ES2111175T3 - Piperazinas 1,4-disustituidas utiles en el tratamiento del asma y de inflamaciones de las vias respiratorias. - Google Patents

Piperazinas 1,4-disustituidas utiles en el tratamiento del asma y de inflamaciones de las vias respiratorias.

Info

Publication number
ES2111175T3
ES2111175T3 ES93919147T ES93919147T ES2111175T3 ES 2111175 T3 ES2111175 T3 ES 2111175T3 ES 93919147 T ES93919147 T ES 93919147T ES 93919147 T ES93919147 T ES 93919147T ES 2111175 T3 ES2111175 T3 ES 2111175T3
Authority
ES
Spain
Prior art keywords
disstituted
piperazines
asthma
inflammation
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93919147T
Other languages
English (en)
Inventor
Giorgio Long
Silvano Spinelli
Antonella Rozzi
Alo' Simonetta D
Licia Gallico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics SpA
Original Assignee
Boehringer Mannheim Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia SpA filed Critical Boehringer Mannheim Italia SpA
Application granted granted Critical
Publication of ES2111175T3 publication Critical patent/ES2111175T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBEN UNOS COMPONENTES DE FORMULA GENERAL (I) EN LA QUE RA, RB, B Y D TIENEN LOS SIGNIFICADOS EXPRESADOS EN LA INVENCION; Y UNOS PROCESOS PARA SU PREPARACION. LOS COMPONENTES DE LA INVENCION TIENEN ACTIVIDADES ANTIASMATICAS Y ANTIINFLAMATORIAS EN LA ZONA RESPIRATORIA.
ES93919147T 1992-09-30 1993-08-24 Piperazinas 1,4-disustituidas utiles en el tratamiento del asma y de inflamaciones de las vias respiratorias. Expired - Lifetime ES2111175T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI922263A IT1255704B (it) 1992-09-30 1992-09-30 Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree

Publications (1)

Publication Number Publication Date
ES2111175T3 true ES2111175T3 (es) 1998-03-01

Family

ID=11364040

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93919147T Expired - Lifetime ES2111175T3 (es) 1992-09-30 1993-08-24 Piperazinas 1,4-disustituidas utiles en el tratamiento del asma y de inflamaciones de las vias respiratorias.

Country Status (15)

Country Link
US (1) US5607930A (es)
EP (1) EP0662957B1 (es)
JP (1) JP3268524B2 (es)
KR (1) KR100270977B1 (es)
CN (1) CN1043141C (es)
AT (1) ATE159937T1 (es)
AU (1) AU680626B2 (es)
CA (1) CA2145775C (es)
DE (1) DE69315085T2 (es)
ES (1) ES2111175T3 (es)
IT (1) IT1255704B (es)
RU (1) RU2119913C1 (es)
TW (1) TW238305B (es)
WO (1) WO1994007856A1 (es)
ZA (1) ZA937147B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601697D0 (en) * 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6809093B2 (en) 2000-10-17 2004-10-26 H. Lee Moffitt Cancer & Research Institute, Inc. 2-substituted heterocyclic compounds
ES2337241T3 (es) * 2001-10-22 2010-04-22 Pfizer Products Inc. Derivados de piperazina con actividad antagonista de receptores ccr1.
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
MX2007003325A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa.
AU2005286793A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
CA2580856A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP1804799B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AU2005286731A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
US7777036B2 (en) 2004-09-20 2010-08-17 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
EP2029138A1 (en) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
WO2009049165A1 (en) * 2007-10-11 2009-04-16 Smithkline Beecham Corporation Novel seh inhibitors and their use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931443A (en) * 1986-10-27 1990-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Piperazine compound and pharmaceutical use thereof
FR2663026B1 (fr) * 1990-06-07 1992-08-07 Synthelabo Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique.
IT1245712B (it) * 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
JPH08291987A (ja) * 1995-04-20 1996-11-05 Hitachi Ltd 冷蔵庫

Also Published As

Publication number Publication date
RU2119913C1 (ru) 1998-10-10
US5607930A (en) 1997-03-04
EP0662957B1 (en) 1997-11-05
CN1088580A (zh) 1994-06-29
CA2145775C (en) 2002-10-08
RU95112577A (ru) 1997-01-10
WO1994007856A1 (en) 1994-04-14
EP0662957A1 (en) 1995-07-19
IT1255704B (it) 1995-11-10
DE69315085D1 (de) 1997-12-11
ATE159937T1 (de) 1997-11-15
AU680626B2 (en) 1997-08-07
JP3268524B2 (ja) 2002-03-25
JPH08501573A (ja) 1996-02-20
DE69315085T2 (de) 1998-03-26
TW238305B (es) 1995-01-11
ITMI922263A0 (it) 1992-09-30
CA2145775A1 (en) 1994-04-14
CN1043141C (zh) 1999-04-28
AU4951893A (en) 1994-04-26
ITMI922263A1 (it) 1994-03-30
KR100270977B1 (ko) 2000-11-01
ZA937147B (en) 1994-05-18

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