Publication of KR100270977B1 publication Critical patent/KR100270977B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019950701200A 1992-09-30 1993-08-24 호흡기의 천식과 염증치료에 유용한 1,4-이치환된 피페라진 Expired - Fee Related KR100270977B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI922263A IT1255704B (it) 1992-09-30 1992-09-30 Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree
ITMI92A002263 1992-09-30
PCT/EP1993/002264 WO1994007856A1 (en) 1992-09-30 1993-08-24 1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract

Publications (1)

Publication Number Publication Date
KR100270977B1 true KR100270977B1 (ko) 2000-11-01

Family

ID=11364040

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950701200A Expired - Fee Related KR100270977B1 (ko) 1992-09-30 1993-08-24 호흡기의 천식과 염증치료에 유용한 1,4-이치환된 피페라진

Country Status (15)

Country Link
US (1) US5607930A (enExample)
EP (1) EP0662957B1 (enExample)
JP (1) JP3268524B2 (enExample)
KR (1) KR100270977B1 (enExample)
CN (1) CN1043141C (enExample)
AT (1) ATE159937T1 (enExample)
AU (1) AU680626B2 (enExample)
CA (1) CA2145775C (enExample)
DE (1) DE69315085T2 (enExample)
ES (1) ES2111175T3 (enExample)
IT (1) IT1255704B (enExample)
RU (1) RU2119913C1 (enExample)
TW (1) TW238305B (enExample)
WO (1) WO1994007856A1 (enExample)
ZA (1) ZA937147B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601697D0 (en) * 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
TW527355B (en) * 1997-07-02 2003-04-11 Bristol Myers Squibb Co Inhibitors of farnesyl protein transferase
JP2000256396A (ja) * 1999-03-03 2000-09-19 Dainippon Pharmaceut Co Ltd 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6809093B2 (en) * 2000-10-17 2004-10-26 H. Lee Moffitt Cancer & Research Institute, Inc. 2-substituted heterocyclic compounds
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
OA12670A (en) * 2001-10-22 2006-06-20 Pfizer Prod Inc Piperazine derivatives with ccr1 receptor antagonist activity.
AR051093A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa desaturasa
AR051090A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
MX2007003332A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
JP5149009B2 (ja) 2004-09-20 2013-02-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体
MX2007003325A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa.
EP1830837B1 (en) 2004-09-20 2013-09-04 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
EP2029138A1 (en) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
JP5411867B2 (ja) * 2007-10-11 2014-02-12 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 新規ｓＥＨ阻害剤およびそれらの使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0788357B2 (ja) * 1986-10-27 1995-09-27 吉富製薬株式会社 ピペラジン化合物
FR2663026B1 (fr) * 1990-06-07 1992-08-07 Synthelabo Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique.
CA2093797C (en) * 1990-10-10 1998-09-22 Richard J. Friary Substituted imidazobenzazepines and imidazopyridoazepines
IT1245712B (it) * 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
JPH08291987A (ja) * 1995-04-20 1996-11-05 Hitachi Ltd 冷蔵庫

Also Published As

Publication number Publication date
RU2119913C1 (ru) 1998-10-10
ATE159937T1 (de) 1997-11-15
CN1043141C (zh) 1999-04-28
JP3268524B2 (ja) 2002-03-25
CN1088580A (zh) 1994-06-29
RU95112577A (ru) 1997-01-10
IT1255704B (it) 1995-11-10
EP0662957B1 (en) 1997-11-05
ITMI922263A1 (it) 1994-03-30
JPH08501573A (ja) 1996-02-20
TW238305B (enExample) 1995-01-11
DE69315085D1 (de) 1997-12-11
ITMI922263A0 (it) 1992-09-30
CA2145775A1 (en) 1994-04-14
AU680626B2 (en) 1997-08-07
WO1994007856A1 (en) 1994-04-14
DE69315085T2 (de) 1998-03-26
EP0662957A1 (en) 1995-07-19
CA2145775C (en) 2002-10-08
AU4951893A (en) 1994-04-26
ZA937147B (en) 1994-05-18
US5607930A (en) 1997-03-04
ES2111175T3 (es) 1998-03-01

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