ATE159937T1 - 1,4-disubstituierte piperazine zur behandlung von asthma und entzündungen der atemwege - Google Patents

1,4-disubstituierte piperazine zur behandlung von asthma und entzündungen der atemwege

Info

Publication number
ATE159937T1
ATE159937T1 AT93919147T AT93919147T ATE159937T1 AT E159937 T1 ATE159937 T1 AT E159937T1 AT 93919147 T AT93919147 T AT 93919147T AT 93919147 T AT93919147 T AT 93919147T AT E159937 T1 ATE159937 T1 AT E159937T1
Authority
AT
Austria
Prior art keywords
asthma
treatment
pct
respiratory inflammation
disubstituted piperazine
Prior art date
Application number
AT93919147T
Other languages
English (en)
Inventor
Giorgio Long
Silvano Spinelli
Antonella Rozzi
Alo' Simonetta D
Licia Gallico
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Application granted granted Critical
Publication of ATE159937T1 publication Critical patent/ATE159937T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT93919147T 1992-09-30 1993-08-24 1,4-disubstituierte piperazine zur behandlung von asthma und entzündungen der atemwege ATE159937T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI922263A IT1255704B (it) 1992-09-30 1992-09-30 Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree

Publications (1)

Publication Number Publication Date
ATE159937T1 true ATE159937T1 (de) 1997-11-15

Family

ID=11364040

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93919147T ATE159937T1 (de) 1992-09-30 1993-08-24 1,4-disubstituierte piperazine zur behandlung von asthma und entzündungen der atemwege

Country Status (15)

Country Link
US (1) US5607930A (de)
EP (1) EP0662957B1 (de)
JP (1) JP3268524B2 (de)
KR (1) KR100270977B1 (de)
CN (1) CN1043141C (de)
AT (1) ATE159937T1 (de)
AU (1) AU680626B2 (de)
CA (1) CA2145775C (de)
DE (1) DE69315085T2 (de)
ES (1) ES2111175T3 (de)
IT (1) IT1255704B (de)
RU (1) RU2119913C1 (de)
TW (1) TW238305B (de)
WO (1) WO1994007856A1 (de)
ZA (1) ZA937147B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601697D0 (en) * 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
US6809093B2 (en) * 2000-10-17 2004-10-26 H. Lee Moffitt Cancer & Research Institute, Inc. 2-substituted heterocyclic compounds
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
DK1438298T3 (da) * 2001-10-22 2010-04-12 Pfizer Prod Inc Piperazin-derivater med CCR1 receptor-antagonist-aktivitet
TW200626138A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
AR051092A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa
CA2580787A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
CN101083992A (zh) 2004-09-20 2007-12-05 泽农医药公司 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
EP2269610A3 (de) 2004-09-20 2011-03-09 Xenon Pharmaceuticals Inc. Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren
MX2007003327A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
CA2618646A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
WO2009049165A1 (en) * 2007-10-11 2009-04-16 Smithkline Beecham Corporation Novel seh inhibitors and their use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931443A (en) * 1986-10-27 1990-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Piperazine compound and pharmaceutical use thereof
FR2663026B1 (fr) * 1990-06-07 1992-08-07 Synthelabo Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique.
IT1245712B (it) * 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
JPH08291987A (ja) * 1995-04-20 1996-11-05 Hitachi Ltd 冷蔵庫

Also Published As

Publication number Publication date
CA2145775A1 (en) 1994-04-14
CN1043141C (zh) 1999-04-28
AU680626B2 (en) 1997-08-07
TW238305B (de) 1995-01-11
ES2111175T3 (es) 1998-03-01
JPH08501573A (ja) 1996-02-20
WO1994007856A1 (en) 1994-04-14
KR100270977B1 (ko) 2000-11-01
ITMI922263A1 (it) 1994-03-30
ZA937147B (en) 1994-05-18
RU95112577A (ru) 1997-01-10
JP3268524B2 (ja) 2002-03-25
EP0662957B1 (de) 1997-11-05
US5607930A (en) 1997-03-04
DE69315085T2 (de) 1998-03-26
DE69315085D1 (de) 1997-12-11
ITMI922263A0 (it) 1992-09-30
CA2145775C (en) 2002-10-08
EP0662957A1 (de) 1995-07-19
IT1255704B (it) 1995-11-10
RU2119913C1 (ru) 1998-10-10
CN1088580A (zh) 1994-06-29
AU4951893A (en) 1994-04-26

Similar Documents

Publication Publication Date Title
DE59409312D1 (de) Imidazopyridine und ihre anwendung zur behandlung von magen-darm krankheiten
ATE167470T1 (de) Heterocyclische amine zur therapie von asthma und entzündungen der atemwege
DE69428791T2 (de) Verwendung vonModafinil zur Behandlung von Atemstillstand im Schlaf und zentral erregten Atembeschwerden
FI972628A (fi) Uudet sulfonamidit
DE69317578D1 (de) Verwendung von riluzole zur behandlung von traumatischen neurologischen-schädigungen
BG103399A (en) New heterocycle-substituted benzamides and their application for the treatment of diseases
PL333429A1 (en) Benzonaphtyridines useful in particular in treating bronchial diseases
ATE159937T1 (de) 1,4-disubstituierte piperazine zur behandlung von asthma und entzündungen der atemwege
FI973221A0 (fi) 1-aryyli-2-asyyliammo-etaaniyhdisteitä ja niiden käyttö neurokiniiniantagonisteina, erityisesti neurokiniini 1 antagonisteina
DE69328193D1 (de) Verwendung von prodelphidinen zur behandlung von arthrose
ES2094545T3 (es) Derivados n-substituidos del 3-azabiciclo(3.2.0)heptano, como neurolepticos etc..
DE59409813D1 (de) Imidazolochinoxalinone zur behandlung zentralnervöser erkrankungen
DK0673377T3 (da) Nye triazoloquinazoliner, fremstilling og anvendelse deraf
DE69413554T2 (de) IMIDAZO [1,5-a] CHINOLINE ZUR BEHANDLUNG VON ANGSTZUSTÄNDEN UND SCHLAFSTÖRUNGEN
ATE177637T1 (de) Triazolochinazoline zur behandlung zentralnervöser erkrankungen
DE69329252D1 (de) Verwendung von piperazinderivaten zur behandlung von kognitiven erkrankungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee