CN1043141C - 杂环胺化合物,其制备方法、含它们的药物组合物及其医药用途 - Google Patents

杂环胺化合物,其制备方法、含它们的药物组合物及其医药用途 Download PDF

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Publication number
CN1043141C
CN1043141C CN93118154A CN93118154A CN1043141C CN 1043141 C CN1043141 C CN 1043141C CN 93118154 A CN93118154 A CN 93118154A CN 93118154 A CN93118154 A CN 93118154A CN 1043141 C CN1043141 C CN 1043141C
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CN
China
Prior art keywords
tetramethyleneimine
compound
piperazine
carbonyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN93118154A
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English (en)
Chinese (zh)
Other versions
CN1088580A (zh
Inventor
G·朗
S·斯皮内利
A·罗兹
S·德·阿洛
L·加利科
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
Boehringer Mannheim Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia SpA filed Critical Boehringer Mannheim Italia SpA
Publication of CN1088580A publication Critical patent/CN1088580A/zh
Application granted granted Critical
Publication of CN1043141C publication Critical patent/CN1043141C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN93118154A 1992-09-30 1993-09-27 杂环胺化合物,其制备方法、含它们的药物组合物及其医药用途 Expired - Fee Related CN1043141C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI922263A IT1255704B (it) 1992-09-30 1992-09-30 Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree
ITMI92A002263 1992-09-30

Publications (2)

Publication Number Publication Date
CN1088580A CN1088580A (zh) 1994-06-29
CN1043141C true CN1043141C (zh) 1999-04-28

Family

ID=11364040

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93118154A Expired - Fee Related CN1043141C (zh) 1992-09-30 1993-09-27 杂环胺化合物,其制备方法、含它们的药物组合物及其医药用途

Country Status (15)

Country Link
US (1) US5607930A (enExample)
EP (1) EP0662957B1 (enExample)
JP (1) JP3268524B2 (enExample)
KR (1) KR100270977B1 (enExample)
CN (1) CN1043141C (enExample)
AT (1) ATE159937T1 (enExample)
AU (1) AU680626B2 (enExample)
CA (1) CA2145775C (enExample)
DE (1) DE69315085T2 (enExample)
ES (1) ES2111175T3 (enExample)
IT (1) IT1255704B (enExample)
RU (1) RU2119913C1 (enExample)
TW (1) TW238305B (enExample)
WO (1) WO1994007856A1 (enExample)
ZA (1) ZA937147B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601697D0 (en) * 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
TW527355B (en) * 1997-07-02 2003-04-11 Bristol Myers Squibb Co Inhibitors of farnesyl protein transferase
JP2000256396A (ja) * 1999-03-03 2000-09-19 Dainippon Pharmaceut Co Ltd 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
US6809093B2 (en) 2000-10-17 2004-10-26 H. Lee Moffitt Cancer & Research Institute, Inc. 2-substituted heterocyclic compounds
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
EP1438298B1 (en) * 2001-10-22 2010-01-27 Pfizer Products Inc. Piperazine derivatives with ccr1 receptor antagonist activity
CA2580856A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP2289510A1 (en) 2004-09-20 2011-03-02 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
EP2316458A1 (en) 2004-09-20 2011-05-04 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
EP1804799B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP1799667B1 (en) 2004-09-20 2013-03-20 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
US7767677B2 (en) 2004-09-20 2010-08-03 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
US7951805B2 (en) 2004-09-20 2011-05-31 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
EP2029138A1 (en) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
JP5411867B2 (ja) * 2007-10-11 2014-02-12 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 新規ｓＥＨ阻害剤およびそれらの使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0788357B2 (ja) * 1986-10-27 1995-09-27 吉富製薬株式会社 ピペラジン化合物
FR2663026B1 (fr) * 1990-06-07 1992-08-07 Synthelabo Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique.
EP0552292B1 (en) * 1990-10-10 1995-06-21 Schering Corporation Substituted imidazobenzazepines and imidazopyridoazepines
IT1245712B (it) * 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
JPH08291987A (ja) * 1995-04-20 1996-11-05 Hitachi Ltd 冷蔵庫

Also Published As

Publication number Publication date
US5607930A (en) 1997-03-04
AU680626B2 (en) 1997-08-07
CA2145775C (en) 2002-10-08
RU95112577A (ru) 1997-01-10
JPH08501573A (ja) 1996-02-20
ES2111175T3 (es) 1998-03-01
EP0662957B1 (en) 1997-11-05
JP3268524B2 (ja) 2002-03-25
ZA937147B (en) 1994-05-18
CA2145775A1 (en) 1994-04-14
RU2119913C1 (ru) 1998-10-10
ITMI922263A0 (it) 1992-09-30
IT1255704B (it) 1995-11-10
DE69315085D1 (de) 1997-12-11
TW238305B (enExample) 1995-01-11
AU4951893A (en) 1994-04-26
CN1088580A (zh) 1994-06-29
ITMI922263A1 (it) 1994-03-30
EP0662957A1 (en) 1995-07-19
DE69315085T2 (de) 1998-03-26
ATE159937T1 (de) 1997-11-15
KR100270977B1 (ko) 2000-11-01
WO1994007856A1 (en) 1994-04-14

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C14 Grant of patent or utility model
GR01 Patent grant
C53 Correction of patent of invention or patent application
COR Change of bibliographic data

Free format text: CORRECT: PATENTEE; FROM: BOEHRINGER MANNHEIM ITALIA S.P.A. TO: FUEL HA FUMAN-LALUOQI LTD.

CP03 Change of name, title or address

Address after: Basel

Patentee after: F. Hoffmann-La Roche AG

Address before: Milan Italy

Patentee before: Boehringer Mannheim Italia S. P. A.

C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee