DE69315085T2 - 1,4-disubstituierte piperazine zur behandlung von asthma und entzündungen der atemwege - Google Patents

1,4-disubstituierte piperazine zur behandlung von asthma und entzündungen der atemwege

Info

Publication number
DE69315085T2
DE69315085T2 DE69315085T DE69315085T DE69315085T2 DE 69315085 T2 DE69315085 T2 DE 69315085T2 DE 69315085 T DE69315085 T DE 69315085T DE 69315085 T DE69315085 T DE 69315085T DE 69315085 T2 DE69315085 T2 DE 69315085T2
Authority
DE
Germany
Prior art keywords
asthma
inflammation
treatment
pct
airway
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69315085T
Other languages
English (en)
Other versions
DE69315085D1 (de
Inventor
Giorgio Long
Silvano Spinelli
Antonella Rozzi
Alo' Simonetta D
Licia Gallico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
Roche Diagnostics SpA
Boehringer Mannheim Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics SpA, Boehringer Mannheim Italia SpA filed Critical Roche Diagnostics SpA
Application granted granted Critical
Publication of DE69315085D1 publication Critical patent/DE69315085D1/de
Publication of DE69315085T2 publication Critical patent/DE69315085T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69315085T 1992-09-30 1993-08-24 1,4-disubstituierte piperazine zur behandlung von asthma und entzündungen der atemwege Expired - Fee Related DE69315085T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI922263A IT1255704B (it) 1992-09-30 1992-09-30 Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree
PCT/EP1993/002264 WO1994007856A1 (en) 1992-09-30 1993-08-24 1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract

Publications (2)

Publication Number Publication Date
DE69315085D1 DE69315085D1 (de) 1997-12-11
DE69315085T2 true DE69315085T2 (de) 1998-03-26

Family

ID=11364040

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69315085T Expired - Fee Related DE69315085T2 (de) 1992-09-30 1993-08-24 1,4-disubstituierte piperazine zur behandlung von asthma und entzündungen der atemwege

Country Status (15)

Country Link
US (1) US5607930A (de)
EP (1) EP0662957B1 (de)
JP (1) JP3268524B2 (de)
KR (1) KR100270977B1 (de)
CN (1) CN1043141C (de)
AT (1) ATE159937T1 (de)
AU (1) AU680626B2 (de)
CA (1) CA2145775C (de)
DE (1) DE69315085T2 (de)
ES (1) ES2111175T3 (de)
IT (1) IT1255704B (de)
RU (1) RU2119913C1 (de)
TW (1) TW238305B (de)
WO (1) WO1994007856A1 (de)
ZA (1) ZA937147B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601697D0 (en) * 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
US6809093B2 (en) * 2000-10-17 2004-10-26 H. Lee Moffitt Cancer & Research Institute, Inc. 2-substituted heterocyclic compounds
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
DK1438298T3 (da) * 2001-10-22 2010-04-12 Pfizer Prod Inc Piperazin-derivater med CCR1 receptor-antagonist-aktivitet
TW200626138A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
AR051092A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa
CA2580787A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
CN101083992A (zh) 2004-09-20 2007-12-05 泽农医药公司 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
EP2269610A3 (de) 2004-09-20 2011-03-09 Xenon Pharmaceuticals Inc. Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren
MX2007003327A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
CA2618646A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
WO2009049165A1 (en) * 2007-10-11 2009-04-16 Smithkline Beecham Corporation Novel seh inhibitors and their use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931443A (en) * 1986-10-27 1990-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Piperazine compound and pharmaceutical use thereof
FR2663026B1 (fr) * 1990-06-07 1992-08-07 Synthelabo Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique.
IT1245712B (it) * 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
JPH08291987A (ja) * 1995-04-20 1996-11-05 Hitachi Ltd 冷蔵庫

Also Published As

Publication number Publication date
CA2145775A1 (en) 1994-04-14
CN1043141C (zh) 1999-04-28
AU680626B2 (en) 1997-08-07
TW238305B (de) 1995-01-11
ATE159937T1 (de) 1997-11-15
ES2111175T3 (es) 1998-03-01
JPH08501573A (ja) 1996-02-20
WO1994007856A1 (en) 1994-04-14
KR100270977B1 (ko) 2000-11-01
ITMI922263A1 (it) 1994-03-30
ZA937147B (en) 1994-05-18
RU95112577A (ru) 1997-01-10
JP3268524B2 (ja) 2002-03-25
EP0662957B1 (de) 1997-11-05
US5607930A (en) 1997-03-04
DE69315085D1 (de) 1997-12-11
ITMI922263A0 (it) 1992-09-30
CA2145775C (en) 2002-10-08
EP0662957A1 (de) 1995-07-19
IT1255704B (it) 1995-11-10
RU2119913C1 (ru) 1998-10-10
CN1088580A (zh) 1994-06-29
AU4951893A (en) 1994-04-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: VOSSIUS & PARTNER, 81675 MUENCHEN

8339 Ceased/non-payment of the annual fee