ATE167470T1 - Heterocyclische amine zur therapie von asthma und entzündungen der atemwege - Google Patents
Heterocyclische amine zur therapie von asthma und entzündungen der atemwegeInfo
- Publication number
- ATE167470T1 ATE167470T1 AT92907564T AT92907564T ATE167470T1 AT E167470 T1 ATE167470 T1 AT E167470T1 AT 92907564 T AT92907564 T AT 92907564T AT 92907564 T AT92907564 T AT 92907564T AT E167470 T1 ATE167470 T1 AT E167470T1
- Authority
- AT
- Austria
- Prior art keywords
- respiratory tract
- asthma
- inflammation
- therapy
- pct
- Prior art date
Links
- 208000006673 asthma Diseases 0.000 title abstract 2
- 210000002345 respiratory system Anatomy 0.000 title abstract 2
- 206010061218 Inflammation Diseases 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI910966A IT1245712B (it) | 1991-04-09 | 1991-04-09 | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE167470T1 true ATE167470T1 (de) | 1998-07-15 |
Family
ID=11359495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92907564T ATE167470T1 (de) | 1991-04-09 | 1992-04-01 | Heterocyclische amine zur therapie von asthma und entzündungen der atemwege |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5453423A (de) |
| EP (1) | EP0580633B1 (de) |
| JP (1) | JP3218037B2 (de) |
| KR (1) | KR100239168B1 (de) |
| AT (1) | ATE167470T1 (de) |
| AU (1) | AU653393B2 (de) |
| CA (1) | CA2107115A1 (de) |
| DE (1) | DE69225967T2 (de) |
| HU (2) | HUT69702A (de) |
| IE (1) | IE921117A1 (de) |
| IT (1) | IT1245712B (de) |
| MX (1) | MX9201621A (de) |
| NO (1) | NO180165C (de) |
| NZ (1) | NZ242282A (de) |
| PH (1) | PH30438A (de) |
| PT (1) | PT100352B (de) |
| RU (1) | RU2108325C1 (de) |
| TW (1) | TW212178B (de) |
| WO (1) | WO1992018478A1 (de) |
| ZA (1) | ZA922541B (de) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1255704B (it) * | 1992-09-30 | 1995-11-10 | Boehringer Mannheim Italia | Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
| US7056935B2 (en) | 1995-06-07 | 2006-06-06 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
| GB9516709D0 (en) * | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
| US5801197A (en) * | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
| AU1608397A (en) | 1996-02-02 | 1997-08-22 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| PL331599A1 (en) * | 1996-08-14 | 1999-08-02 | Zeneca Ltd | Substituted derivatives of pyrimidine and their pharmaceutical application |
| NZ334389A (en) * | 1996-08-28 | 2001-05-25 | Ube Industries | Cyclic amine derivatives |
| US6218424B1 (en) | 1996-09-25 | 2001-04-17 | Gpi Nil Holdings, Inc. | Heterocyclic ketone and thioester compounds and uses |
| US5786378A (en) * | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
| US5801187A (en) | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
| UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| ATE242774T1 (de) | 1997-02-13 | 2003-06-15 | Astrazeneca Ab | Heterozyklische verbindungen die als oxido- squalen-zyklase-inhibitoren anwendung finden |
| AU5999698A (en) | 1997-02-13 | 1998-09-08 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
| US6187796B1 (en) | 1998-06-03 | 2001-02-13 | Gpi Nil Holdings, Inc. | Sulfone hair growth compositions and uses |
| US6271244B1 (en) | 1998-06-03 | 2001-08-07 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses |
| US6274602B1 (en) | 1998-06-03 | 2001-08-14 | Gpi Nil Holdings, Inc. | Heterocyclic thioester and ketone hair growth compositions and uses |
| US20010049381A1 (en) | 1997-06-04 | 2001-12-06 | Gpl Nil Holdings, Inc., | Pyrrolidine derivative hair growth compositions and uses |
| US6187784B1 (en) | 1998-06-03 | 2001-02-13 | Gpi Nil Holdings, Inc. | Pipecolic acid derivative hair growth compositions and uses |
| US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
| GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| US6172087B1 (en) | 1998-06-03 | 2001-01-09 | Gpi Nil Holding, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
| US6429215B1 (en) | 1998-06-03 | 2002-08-06 | Gpi Nil Holdings, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
| CA2334204A1 (en) | 1998-06-03 | 1999-12-09 | Gpi Nil Holdings, Inc. | Heterocyclic ester and amide hair growth compositions and uses |
| US6339101B1 (en) | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
| US6218423B1 (en) | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
| US6506788B1 (en) | 1998-08-14 | 2003-01-14 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders |
| US7338976B1 (en) | 1998-08-14 | 2008-03-04 | Gpi Nil Holdings, Inc. | Heterocyclic esters or amides for vision and memory disorders |
| US6335348B1 (en) | 1998-08-14 | 2002-01-01 | Gpi Nil Holdings, Inc. | Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders |
| US6376517B1 (en) | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
| US6333340B1 (en) | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
| US6399648B1 (en) | 1998-08-14 | 2002-06-04 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
| US6395758B1 (en) | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
| US6337340B1 (en) | 1998-08-14 | 2002-01-08 | Gpi Nil Holdings, Inc. | Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders |
| US6384056B1 (en) | 1998-08-14 | 2002-05-07 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters or ketones for vision and memory disorders |
| US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
| RU2202539C2 (ru) * | 1998-11-10 | 2003-04-20 | Ф.Хоффманн-Ля Рош Аг | Производные n-(4-карбамимидофенил)глицинамида, промежуточные соединения, способ получения и фармкомпозиция |
| GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
| JP2000256396A (ja) * | 1999-03-03 | 2000-09-19 | Dainippon Pharmaceut Co Ltd | 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤 |
| US6797820B2 (en) | 1999-12-17 | 2004-09-28 | Vicuron Pharmaceuticals Inc. | Succinate compounds, compositions and methods of use and preparation |
| US6809093B2 (en) | 2000-10-17 | 2004-10-26 | H. Lee Moffitt Cancer & Research Institute, Inc. | 2-substituted heterocyclic compounds |
| US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| PL204456B1 (pl) * | 2001-02-20 | 2010-01-29 | Chugai Pharmaceutical Co Ltd | Związki azolowe, ich zastosowanie i środek farmaceutyczny |
| EP1406893B1 (de) * | 2001-06-15 | 2007-04-18 | Vicuron Pharmaceuticals, Inc. | Bicyclische pyrrolidinverbindungen |
| AR036053A1 (es) * | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
| DE10228132A1 (de) * | 2002-06-24 | 2004-01-22 | Arzneimittelwerk Dresden Gmbh | Amide cyclischer Aminosäuren als PDE 4 Inhibitoren |
| EP1695961A4 (de) * | 2003-12-17 | 2007-10-24 | Takeda Pharmaceutical | Harnstoffderivative, verfahren zu deren herstellung und verwendung |
| US8071603B2 (en) | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
| CA2580855A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| AR051026A1 (es) | 2004-09-20 | 2006-12-13 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| WO2006034341A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| BRPI0515482A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| US8541457B2 (en) | 2005-06-03 | 2013-09-24 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors |
| EA201201081A1 (ru) * | 2010-02-05 | 2013-03-29 | Мерк Патент Гмбх | Производные гетарил[1,8]нафтиридина |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1216119B (it) * | 1988-03-17 | 1990-02-22 | Boehringer Biochemia Srl | Beta_carbonil_carbossiamidi di 1,3_tiazolidine. |
| EP0348541B1 (de) * | 1988-06-29 | 1992-04-01 | YASON S.r.l | N-Karbethoxy-4-thiazolin-karbonsäure, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| FR2663026B1 (fr) * | 1990-06-07 | 1992-08-07 | Synthelabo | Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique. |
| FR2669029B1 (fr) * | 1990-11-14 | 1994-09-02 | Adir | Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2680508B1 (fr) * | 1991-08-20 | 1995-03-03 | Adir | Nouveaux composes amidiques des 1-(alcoxybenzyl)piperazines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1991
- 1991-04-09 IT ITMI910966A patent/IT1245712B/it active IP Right Grant
-
1992
- 1992-03-31 PH PH44135A patent/PH30438A/en unknown
- 1992-04-01 CA CA002107115A patent/CA2107115A1/en not_active Abandoned
- 1992-04-01 RU RU93058261/04A patent/RU2108325C1/ru not_active IP Right Cessation
- 1992-04-01 AU AU14475/92A patent/AU653393B2/en not_active Ceased
- 1992-04-01 US US08/119,202 patent/US5453423A/en not_active Expired - Fee Related
- 1992-04-01 HU HU9302701A patent/HUT69702A/hu unknown
- 1992-04-01 JP JP50686392A patent/JP3218037B2/ja not_active Expired - Fee Related
- 1992-04-01 EP EP92907564A patent/EP0580633B1/de not_active Expired - Lifetime
- 1992-04-01 WO PCT/EP1992/000724 patent/WO1992018478A1/en not_active Ceased
- 1992-04-01 DE DE69225967T patent/DE69225967T2/de not_active Expired - Fee Related
- 1992-04-01 AT AT92907564T patent/ATE167470T1/de not_active IP Right Cessation
- 1992-04-07 PT PT100352A patent/PT100352B/pt not_active IP Right Cessation
- 1992-04-08 IE IE111792A patent/IE921117A1/en unknown
- 1992-04-08 MX MX9201621A patent/MX9201621A/es unknown
- 1992-04-08 NZ NZ242282A patent/NZ242282A/xx unknown
- 1992-04-08 ZA ZA922541A patent/ZA922541B/xx unknown
- 1992-04-11 TW TW081102834A patent/TW212178B/zh active
-
1993
- 1993-09-27 KR KR1019930702928A patent/KR100239168B1/ko not_active Expired - Fee Related
- 1993-10-08 NO NO933599A patent/NO180165C/no not_active IP Right Cessation
-
1995
- 1995-06-29 HU HU95P/P00590P patent/HU211968A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT100352A (pt) | 1993-07-30 |
| NO933599L (no) | 1993-11-12 |
| EP0580633B1 (de) | 1998-06-17 |
| KR100239168B1 (en) | 2000-02-01 |
| AU653393B2 (en) | 1994-09-29 |
| RU2108325C1 (ru) | 1998-04-10 |
| PH30438A (en) | 1997-05-09 |
| HU9302701D0 (en) | 1993-12-28 |
| ITMI910966A0 (it) | 1991-04-09 |
| HUT69702A (en) | 1995-09-28 |
| PT100352B (pt) | 1999-06-30 |
| EP0580633A1 (de) | 1994-02-02 |
| WO1992018478A1 (en) | 1992-10-29 |
| CA2107115A1 (en) | 1992-10-10 |
| IT1245712B (it) | 1994-10-14 |
| NO933599D0 (no) | 1993-10-08 |
| AU1447592A (en) | 1992-11-17 |
| MX9201621A (es) | 1992-10-01 |
| NO180165C (no) | 1997-02-26 |
| DE69225967D1 (de) | 1998-07-23 |
| ITMI910966A1 (it) | 1992-10-09 |
| TW212178B (de) | 1993-09-01 |
| US5453423A (en) | 1995-09-26 |
| NZ242282A (en) | 1993-07-27 |
| HU211968A9 (en) | 1996-01-29 |
| NO180165B (no) | 1996-11-18 |
| ZA922541B (en) | 1993-10-08 |
| JPH06506450A (ja) | 1994-07-21 |
| IE921117A1 (en) | 1992-10-21 |
| JP3218037B2 (ja) | 2001-10-15 |
| DE69225967T2 (de) | 1999-02-18 |
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