DE69315085T2 - 1,4-DISUBSTITUTED PIPERAZINE FOR THE TREATMENT OF ASTHMA AND INFLAMMATION OF THE AIRWAY - Google Patents

1,4-DISUBSTITUTED PIPERAZINE FOR THE TREATMENT OF ASTHMA AND INFLAMMATION OF THE AIRWAY

Info

Publication number
DE69315085T2
DE69315085T2 DE69315085T DE69315085T DE69315085T2 DE 69315085 T2 DE69315085 T2 DE 69315085T2 DE 69315085 T DE69315085 T DE 69315085T DE 69315085 T DE69315085 T DE 69315085T DE 69315085 T2 DE69315085 T2 DE 69315085T2
Authority
DE
Germany
Prior art keywords
asthma
inflammation
treatment
pct
airway
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69315085T
Other languages
German (de)
Other versions
DE69315085D1 (en
Inventor
Giorgio Long
Silvano Spinelli
Antonella Rozzi
Alo' Simonetta D
Licia Gallico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
Roche Diagnostics SpA
Boehringer Mannheim Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics SpA, Boehringer Mannheim Italia SpA filed Critical Roche Diagnostics SpA
Application granted granted Critical
Publication of DE69315085D1 publication Critical patent/DE69315085D1/en
Publication of DE69315085T2 publication Critical patent/DE69315085T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PCT No. PCT/EP93/02264 Sec. 371 Date Mar. 28, 1995 Sec. 102(e) Date Mar. 28, 1995 PCT Filed Aug. 24, 1993 PCT Pub. No. WO94/07856 PCT Pub. Date Apr. 14, 1994Compounds of formula (I): <IMAGE> (I) wherein Ra, Rb, B and D have the meanings reported in the disclosure, processes for making the same, and methods of using the same in the treatment of asthma and/or inflammation of the respiratory tract are disclosed.
DE69315085T 1992-09-30 1993-08-24 1,4-DISUBSTITUTED PIPERAZINE FOR THE TREATMENT OF ASTHMA AND INFLAMMATION OF THE AIRWAY Expired - Fee Related DE69315085T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI922263A IT1255704B (en) 1992-09-30 1992-09-30 HETEROCYCLIC AMINES USEFUL IN THERAPY OF ASTHMA AND AIRWAY INFLAMMATION
PCT/EP1993/002264 WO1994007856A1 (en) 1992-09-30 1993-08-24 1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract

Publications (2)

Publication Number Publication Date
DE69315085D1 DE69315085D1 (en) 1997-12-11
DE69315085T2 true DE69315085T2 (en) 1998-03-26

Family

ID=11364040

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69315085T Expired - Fee Related DE69315085T2 (en) 1992-09-30 1993-08-24 1,4-DISUBSTITUTED PIPERAZINE FOR THE TREATMENT OF ASTHMA AND INFLAMMATION OF THE AIRWAY

Country Status (15)

Country Link
US (1) US5607930A (en)
EP (1) EP0662957B1 (en)
JP (1) JP3268524B2 (en)
KR (1) KR100270977B1 (en)
CN (1) CN1043141C (en)
AT (1) ATE159937T1 (en)
AU (1) AU680626B2 (en)
CA (1) CA2145775C (en)
DE (1) DE69315085T2 (en)
ES (1) ES2111175T3 (en)
IT (1) IT1255704B (en)
RU (1) RU2119913C1 (en)
TW (1) TW238305B (en)
WO (1) WO1994007856A1 (en)
ZA (1) ZA937147B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601697D0 (en) * 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6809093B2 (en) 2000-10-17 2004-10-26 H. Lee Moffitt Cancer & Research Institute, Inc. 2-substituted heterocyclic compounds
CZ2004519A3 (en) * 2001-10-22 2004-12-15 Pfizer Products Inc. Piperazine derivatives exhibiting CCR1 receptor antagonist activity
CN101084212A (en) 2004-09-20 2007-12-05 泽农医药公司 Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
US7592343B2 (en) 2004-09-20 2009-09-22 Xenon Pharmaceuticals Inc. Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors
EP2316458A1 (en) 2004-09-20 2011-05-04 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
EP2289510A1 (en) 2004-09-20 2011-03-02 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
MX2007003321A (en) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents.
WO2006034440A2 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
CN101084207A (en) 2004-09-20 2007-12-05 泽农医药公司 Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
CN101208089A (en) 2005-06-03 2008-06-25 泽农医药公司 Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors
US8008483B2 (en) * 2007-10-11 2011-08-30 GlaxoSmithKline, LLC sEH inhibitors and their use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0788357B2 (en) * 1986-10-27 1995-09-27 吉富製薬株式会社 Piperazine compound
FR2663026B1 (en) * 1990-06-07 1992-08-07 Synthelabo DERIVATIVES OF [(1-ARYLPYRROLIDIN-2-YL) METHYL] PIPERAZINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
IT1245712B (en) * 1991-04-09 1994-10-14 Boehringer Mannheim Italia USEFUL HETEROCYCLIC AMINES THERAPY OF ASTHMA AND AIRWAY INFLAMMATION
JPH08291987A (en) * 1995-04-20 1996-11-05 Hitachi Ltd Refrigerator

Also Published As

Publication number Publication date
WO1994007856A1 (en) 1994-04-14
ATE159937T1 (en) 1997-11-15
RU2119913C1 (en) 1998-10-10
CN1088580A (en) 1994-06-29
AU4951893A (en) 1994-04-26
TW238305B (en) 1995-01-11
CA2145775A1 (en) 1994-04-14
EP0662957B1 (en) 1997-11-05
CN1043141C (en) 1999-04-28
US5607930A (en) 1997-03-04
ITMI922263A1 (en) 1994-03-30
DE69315085D1 (en) 1997-12-11
AU680626B2 (en) 1997-08-07
RU95112577A (en) 1997-01-10
ITMI922263A0 (en) 1992-09-30
JPH08501573A (en) 1996-02-20
EP0662957A1 (en) 1995-07-19
ES2111175T3 (en) 1998-03-01
ZA937147B (en) 1994-05-18
IT1255704B (en) 1995-11-10
KR100270977B1 (en) 2000-11-01
CA2145775C (en) 2002-10-08
JP3268524B2 (en) 2002-03-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: VOSSIUS & PARTNER, 81675 MUENCHEN

8339 Ceased/non-payment of the annual fee